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1. 发明申请

WO2005045413A1 A METHOD OF REDUCING INTERFERENCES IN AN ELECTROCHEMICAL SENSOR USING TWO DIFFERENT APPLIED POTENTIALS 审中-公开
标题翻译：使用两种不同应用电位降低电化学传感器干扰的方法
公开(公告)号：WO2005045413A1
公开(公告)日：2005-05-19
申请号：PCT/GB2004/004588
申请日：2004-10-29
申请人： LIFESCAN SCOTLAND LIMITED , DAVIES, Oliver, William, Hardwicke
发明人： DAVIES, Oliver, William, Hardwicke
IPC分类号： G01N27/327
CPC分类号： C12Q1/001 , A61B5/14532 , A61B5/1486 , A61B5/150022 , A61B5/150282 , A61B5/150358 , A61B5/150435 , A61B5/150503 , C12Q1/006 , G01N27/3274
摘要： The present invention is directed to a method of reducing the effects of interfering compounds in the measurement of analytes and more particularly to a method of reducing the effects of interfering compounds in a system wherein the test strip (600) utilizes two or more working electrodes (12, 14). In the present invention, a first potential (E1) is applied to a first working electrode (12) and a second potential (E2), having the same polarity but a greater magnitude than the first potential (E1), is applied to a second working electrode (14).
摘要翻译：本发明涉及一种降低干扰化合物在分析物测量中的作用的方法，更具体地说，涉及一种降低系统中干扰化合物的作用的方法，其中测试条（600）利用两个或多个工作电极 12,14）。在本发明中，将第一电位（E1）施加到第一工作电极（12），并且具有与第一电位（E1）相同的极性但大于数量的第二电位（E2）施加到第二电位工作电极（14）。

2. 发明申请

WO2005045414A1 ELECTROCHEMICAL TEST STRIP FOR REDUCING THE EFFECT OF DIRECT INTERFERENCE CURRENT 审中-公开
标题翻译：电化学测试条，用于减少直接干扰电流的影响
公开(公告)号：WO2005045414A1
公开(公告)日：2005-05-19
申请号：PCT/GB2004/004592
申请日：2004-10-29
申请人： LIFESCAN SCOTLAND LIMITED , DAVIES, Oliver, William, Hardwicke , MARSHALL, Robert , BASKEYFIELD, Damian, Edward, Haydon , WHYTE, Lynsey , LEIPER, Elaine
发明人： DAVIES, Oliver, William, Hardwicke , MARSHALL, Robert , BASKEYFIELD, Damian, Edward, Haydon , WHYTE, Lynsey , LEIPER, Elaine
IPC分类号： G01N27/327
CPC分类号： C12Q1/001 , A61B5/14532 , A61B5/1486 , A61B5/150022 , A61B5/150282 , A61B5/150358 , A61B5/150435 , A61B5/150503 , C12Q1/006 , G01N27/3274
摘要： This invention describes an electrochemical sensor which is adapted to reduce the effects of interfering compounds in bodily fluids when measuring an analyte in such fluids using an electrochemical strip (62). The sensor includes a substrate (50), a first and second working electrodes (10, 12), and a reference electrode (14). A reagent layer (22) is disposed on the electrodes such that, in one embodiment it completely covers all of the first working electrode (10), but only partially covers the second working electrode (12) and, in a second embodiment, it only covers a portion of the first and the second working electrode. The portion of the working electrodes not covered by the reagent layer and is used to correct for the interference effect on the analyte measurement.
摘要翻译：本发明描述了一种电化学传感器，其适于在使用电化学条（62）测量这种流体中的分析物时减少干扰化合物在体液中的影响。传感器包括基板（50），第一和第二工作电极（10,12）和参考电极（14）。试剂层（22）设置在电极上，使得在一个实施例中，它完全覆盖所有第一工作电极（10），但仅部分地覆盖第二工作电极（12），并且在第二实施例中仅覆盖第一和第二工作电极的一部分。工作电极的一部分未被试剂层覆盖，用于校正分析物测量的干扰效应。

