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1. 发明申请

WO2022155588A2 COMPOSITIONS, KITS AND METHODS FOR DIRECT AMPLIFICATION FROM CRUDE BIOLOGICAL SAMPLES 审中-公开
公开(公告)号：WO2022155588A2
公开(公告)日：2022-07-21
申请号：PCT/US2022/012755
申请日：2022-01-18
申请人： LIFE TECHNOLOGIES CORPORATION
发明人： SHANNON, Mark , ELDER, Noah , RAMAMOORTHI, Kalpith , LA, Jason , BLANCHARD, Daniel
IPC分类号： C12Q1/6806
摘要： Disclosed are compositions, assays, methods, diagnostic methods, kits and diagnostic kits for the detection of target nucleic acids, including those from microbes and/or from infectious agents such as SARS-CoV-2 and other viruses. Embodiments described herein are designed to enable processing and analysis of the sample to detect target nucleic acids within the sample without requiring extraction and/or isolation of nucleic acid from the sample prior to subsequent processing steps. Samples analyzed can thus be "crude" biological samples that do not require pre-processing prior to placement in the workflow.

2. 发明申请

WO2022203748A1 COMPOSITIONS, KITS, AND METHODS FOR VARIANT-RESISTANT DETECTION OF TARGET VIRAL SEQUENCES 审中-公开
公开(公告)号：WO2022203748A1
公开(公告)日：2022-09-29
申请号：PCT/US2022/012805
申请日：2022-01-18
申请人： LIFE TECHNOLOGIES CORPORATION
发明人： WANG, Chunling , SHANG, Yulei , PABBATI, Namrata , LI, Kelly , PAGANI, Ioanna , BRZOSKA, Pius , TANNER, Michael , SHANNON, Mark , ELDER, Noah , RAMAMOORTHI, Kalpith , LA, Jason , BLANCHARD, Daniel , LI, Jisheng
IPC分类号： C12Q1/6888 , C12Q2537/143
摘要： Disclosed are compositions, assays, methods, diagnostic methods, kits and diagnostic kits for the specific and differential detection of SARS-CoV-2, including SARS-CoV-2 variants, or other coronaviruses from samples including veterinary samples, clinical samples, food samples, forensic sample, an environmental sample (e.g., soil, dirt, garbage, sewage, air, or water), including food processing and manufacturing surfaces, or a biological sample.

3. 发明申请

WO2017027627A1 BIOLOGICAL SAMPLE PREPARATION FOR TESTING 审中-公开
标题翻译：生物样品制备测试
公开(公告)号：WO2017027627A1
公开(公告)日：2017-02-16
申请号：PCT/US2016/046410
申请日：2016-08-10
申请人： LIFE TECHNOLOGIES CORPORATION
发明人： RATH, Mousumi , SHANNON, Mark , LA, Jason
IPC分类号： C12Q1/68 , C12N15/10 , G01N1/28 , G01N1/02 , G01N1/34
CPC分类号： G01N1/04 , B01L3/50825 , B01L2300/042 , B01L2300/046 , B01L2300/0838 , C12Q1/6806 , G01N1/2813 , G01N1/286 , G01N1/34 , G01N2001/028 , G01N2001/045 , G01N2001/284 , G01N2001/2886 , C12Q2521/327 , C12Q2527/101 , C12Q2527/113 , C12Q2531/113 , C12Q2565/601 , C12Q2535/122
摘要： In one embodiment, a method for processing a sample includes selecting a selected sample from a biological specimen, the selected sample being in contact with a first surface of a first substrate. The method also includes transferring the selected sample directly from the first surface to a container comprising an internal volume. The method also includes forming or providing a sample solution within the internal volume of the container by contacting the selected sample with a lysis mixture using a protocol. The method further includes performing an assay, experiment, or test on the sample solution while the sample solution disposed is within the internal volume of the container. In another embodiment, a method for processing a sample includes providing a selected sample comprising one or more cells. The method also includes transferring the selected sample into an internal volume of a container. The method also includes contacting the selected sample with a lysis mixture using a protocol to provide a sample solution, wherein the protocol comprises heating the sample solution to a first temperature that is greater than 37 degrees Celsius and less than or equal to 75 degrees Celsius.
摘要翻译：在一个实施例中，用于处理样本的方法包括从生物样本中选择所选择的样本，所选择的样本与第一基底的第一表面接触。该方法还包括将所选样品直接从第一表面转移到包含内部容积的容器中。该方法还包括通过使用方案使选定的样品与裂解混合物接触来形成或提供在容器的内部体积内的样品溶液。该方法还包括在样品溶液处于容器的内部容积内时对样品溶液进行测定，实验或测试。在另一个实施方案中，用于处理样品的方法包括提供包含一个或多个细胞的选定样品。该方法还包括将所选择的样品转移到容器的内部容积中。该方法还包括使用方案使所选择的样品与裂解混合物接触以提供样品溶液，其中所述方案包括将样品溶液加热至大于37摄氏度且小于或等于75摄氏度的第一温度。

