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1. 发明申请

WO2006024296A1 EPIMERISATION OF ALLYLIC ALCOHOLS 审中-公开
标题翻译：各种酒精的消除
公开(公告)号：WO2006024296A1
公开(公告)日：2006-03-09
申请号：PCT/DK2005/000533
申请日：2005-08-22
申请人： LEO PHARMA A/S , PEDERSEN, Henrik , BRETTING, Claus, Aage, Svensgaard , BINDERUP, Ernst, Torndal
发明人： PEDERSEN, Henrik , BRETTING, Claus, Aage, Svensgaard , BINDERUP, Ernst, Torndal
IPC分类号： C07C401/00 , C07J9/00
CPC分类号： C07J9/00 , C07C401/00 , C07C2601/02
摘要： The present invention relates to processes for epimerising alcohols of compounds having a hydroxyl substituent on an asymmetric allylic carbon, such as compounds useful for the synthesis of vitamin D analogues where the epimeric hydroxyl substituent is at the 24 position. The invention further relates to methods of producing intermediates useful for the synthesis of calcipotriol by said epimerisation processes.
摘要翻译：本发明涉及在不对称烯丙基碳上具有羟基取代基的化合物的差向异构化方法，例如可用于合成维甲酸类似物的化合物，其中差向异构羟基取代基在24位。本发明还涉及通过所述差向异构化方法生产可用于合成卡泊三醇的中间体的方法。

2. 发明申请

WO2005095336A2 NOVEL METHOD FOR THE PREPARATION OF INTERMEDIATES USEFUL FOR THE SYNTHESIS OF VITAMIN D ANALOGUES 审中-公开
标题翻译：制备维生素D类似物合成有用的中间体的新方法
公开(公告)号：WO2005095336A2
公开(公告)日：2005-10-13
申请号：PCT/DK2005/000203
申请日：2005-03-23
申请人： LEO PHARMA A/S , HANSEN, Erik, Torngaard , SABROE, Thomas, Peter , CALVERLEY, Martin, John , PEDERSEN, Henrik , DEUSSEN, Heinz-Josef, Wilhelm
发明人： HANSEN, Erik, Torngaard , SABROE, Thomas, Peter , CALVERLEY, Martin, John , PEDERSEN, Henrik , DEUSSEN, Heinz-Josef, Wilhelm
IPC分类号： C07C401/00
CPC分类号： C07C401/00 , C07C2601/02 , C07D333/72
摘要： The present invention relates to novel methods for the preparation of intermediates which are useful in the synthesis of cacipotriol. The present invention relates further to the use of intermediates produced with said methods for making calcipotriol or calcipotriol monohydrate.
摘要翻译：本发明涉及制备可用于合成卡波头三醇的中间体的新方法。本发明进一步涉及用所述方法生产卡培三酚或卡泊三醇一水合物生产的中间体的用途。

3. 发明公开

EP1789384A1 EPIMERISATION OF ALLYLIC ALCOHOLS 失效
标题翻译：烯丙醇差向异构
公开(公告)号：EP1789384A1
公开(公告)日：2007-05-30
申请号：EP05770141.9
申请日：2005-08-22
申请人： LEO PHARMA A/S
发明人： PEDERSEN, Henrik , BRETTING, Claus, Aage, Svensgaard , BINDERUP, Ernst, Torndal
IPC分类号： C07C401/00 , C07J9/00
CPC分类号： C07J9/00 , C07C401/00 , C07C2601/02
摘要： The present invention relates to processes for epimerising alcohols of compounds having a hydroxyl substituent on an asymmetric allylic carbon, such as compounds useful for the synthesis of vitamin D analogues where the epimeric hydroxyl substituent is at the 24 position. The invention further relates to methods of producing intermediates useful for the synthesis of calcipotriol by said epimerisation processes.

