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1. 发明申请

WO2013180584A1 RECOMBINANT MICROORGANISMS AND USES THEREFOR 审中-公开
标题翻译：重组微生物及其用途
公开(公告)号：WO2013180584A1
公开(公告)日：2013-12-05
申请号：PCT/NZ2013/000095
申请日：2013-06-04
申请人： LANZATECH NEW ZEALAND LIMITED
发明人： CHEN, Wendy , LIEW, FungMin , KOEPKE, Michael
IPC分类号： C12N1/21 , C12N15/52 , C12N15/63 , C12N15/74 , C12P5/02
CPC分类号： C12P5/007 , C12N15/52 , C12N15/74 , C12P7/42 , C12P9/00 , C12Y101/01088 , C12Y101/01267 , C12Y117/07001 , C12Y202/01007 , C12Y203/01009 , C12Y203/0301 , C12Y205/0101 , C12Y205/0109 , C12Y207/01036 , C12Y207/01148 , C12Y207/04002 , C12Y207/0706 , C12Y401/01033 , C12Y402/03027 , C12Y402/03046 , C12Y406/01012 , C12Y503/03002 , Y02E50/343
摘要： Terpenes are valuable commercial products used in a diverse number of industries. Terpenes may be produced from petrochemical sources and from terpene feed-stocks, such as turpentine. However, these production methods are expensive, unsustainable and often cause environmental problems including contributing to climate change. Microbial fermentation provides an alternative option for the production of terpenes. One or more terpenes and/or precursors can be produced by microbial fermentation of a substrate comprising CO. Recombinant microorganisms may be used in such methods. Carboxydotrophic, acetogenic, recombinant microorganisms can be used in such methods. The recombinant microorgnsims may contain exogenous mevalonate (MVA) pathway enzymes and/or DXS pathway enzymes, for example.
摘要翻译：萜烯是用于不同行业的有价值的商业产品。萜烯可以由石化源和萜烯原料如松节油生产。然而，这些生产方法是昂贵的，不可持续的，并且常常导致包括气候变化的环境问题。微生物发酵为萜烯的生产提供了替代选择。一种或多种萜烯和/或前体可以通过包含CO的底物的微生物发酵产生。重组微生物可以用于这些方法。在这些方法中可以使用羧基营养型，乙酰酵素，重组微生物。例如，重组微型蛋白可以含有外源性甲羟戊酸（MVA）途径酶和/或DXS途径酶。

2. 发明申请

WO2013191567A1 RECOMBINANT MICROORGANISMS MAKE BIODIESEL 审中-公开
标题翻译：重组微生物生物生物
公开(公告)号：WO2013191567A1
公开(公告)日：2013-12-27
申请号：PCT/NZ2013/000108
申请日：2013-06-21
申请人： LANZATECH NEW ZEALAND LIMITED
发明人： LIEW, FungMin , KOEPKE, Michael
IPC分类号： C12N1/21 , C12N15/52 , C12P7/64
CPC分类号： C12P7/649 , C10L1/026 , C12N9/1029 , C12Y203/0102 , C12Y203/01075 , Y02E50/13 , Y02P20/52
摘要： A carboxydotrophic acetogenic recombinant microorganism is modified so that it produces biodiesel and optionally one or more other products by fermentation of a substrate comprising CO. Biodiesel is produced by microbial fermentation of a substrate comprising CO. The recombinant microorganism is modified to express one or more exogenous enzymes in the biodiesel biosynthesis pathway not present in a parental microorganism from which the recombinant microorganism is derived. The one or more enzymes comprise a nonspecific acyltransferase.
摘要翻译：改变羧基营养型乙酰基重组微生物，使其通过发酵包含CO的底物生产生物柴油和任选的一种或多种其它产物。通过包含CO的底物的微生物发酵产生生物柴油。重组微生物被修饰以表达一种或多种外源生物柴油生物合成途径中的酶不存在于衍生重组微生物的亲本微生物中。一种或多种酶包含非特异性酰基转移酶。

