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1. 发明申请

WO2008142155A2 METHOD FOR PREPARING C-6 PHOSPHORYLATED D-ALDOHEXOSES AND C-6 PHOSPHORYLATED D-ALDOHEXOSES DERIVATIVES AND NEW C-6 PHOSPHORYLATED D-ALDOHEXOSES DERIVATIVES 审中-公开
标题翻译：用于制备C-6磷酸化D-糖苷和C-6磷酸化D-糖苷衍生物的方法和新的C-6磷酸化D-糖苷衍生物
公开(公告)号：WO2008142155A2
公开(公告)日：2008-11-27
申请号：PCT/EP2008/056350
申请日：2008-05-23
申请人： LIBRAGEN , AURIOL, Daniel , NALIN, Renaud , LEFEVRE, Fabrice , GINOLHAC, Aurélien , DE GUEMBECKER, Daphné , ZAGO, Caroline
发明人： AURIOL, Daniel , NALIN, Renaud , LEFEVRE, Fabrice , GINOLHAC, Aurélien , DE GUEMBECKER, Daphné , ZAGO, Caroline
IPC分类号： C12P17/00 , C12P19/02 , C12P19/26 , C12P19/28 , C07D309/10 , C07D309/14 , C07D335/02 , C07H1/02 , C07H5/10 , C07H11/04 , C07H15/04 , C07H15/12 , C07D211/40 , C07D211/54 , C07D211/56 , C07D309/08
CPC分类号： C12P19/02 , C07D211/46 , C07D211/54 , C07D309/10 , C07D309/14 , C07D335/02 , C07H11/04 , C07H15/04 , C12P17/00 , C12P19/26 , C12P19/28
摘要： The present invention concerns a method for preparing C-6 phosphorylated D- aldohexoses and C-6 phosphorylated D-aldohexose derivatives, new C-6 phosphorylated D-aldohexoses derivatives and uses thereof. The method comprises incubating polyphosphate as sole source of phosphate donor and a polyphosphate-glucose phosphotransferase (polyphosphate: D-glucose 6-phosphotransferase, EC 2.7.1.63) in an aqueous solution with aD-aldohexose or a D-aldohexose derivative.
摘要翻译：本发明涉及一种制备C-6磷酸化D-己糖和C-6磷酸化D-己糖衍生物的方法，新的C-6磷酸化D-己内酯衍生物及其用途。该方法包括将多磷酸盐作为磷酸供体的唯一来源，并在含有D-己糖或D-己糖衍生物的水溶液中多聚磷酸 - 葡萄糖磷酸转移酶（多磷酸盐：D-葡萄糖-6-磷酸转移酶，EC 2.7.1.63）。

