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1. 发明申请

WO2005034802A2 APPARATUS AND METHOD FOR THE LIGATION OF TISSUE 审中-公开
标题翻译：用于组织结构的装置和方法
公开(公告)号：WO2005034802A2
公开(公告)日：2005-04-21
申请号：PCT/US2004/033459
申请日：2004-10-11
申请人： LIDDICOAT, John, R. , COHN, William, E. , LAHAM, Roger
发明人： LIDDICOAT, John, R. , COHN, William, E. , LAHAM, Roger
IPC分类号： A61F
CPC分类号： A61B17/12013 , A61B17/00234 , A61B17/0467 , A61B17/12009 , A61B17/30 , A61B2017/00243 , A61B2017/00867 , A61B2017/00876 , A61B2017/12018 , A61B2017/308 , A61B2090/0811 , A61B2090/3966 , A61B2576/023 , A61F2/013 , A61F2230/0006 , A61F2230/005 , A61M25/0108 , A61M25/0127 , A61M25/10 , A61M29/02
摘要： A novel catheter-based system which ligates the left atrial appendage (LAA) on the outside of the heart, preferably using a combination of catheters and/or instruments, e.g., a guide catheter positioned inside the left atrial appendage which may assist in locating the left atrial appendage and/or assist in the optimal placement of a ligature on the outside of the appendage, and a ligating catheter and/or instrument outside the heart in the pericardial space to set a ligating element at the neck of the left atrial appendage.
摘要翻译：一种新颖的基于导管的系统，其将心脏外侧的左心耳（LAA）结合，优选地使用导管和/或器械的组合，例如位于左心耳内的引导导管，其可以协助定位左心耳和/或辅助将附件最佳放置在附肢的外侧，以及在心包空间内的心脏外的结扎导管和/或器械，以将结扎元件设置在左心耳的颈部。

2. 发明申请

WO2004050971A2 APPARATUS AND METHOD FOR MANIPULATING TISSUE 审中-公开
标题翻译：用于操作组织的装置和方法
公开(公告)号：WO2004050971A2
公开(公告)日：2004-06-17
申请号：PCT/US2003/038110
申请日：2003-12-01
申请人： LIDDICOAT, John, R. , COHN, William, E.
发明人： LIDDICOAT, John, R. , COHN, William, E.
IPC分类号： D03D
CPC分类号： A61B17/072 , A61B17/00234 , A61B17/0218 , A61B17/07292 , A61B2017/00349 , A61B2017/00818 , A61B2017/00827 , A61B2017/00876 , A61B2017/07214 , A61B2017/2905 , A61B2017/306
摘要： Apparatus for reconfiguring tissue, the apparatus comprising a shaft having a distal end and a proximal end; at least one effector mechanism movably mounted to the distal end of the shaft, each effector mechanism comprising at least one gripping element for gripping tissue to that effector mechanism, the at least one effector mechanism being configured to capture the gripped tissue against said shaft, at least one actuating mechanism mounted to the proximal end of the shaft, and at least one connection mechanism connecting the at least one actuating mechanism to the at least one effector mechanism, whereby a user may utilize the at least one actuating mechanism to actuate the at least one effector mechanism so as to reconfigure tissue.
摘要翻译：用于重组组织的装置，该装置包括具有远端和近端的轴; 至少一个效应器机构，其可移动地安装到所述轴的远端，每个效应器机构包括用于将组织夹持到所述效应器机构的至少一个夹紧元件，所述至少一个效应器机构被构造成将夹持的组织捕获在所述轴上，安装到所述轴的近端的至少一个致动机构以及将所述至少一个致动机构连接到所述至少一个效应器机构的至少一个连接机构，由此使用者可以利用所述至少一个致动机构致动所述至少一个一个效应器机制，以重新配置组织。