3. 发明申请

WO2013185123A1 RECOMBINANT MICROORGANISMS AND USES THEREFOR 审中-公开
标题翻译：重组微生物及其用途
公开(公告)号：WO2013185123A1
公开(公告)日：2013-12-12
申请号：PCT/US2013/044865
申请日：2013-06-09
申请人： LANZATECH NEW ZEALAND LIMITED , MUELLER, Alexander
发明人： MUELLER, Alexander , KOEPKE, Michael , LIEW, FungMin
IPC分类号： C12N1/21 , C12N15/53 , C12N15/60 , C12N15/63 , C12P7/16
CPC分类号： C12N15/74 , C12N1/20 , C12N9/0006 , C12N9/88 , C12P7/16 , C12Y101/01004 , C12Y402/01028 , C12Y402/0103 , Y02E50/10
摘要： Carboxydotrophic acetogenic microorganisms do not produce MEK and/or 2-butanol. They lack the biosynthesis pathways to make these products. In addition, they produce the intermediate (R,R)-2,3-butanediol whereas the production of MEK and 2-butanol requires production of the intermediate (R,S)-2,3-butanediol. Nonetheless, the production of MEK and/or 2-butanol can be accomplished using recombinant microorganisms adapted to express or overexpress key enzymes in the MEK and/or 2-butanol biosynthesis pathways. Such microorganisms, such as the carboxydotrophic acetogen Clostridium autoethanogenum, can ferment substrates comprising CO. The overall scheme ivolves the production of 2-butanol from (R,S)-2,3-butanediol and the conversion of (R)-acetoin to (S)-2,3-butanediol. These steps are involved in the production of both MEK and 2-butanol. Such fermentation methods offer a means of using carbon monoxide from industrial processes which would otherwise be released into the atmosphere and pollute the environment.
摘要翻译：羧化营养性致病微生物不产生MEK和/或2-丁醇。他们缺乏制作这些产品的生物合成途径。此外，它们生产中间体（R，R）-2,3-丁二醇，而生产MEK和2-丁醇需要生产中间体（R，S）-2,3-丁二醇。然而，可以使用适于在MEK和/或2-丁醇生物合成途径中表达或过表达关键酶的重组微生物来实现MEK和/或2-丁醇的生产。这种微生物，如羧基营养型乙酰胆碱梭菌，可以发酵包含CO的底物。总体方案是从（R，S）-2,3-丁二醇生产2-丁醇，并将（R） - 乙酰胆碱转化为（ S）-2,3-丁二醇。这些步骤涉及MEK和2-丁醇的生产。这种发酵方法提供了使用工业过程中的一氧化碳的方法，否则这些方法将被释放到大气中并污染环境。

4. 发明申请

WO2009151342A1 PRODUCTION OF BUTANEDIOL BY ANAEROBIC MICROBIAL FERMENTATION 审中-公开
标题翻译：通过微生物发酵生产丁醇
公开(公告)号：WO2009151342A1
公开(公告)日：2009-12-17
申请号：PCT/NZ2009/000101
申请日：2009-06-05
申请人： LANZATECH NEW ZEALAND LIMITED , SIMPSON, Sean, Dennis , TRAN, Phuong, Loan , MIHALCEA, Christophe, Daniel , FUNG, Jennifer, Mon, Yee , LIEW, FungMin
发明人： SIMPSON, Sean, Dennis , TRAN, Phuong, Loan , MIHALCEA, Christophe, Daniel , FUNG, Jennifer, Mon, Yee , LIEW, FungMin
IPC分类号： C12P7/18 , C10L1/182 , C12R1/145
CPC分类号： C12P7/18 , C12N1/20
摘要： The invention provides methods for producing 2,3-butanediol by anaerobic fermentation. According to particular methods of the invention, 2,3-butaendiol is produced by anaerobic fermentation of substrates including carbohydrate and carbon monoxide.
摘要翻译：本发明提供了通过厌氧发酵生产2,3-丁二醇的方法。根据本发明的具体方法，通过包括碳水化合物和一氧化碳在内的底物的厌氧发酵产生2,3-丁醛。

5. 发明申请

WO2012105853A1 RECOMBINANT MICROORGANISMS WITH INCREASED TOLERANCE TO ETHANOL 审中-公开
标题翻译：重组微生物对乙醇的耐受性较差
公开(公告)号：WO2012105853A1
公开(公告)日：2012-08-09
申请号：PCT/NZ2011/000221
申请日：2011-10-20
申请人： LANZATECH NEW ZEALAND LIMITED , SIMPSON, Sean, Dennis , KOEPKE, Michael , LIEW, FungMin
发明人： SIMPSON, Sean, Dennis , KOEPKE, Michael , LIEW, FungMin
IPC分类号： C12P7/06 , C12N1/21 , C12R1/01 , C12N1/00 , C12N15/74 , C12R1/145
CPC分类号： C12N1/20 , C07K14/33 , C12P7/065 , C12P7/08 , Y02E50/17
摘要： The invention provides a recombinant microorganism capable of producing one or more products by fermentation of a substrate comprising CO, wherein the microorganisms has an increased tolerance to ethanol. The invention also provides, inter alia, methods for the production of ethanol and one or more other products from a substrate comprising CO.
摘要翻译：本发明提供能够通过发酵包含CO的底物产生一种或多种产物的重组微生物，其中微生物对乙醇的耐受性增加。本发明尤其提供了用于从包含CO的底物生产乙醇和一种或多种其它产物的方法。