2. 发明申请

WO2010072754A1 HYDROSOLUBLE [6)O-α-D-GLCP-(1→]n-6-O-β-D-GLCP-(1→-PHENOLIC DERIVATIVES WITH DERMOCOSMETIC, NUTRITIONAL AND THERAPEUTIC APPLICATIONS, AND COMPOSITIONS CONTAINING SAID WATER SOLUBLE COMPOUNDS 审中-公开
标题翻译： [6] O-a-D-GLCP-（1β）n-6-O-β-D-GLCP-（具有灭菌，营养和治疗应用的1α-苯酚衍生物，以及含有可溶性水溶性化合物的组合物
公开(公告)号：WO2010072754A1
公开(公告)日：2010-07-01
申请号：PCT/EP2009/067736
申请日：2009-12-22
申请人： LIBRAGEN , AURIOL, Daniel , GINOLHAC, Aurélien , LEFEVRE, Fabrice , NALIN, Renaud
发明人： AURIOL, Daniel , GINOLHAC, Aurélien , LEFEVRE, Fabrice , NALIN, Renaud
IPC分类号： C07H15/203 , C07H15/26 , A61K8/00 , A61K31/7034 , A61P35/00
CPC分类号： C07H15/203 , A61K8/602 , A61K2800/522 , A61Q19/00 , C07H15/26
摘要： The invention relates to [6)-O-α-D-Glcp→]1 →] n -6-O-β-D-Glcp-(1→-phenolic derivatives. These [6)-O-α-D-Glcp-(1→] n -6-O-β-D-Glcp-(1→-phenolic derivatives of selected phenolics are new, have a solubility in water higher than that of their parent O-β-D-Glcp- (1→-phenolic derivatives and have useful applications in cosmetic, nutrition and pharmaceutical compositions, such as treating or preventing oxidative stress, a cancer, a cardiovascular disease, a bacterial infection, a viral infection, a fungal infection, a UV- induced erythema, an allergy, a metabolism disorder, diabetes, an obesity, an hormonal disorder, a bone disease, a pain, a brain disease, a mouth or teeth disease, an inflammatory or immune disorder.
摘要翻译：本发明涉及[6] -OaD-Glcp1]1β] n-6-O-β-D-Glcp-（1α-酚衍生物），这些[6] -OaD-Glcp-（1α） 6-O-β-D-Glcp-（所选酚类的1α-酚衍生物是新的，在水中的溶解度高于其亲本O-β-D-Glcp-（1α-酚衍生物）的溶解度，并且具有有用的化妆品，营养和药物组合物中的应用，例如治疗或预防氧化应激，癌症，心血管疾病，细菌感染，病毒感染，真菌感染，紫外线诱发的红斑，过敏，代谢障碍，糖尿病肥胖症，激素失调，骨病，疼痛，脑疾病，口腔或牙齿疾病，炎症或免疫疾病。

3. 发明申请

WO2011121250A2 COMPOSITION COSMETIQUE ET PHARMACEUTIQUE COMPRENANT DU N-ACETYL-GLUCOSAMINE-6-PHOSPHATE 审中-公开
标题翻译：包含N-乙酰氨基葡萄糖-6-磷酸酯的化妆品和药物组合物
公开(公告)号：WO2011121250A2
公开(公告)日：2011-10-06
申请号：PCT/FR2011/050732
申请日：2011-04-01
申请人： LIBRAGEN , AURIOL, Daniel , LEFEVRE, Fabrice , NALIN, Renaud , REDZINIAK, Gérard
发明人： AURIOL, Daniel , LEFEVRE, Fabrice , NALIN, Renaud , REDZINIAK, Gérard
IPC分类号： A61K8/60
CPC分类号： A61K31/07 , A61K8/60 , A61K8/671 , A61K31/11 , A61K31/192 , A61K31/203 , A61K31/232 , A61K31/7008 , A61Q1/14 , A61Q19/08
摘要： La présente invention est relative à une composition cosmétique ou pharmaceutique comprenant de la N-acétyl-glucosamine-6-phosphate ou un sel de celle-ci et, facultativement un composé de la famille de la vitamine A, ainsi qu'un dispositif la contenant.
摘要翻译：本发明涉及包含N-乙酰氨基葡萄糖-6-磷酸或其盐，以及任选的维生素A族的化合物的化妆品或药物组合物，还涉及包含其的装置。

4. 发明申请

WO2017178415A1 SKIN RESTORATION PRODUCT 审中-公开
标题翻译：皮肤修复产品
公开(公告)号：WO2017178415A1
公开(公告)日：2017-10-19
申请号：PCT/EP2017/058516
申请日：2017-04-10
申请人： LIBRAGEN
发明人： AURIOL, Daniel , CHAJRA, Hanane , LEFEVRE, Fabrice
IPC分类号： A61K8/60 , A61Q19/08 , A61K8/19
摘要： A composition comprising N-acetyl-glucosamine-6-phosphate, glucuronic acid, and a magnesium sulfate in the proportions of 50 to 75, 55 to 83 and 33 to 66 mmoles/kg respectively. The composition has restorative effects on aged and wrinkled skin.
摘要翻译：包含比例分别为50至75,55至83和33至66毫摩尔/ kg的N-乙酰基葡糖胺-6-磷酸，葡糖醛酸和硫酸镁的组合物。该组合物对老化和皱纹皮肤具有修复作用。