3. 发明申请

WO2005045412A1 METHOD OF REDUCING THE EFFECT OF DIRECT INTERFERENCE CURRENT IN AN ELECTROCHEMICAL TEST STRIP 审中-公开
标题翻译：降低直接干扰电流在电化学测试条中的作用的方法
公开(公告)号：WO2005045412A1
公开(公告)日：2005-05-19
申请号：PCT/GB2004/004574
申请日：2004-10-29
申请人： LIFESCAN SCOTLAND LIMITED , DAVIES, Oliver, William, Hardwicke , MARSHALL, Robert , BASKEYFIELD, Damian, Edward, Haydon , WHYTE, Lynsey , LEIPER, Elaine
发明人： DAVIES, Oliver, William, Hardwicke , MARSHALL, Robert , BASKEYFIELD, Damian, Edward, Haydon , WHYTE, Lynsey , LEIPER, Elaine
IPC分类号： G01N27/327
CPC分类号： C12Q1/001 , A61B5/14532 , A61B5/1486 , A61B5/150022 , A61B5/150282 , A61B5/150358 , A61B5/150435 , A61B5/150503 , C12Q1/006 , G01N27/3274
摘要： This invention describes a method of reducing the effect of interfering compounds in a bodily fluid when measuring an analyte using an electrochemical sensor (62). In particular, the present method is applicable to electrochemical sensors where (62) the sensor includes a substrate (50), first and second working electrodes (10,12), and a reference electrode (14) and either the first and second or only the second working electrode include regions which are bare of reagent (22). In this invention, an algorithm is described with mathematically corrects for the interference effect using the test strip embodiments of the present invention.
摘要翻译：本发明描述了当使用电化学传感器（62）测量分析物时减少干扰化合物在体液中的影响的方法。特别地，本方法适用于电化学传感器，其中（62）传感器包括基底（50），第一和第二工作电极（10,12）以及参比电极（14），以及第一和第二或第二第二工作电极包括裸露的试剂（22）的区域。在本发明中，使用本发明的测试条实施例来描述使用数学校正干扰效应的算法。

4. 发明申请

WO2005045416A1 ELECTROCHEMICAL TEST STRIP FOR REDUCING THE EFFECT OF DIRECT AND MEDIATED INTERFERENCE CURRENT 审中-公开
标题翻译：电化学测试条，用于减少直接和介质干扰电流的影响
公开(公告)号：WO2005045416A1
公开(公告)日：2005-05-19
申请号：PCT/GB2004/004598
申请日：2004-10-29
申请人： LIFESCAN SCOTLAND LIMITED , DAVIES, Oliver, William, Hardwicke , MARSHALL, Robert , BASKEYFIELD, Damian, Edward, Haydon , WHYTE, Lynsey , LEIPER, Elaine
发明人： DAVIES, Oliver, William, Hardwicke , MARSHALL, Robert , BASKEYFIELD, Damian, Edward, Haydon , WHYTE, Lynsey , LEIPER, Elaine
IPC分类号： G01N27/327
CPC分类号： C12Q1/001 , A61B5/14532 , A61B5/1486 , A61B5/150022 , A61B5/150282 , A61B5/150358 , A61B5/150435 , A61B5/150503 , C12Q1/006 , G01N27/3274
摘要： The present invention is directed to an electrochemical sensor (800) or electrochemical strip which includes a substrate (50), a first working electrode (808) disposed on the substrate, a second working electrode (806) disposed on the substrate, a refèrence electrode (810), an active reagent layer (820) disposed on the first working electrode (808), wherein the active reagent layer (820) completely covers the first working electrode (808) and an inactive reagent layer (818) disposed on the second working electrode (806), wherein the inactive reagent (818) completely covers the second working electrode (806). The present invention is also, directed to an electrochemical sensor (1000) including a substrate (50), a first working electrode (100) disposed on the substrate, a second working electrode (102) disposed on the substrate, a reference electrode (104), an active reagent layer (820) disposed on the first working electrode (100), wherein the active reagent layer (820) completely covers the first working electrode (100), the second working electrode (102) having an active region (102a) and an inactive region (102i), the active reagent layer (820) disposed on a active region (102a) of the second working electrode (102) and an inactive reagent layer (818) disposed on the inactive region (102i) of the second working electrode (102).
摘要翻译：本发明涉及一种电化学传感器（800）或电化学条带，其包括基板（50），设置在基板上的第一工作电极（808），设置在基板上的第二工作电极（806），反射电极（810），设置在第一工作电极（808）上的活性试剂层（820），其中活性试剂层（820）完全覆盖第一工作电极（808）和设置在第二工作电极工作电极（806），其中所述非活性试剂（818）完全覆盖所述第二工作电极（806）。本发明还涉及一种电化学传感器（1000），其包括基板（50），设置在基板上的第一工作电极（100），设置在基板上的第二工作电极（102），参考电极），设置在第一工作电极（100）上的活性试剂层（820），其中活性试剂层（820）完全覆盖第一工作电极（100），第二工作电极（102）具有有源区（102a ）和非活性区域（102i），设置在第二工作电极（102）的有源区域（102a）上的活性试剂层（820）和设置在第二工作电极的非活性区域（108）上的无活性试剂层第二工作电极（102）。