4. 发明公开

EP1255732A1 USE OF VITAMIN D-DERIVATIVES IN THE TREATMENT OF OSTEOPOROSIS AND RELATED BONE DISORDERS, AS WELL AS NOVEL VITAMIN D3-DERIVATIVES 审中-公开
标题翻译：维生素D衍生物在骨质疏松症和相关的骨疾病的治疗，随着新的维生素D3衍生物
公开(公告)号：EP1255732A1
公开(公告)日：2002-11-13
申请号：EP01948978.0
申请日：2001-01-31
申请人： Leo Pharma A/S
发明人： GRUE-SORENSEN, Gunnar , PEDERSEN, Henrik , BINDERUP, Ernst, Torndal , TRANHOLM, Mikael
IPC分类号： C07C401/00 , A61K31/593 , A61P19/10
CPC分类号： A61K31/593 , A61K31/59 , C07C401/00 , C07C2601/14 , C07C2602/24
摘要： Compounds of the formula (I) wherein X represents hydrogen or hydroxy; Y represents oxygen or sulphur or oxidized sulphur selected from the groups S(O) and S(O2); R?1 and R2¿, which may be the same or different, represent hydrogen or a residue after removal of 1 hydrogen atom from a straight, branched or cyclic, saturated or unsaturated, C¿1?-C6-hydrocarbon; or R?1 and R2, together with the carbon atom to which they are attached (marked with an asterisk in formula (I)), bearing the group X, form a C3-C8 carbocyclic ring; Q represents a diradical residue after removal of 2 hydrogen atoms from a straight, branched or cyclic, saturated or unsaturated C1-C8-hydrocarbon; R?3¿ represents hydrogen or a residue after removal of 1 hydrogen atom from a straight, branched or cyclic, saturated or unsaturated C¿1?-C6-hydrocarbon; R?1, R2¿ and/or Q is optionally substituted with one or more deuterium or fluorine atoms; and n is 0 or 1; and derivatives of the compounds of formula (I) in which one or more hydroxy groups have been transformed into -O-acyl or -O-glycosyl groups, or a phosphate ester, such masked groups being hydrolyzable in vivo; may be used for the preparation of a medicament for the treatment and/or prophylaxis of osteoporosis and related bone disorders.
摘要翻译：式I worin X darstellt氢或羟基的化合物; ÿdarstellt氧或硫或者选自基团S（O）和S（O _{2 ）选择氧化的硫; [R ^{1 和R ^{2 ，其可以是相同或不同，代表氢或选自直链，支链或环状，饱和或不饱和除去一个氢原子后的残基，C _{1 -C _{6 - 烃; 或R ^{1 和R ^{2 ，连同它们所连接的碳原子（标有上式中星号I）带有基团X，形成C < SUB> 3 -C _{8 碳环; Q darstellt双基残基，从直链，支链或环状，饱和或不饱和的C _{除去2个氢原子后1 -C _{8 - 烃; 且R ^{3 darstellt氢或选自直链，支链或环状，饱和或不饱和的C _{1 -C _{6 - 烃; 可用于制备用于治疗和/或预防骨质疏松症和相关骨疾病的药物的制备。}}}}}}}}}}}}}

5. 发明授权

EP1735276B1 NOVEL METHOD FOR THE PREPARATION OF INTERMEDIATES USEFUL FOR THE SYNTHESIS OF VITAMIN D ANALOGUES 失效
标题翻译：用于制备维生素D的合成新工艺类似物合适中间体
公开(公告)号：EP1735276B1
公开(公告)日：2011-02-16
申请号：EP05715124.3
申请日：2005-03-23
申请人： LEO PHARMA A/S
发明人： HANSEN, Erik, Torngaard , SABROE, Thomas, Peter , CALVERLEY, Martin, John , PEDERSEN, Henrik , DEUSSEN, Heinz-Josef, Wilhelm
IPC分类号： C07C401/00
CPC分类号： C07C401/00 , C07C2601/02 , C07D333/72
摘要： The present invention relates to novel methods for the preparation of intermediates which are useful in the synthesis of cacipotriol. The present invention relates further to the use of intermediates produced with said methods for making calcipotriol or calcipotriol monohydrate.

6. 发明公开

EP1735276A2 NOVEL METHOD FOR THE PREPARATION OF INTERMEDIATES USEFUL FOR THE SYNTHESIS OF VITAMIN D ANALOGUES 失效
标题翻译：用于制备维生素D的合成新工艺类似物合适中间体
公开(公告)号：EP1735276A2
公开(公告)日：2006-12-27
申请号：EP05715124.3
申请日：2005-03-23
申请人： LEO PHARMA A/S
发明人： HANSEN, Erik, Torngaard , SABROE, Thomas, Peter , CALVERLEY, Martin, John , PEDERSEN, Henrik , DEUSSEN, Heinz-Josef, Wilhelm
IPC分类号： C07C401/00
CPC分类号： C07C401/00 , C07C2601/02 , C07D333/72
摘要： The present invention relates to novel methods for the preparation of intermediates which are useful in the synthesis of cacipotriol. The present invention relates further to the use of intermediates produced with said methods for making calcipotriol or calcipotriol monohydrate.
摘要翻译：本发明涉及一种用于中间体哪些是在cacipotriol的合成中有用的制备新方法。本发明进一步涉及使用与所述方法用于制备钙泊三醇或单水合钙泊三醇产生的中间体。

7. 发明授权

EP1789384B1 EPIMERISATION OF ALLYLIC ALCOHOLS 失效
标题翻译： EPIMERISATION VON ALLYLALKOHOLEN
公开(公告)号：EP1789384B1
公开(公告)日：2008-10-15
申请号：EP05770141.9
申请日：2005-08-22
申请人： LEO PHARMA A/S
发明人： PEDERSEN, Henrik , BRETTING, Claus, Aage, Svensgaard , BINDERUP, Ernst, Torndal
IPC分类号： C07C401/00 , C07J9/00
CPC分类号： C07J9/00 , C07C401/00 , C07C2601/02
摘要： The present invention relates to processes for epimerising alcohols of compounds having a hydroxyl substituent on an asymmetric allylic carbon, such as compounds useful for the synthesis of vitamin D analogues where the epimeric hydroxyl substituent is at the 24 position. The invention further relates to methods of producing intermediates useful for the synthesis of calcipotriol by said epimerisation processes.
摘要翻译：本发明涉及在不对称烯丙基碳上具有羟基取代基的化合物的差向异构化方法，例如可用于合成维甲酸类似物的化合物，其中差向异构羟基取代基位于24位。本发明还涉及通过所述差向异构化方法制备可用于合成卡泊三醇的中间体的方法。