5. 发明申请

WO2007144368A3 WATER SOLUBLE PHENOLICS DERIVATIVES WITH DERMOCOSMETIC AND THERAPEUTIC APPLICATIONS 审中-公开
公开(公告)号：WO2007144368A3
公开(公告)日：2007-12-21
申请号：PCT/EP2007/055815
申请日：2007-06-13
申请人： LIBRAGEN , AURIOL, Daniel , NALIN, Renaud , ROBE, Patrick , LEFEVRE, Fabrice
发明人： AURIOL, Daniel , NALIN, Renaud , ROBE, Patrick , LEFEVRE, Fabrice
IPC分类号： C12P17/02 , C12P19/02
摘要： The invention relates to the preparation of phenolics derivatives by enzymatic condensation of phenolics selected among pyrocatechol or its derivatives with the glucose moiety of sucrose. The production of said phenolics derivatives is achieved with a glucosyltransferase (EC 2.4.1.5). These O-α-glucosides of selected phenolics are new, have a solubility in water higher than that of their parent polyphenol and have useful applications in cosmetic and pharmaceutical compositions, such as antioxidative, antiviral, antibacterial, immune-stimulating, antiallergic, antihypertensive, antiischemic, antiarrhytmic, antithrombotic, hypocholesterolemic, antilipoperoxidant, hepatoprotective, anti-inflammatory, anticarcinogenic antimutagenic, antineoplastic, anti-thrombotic, and vasodilatory formulations, or in any other field of application.

6. 发明公开

EP2379576A1 HYDROSOLUBLE [6)-O-alpha-D-GLCP-(1->]n-6-O-beta-D-GLCP-(1->-PHENOLIC DERIVATIVES WITH DERMOCOSMETIC, NUTRITIONAL AND THERAPEUTIC APPLICATIONS, AND COMPOSITIONS CONTAINING SAID WATER SOLUBLE COMPOUNDS 审中-公开
标题翻译：水溶性[6）O-A-D-GLC P（1 - >] N-6-O-B-D-GLC P（1 - > - WITH皮肤化妆品，食品关心，治疗应用中，和组合物本水溶性化合物苯酚衍生物
公开(公告)号：EP2379576A1
公开(公告)日：2011-10-26
申请号：EP09795446.5
申请日：2009-12-22
申请人： Libragen
发明人： AURIOL, Daniel , GINOLHAC, Aurélien , LEFEVRE, Fabrice , NALIN, Renaud
IPC分类号： C07H15/203 , C07H15/26 , A61K8/00 , A61K31/7034 , A61P35/00
CPC分类号： C07H15/203 , A61K8/602 , A61K2800/522 , A61Q19/00 , C07H15/26
摘要： The invention relates to [6)-O-α-D-Glcp→]1 →]
n -6-O-β-D-Glcp-(1→-phenolic derivatives. These [6)-O-α-D-Glcp-(1→]
n -6-O-β-D-Glcp-(1→-phenolic derivatives of selected phenolics are new, have a solubility in water higher than that of their parent O-β-D-Glcp- (1→-phenolic derivatives and have useful applications in cosmetic, nutrition and pharmaceutical compositions, such as treating or preventing oxidative stress, a cancer, a cardiovascular disease, a bacterial infection, a viral infection, a fungal infection, a UV- induced erythema, an allergy, a metabolism disorder, diabetes, an obesity, an hormonal disorder, a bone disease, a pain, a brain disease, a mouth or teeth disease, an inflammatory or immune disorder.