5. 发明申请

WO2005045417A1 METHOD OF REDUCING THE EFFECT OF DIRECT AND MEDIATED INTERFERENCE CURRENT IN AN ELECTROCHEMICAL TEST STRIP 审中-公开
标题翻译：降低直接和介质干扰电流在电化学测试条中的影响的方法
公开(公告)号：WO2005045417A1
公开(公告)日：2005-05-19
申请号：PCT/GB2004/004599
申请日：2004-10-29
申请人： LIFESCAN SCOTLAND LIMITED , DAVIES, Oliver, William, Hardwicke , MARSHALL, Robert , BASKEYFIELD, Damian, Edward, Haydon , WHYTE, Lynsey , LEIPER, Elaine
发明人： DAVIES, Oliver, William, Hardwicke , MARSHALL, Robert , BASKEYFIELD, Damian, Edward, Haydon , WHYTE, Lynsey , LEIPER, Elaine
IPC分类号： G01N27/327
CPC分类号： C12Q1/001 , A61B5/14532 , A61B5/1486 , A61B5/150022 , A61B5/150282 , A61B5/150358 , A61B5/150435 , A61B5/150503 , C12Q1/006 , G01N27/3274
摘要： The present invention is directed to a method of reducing interference in an electrochemical sensor (800) wherein the method includes the step of measuring a first current at a first working electrode (808), the first working electrode (808) being covered by an active reagent layer (820), the step of measuring a second current at a second working electrode (806), the second working electrode (806) being covered by an inactive reagent layer (818) and the step of calculating a corrected current value representative of a glucose concentration using a ratio of an active area of the first working electrode (808) to an inactive area of the second working electrode (806). The present invention is further directed to a method of reducing interferences in an electrochemical sensor (1000) wherein the method includes the step of measuring a first current at a first working electrode (100), the first working electrode (100) being covered by an active reagent layer (820), the step of measuring a second current at a second working electrode (102), wherein the active reagent layer (820) is disposed on an active region (102a) of the second working electrode (102) and an inactive region (102i) of the second working electrode (102) is covered by an inactive reagent layer (818) and the step of calculating a corrected current value representative of a glucose concentration using a ratio of an active region on the first and second working electrodes and an inactive region on the second working electrode.
摘要翻译：本发明涉及减少电化学传感器（800）中的干扰的方法，其中该方法包括测量第一工作电极（808）处的第一电流的步骤，第一工作电极（808）由有源试剂层（820），在第二工作电极（806）测量第二电流的步骤，第二工作电极（806）被非活性试剂层（818）覆盖，并且计算代表使用第一工作电极（808）的有效面积与第二工作电极（806）的无效区域的比率的葡萄糖浓度。本发明还涉及减少电化学传感器（1000）中的干扰的方法，其中该方法包括测量第一工作电极（100）处的第一电流的步骤，第一工作电极（100）由活性试剂层（820），在第二工作电极（102）测量第二电流的步骤，其中活性试剂层（820）设置在第二工作电极（102）的有源区（102a）上，第二工作电极（102）的非活性区域（102i）被非活性试剂层（818）覆盖，并且使用第一和第二工作区域上的有效区域的比率来计算代表葡萄糖浓度的校正电流值的步骤电极和第二工作电极上的非活性区域。

