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1. 发明申请

WO0009097A3 PHARMACEUTICAL COMPOSITION WITH ANTITUMOR ACTIVITY ON THE BASIS OF CARBOPLATIN 审中-公开
标题翻译：基于卡铂的抗肿瘤活性药物组合物
公开(公告)号：WO0009097A3
公开(公告)日：2000-05-18
申请号：PCT/CZ9900028
申请日：1999-08-10
申请人： LACHEMA AS , KYSILKA VLADIMIR , ZATLOUKALOVA LIBUSE , MALECEK MIROSLAV , GUST RONALD
发明人： KYSILKA VLADIMIR , ZATLOUKALOVA LIBUSE , MALECEK MIROSLAV , GUST RONALD
IPC分类号： A61K31/555 , A61K9/08 , A61K31/00 , A61K31/194 , A61K31/282 , A61K47/12 , A61P35/00 , C08K5/00 , A61K31/28
CPC分类号： A61K31/00 , C08K5/0091
摘要： The invention concerns a pharmaceutical composition with antitumor activity based on carboplatin and comprising an aqueous solution of carboplatin with a carboplatin content from 1 to 20 mg/ml, which is characterised in that it contains immediately after its preparation an amount of impurities causing a nucleophilic substitution of the carboxylate ligand of carboplatin, especially 1,1-cyclobutanedicarboxylic acid and/or a salt thereof, which is less than 0.1 % by weight based on the weight of the present carboplatin.
摘要翻译：本发明涉及基于卡铂的具有抗肿瘤活性的药物组合物，其包含卡铂含量为1至20mg / ml的卡铂水溶液，其特征在于其在制备后立即含有一定量的引起亲核取代的杂质的卡铂羧酸盐配体，特别是1,1-环丁烷二羧酸和/或其盐，其基于本发明卡铂的重量计小于0.1重量％。

2. 发明申请

WO2008089709A3 OXALIPLATIN PHARMACEUTICAL COMPOSITION WITH ALCOHOLIC SUGAR-BASED BUFFER 审中-公开
标题翻译：含有酒精基糖的缓冲剂的奥沙利铂药物组合物
公开(公告)号：WO2008089709A3
公开(公告)日：2009-06-18
申请号：PCT/CZ2008000006
申请日：2008-01-10
申请人： PLIVA LACHEMA AS , ZALUDEK BOREK , ZATLOUKALOVA LIBUSE , ZAK FRANTISEK , MATEJKOVA BOZENA , TKADLECKOVA HANA
发明人： ZALUDEK BOREK , ZATLOUKALOVA LIBUSE , ZAK FRANTISEK , MATEJKOVA BOZENA , TKADLECKOVA HANA
IPC分类号： A61K9/08 , A61K9/00 , A61K31/282 , A61K47/26
CPC分类号： A61K9/0019 , A61K31/282 , A61K47/12
摘要： A pharmaceutical composition, intended particularly for potential administration and for treatment of tumor diseases sensitive to oxaliplatinum, comprises oxaliplatinum as the active compound, a pharmaceutically acceptable aqueous solvent and a stabilizing agent in stabilizingly effective amount. The stabilizing agent includes at least one compound selected from the group consisting of acids derived from neutral alcoholic sugars, lactones of these acids and salts of these acids. In a method of producing such a pharmaceutical composition, oxaliplatinum is dissolved in an aqueous solvent, whereupon to the obtained oxaliplatinum solution is added at least one acid derived from a neutral alcoholic sugar and/or at least one lactone of these acids and/or at least one salt of these acids, and optionally the pH value of the solution is adjusted by addition of an alkali metal hydroxide and/or an alkali earth metal hydroxide to pH 3.5 - 6.5, whereupon the obtained solution is sterilized and filled into individual package units and optionally inertized with nitrogen or argon.
摘要翻译：特别用于潜在给药和治疗对奥沙利铂敏感的肿瘤疾病的药物组合物包含奥沙利铂作为活性化合物，药学上可接受的水性溶剂和稳定有效量的稳定剂。稳定剂包括选自由中性酒精糖衍生的酸，这些酸的内酯和这些酸的盐中的至少一种化合物。在制备这种药物组合物的方法中，将奥沙利铂溶解在水性溶剂中，然后向得到的奥沙利铂溶液中加入至少一种衍生自中性酒精糖和/或这些酸的至少一种内酯的酸和/或这些酸的至少一种盐，并且任选地通过将碱金属氢氧化物和/或碱土金属氢氧化物加入到pH 3.5-6.5来调节溶液的pH值，由此将所得溶液灭菌并填充到各个包装单元并任选地用氮气或氩气惰性化。

