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1. 发明授权

US3868358A Protamine-insulin product 失效
标题翻译：鱼精蛋白 - 胰岛素产品
公开(公告)号：US3868358A
公开(公告)日：1975-02-25
申请号：US33751173
申请日：1973-03-02
申请人： LILLY CO ELI
发明人： JACKSON RICHARD L
IPC分类号： C07C103/52 , A61K17/02 , C07G7/00
CPC分类号： A61K38/28
摘要： The invention relates to a combination of protamine with an insulin salt. The insulin salt is derived by crystallization of insulin in the presence of ions of an alkali metal or metalloid such as sodium, potassium, lithium, cesium or ammonium at an alkaline pH range. The protamine is present in an amount from about 0.2 to about 1.5 mg. of protamine for each 100 units of insulin. The insulin salt and protamine form an insoluble complex at a pH from 6.5 to 8 in an aqueous medium, which complex when dried is easily reconstituted without activity loss.
摘要翻译：本发明涉及鱼精蛋白与胰岛素盐的组合。胰岛素盐通过在碱性pH范围内在碱金属或准金属例如钠，钾，锂，铯或铵的离子存在下结晶而得到。鱼精蛋白以约0.2至约1.5mg的量存在。每100个胰岛素的鱼精蛋白。胰岛素盐和鱼精蛋白在水性介质中在6.5至8的pH下形成不溶性络合物，当干燥时复合物容易重构而没有活性损失。

4. 发明授权

US3875138A Process for recovering glucagon 失效
标题翻译：回收胰高血糖素的方法
公开(公告)号：US3875138A
公开(公告)日：1975-04-01
申请号：US40147273
申请日：1973-09-27
申请人： LILLY CO ELI
发明人： JACKSON RICHARD L
IPC分类号： C07K14/605 , C07C103/52 , A61K17/04 , C07G7/00
CPC分类号： C07K14/605
摘要： Glucagon is recovered by precipitating glucagon under acidic conditions from the insulin alkaline crystallization supernatant, converting the crude glucagon thus obtained to glucagon fibrils, and recrystallizing the glucagon fibrils.
摘要翻译：通过在酸性条件下从胰岛素碱性结晶上清液中沉淀胰高血糖素，将由此获得的粗制胰高血糖素转化为胰高血糖素原纤维，并重结晶胰高血糖素原纤维来回收胰高血糖素。

5. 发明专利

PT87265B 未知
公开(公告)号：PT87265B
公开(公告)日：1992-08-31
申请号：PT8726588
申请日：1988-04-18
申请人： LILLY CO ELI
发明人： JACKSON RICHARD L , MASSEY EDDIE HERMAN
IPC分类号： A61K38/28 , C07K1/02 , C07K1/14 , C07K14/62 , C07K7/00 , A61K38/00
摘要： Human proinsulin in crystalline form which comprises a salt of a complex of human proinsulin and divalent zinc ion, the cation of said salt being selected from the group consisting of lithium, calcium, sodium, potassium, ammonium, magnesium, and barium. The preparation comprises (a) preparing an aqueous mixture containing from about 5 to about 50 mg/ml human proinsulin, from about 0.1 to about 5 mg/ml of a phenolic substance, from about 0.03 to about 0.6 milliequivalents/ml of a salt of a cation selected from the group consisting of lithium, calcium, sodium, potassium, ammonium, magnesium, and barium, and from about 0.2 to about 5 milliequivalents of Zn cation; (b) adjusting the aqueous mixture to a pH in the range of from about 5.4 to about 6.5; (c) allowing crystal formation to occur; and (d) recovering crystalline human proinsulin from the aqueous mixture.

8. 发明专利

CS199576B2 METHOD FOR THE PURIFICATION OF INSULIN COMPLEX WITH ALKALINE METALS OR AMMONIUM IONS 未知
公开(公告)号：CS199576B2
公开(公告)日：1980-07-31
申请号：CS83375
申请日：1975-02-10
申请人： LILLY CO ELI
发明人： JACKSON RICHARD L
IPC分类号： B01D15/08 , A61K37/26

10. 发明专利

RO65297A 未知
公开(公告)号：RO65297A
公开(公告)日：1979-05-15
申请号：RO7948874
申请日：1974-07-15
申请人： LILLY CO ELI
发明人： JACKSON RICHARD L
IPC分类号： C07K14/62 , A61K38/28 , A61P5/00 , C07C231/00 , C07K14/575 , C07K14/625 , A61K37/26

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