专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO02059107A8 SUBSTITUTED PIPERIDINES/PIPERAZINES AS MELANOCORTIN RECEPTOR AGONISTS 审中-公开
标题翻译：作为MELANOCORTIN受体激动剂的替代哌啶/哌嗪
公开(公告)号：WO02059107A8
公开(公告)日：2003-11-06
申请号：PCT/US0200516
申请日：2002-01-23
申请人： LILLY CO ELI , BACKER RYAN THOMAS , BRINER KARIN , DOECKE CHRISTOPHER WILLIAM , FISHER MATTHEW JOSEPH , KUKLISH STEVEN LEE , MANCUSO VINCENT , MARTINELLI MICHAEL JOHN , MULLANEY JEFFREY THOMAS , XIE CHAOYU
发明人： BACKER RYAN THOMAS , BRINER KARIN , DOECKE CHRISTOPHER WILLIAM , FISHER MATTHEW JOSEPH , KUKLISH STEVEN LEE , MANCUSO VINCENT , MARTINELLI MICHAEL JOHN , MULLANEY JEFFREY THOMAS , XIE CHAOYU
IPC分类号： A61K31/4725 , A61K31/496 , A61K31/5377 , A61P3/04 , A61P3/10 , A61P15/00 , A61P15/10 , C07B61/00 , C07D209/44 , C07D217/26 , C07D401/12 , C07D401/14 , A61K31/44 , A61K31/495
CPC分类号： C07D401/12 , C07D209/44 , C07D217/26 , C07D401/14
摘要： The present invention relates to melanocortin receptor agonists of formula I, which is useful in the treatment of obesity, diabetes and male and/or female sexual dysfunction.
摘要翻译：本发明涉及式I的黑皮质素受体激动剂，其可用于治疗肥胖症，糖尿病和男性和/或女性性功能障碍。

2. 发明申请

WO02059108A8 MELANOCORTIN RECEPTOR AGONISTS 审中-公开
标题翻译：梅兰康汀受体激动剂
公开(公告)号：WO02059108A8
公开(公告)日：2003-11-06
申请号：PCT/US0200517
申请日：2002-01-23
申请人： LILLY CO ELI , BIGGERS CHRISTOPHER KELLY , BRINER KARIN , DOECKE CHRISTOPHER WILLIAM , FISHER MATTHEW JOSEPH , HERTEL LARRY WAYNE , MANCUSO VINCENT , MARTINELLI MICHAEL JOHN , MAYER JOHN PHILIP , ORNSTEIN PAUL LESLIE , RICHARDSON TIMOTHY IVO , SHAH JIKESH ARVIND , SHI QING , WU ZHIPEI , XIE CHAOYU
发明人： BIGGERS CHRISTOPHER KELLY , BRINER KARIN , DOECKE CHRISTOPHER WILLIAM , FISHER MATTHEW JOSEPH , HERTEL LARRY WAYNE , MANCUSO VINCENT , MARTINELLI MICHAEL JOHN , MAYER JOHN PHILIP , ORNSTEIN PAUL LESLIE , RICHARDSON TIMOTHY IVO , SHAH JIKESH ARVIND , SHI QING , WU ZHIPEI , XIE CHAOYU
IPC分类号： C07D217/12 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/5513 , A61K38/00 , A61K45/00 , A61K45/06 , A61P3/00 , A61P3/04 , A61P3/10 , A61P15/00 , A61P15/08 , A61P15/10 , A61P43/00 , C07B61/00 , C07D209/18 , C07D209/44 , C07D217/14 , C07D217/26 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12 , A61K31/495 , A61K31/535 , A61K31/55 , C07D403/14 , C07D409/14 , C07D413/14 , C07D417/14
CPC分类号： A61K45/06 , C07D209/44 , C07D217/14 , C07D217/26 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D417/12
摘要： The present invention relates to melanocortin receptor agonists of formula (I), which is useful in the treatment of obesity, diabetes and male and/or female sexual dysfunction.
摘要翻译：本发明涉及式（I）的黑皮质素受体激动剂，其可用于治疗肥胖症，糖尿病和男性和/或女性性功能障碍。