3. 发明专利

CA2675788A1 OXALIPLATIN PHARMACEUTICAL COMPOSITION WITH ALCOHOLIC SUGAR-BASED BUFFER 未知
公开(公告)号：CA2675788A1
公开(公告)日：2008-07-31
申请号：CA2675788
申请日：2008-01-10
申请人： PLIVA LACHEMA AS
发明人： ZALUDEK BOREK , ZATLOUKALOVA LIBUSE , TKADLECKOVA HANA , ZAK FRANTISEK , MATEJKOVA BOZENA
IPC分类号： A61K9/08 , A61K9/00 , A61K31/282 , A61K47/26
摘要： A pharmaceutical composition, intended particularly for potential adminis tration and for treatment of tumor diseases sensitive to oxaliplatinum, comp rises oxaliplatinum as the active compound, a pharmaceutically acceptable aq ueous solvent and a stabilizing agent in stabilizingly effective amount. The stabilizing agent includes at least one compound selected from the group co nsisting of acids derived from neutral alcoholic sugars, lactones of these a cids and salts of these acids. In a method of producing such a pharmaceutica l composition, oxaliplatinum is dissolved in an aqueous solvent, whereupon t o the obtained oxaliplatinum solution is added at least one acid derived fro m a neutral alcoholic sugar and/or at least one lactone of these acids and/or at least one salt of these acids, and optionally the pH value of the solut ion is adjusted by addition of an alkali metal hydroxide and/or an alkali ea rth metal hydroxide to pH 3.5 - 6.5, whereupon the obtained solution is ster ilized and filled into individual package units and optionally inertized wit h nitrogen or argon.

4. 发明专利

PL372071A1 STABILISED PHARMACEUTICAL COMPOSITIONS ON THE BASIS OF POLYOXYETHYLATED CASTOR OIL AND METHOD FOR MANUFACTURING THE SAME 未知
公开(公告)号：PL372071A1
公开(公告)日：2005-07-11
申请号：PL37207103
申请日：2003-05-16
申请人： PLIVA LACHEMA AS
发明人： KYSILKA VLADIMIR , ZATLOUKALOVA LIBUSE , ZALUDEK BOREK , POSPISILIK KAREL , CIGANKOVA MARIE , KUBAT MARTIN , CIRKVA ALES
IPC分类号： A61K20060101 , A61K9/00 , A61K31/337 , A61K31/4375 , A61K31/4745 , A61K36/47 , A61K47/02 , A61K47/10 , A61K47/44 , A61P35/00 , C11B1/00
摘要： The invention relates to a stabilised pharmaceutical composition comprising a pharmaceutically active substance poorly soluble in water, a solubilising agent with a low content of both basic and acidlic compounds and a polar organic solvent, in particular a stabilised injection concentrate, methods for preparing such stabilised pharmaceutical compositions and the use of a solubilising agent with a low content of both basic and acidic compounds to stabilise pharmaceutical compositions for pharmaceutically active substances.

5. 发明专利

AU2003240661A1 STABILISED PHARMACEUTICAL COMPOSITIONS ON THE BASIS OF POLYOXYETHYLATED CASTOR OIL AND METHOD FOR MANUFACTURING THE SAME 未知
公开(公告)号：AU2003240661A1
公开(公告)日：2003-12-22
申请号：AU2003240661
申请日：2003-05-16
申请人： PLIVA LACHEMA AS
发明人： CIRKVA ALES , KYSILKA VLADIMIR , ZATLOUKALOVA LIBUSE , ZALUDEK BOREK , POSPISILIK KAREL , CIGANKOVA MARIE , KUBAT MARTIN
IPC分类号： A61K20060101 , A61K9/00 , A61K31/337 , A61K31/4375 , A61K31/4745 , A61K36/47 , A61K47/02 , A61K47/10 , A61K47/44 , A61P35/00 , C11B1/00
摘要： The invention relates to a stabilised pharmaceutical composition comprising a pharmaceutically active substance poorly soluble in water, a solubilising agent with a low content of both basic and acidlic compounds and a polar organic solvent, in particular a stabilised injection concentrate, methods for preparing such stabilised pharmaceutical compositions and the use of a solubilising agent with a low content of both basic and acidic compounds to stabilise pharmaceutical compositions for pharmaceutically active substances.