3. 发明申请

WO2006110734A2 APPARATUS AND METHOD FOR THE LIGATION OF TISSUE 审中-公开
标题翻译：用于组织结构的装置和方法
公开(公告)号：WO2006110734A2
公开(公告)日：2006-10-19
申请号：PCT/US2006/013459
申请日：2006-04-07
申请人： SentreHEART, Inc. , LIDDICOAT, John, R. , COHN, William, E.
发明人： LIDDICOAT, John, R. , COHN, William, E.
IPC分类号： A61B17/10
CPC分类号： A61B17/12013 , A61B17/00234 , A61B2017/00243
摘要： A novel catheter-based system that ligates the left atrial appendage (LAA) on the outside of the heart, preferably using a combination of catheters and/or instruments, e.g., a guide catheter inserted into the interior of the left atrial appendage that may assist in locating the left atrial appendage and/or assist in the optimal placement of a ligature or constricting element on the outside of the appendage, and a ligating catheter and/or instrument outside the heart in the pericardial space to set the ligature or constricting element at the neck of the left atrial appendage.
摘要翻译：一种新颖的基于导管的系统，其将心脏外侧的左心耳（LAA）结合，优选地使用导管和/或器械的组合，例如插入左心耳内部的引导导管，其可以协助在确定左心耳和/或协助在附件外侧的结扎或收缩元件的最佳放置以及在心包空间内的心脏外的结扎导管和/或器械以将结扎或收缩元件设置在左心耳的颈部。

4. 发明授权

EP0889705B1 CATHETER APPARATUS FOR GENERATING A FISTULA ON-DEMAND BETWEEN CLOSELY ASSOCIATED BLOOD VESSELS AT A PRE-CHOSEN ANATOMIC SITE IN-VIVO 失效
标题翻译：导管装置点播体内产生瘘之间近域血管选择性解剖部位
公开(公告)号：EP0889705B1
公开(公告)日：2009-10-28
申请号：EP97907789.8
申请日：1997-02-21
申请人： Beth Israel Deaconess Medical Center , Cohn, William E. , Kim, Ducksoo
发明人： COHN, William, E. , KIM, Ducksoo
IPC分类号： A61B17/32
CPC分类号： A61B17/3207 , A61B17/11 , A61B17/320016 , A61B17/320783 , A61B18/1492 , A61B18/1815 , A61B2017/00876 , A61B2017/1139

5. 发明公开

EP2906143A2 CARDIAC TREATMENT SYSTEM AND METHOD 无效
标题翻译：心脏治疗的系统和方法
公开(公告)号：EP2906143A2
公开(公告)日：2015-08-19
申请号：EP13844676.0
申请日：2013-10-14
申请人： Mardil, Inc. , Hjelle, Aaron , Cohn, William E. , Schroeder, Richard F. , Buck, James F. , Leinsing, Karl R.
发明人： HJELLE, Aaron , COHN, William, E. , SCHROEDER, Richard, F. , BUCK, James, F. , LEINSING, Karl, R.
IPC分类号： A61F2/02 , A61F2/00
CPC分类号： A61F2/2481 , A61B2090/3966 , A61F2002/2484 , A61F2002/9517 , A61F2250/0003 , A61F2250/0098 , A61M1/1008 , A61M1/106 , A61M1/1068 , A61M1/107 , A61M1/12 , A61M1/122 , A61M2205/32 , D04B21/12 , D10B2509/08
摘要： Devices and methods for providing localized pressure to a region of a patient's heart to improve heart functioning, including: (a) a jacket made of a flexible biocompatible material, the jacket having an open top end that is received around the heart and a bottom portion that is received around the apex of the heart; and (b) at least one inflatable bladder disposed on an interior surface of the jacket, the inflatable bladder having an inelastic outer surface positioned adjacent to the jacket and an elastic inner surface such that inflation of the bladder causes the bladder to deform substantially inwardly to exert localized pressure against a region of the heart.