6. 发明申请

WO2012053905A1 PRODUCTION OF BUTANOL FROM CARBON MONOXIDE BY A RECOMBINANT MICROORGANISM 审中-公开
标题翻译：通过重组微生物从一氧化碳生产丁醇
公开(公告)号：WO2012053905A1
公开(公告)日：2012-04-26
申请号：PCT/NZ2011/000203
申请日：2011-09-29
申请人： LANZATECH NEW ZEALAND LIMITED , KOEPKE, Michael , LIEW, FungMin
发明人： KOEPKE, Michael , LIEW, FungMin
IPC分类号： C12P7/16 , C12N15/74 , C12R1/02 , C07C31/12 , C12P7/52 , C12R1/145 , C12N1/21 , C12R1/01
CPC分类号： C12N15/74 , C12N9/0006 , C12N9/0008 , C12P7/16 , C12R1/145 , Y02E50/10 , Y02P20/52
摘要： The invention relates, inter alia, to novel genetically modified microorganisms capable of using CO to produce 1-butanol and/or a precursor thereof, novel methyltranferases and nucleic acids encoding same, methods for producing genetically modified microorganisms using said novel methyltransferases, and methods of producing 1-butanol and/or a precursor thereof by microbial fermentation.
摘要翻译：本发明尤其涉及能够使用CO来生产1-丁醇和/或其前体的新型遗传修饰的微生物，新的甲基转移酶和编码其的核酸，使用所述新的甲基转移酶生产转基因微生物的方法，以及通过微生物发酵生产1-丁醇和/或其前体。

7. 发明申请

WO2012015317A1 NOVEL BACTERIA AND METHODS OF USE THEREOF 审中-公开
标题翻译：新颖细菌及其使用方法
公开(公告)号：WO2012015317A1
公开(公告)日：2012-02-02
申请号：PCT/NZ2011/000144
申请日：2011-07-28
申请人： LANZATECH NEW ZEALAND LIMITED , HEIJSTRA, Bjorn, Daniel , KERN, Evgenia , KOEPKE, Michael , SEGOVIA, Simon , LIEW, FungMin
发明人： HEIJSTRA, Bjorn, Daniel , KERN, Evgenia , KOEPKE, Michael , SEGOVIA, Simon , LIEW, FungMin
IPC分类号： C12N1/20 , C12P7/06 , C12R1/145
CPC分类号： C12N1/20 , C12P7/065 , C12P7/24 , C12P7/54 , C12R1/145 , Y02E50/17
摘要： This invention relates generally to the field of microbial fermentation of gases. It more particularly relates to a novel strain of Clostridium autoethanogenum bacteria with improved efficiency in the production of ethanol by anaerobic fermentation of substrates containing carbon monoxide (CO).
摘要翻译：本发明一般涉及气体的微生物发酵领域。更具体地说，涉及一种通过厌氧发酵含有一氧化碳（CO）的底物，提高了乙醇生产效率的新型梭菌自发生产菌。