3. 发明申请

WO02059117A8 PIPERAZINE- AND PIPERIDINE-DERIVATIVES AS MELANOCORTIN RECEPTOR AGONISTS 审中-公开
标题翻译：哌拉西平和哌啶衍生物作为梅毒胆碱受体激动剂
公开(公告)号：WO02059117A8
公开(公告)日：2003-11-06
申请号：PCT/US0200515
申请日：2002-01-23
申请人： LILLY CO ELI , BRINER KARIN , DOECKE CHRISTOPHER WILLIAM , MANCUSO VINCENT , MARTINELLI MICHAEL JOHN , RICHARDSON TIMOTHY IVO , ROTHHAAR ROGER RYAN , SHI QING , XIE CHAOYU
发明人： BRINER KARIN , DOECKE CHRISTOPHER WILLIAM , MANCUSO VINCENT , MARTINELLI MICHAEL JOHN , RICHARDSON TIMOTHY IVO , ROTHHAAR ROGER RYAN , SHI QING , XIE CHAOYU
IPC分类号： C07D217/12 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/5513 , A61K38/00 , A61K45/00 , A61K45/06 , A61P3/00 , A61P3/04 , A61P3/10 , A61P15/00 , A61P15/08 , A61P15/10 , A61P43/00 , C07B61/00 , C07D209/18 , C07D209/44 , C07D217/14 , C07D217/26 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12 , C07D413/14 , A61K31/44 , A61K31/495
CPC分类号： A61K45/06 , C07D209/44 , C07D217/14 , C07D217/26 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D417/12
摘要： The present invention relates to melanocortin receptor agonists of formula I,which is useful in the treatment of obesity, diabetes and male and/or female sexual dysfunction.
摘要翻译：本发明涉及式I的黑皮质素受体激动剂，其可用于治疗肥胖症，糖尿病和男性和/或女性性功能障碍。

4. 发明专利

CA2433025A1 SUBSTITUTED PIPERIDINES/PIPERAZINES AS MELANOCORTIN RECEPTORAGONISTS 未知
公开(公告)号：CA2433025A1
公开(公告)日：2002-08-01
申请号：CA2433025
申请日：2002-01-23
申请人： LILLY CO ELI
发明人： XIE CHAOYU , BACKER RYAN THOMAS , FISHER MATTHEW JOSEPH , KUKLISH STEVEN LEE , MULLANEY JEFFREY THOMAS , MANCUSO VINCENT , MARTINELLI MICHAEL JOHN , BRINER KARIN , DOECKE CHRISTOPHER WILLIAM
IPC分类号： A61K31/4725 , A61K31/496 , A61K31/5377 , A61P3/04 , A61P3/10 , A61P15/00 , A61P15/10 , C07B61/00 , C07D209/44 , C07D217/26 , C07D401/12 , C07D401/14 , A61K31/44 , A61K31/495
摘要： The present invention relates to melanocortin receptor agonists of formula I , which is useful in the treatment of obesity, diabetes and male and/or female sexual dysfunction.

5. 发明专利

ES2247298T3 DERIVADOS DE PIPERAZINA Y PIPERIDINA COMO AGONISTAS DEL RECEPTOR DE MELANOCORTINA. 未知
公开(公告)号：ES2247298T3
公开(公告)日：2006-03-01
申请号：ES02701922
申请日：2002-01-23
申请人： LILLY CO ELI
发明人： BRINER KARIN , DOECKE CHRISTOPHER WILLIAM , MANCOSO VINCENT LILLY , MARTINELLI MICHAEL JOHN , RICHARDSON TIMOTHY IVO , ROTHHAAR ROGER RYAN
IPC分类号： C07D217/12 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/5513 , A61K38/00 , A61K45/00 , A61K45/06 , A61P3/00 , A61P3/04 , A61P3/10 , A61P15/00 , A61P15/08 , A61P15/10 , A61P43/00 , C07B61/00 , C07D209/18 , C07D209/44 , C07D217/14 , C07D217/26 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12 , C07D413/14 , A61K31/44 , A61K31/495
摘要： Un compuesto de fórmula I: o una sal o estereoisómero farmacéuticamente aceptable del mismo, en la que G es CR1 o N; A es alquilo C1-C8 o cicloalquilo C3-C7; L y L1 son independientemente: hidrógeno o juntos oxo. Los compuestos de la presente invención son útiles en la prevención o tratamiento de la obesidad o diabetes mellitus en un mamífero que comprende la administración de una cantidad terapéuticamente eficaz del compuesto de fórmula I. Los compuestos de la presente invención también son útiles en la prevención o tratamiento de la disfunción sexual masculina o femenina en mamíferos, más específicamente en la disfunción eréctil, comprendiendo la administración una cantidad terapéuticamente eficaz del compuesto de fórmula I. También dentro del alcance de la presente invención está una composición o formulación farmacéutica que comprende un vehículo farmacéutico y al menos un compuesto de fórmula I o sus sales farmacéuticamente aceptables o estereoisómeros del mismo.