6. 发明专利

BRPI0806728A2 未知
公开(公告)号：BRPI0806728A2
公开(公告)日：2011-09-13
申请号：BRPI0806728
申请日：2008-01-10
申请人： PLIVA LACHEMA AS
发明人： ZALUDEK BOREK , ZATLOUKALOVA LIBUSE , ZAK FRANTISEK , MATEJKOVA BOZENA , TKADLECKOVA HANA
IPC分类号： A61K9/08 , A61K9/00 , A61K31/282 , A61K47/26
摘要： A pharmaceutical composition, intended particularly for potential administration and for treatment of tumor diseases sensitive to oxaliplatinum, comprises oxaliplatinum as the active compound, a pharmaceutically acceptable aqueous solvent and a stabilizing agent in stabilizingly effective amount. The stabilizing agent includes at least one compound selected from the group consisting of acids derived from neutral alcoholic sugars, lactones of these acids and salts of these acids. In a method of producing such a pharmaceutical composition, oxaliplatinum is dissolved in an aqueous solvent, whereupon to the obtained oxaliplatinum solution is added at least one acid derived from a neutral alcoholic sugar and/or at least one lactone of these acids and/or at least one salt of these acids, and optionally the pH value of the solution is adjusted by addition of an alkali metal hydroxide and/or an alkali earth metal hydroxide to pH 3.5-6.5, whereupon the obtained solution is sterilized and filled into individual package units and optionally inertized with nitrogen or argon.

7. 发明专利

AR040184A1 COMPOSICIONES FARMACEUTICAS ESTABILIZADAS BASADAS EN ACEITE DE RICINO POLIOXIETILADO Y METODO PARA LA FABRICACION DE LAS MISMAS 未知
公开(公告)号：AR040184A1
公开(公告)日：2005-03-16
申请号：ARP030102055
申请日：2003-06-10
申请人： PLIVA LACHEMA AS
发明人： KYSILKA VLADIMIR , ZATLOUKALOVA LIBUSE , ZALUDEK BOREK , POSPISILIK KAREL , KUBAT MARTIN , CIRKVA ALES , CIGANKOVA MARIE
IPC分类号： A61K47/44 , A61K31/337 , A61K31/4353 , A61P35/00
摘要： Composición farmacéutica estabilizada que comprende una sustancia farmacológicamente activa escasamente soluble en agua, un agente de solubilización con un bajo contenido de compuestos ácidos y básicos, y un solvente orgánico polar, en particular, un concentrado estabilizado de inyección, métodos para preparar dichas composiciones farmacéuticas estabilizadas y el uso de un agente de solubilización con un bajo contenido de compuestos ácidos y básicos para estabilizar composiciones farmacéuticas de sustancias farmacológicamente activas. Reivindicación 1: Una composición farmacéutica estabilizada caracterizada porque comprende una sustancia farmacológicamente activa y un sistema de solventes que comprende un solvente orgánico polar y un agente de solubilización, donde el agente es un aceite de ricino polioxietilado, caracterizado porque el contenido de compuestos básicos es menor que 0,6 x 10-6 gramos equivalentes / ml y el contenido de compuestos ácidos es menor que 0,06% en masa, sobre la base de la masa del aceite de ricino polioxietilado. Reivindicación 6: La composición estabilizada de acuerdo con la reivindicación 5, caracterizada porque el compuesto farmacológicamente activo se selecciona del grupo que consiste en paclitaxel, camptotecina y sus derivados.

8. 发明专利

DE69921832D1 未知
公开(公告)号：DE69921832D1
公开(公告)日：2004-12-16
申请号：DE69921832
申请日：1999-08-10
申请人： PLIVA LACHEMA AS
发明人： KYSILKA VLADIMIR , ZATLOUKALOVA LIBUSE , MALECEK MIROSLAV , GUST RONALD
IPC分类号： A61K31/555 , A61K9/08 , A61K31/00 , A61K31/194 , A61K31/282 , A61K47/12 , A61P35/00 , C08K5/00 , A61K31/28
摘要： The invention concerns a pharmaceutical composition with antitumor activity based on carboplatin, comprising an aqueous solution of carboplatin with the carboplatin content from 1 to 20 mg.ml.-1. The pharmaceutical composition contains, immediately after its preparation, less than 0.1% by weight 1,1-cyclobutanedicarboxylic acid ("CBDCA") and/or salt thereof, based on the weight of the present carboplatin.

9. 发明专利

NO20045398L 未知
公开(公告)号：NO20045398L
公开(公告)日：2004-12-10
申请号：NO20045398
申请日：2004-12-10
申请人： PLIVA LACHEMA AS
发明人： KYSILKA VLADIMIR , ZATLOUKALOVA LIBUSE , ZALUDEK BOREK , POSPISILIK KAREL , CIGANKOVA MARIE , KUBAT MARTIN , CIRKVA ALES
IPC分类号： A61K47/44

10. 发明专利

NO20045398A 未知
公开(公告)号：NO20045398A
公开(公告)日：2004-12-10
申请号：NO20045398
申请日：2004-12-10
申请人： PLIVA LACHEMA AS
发明人： KYSILKA VLADIMIR , ZATLOUKALOVA LIBUSE , ZALUDEK BOREK , POSPISILIK KAREL , CIGANKOVA MARIE , KUBAT MARTIN , CIRKVA ALES
IPC分类号： A61K47/44

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