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1. 发明申请

WO2012095519A1 POTENT INHIBITORS OF COMPLEMENT ACTIVATION 审中-公开
标题翻译：补充激活的药物抑制剂
公开(公告)号：WO2012095519A1
公开(公告)日：2012-07-19
申请号：PCT/EP2012/050494
申请日：2012-01-13
申请人： LEIBNIZ-INSTITUT FÜR NATURSTOFF-FORSCHUNG UND INFEKTIONSBIOLOGIE , HEINEN, Stefan , LAMBRIS, John D. , LAUER, Nadine , SKERKA, Christine , ZIPFEL, Peter F.
发明人： HEINEN, Stefan , LAMBRIS, John D. , LAUER, Nadine , SKERKA, Christine , ZIPFEL, Peter F.
IPC分类号： C12N15/62
CPC分类号： C07K14/472 , C07K2319/00 , C12N9/6424 , C12Y304/21043 , C12Y304/21047
摘要： The present invention provides a chimeric recombinant polypeptide representing a potent inhibitor of complement activation. Said recombinant polypeptide is a chimeric recombinant polypeptide comprising at five, three or any other number of the C- terminal fragment of complement factor H (CFH) comprising at least one, two or even five of the short consensus repeats C15 to C20 of Factor H or of an CFHR protein linked with an inhibitor of the complement allowing inhibition of complement activation. Further, isolated nucleic acid molecules encoding the chimeric polypeptide, expression vectors and cells are provided as well as pharmaceutical compositions containing the same. Moreover, the present invention relates to methods allowing prophylaxis or treatment of complement-mediated diseases, disorders or conditions, like inflammatory diseases or autoimmune diseases as well as combating overshooting complement activation in a subject, comprising the step of administering the potent inhibitor according to the present invention. In addition, the present invention relates to the use of the inhibitor of the present invention for coating any biomaterial that is exposed to blood, human serum, or any kind of body fluid.
摘要翻译：本发明提供了表达补体活化的有效抑制剂的嵌合重组多肽。所述重组多肽是包含5个，3个或任何其它数目的补体因子H（CFH）的C-末端片段的嵌合重组多肽，其包含至少一个，两个或甚至五个因子H的短共有重复C15至C20 或与补体抑制剂连接的CFHR蛋白质，允许抑制补体活化。此外，提供编码嵌合多肽，表达载体和细胞的分离的核酸分子以及含有它们的药物组合物。此外，本发明涉及允许预防或治疗补体介导的疾病，病症或病症，如炎性疾病或自身免疫性疾病以及对抗受试者中的过量补体活化的方法，其包括根据本发明。此外，本发明涉及本发明的抑制剂用于涂覆暴露于血液，人血清或任何种类体液的任何生物材料的用途。

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