6. 发明专利

NO20020193A 未知
公开(公告)号：NO20020193A
公开(公告)日：2002-03-14
申请号：NO20020193
申请日：2002-01-14
申请人： LILLY CO ELI
发明人： BELVO MATTHEW DAVID , CHEN SHU-HUI , DOECKE CHRISTOPHER WILLIAM , HELLMAN SARAH LYNNE , JAMISON JAMES ANDREW , PATTERSON LAWRENCE EDWARD , RODRIGUEZ LAWRENCE EDWARD , SUN XICHENG , TURNER WILLIAM WILSON , VASUDEVAN VENKATRAGHAVAN , ZWEIFEL MARK JAMES
IPC分类号： A61K38/00 , A61P31/10 , C07K7/06 , C07K
CPC分类号： C07K7/06 , A61K38/00

7. 发明专利

CO4930266A1 SINTESIS DE BENZO[F]QUINOLINAS 未知
公开(公告)号：CO4930266A1
公开(公告)日：2000-06-27
申请号：CO97063173
申请日：1997-10-28
申请人： LILLY CO ELI
发明人： BRENNAN JOHN , DOECKE CHRISTOPHER WILLIAM , CLARK HEATH PERRY , PATTERSON LAWRENCE EDWARD , UKO EFFIONG UDODONG
IPC分类号： C07D221/06 , A61K31/12 , A61K31/47 , A61K31/473 , A61P13/08 , A61P17/14 , C07C319/14 , C07C319/20 , C07C323/22 , C07C323/32 , C07D221/10 , C07D417/12
摘要： Un procedimiento para la preparación de un compuestode fórmula I en la que R1 representa:2-nitrofenilo, 4-nitrofenilo, 2-cianofenilo, 4-cianofenilo, 2-nitronaftilo, 4-nitronaftilo, 2-cianonaftilo, 4-cianonaftilo, 2-quinolinilo, 4-quinolinilo, 7-quinolinilo, 1-isoquinolinilo, 3-isoquinolinilo, 8-isoquinolinilo, 2-quinoxalinilo, 2-benzotiazolilo, 3-1H-indazolilo, 2-benzoxazolilo, 3-1,2-benzoisotiazolilo, 2-piridinilo, 4-piridinilo, 2-pirazinilo, 2-nafto[2.3-d]tiazolilo, 2-nafto[1.2-d]tiazolilo, 9-antrilo, 2-tiazolilo, 2-bencimidazolilo, 1-benzo[g]isoquinolinilo, 8-benzo[g]isoquinolinilo, 5-1H-tetrazolilo, 2-quinazolinilo, 2-tiazolo[4.5-b]piridinilo, 4-10H-piridazino[3.2-b]-2-quinazolinilo, 2-1,4-benzodioxinilo, 2-triazina, 2-benzoxazina,4-benzoxazina, 2-purina u 8-purina; en la que los grupos R1 anteriores están no sustituidos, o sustituidos con 1-3 grupos elegidos entre el grupo formado por trifluorometilo, trifluoroetoxi, alquilo C1 -C4 , trifluorometoxi, hidroxi, alcoxi C1 -C3 , nitro, (alquilo C1 -C3 )tio, alcanoílo C1 -C6 , fenilo, oxo, fenoxi, feniltio, (alquilo C1 -C3 )sulfinilo, (alquilo C1 -C3 )sulfonilo, ciano, amino, (alquilo C1 -C3 )amino,difenilmetilamino, trifenilmetilamino, benciloxi, benciltio, (monohalógeno, nitro o CF3 )bencil(oxi o tio), di(alquilo C1 -C3 , cicloalquilo C3 -C6 o (cicloalquilo C4 -C8 ) alquil)amino, (mono(alquilo C1 -C3 ), alcoxi C1 -C3 o halógeno)(fenil, fenoxi,feniltio, fenilsulfonilo o fenoxisulfonilo), (alcanoílo C2 -C6 )amino, benzoilamino, difenilmetilamino(alquilo C1 -C3 ), aminocarbonilo, (alquilo C1 -C3 )aminocarbonilo, di(alquilo C1 -C3 )aminocarbonilo, halógeno-alcanoílo C1 -C6 , aminosulfonilo, (alquilo C1 -C3 )aminosulfonilo, di(alquilo C1 -C3 )aminosulfonilo, fenil(oxi o tio)(alquilo C1 -C3 ), (halógeno, alquilo C1 -C3 o alcoxi C1 -C3 )fenil(oxi o tio)(alquilo C1 -C3 ), benzoílo o (amino, (alquilo C1 -C3 )amino o di(alquilo C1 -C3 )amino)(alquilo C1 -C3 );...