7. 发明公开

EP2552397A2 COMPOSITION COSMETIQUE ET PHARMACEUTIQUE COMPRENANT DU N-ACETYL-GLUCOSAMINE-6-PHOSPHATE 有权
标题翻译：与N-乙酰氨基葡糖-6-磷酸和维生素A化合物的化妆品和药物组合物
公开(公告)号：EP2552397A2
公开(公告)日：2013-02-06
申请号：EP11720140.0
申请日：2011-04-01
申请人： Libragen
发明人： AURIOL, Daniel , LEFEVRE, Fabrice , NALIN, Renaud , REDZINIAK, Gérard
IPC分类号： A61K8/60 , A61K8/67 , A61K31/07 , A61K31/11 , A61K31/192 , A61K31/203 , A61K31/232 , A61K31/7008 , A61Q19/00 , A61Q19/08 , A61P17/06 , A61P17/16 , A61P19/02 , A61P29/00
CPC分类号： A61K31/07 , A61K8/60 , A61K8/671 , A61K31/11 , A61K31/192 , A61K31/203 , A61K31/232 , A61K31/7008 , A61Q1/14 , A61Q19/08
摘要： The present invention relates to a cosmetic or pharmaceutical composition comprising N-acetylglucosamine-6-phosphate or a salt thereof and, optionally, a compound of the vitamin A family, and also to a device containing same. The composition can be used to treat dry skin, skin aging and wrinkles, to improve elasticity and to tighten the skin, to enhance the synthesis of structural macromolecules, e.g. hyaluronan and collagen, to treat psoriasis, atopic dermatitis or eczema or for treatments associated with surgery.

8. 发明公开

EP2150620A2 METHOD FOR PREPARING C-6 PHOSPHORYLATED D-ALDOHEXOSES AND C-6 PHOSPHORYLATED D-ALDOHEXOSE DERIVATIVES, AND NEW C-6 PHOSPHORYLATED D-ALDOHEXOSE DERIVATIVES 有权
标题翻译：一种用于C-6磷酸化的D-己醛糖的C-6磷酸化的D-己醛糖和其衍生物，和C-6磷酸化的D-己醛糖的新衍生物的制备过程
公开(公告)号：EP2150620A2
公开(公告)日：2010-02-10
申请号：EP08759951.0
申请日：2008-05-23
申请人： Libragen
发明人： AURIOL, Daniel , NALIN, Renaud , LEFEVRE, Fabrice , GINOLHAC, Aurélien , DE GUEMBECKER, Daphné , ZAGO, Caroline
IPC分类号： C12P17/00 , C12P19/02 , C12P19/26 , C12P19/28 , C07D309/10 , C07D309/14 , C07D335/02 , C07H1/02 , C07H5/10 , C07H11/04 , C07H15/04 , C07H15/12 , C07D211/40 , C07D211/54 , C07D211/56 , C07D309/08
CPC分类号： C12P19/02 , C07D211/46 , C07D211/54 , C07D309/10 , C07D309/14 , C07D335/02 , C07H11/04 , C07H15/04 , C12P17/00 , C12P19/26 , C12P19/28
摘要： The present invention concerns a method for preparing C-6 phosphorylated D- aldohexoses and C-6 phosphorylated D-aldohexose derivatives, new C-6 phosphorylated D-aldohexoses derivatives and uses thereof. The method comprises incubating polyphosphate as sole source of phosphate donor and a polyphosphate-glucose phosphotransferase (polyphosphate: D-glucose 6-phosphotransferase, EC 2.7.1.63) in an aqueous solution with aD-aldohexose or a D-aldohexose derivative.