8. 发明公开

EP3218427A1 DESIGN OF COMPOSITE MATERIALS WITH DESIRED CHARACTERISTICS 审中-公开
标题翻译：具有所需特性的复合材料设计
公开(公告)号：EP3218427A1
公开(公告)日：2017-09-20
申请号：EP15797248.0
申请日：2015-11-11
申请人： NANOCORE APS , Lundorf, Mikkel Dybro , Pedersen, Henrik
发明人： LUNDORF, Mikkel Dybro , PEDERSEN, Henrik , DEHLI, Tore
IPC分类号： C08J5/00 , B82Y30/00 , B82Y40/00
CPC分类号： C08J5/005 , B82Y30/00 , B82Y40/00 , C01B32/05 , C01B32/152 , C01B32/174 , C01B32/194 , C08K3/041 , C08K3/042 , C08K9/04 , C08K9/08 , C08K2201/001 , C08K2201/011 , C08L23/04
摘要： Composite material, where the matrix material and the additive are held togehter by covalently or non-covalently bound ligands. The linker unit between matrix and additive has the structure Ligandl - LinkerL - Ligand 2, whrein Ligandl and Ligand2 are a bond or a chemical entity that is capable of binding covalently or non-covalently to a structural entity, such as a polymer matrix or the additive (ex. CNT, graphene, carbon nanofiber, etc), and LinkerL is a chemical bond or entity that links Ligandl and Ligand2.
摘要翻译：复合材料，其中基质材料和添加剂通过共价或非共价结合的配体保持形成。基质和添加剂之间的接头单元具有结构配体1 - 接头L - 配体2，其中配体1和配体2是能够共价或非共价结合至结构实体的键或化学实体，例如聚合物基质或添加剂（例如CNT，石墨烯，碳纳米纤维等），并且连接子L是连接配体1和配体2的化学键或实体。

9. 发明公开

EP3218479A1 METHOD FOR IDENTIFICATION OF MOLECULES WITH DESIRED CHARACTERISTICS 审中-公开
标题翻译：鉴定具有所需特性的分子的方法
公开(公告)号：EP3218479A1
公开(公告)日：2017-09-20
申请号：EP15801669.1
申请日：2015-11-11
申请人： Nanocore ApS , Lundorf, Mikkel Dybro , Pedersen, Henrik
发明人： LUNDORF, Mikkel Dybro , PEDERSEN, Henrik , DEHLI, Tore
IPC分类号： C12N15/10
CPC分类号： C12N15/1034 , C12N15/1065 , C12N15/1068
摘要： A method for identifying molecules with desired characteristics such as high affinity for a surface or material is described. A particularly useful method covered by the present invention allows identification of molecules which bind a material with high affinity in the presence of fluid or soluble polymers, such that said molecules can be used to produce a composite in which they efficiently anchor a material in a matrix comprising solid forms of a polymer. Compositions/kits useful for identification of molecules with desired characteristics are also described.
摘要翻译：描述了用于鉴定具有期望特性（例如对表面或材料的高亲和力）的分子的方法。本发明所涵盖的特别有用的方法允许鉴定在流体或可溶性聚合物存在下以高亲和力结合材料的分子，使得所述分子可用于生产复合物，其中它们有效地将材料锚定在基质中包含固体形式的聚合物。还描述了用于鉴定具有期望特性的分子的组合物/试剂盒。

10. 发明申请

WO2020159418A1 A METHOD AND APPARATUS FOR CHEMICAL VAPOUR DEPOSITION 审中-公开
公开(公告)号：WO2020159418A1
公开(公告)日：2020-08-06
申请号：PCT/SE2020/050036
申请日：2020-01-15
申请人： PEDERSEN, Henrik , NADHOM, Hama
发明人： PEDERSEN, Henrik , NADHOM, Hama
IPC分类号： C23C20/02
摘要： The present disclosure relates to a method for chemical vapour deposition on a substrate, the method comprising a precursor step and a reactant step, wherein the precursor step comprises chemisorbing a layer of precursor molecules on the substrate (170), and wherein the reactant step comprises adding to at least part of the substrate (170) surface species able to reduce the precursor molecule, whereby at least a part of the reduced precursor molecule is deposited on the substrate (170) surface, characterized by applying by means of a voltage source (130) a positive bias to at least part of the substrate (170) surface during at least part of the reactant step, wherein the step of adding the reducing species comprises providing by means of an electron source (150) electrons as free particles, whereby during the reactant step a closed electrical circuit is formed as the free electrons are transmitted to the substrate (170) surface.

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