6. 发明申请

WO2005045415A1 A METER FOR USE IN AN IMPROVED METHOD OF REDUCING INTERFERENCES IN AN ELECTROCHEMICAL SENSOR USING TWO DIFFERENT APPLIED POTENTIALS 审中-公开
标题翻译：在使用两种不同应用电位的电化学传感器中减少干扰的改进方法中使用的计量表
公开(公告)号：WO2005045415A1
公开(公告)日：2005-05-19
申请号：PCT/GB2004/004594
申请日：2004-10-29
申请人： LIFESCAN SCOTLAND LIMITED , DAVIES, Oliver, William, Hardwicke
发明人： DAVIES, Oliver, William, Hardwicke
IPC分类号： G01N27/327
CPC分类号： C12Q1/001 , A61B5/14532 , A61B5/1486 , A61B5/150022 , A61B5/150282 , A61B5/150358 , A61B5/150435 , A61B5/150503 , C12Q1/006 , G01N27/3274
摘要： The present invention is directed to an improved meter that utilizes a method of reducing the effects of interfering compounds in the measurement of analytes and more particularly to a method of reducing the effects of interfering compounds in a system wherein the test strip utilizes two or more working electrodes. In the present invention, a meter is described which applies a first potential (E1) to a first working electrode (12) and a second potential (E2), having the same polarity but a greater magnitude than the first potential is applied to a second working electrode (14). The meter then measures the generated current and utilizes a predetermined algorithm to correct the measured current to compensate for the presence of interfering compounds in the sample.
摘要翻译：本发明涉及一种改进的仪表，其利用减少干扰化合物在分析物测量中的作用的方法，更具体地说涉及减少干扰化合物在系统中的作用的方法，其中测试条使用两个或多个工作电极。在本发明中，描述了将具有与第一电位相同的极性但大于第一电位的第一电位（E1）施加到第一工作电极（12）的第二电位（E2）的第二电位（E2）施加到第二电位工作电极（14）。仪表然后测量所产生的电流并利用预定的算法来校正测量的电流以补偿样品中干扰化合物的存在。

7. 发明申请

WO2007010368A1 ASSAY DEVICE AND METHOD 审中-公开
标题翻译：测定装置和方法
公开(公告)号：WO2007010368A1
公开(公告)日：2007-01-25
申请号：PCT/IB2006/001985
申请日：2006-07-19
申请人： INVERNESS MEDICAL SWITZERLAND GMBH , DAVIES, Oliver, William, Hardwicke , LANG, David, Kinniburgh , DILLEEN, John, William , LOWE, Phillip , HOWELL, Steven , SLEVIN, Christopher, John
发明人： DAVIES, Oliver, William, Hardwicke , LANG, David, Kinniburgh , DILLEEN, John, William , LOWE, Phillip , HOWELL, Steven , SLEVIN, Christopher, John
IPC分类号： G01N33/543
CPC分类号： G01N33/54326
摘要： An assay device includes a first reagent including a magnetic particle and a second reagent including detectable component. The first and second reagent can each independently bind to an analyte in a sample . Applying a magnetic field can selectively concentrate the detectable component in a detection zone, where a detectable change ca be measured and related to the amount of analyte in the sample .
摘要翻译：测定装置包括包含磁性颗粒的第一试剂和包含可检测组分的第二试剂。第一和第二试剂可以各自独立地结合样品中的分析物。施加磁场可以选择性地将可检测组分浓缩在检测区域，其中可测量可检测的变化并与样品中分析物的量相关。

8. 发明申请

WO2004039600A2 ENZYME PRINT HUMIDIFICATION IN A CONTINUOUS PROCESS FOR MANUFACTURE OF ELECTROCHEMICAL SENSORS 审中-公开
标题翻译：在电化学传感器制造的连续过程中，酶的印刷加湿
公开(公告)号：WO2004039600A2
公开(公告)日：2004-05-13
申请号：PCT/GB2003/004708
申请日：2003-10-30
申请人： INVERNESS MEDICAL LIMITED , DAVIES, Oliver, William, Hardwicke , HALLFORD, John, Thomas , SIM, Andrew, Graham , YEUDALL, Robert, Malcolm
发明人： DAVIES, Oliver, William, Hardwicke , HALLFORD, John, Thomas , SIM, Andrew, Graham , YEUDALL, Robert, Malcolm
IPC分类号： B41M
CPC分类号： H05K3/1216 , B41M3/006 , C09D11/52 , G01N27/3271 , H05K1/0269 , H05K1/0393 , H05K1/162 , H05K2201/09918 , H05K2203/081 , H05K2203/1545 , H05K2203/166
摘要： In a web manufacturing process according to the present invention, the process includes at least one print station adapted to print enzymes on a moving substrate. In one embodiment, the web manufacturing process includes continuously moving the substrate, depositing enzyme ink onto the substrate through a screen printing process wherein ink is deposited on a top side of the screen and forced through the top side onto the substrate which is positioned adjacent to the bottom side of the screen. In order to improve ink transfer, air at the top side of the screen is humidified to a first relative humidity and air at the bottom side of the screen is humidified to a second relative humidity.
摘要翻译：在根据本发明的卷筒纸制造过程中，该方法包括至少一个适于在移动的基材上印刷酶的印刷站。在一个实施方案中，幅材制造过程包括连续移动基材，通过丝网印刷工艺将酶油墨沉积到基材上，其中油墨沉积在筛网的顶侧上并且迫使通过顶侧到位于邻近屏幕的底部。为了改善油墨转移，将屏幕顶部的空气加湿至第一相对湿度，并将屏幕底部的空气加湿至第二相对湿度。