8. 发明专利

BR9712711A 未知
公开(公告)号：BR9712711A
公开(公告)日：1999-10-26
申请号：BR9712711
申请日：1997-10-27
申请人： LILLY CO ELI
发明人： BRENNAN JOHN , DOECKE CHRISTOPHER WILLIAM , HEATH PERRY CLARK , PATTERSON LAWRENCE EDWARD , WEIGEL LELAND OTTO , UDODONG UKO EFFIONG
IPC分类号： C07D221/06 , A61K31/473 , A61P13/08 , A61P17/14 , C07C319/14 , C07C319/20 , C07C323/22 , C07C323/32 , C07D221/10 , C07D417/12 , C07C321/28 , C07D215/227 , A61K31/435
摘要： A process for preparing intermediates and benzoquinolin-3-one pharmaceuticals, of the following formula I: wherein R represents: 2-nitrophenyl, 4-nitrophenyl, 2-cyanophenyl, 4-cyanophenyl, 2-nitronaphthyl, 4-nitronaphthyl, 2-cyanonaphthyl, 4-cyanonaphthyl, 2-quinolinyl, 4-quinolinyl, 7-quinolinyl, 1-isoquinolinyl, 3-isoquinolinyl, 8-isoquinolinyl, 2-quinoxalinyl, 2-benzothiazolyl, 3-1H-indazolyl, 2-benzoxazolyl, 3-1,2-benzisothiazolyl, 2-pyridinyl, 4-pyridinyl, 2-pyrazinyl, 2-naphthoÄ2,3-dÜthiazolyl, 2-naphtoÄ1,2-dÜthiazolyl, 9-anthryl, 2-thiazolyl, 2-benzimidazolyl, 1-benzÄgÜisoquinolinyl, 8-benzÄgÜisoquinolinyl, 5-1H-tetrazolyl, 2-quinazolinyl, 2-thiazoloÄ4,5-bÜpyridinyl, 4-10H-pyridazinoÄ3,2-bÜ-2-quinazolinyl, 2-1,4-benzodioxinyl, 2-triazine, 2-benzoxazine, 4-benzoxazine, 2-purine or 8-purine. Such pharmaceuticals are effective in treating conditions consequent on 5 alpha -reductase.

9. 发明专利

ES2246390T3 DERIVADOS DE PIPERAZINA COMO AGONISTAS DEL RECEPTOR DE MELANOCORTINA. 未知
公开(公告)号：ES2246390T3
公开(公告)日：2006-02-16
申请号：ES02714719
申请日：2002-01-23
申请人： LILLY CO ELI
发明人： BIGGERS CHRISTOPHER KELLY , BRINER KARIN , DOECKE CHRISTOPHER WILLIAM , FISHER MATTHEW JOSEPH , HERTEL LARRY WAYNE , MANCUSO VINCENT
IPC分类号： C07D217/12 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/5513 , A61K38/00 , A61K45/00 , A61K45/06 , A61P3/00 , A61P3/04 , A61P3/10 , A61P15/00 , A61P15/08 , A61P15/10 , A61P43/00 , C07B61/00 , C07D209/18 , C07D209/44 , C07D217/14 , C07D217/26 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12 , A61K31/495 , A61K31/535 , A61K31/55 , C07D403/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： Un compuesto de **fórmula** o una sal o estereoisómero farmacéuticamente aceptables del mismo, en la que L y L1 son independientemente: hidrógeno o juntos oxo; T es: R es independientemente: hidrógeno, hidroxi, ciano, nitro, halo, alquilo C1-C8, alcoxi C1-C8, haloalquilo C1-C4, (D)C(O)R9, (D)C(O)OR9, (D)C(O)SR9, (D)C(O)heteroarilo, (D)C(O)heterociclilo, (D)C(O)N(R9)2, (D)N(R9)2, (D)NR9COR9, (D)NR9CON(R9)2, (D)NR9C(O)OR9, (D)NR9C(R9)=N(R9), (D)NR9C(=NR9)N(R9)2, (D)NR9SO2R9, (D)NR9SO2N(R9)2, (D)NR9(CH2)nheterociclilo, (D)NR9(CH2)nheteroarilo, (D)OR9, OSO2R9, (D)[O]q(cicloalquilo C3-C7), (D)[O]q(CH2)narilo, (D)[O]q(CH2)nheteroarilo, (D)[O]q(CH2)nheterociclilo, donde el heterociclilo excluye un heterociclilo que contiene un único nitrógeno cuando q=1, (D)SR9, (D)SOR9, (D)SO2R9 o (D)SO2N(R9)2.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式