6. 发明公开

EP0889705A1 CATHETER APPARATUS AND METHODOLOGY FOR GENERATING A FISTULA ON-DEMAND BETWEEN CLOSELY ASSOCIATED BLOOD VESSELS AT A PRE-CHOSEN ANATOMIC SITE IN-VIVO 失效
标题翻译：导管装置点播体内产生瘘之间近域血管选择性解剖部位
公开(公告)号：EP0889705A1
公开(公告)日：1999-01-13
申请号：EP97907789.0
申请日：1997-02-21
申请人： Beth Israel Deaconess Medical Center , Cohn, William E. , Kim, Ducksoo
发明人： COHN, William, E. , KIM, Ducksoo
IPC分类号： A61M25 , A61B17 , A61B18
CPC分类号： A61B17/3207 , A61B17/11 , A61B17/320016 , A61B17/320783 , A61B18/1492 , A61B18/1815 , A61B2017/00876 , A61B2017/1139
摘要： The present invention provides catheter apparatus (10, 200) and catheterization methodology for generating an arteriovenous fistula or a veno-venous fistula on demand between closely associated blood vessels and at a chosen anatomic site in vivo. The catheter apparatus is preferably employed in pairs, each catheter of the pair being suitable for percutaneous introduction into and extension through a blood vessel. The catheterization methodology employs the catheter apparatus preferably in conjunction with conventional radiological techniques in order to place, verify, and confirm a proper alignment, orientation, and positioning for the catheters in vivo prior to activating the perforation means for generating a fistula. The invention permits the generation of arteriovenous fistulae and veno-venous fistulae anatomically anywhere in the vascular system of a patient; nevertheless, the invention is most desirably employed in the peripheral vascular system as exists in the extremities of the body to aid in the treatment of the patient under a variety of different medical ailments and pathologies.

7. 发明申请

WO2008018892A3 METHODS AND KITS FOR TREATING LACERATIONS AND PUNCTURE WOUNDS USING INVERSE THERMOSENSITIVE POLYMERS 审中-公开
公开(公告)号：WO2008018892A3
公开(公告)日：2008-02-14
申请号：PCT/US2006/048033
申请日：2006-12-18
申请人： PLUROMED, INC. , COHN, William, E. , VOGEL, Jean-Marie
发明人： COHN, William, E. , VOGEL, Jean-Marie
IPC分类号： A61K9/36
摘要： In certain embodiments, the present invention relates to methods and kits for treating wounds, comprising the step of introducing into said wound a composition comprising at least one optionally purified inverse thermosensitive polymer, wherein said at least one optionally purified inverse thermosensitive polymer forms a gel in said wound, thereby temporarily occluding said wound. In certain embodiments, the present invention relates to the aforementioned method wherein a wound to a blood vessel or a segment of the GI tract is occluded, thereby preventing exsanguination and/or septicemia. In other embodiments, the inventive methods and kits described herein may be used to ameliorate (e.g., fill) temporarily a defect in a biological lumen, thereby strengthening said defect, preventing rupture of, or maintaining, improving or optimizing fluid flow through said lumen.

8. 发明申请

WO2010006335A1 METHODS AND APPARATUS FOR INTRODUCING A MEDICAL DEVICE INTO THE BODY OF A PATIENT 审中-公开
标题翻译：将医疗设备引入患者身体的方法和装置
公开(公告)号：WO2010006335A1
公开(公告)日：2010-01-14
申请号：PCT/US2009/050415
申请日：2009-07-13
申请人： HOUSTON MEDICAL ROBOTICS, LLC , HERLIHY, J., Patrick , COHN, William, E. , RENNICKS, K., Wayne
发明人： HERLIHY, J., Patrick , COHN, William, E. , RENNICKS, K., Wayne
IPC分类号： A61B19/00 , A61M25/00
CPC分类号： A61B90/11 , A61B17/3403 , A61B34/30 , A61B2034/301 , A61B2090/372 , A61B2090/378
摘要： An image guided robotic device is provided to perform a diagnostic or therapeutic medical procedure. In one embodiment, the robotic device includes an imaging machine, an actuator, and a controller for controlling the actuator. The robotic device may be configured to introduce a needle, a catheter, or a cannula into an anatomical structure. The device and its components may be sized for use as a portable device and/or operable using one hand of the operator.
摘要翻译：提供图像引导机器人装置以执行诊断或治疗医疗程序。在一个实施例中，机器人装置包括成像机，致动器和用于控制致动器的控制器。机器人装置可以被配置成将针，导管或套管引入解剖结构中。该装置及其部件的尺寸可以用作便携式装置和/或使用操作者的一只手可操作。