8. 发明公开

EP2859089A1 RECOMBINANT MICROORGANISMS AND USES THEREFOR 有权
标题翻译：重组微生物及其用途
公开(公告)号：EP2859089A1
公开(公告)日：2015-04-15
申请号：EP13800454.4
申请日：2013-06-09
申请人： Lanzatech New Zealand Limited
发明人： KOEPKE, Michael , LIEW, FungMin
IPC分类号： C12N1/21 , C12N15/53 , C12N15/60 , C12N15/63 , C12P7/16
CPC分类号： C12N15/74 , C12N1/20 , C12N9/0006 , C12N9/88 , C12P7/16 , C12Y101/01004 , C12Y402/01028 , C12Y402/0103 , Y02E50/10
摘要： Carboxydotrophic acetogenic microorganisms do not produce MEK and/or 2-butanol. They lack the biosynthesis pathways to make these products. In addition, they produce the intermediate (R,R)-2,3-butanediol whereas the production of MEK and 2-butanol requires production of the intermediate (R,S)-2,3-butanediol. Nonetheless, the production of MEK and/or 2-butanol can be accomplished using recombinant microorganisms adapted to express or overexpress key enzymes in the MEK and/or 2-butanol biosynthesis pathways. Such microorganisms, such as the carboxydotrophic acetogen Clostridium autoethanogenum, can ferment substrates comprising CO. The overall scheme involves the production of 2-butanol from (R,S)-2,3-butanediol and the conversion of (R)-acetoin to (S)-2,3-butanediol. These steps are involved in the production of both MEK and 2-butanol. Such fermentation methods offer a means of using carbon monoxide from industrial processes which would otherwise be released into the atmosphere and pollute the environment.
摘要翻译：嗜羧酸产乙酸微生物不产生MEK和/或2-丁醇。他们缺乏生产这些产品的生物合成途径。另外，它们生产中间体（R，R）-2,3-丁二醇，而生产MEK和2-丁醇需要生产中间体（R，S）-2,3-丁二醇。尽管如此，MEK和/或2-丁醇的生产可以使用适合在MEK和/或2-丁醇生物合成途径中表达或过表达关键酶的重组微生物完成。这样的微生物，如一氧化碳营养型乙酸产气荚膜梭菌（Clostridium autoethanogenum），可以发酵包含CO的底物。总体方案包括从（R，S）-2,3-丁二醇制备2-丁醇和（R） - 乙酸乙酯转化成 S）-2,3-丁二醇。这些步骤涉及MEK和2-丁醇的生产。这种发酵方法提供了从工业过程中使用一氧化碳的手段，否则这些过程会释放到大气中并污染环境。

9. 发明授权

EP2855662B1 RECOMBINANT MICROORGANISMS AND USES THEREFOR 有权
标题翻译：重组微生物及其用途
公开(公告)号：EP2855662B1
公开(公告)日：2018-03-21
申请号：EP13797982.9
申请日：2013-06-04
申请人： Lanzatech New Zealand Limited
发明人： CHEN, Wendy , LIEW, FungMin , KOEPKE, Michael
IPC分类号： C12N15/52 , C12P5/00
CPC分类号： C12P5/007 , C12N15/52 , C12N15/74 , C12P7/42 , C12P9/00 , C12Y101/01088 , C12Y101/01267 , C12Y117/07001 , C12Y202/01007 , C12Y203/01009 , C12Y203/0301 , C12Y205/0101 , C12Y205/0109 , C12Y207/01036 , C12Y207/01148 , C12Y207/04002 , C12Y207/0706 , C12Y401/01033 , C12Y402/03027 , C12Y402/03046 , C12Y406/01012 , C12Y503/03002 , Y02E50/343
摘要： The invention provides a method for producing a terpene or a precursor thereof by microbial fermentation. Typically, the method involves culturing a recombinant bacterium in the presence of a gaseous substrate whereby the bacterium produces a terpene or a precursor thereof, such as mevalonic acid, isopentenyl pyrophosphate, dimethylallyl pyrophosphate, isoprene, geranyl pyrophosphate, farnesyl pyrophosphate, and/or farnesene. The bacterium may comprise one or more exogenous enzymes, such as enzymes in mevalonate, DXS, or terpene biosynthesis pathways.

10. 发明公开

EP3795680A1 RECOMBINANT MICROORGANISMS AND USES THEREFOR 审中-公开
公开(公告)号：EP3795680A1
公开(公告)日：2021-03-24
申请号：EP20192584.9
申请日：2013-06-04
申请人： LanzaTech New Zealand Limited
发明人： CHEN, Wendy , LIEW, FungMin , KOEPKE, Michael
IPC分类号： C12N9/04 , C12N9/10 , C12N9/12 , C12N9/88 , C12N15/52 , C12P5/00
摘要： Terpenes are valuable commercial products used in a diverse number of industries. Terpenes may be produced from petrochemical sources and from terpene feed-stocks, such as turpentine. However, these production methods are expensive, unsustainable and often cause environmental problems including contributing to climate change. Microbial fermentation provides an alternative option for the production of terpenes. One or more terpenes and/or precursors can be produced by microbial fermentation of a substrate comprising CO. Recombinant microorganisms may be used in such methods. Carboxydotrophic, acetogenic, recombinant microorganisms can be used in such methods. The recombinant microorgnsims may contain exogenous mevalonate (MVA) pathway enzymes and/or DXS pathway enzymes, for example.

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