9. 发明申请

WO2004040290A1 MANUFACTURE OF ELECTROCHEMICAL SENSORS BY MOVEABLE FLAT SCREEN PRINTING 审中-公开
标题翻译：电动平面印刷电化学传感器的制造
公开(公告)号：WO2004040290A1
公开(公告)日：2004-05-13
申请号：PCT/GB2003/004694
申请日：2003-10-30
申请人： INVERNESS MEDICAL LIMITED , DAVIES, Oliver, William, Hardwicke , MARSHALL, Robert , MCNEILLY, Brian, Andrew , SIM, Andrew, Graham , YEUDALL, Robert, Malcom
发明人： DAVIES, Oliver, William, Hardwicke , MARSHALL, Robert , MCNEILLY, Brian, Andrew , SIM, Andrew, Graham , YEUDALL, Robert, Malcom
IPC分类号： G01N27/403
CPC分类号： H05K3/1216 , B41M3/006 , C09D11/52 , G01N27/3271 , H05K1/0269 , H05K1/0393 , H05K1/162 , H05K2201/09918 , H05K2203/081 , H05K2203/1545 , H05K2203/166
摘要： The present invention describes a method and apparatus for manufacturing an electrochemical sensor comprising transporting a web of a substrate past one or more print stations and printing one or more electrodes on the substrate at one or more print stations by screen printing electrically conductive ink using flat screen printing.
摘要翻译：本发明描述了一种用于制造电化学传感器的方法和装置，包括将基板的幅材传送通过一个或多个印刷站，并且在一个或多个印刷站上通过丝网印刷导电油墨在一个或多个印刷站上印刷一个或多个电极打印。

10. 发明申请

WO2004040287A1 METHOD OF MANUFACTURE OF ELECTROCHEMICAL SENSORS 审中-公开
标题翻译：电化学传感器的制造方法
公开(公告)号：WO2004040287A1
公开(公告)日：2004-05-13
申请号：PCT/GB2003/004656
申请日：2003-10-30
申请人： INVERNESS MEDICAL LIMITED , DAVIES, Oliver, William, Hardwicke , ARMSTRONG, Malcolm, Gordon , LONGDEN, Donald, Roderick , SIM, Andrew, Graham , YEUDALL, Robert, Malcolm
发明人： DAVIES, Oliver, William, Hardwicke , ARMSTRONG, Malcolm, Gordon , LONGDEN, Donald, Roderick , SIM, Andrew, Graham , YEUDALL, Robert, Malcolm
IPC分类号： G01N27/30
CPC分类号： H05K3/1216 , B41M3/006 , C09D11/52 , G01N27/3271 , H05K1/0269 , H05K1/0393 , H05K1/162 , H05K2201/09918 , H05K2203/081 , H05K2203/1545 , H05K2203/166
摘要： The present invention describes a method and apparatus for manufacturing an electrochemical sensor comprising transporting a web of a substrate past one or more print stations and printing one or more electrodes on the substrate at one or more print stations splicing a second roll of substrate material to the end of the first roll and passing the spliced substrate through the one or more print stations.
摘要翻译：本发明描述了一种用于制造电化学传感器的方法和装置，包括：将衬底的幅材传送经过一个或多个印刷站，并在一个或多个印刷站上将基片上的一个或多个电极印刷在第二层衬底材料上，第一辊的端部并且使拼接的基板通过一个或多个打印站。

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