9. 发明申请

WO2008033728A2 ATRAUMATIC OCCLUSION BALLOONS AND SKIRTS, AND METHODS OF USE THEREOF 审中-公开
标题翻译： ATRAUMATIC OCCLUSION BALLOONS和SKIRTS及其使用方法
公开(公告)号：WO2008033728A2
公开(公告)日：2008-03-20
申请号：PCT/US2007/077879
申请日：2007-09-07
申请人： PLUROMED, INC. , VOGEL, Jean-marie , COHN, William, E.
发明人： VOGEL, Jean-marie , COHN, William, E.
IPC分类号： A61M25/10 , A61L29/06
CPC分类号： A61B17/12195 , A61B17/08 , A61B17/12031 , A61B17/1204 , A61B17/12045 , A61B17/12109 , A61B17/12131 , A61B17/12136 , A61B17/12186 , A61B2017/1205 , A61M29/02 , A61M2025/1052
摘要： One aspect of the present invention relates to catheters that can be placed in or around bodily conduits to occlude or widen a biological lumen without imparting significant trauma to the lumen, hi certain embodiments, the invention particularly relates to the use of a polymer composition which can be made to gel upon insertion into said balloon or skirt, hi certain embodiments, the inflating viscous polymer composition is a liquid at room temperature and a gel at mammalian physiological temperature. In certain embodiments, the inflating viscous polymer composition comprises an optionally purified inverse thermosensitive polymer.
摘要翻译：本发明的一个方面涉及可以放置在身体导管内或周围的导管，以封闭或加宽生物腔而不对内腔产生显着的创伤。在某些实施方案中，本发明特别涉及使用可以在插入所述气囊或裙部时使其凝胶化。在某些实施方案中，充气粘性聚合物组合物在室温下为液体，在哺乳动物生理温度下为凝胶。在某些实施方案中，充气粘性聚合物组合物包含任选纯化的反相热敏聚合物。

10. 发明申请

WO2008005990A2 SURGICAL TOOLS FOR LVAD IMPLANTATION 审中-公开
标题翻译：手术植入手术
公开(公告)号：WO2008005990A2
公开(公告)日：2008-01-10
申请号：PCT/US2007/072759
申请日：2007-07-03
申请人： SEMMT, INC. , COHN, William, E.
发明人： COHN, William, E.
IPC分类号： A61B17/00
CPC分类号： A61B17/32 , A61B17/32053 , A61B17/34 , A61B90/50 , A61B2017/00243 , A61B2017/00278 , A61B2017/0243 , A61B2017/1135 , A61B2017/306 , A61B2017/3425 , A61B2017/3484 , A61B2017/3488 , A61M1/10 , A61M1/1008 , A61M1/12 , A61M1/122 , A61M1/3653 , A61M1/3659
摘要： Novel tools for surgery are described herein. The disclosed devices incorporate novel features which enable a surgeon to perform artificial device ( e.g. , left ventricular assist devices (LVAD)) implantations and other procedures more efficiently and easily. One embodiment of an apparatus employs a suction element that is adapted to releasably couple to a surgical connector. The suction element simultaneously positions and stabilizes the organ and the surgical connector to the organ. In an embodiment of another device, a coring system employs a balloon catheter and a coring tool which is adapted to be threaded on to a guide wire. Embodiments of the coring tool ensure removal and excision of cored tissue while preventing blood loss. In an embodiment of yet another device, an automated surgical connector employs a novel press-fit mechanism. The press-fit mechanism allows a surgeon to attach the connector to an organ without the use of sutures.
摘要翻译：本文描述了用于手术的新型工具。所公开的设备结合了新颖特征，其使得外科医生能够更有效和更容易地执行人工装置（例如，左心室辅助装置（LVAD））植入和其它手术。装置的一个实施例采用适于可释放地联接到手术连接器的抽吸元件。抽吸元件同时将器官和手术连接器定位并稳定到器官。在另一装置的一个实施例中，取芯系统采用球囊导管和取芯工具，其适于螺纹连接到导丝上。取芯工具的实施例确保了去除和切除核心组织，同时防止失血。在另一个装置的实施例中，自动手术连接器采用新的压配合机构。压合机构允许外科医生将连接器附接到器官而不使用缝合线。

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