4. 发明申请

WO2012099896A2 WORKFLOW FOR DETECTION OF LIGANDS USING NUCLEIC ACIDS 审中-公开
标题翻译：使用核酸检测配体的工作流程
公开(公告)号：WO2012099896A2
公开(公告)日：2012-07-26
申请号：PCT/US2012/021585
申请日：2012-01-17
申请人： LIFE TECHNOLOGIES CORPORATION , CHEN, Shiaw-Min , SWARTZMAN, Elana , RUFF, David , SHANNON, Mark , LU, Julia , HENDRICKS, Stephen
发明人： CHEN, Shiaw-Min , SWARTZMAN, Elana , RUFF, David , SHANNON, Mark , LU, Julia , HENDRICKS, Stephen
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6855 , C12Q1/6804 , C12Q2537/101 , C12Q2561/101 , C12Q2561/125
摘要： This application relates to methods for ligating oligonucleotides having complementarity to a target nucleic acid, and amplifying the ligated oligonucleotides, where ligation and amplification occur in the same reaction mixture.
摘要翻译：本申请涉及用于连接与靶核酸具有互补性的寡核苷酸并扩增连接的寡核苷酸的方法，其中连接和扩增发生在相同的反应混合物中。

5. 发明公开

EP2665833A2 WORKFLOW FOR DETECTION OF LIGANDS USING NUCLEIC ACIDS 有权转让
标题翻译：操作检测配体与NUCLEIC的
公开(公告)号：EP2665833A2
公开(公告)日：2013-11-27
申请号：EP12702099.8
申请日：2012-01-17
申请人： Life Technologies Corporation
发明人： CHEN, Shiaw-Min , SWARTZMAN, Elana , RUFF, David , SHANNON, Mark , LU, Julia , HENDRICKS, Stephen
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6855 , C12Q1/6804 , C12Q2537/101 , C12Q2561/101 , C12Q2561/125
摘要： This application relates to methods for ligating oligonucleotides having complementarity to a target nucleic acid, and amplifying the ligated oligonucleotides, where ligation and amplification occur in the same reaction mixture.

7. 发明公开

EP4278002A2 COMPOSITIONS, KITS AND METHODS FOR DIRECT AMPLIFICATION FROM CRUDE BIOLOGICAL SAMPLES 审中-实审
公开(公告)号：EP4278002A2
公开(公告)日：2023-11-22
申请号：EP22703196.0
申请日：2022-01-18
申请人： Life Technologies Corporation
发明人： SHANNON, Mark , ELDER, Noah , RAMAMOORTHI, Kalpith , LA, Jason , BLANCHARD, Daniel
IPC分类号： C12Q1/6806

8. 发明授权

EP3216878B1 WORKFLOW FOR DETECTION OF LIGANDS USING NUCLEIC ACIDS 有权
公开(公告)号：EP3216878B1
公开(公告)日：2019-04-03
申请号：EP17166444.4
申请日：2012-01-17
申请人： Life Technologies Corporation
发明人： CHEN, Shiaw-Min , SWARTZMAN, Elana , RUFF, David , SHANNON, Mark , LU, Julia , HENDRICKS, Stephen
IPC分类号： C12Q1/68

9. 发明授权

EP2665833B1 WORKFLOW FOR DETECTION OF LIGANDS USING NUCLEIC ACIDS 有权转让
标题翻译： ARBEITSABLAUF ZUR NACHWEIS VON LIGANDEN MITNUKLEINSÄUREN
公开(公告)号：EP2665833B1
公开(公告)日：2017-04-19
申请号：EP12702099.8
申请日：2012-01-17
申请人： Life Technologies Corporation
发明人： CHEN, Shiaw-Min , SWARTZMAN, Elana , RUFF, David , SHANNON, Mark , LU, Julia , HENDRICKS, Stephen
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6855 , C12Q1/6804 , C12Q2537/101 , C12Q2561/101 , C12Q2561/125

10. 发明公开

EP3567121A1 WORKFLOW FOR DETECTION OF LIGANDS USING NUCLEIC ACIDS 有权
公开(公告)号：EP3567121A1
公开(公告)日：2019-11-13
申请号：EP19166484.6
申请日：2012-01-17
申请人： Life Technologies Corporation
发明人： CHEN, Shiaw-Min , SWARTZMAN, Elana , RUFF, David , SHANNON, Mark , LU, Julia , HENDRICKS, Stephen
IPC分类号： C12Q1/68
摘要： This application relates to methods for ligating oligonucleotides having complementarity to a target nucleic acid, and amplifying the ligated oligonucleotides, where ligation and amplification occur in the same reaction mixture.

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