9. 发明授权

EP2027279B1 Phenolic compounds with cosmetic and therapeutic applications 有权
标题翻译：与化妆品和治疗应用的酚类化合物
公开(公告)号：EP2027279B1
公开(公告)日：2012-04-18
申请号：EP07730118.2
申请日：2007-06-13
申请人： Libragen
发明人： AURIOL, Daniel , NALIN, Renaud , ROBE, Patrick , LEFEVRE, Fabrice
IPC分类号： C12P19/46
CPC分类号： C07H17/075 , C07H15/203 , C07H15/24 , C07H15/26 , C12P17/02 , C12P19/02 , C12P19/44 , C12P19/60
摘要： The invention relates to the preparation of phenolics derivatives by enzymatic condensation of phenolics selected among pyrocatechol or its derivatives including (i) protocatechuic acid and its derivatives, (ii) 3,4-dihydroxycinnamic acid with its trans isomer or caffeic acid and its derivatives, especially hydrocaffeic acid, rosmarinic acid, chlorogenic acid and caffeic acid phenethyl ester, and with its cis-isomer and its derivatives, especially esculin, (iii) dihydroxyphenylglycol, and (iv) members of the flavonoid familly such as taxifolin and fustin (dihydroflavonols), fisetin (a flavonol), eriodictyol (a flavanone), , with the glucose moiety of sucrose. The production of said phenolics derivatives is achieved with a glucosyltransferase (EC 2.4.1.5) obtained from a culture of Leuconostoc species, and more particularly from the culture of Leuconostoc mesenteroides NRRL B-512F. These O-glucosides of selected phenolics are new, have a solubility in water higher than that of their parent polyphenol and have useful applications in cosmetic and pharmaceutical compositions, such as antioxidative, antiviral, antibacterial, immune-stimulating, antiallergic, antihypertensive, antiischemic, antiarrhytmic, antithrombotic, hypocholesterolemic, antilipoperoxidant, hepatoprotective, anti-inflammatory, anticarcinogenic antimutagenic, antineoplastic, anti-thrombotic, and vasodilatory formulations, or in any other field of application. All the more, glucosylated phenolics derivatives objects of the invention can be hydrolyzed by the human natural microbiotes, thus releasing the active part of the phenolic compound upon time during their usage or by an ±-glucosidase (EC 3.2.1.20).

10. 发明公开

EP2027279A2 WATER SOLUBLE AND ACTIVABLE PHENOLICS DERIVATIVES WITH DERMOCOSMETIC AND THERAPEUTIC APPLICATIONS AND PROCESS FOR PREPARING SAID DERIVATIVES 有权
标题翻译：与化妆品和治疗应用的酚类化合物
公开(公告)号：EP2027279A2
公开(公告)日：2009-02-25
申请号：EP07730118.2
申请日：2007-06-13
申请人： Libragen
发明人： AURIOL, Daniel , NALIN, Renaud , ROBE, Patrick , LEFEVRE, Fabrice
IPC分类号： C12P17/02 , C12P19/02
CPC分类号： C07H17/075 , C07H15/203 , C07H15/24 , C07H15/26 , C12P17/02 , C12P19/02 , C12P19/44 , C12P19/60
摘要： The invention relates to the preparation of phenolics derivatives by enzymatic condensation of phenolics selected among pyrocatechol or its derivatives including (i) protocatechuic acid and its derivatives, (ii) 3,4-dihydroxycinnamic acid with its trans isomer or caffeic acid and its derivatives, especially hydrocaffeic acid, rosmarinic acid, chlorogenic acid and caffeic acid phenethyl ester, and with its cis-isomer and its derivatives, especially esculin, (iii) dihydroxyphenylglycol, and (iv) members of the flavonoid familly such as taxifolin and fustin (dihydroflavonols), fisetin (a flavonol), eriodictyol (a flavanone), , with the glucose moiety of sucrose. The production of said phenolics derivatives is achieved with a glucosyltransferase (EC 2.4.1.5) obtained from a culture of Leuconostoc species, and more particularly from the culture of Leuconostoc mesenteroides NRRL B-512F. These O-glucosides of selected phenolics are new, have a solubility in water higher than that of their parent polyphenol and have useful applications in cosmetic and pharmaceutical compositions, such as antioxidative, antiviral, antibacterial, immune-stimulating, antiallergic, antihypertensive, antiischemic, antiarrhytmic, antithrombotic, hypocholesterolemic, antilipoperoxidant, hepatoprotective, anti-inflammatory, anticarcinogenic antimutagenic, antineoplastic, anti-thrombotic, and vasodilatory formulations, or in any other field of application. All the more, glucosylated phenolics derivatives objects of the invention can be hydrolyzed by the human natural microbiotes, thus releasing the active part of the phenolic compound upon time during their usage or by an ±-glucosidase (EC 3.2.1.20).

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