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1. 发明申请

WO2010084052A2 USE OF CATIONIC SURFACTANTS AS ACARICIDAL AGENTS 审中-公开
标题翻译：使用阳离子表面活性剂作为杀菌剂
公开(公告)号：WO2010084052A2
公开(公告)日：2010-07-29
申请号：PCT/EP2010/050253
申请日：2010-01-12
申请人： LABORATORIOS MIRET, S. A. , ROCABAYERA BONVILA, Xavier , FIGUERAS ROCA, Sergi
发明人： ROCABAYERA BONVILA, Xavier , FIGUERAS ROCA, Sergi
CPC分类号： A01N43/50 , A01N37/30 , A01N47/44 , A23B4/20 , A23L3/3463 , A23L3/3526 , A61K31/216 , A61K31/4164
摘要： This invention relates to a use of a composition for protecting against mites and ticks containing cationic surfactants such as ethyl-Nα-lauroyl-L-arginate HCI (LAE). It has been found that cationic surfactants such as ethyl -N α- lauroyl-L-arginate HCI (LAE) and its salts are effective acaricidal agents.
摘要翻译：本发明涉及用于防止含有阳离子表面活性剂如乙基月桂酰-L-精氨酸盐酸盐（LAE）的螨虫和蜱的组合物的用途。已经发现阳离子表面活性剂如月桂酰-L-精氨酸乙酯盐酸盐（LAE）及其盐是有效的杀螨剂。

2. 发明申请

WO2009101115A1 USE OF CATIONIC SURFACTANTS FOR THE PROTECTION AGAINST TOOTH EROSION 审中-公开
标题翻译：使用阳离子表面活性剂防止牙齿腐蚀
公开(公告)号：WO2009101115A1
公开(公告)日：2009-08-20
申请号：PCT/EP2009/051587
申请日：2009-02-11
申请人： LABORATORIOS MIRET, S.A. , ROCABAYERA BONVILA, Xavier , FIGUERAS ROCA, Sergi , SEGRET PONS, Roger , PIERA EROLES, Eva
发明人： ROCABAYERA BONVILA, Xavier , FIGUERAS ROCA, Sergi , SEGRET PONS, Roger , PIERA EROLES, Eva
IPC分类号： A61Q11/00 , A23G4/12
CPC分类号： A61Q11/00 , A23G3/364 , A23G3/40 , A23G4/066 , A23G4/12 , A23V2002/00 , A61K8/0216 , A61K8/44 , A61K8/494 , A23V2200/312 , A23V2200/222
摘要： This invention relates to a use of a composition for protecting oral cavity and teeth containing ethyl-Nα-lauroyl-L-arginate HCI (LAE), a corresponding composition and a corresponding method for protecting teeth. Because of nearly epidemic incidence of dental erosion, there is a continuing need for improved products that provide protection against dental erosion. Hence, it is an object of the present invention to protect teeth against dental erosion. Surprisingly, it has been found that ethyl-Nα-lauroyl-L-arginate HCI (LAE) and its salts attach to teeth and provide protection of teeth from erosion especially caused by the action of acid in food products and drinks such as chewing gum and lozenges compositions. Special advantages of this invention are: (a) sustained coating of the teeth by LAE and its homologues; (b) the coating agent provides a source of neutralizing plaque acids by providing sustained base formation. This is because arginines in LAE is degraded by bacteria on tooth in the mouth to produce ammonia. Thus, this chemistry not only provides the coating protection but also generates base to maintain pH balance on a sustained basis; and (c) avoid the use of brushing with abrasive cleansers.
摘要翻译：本发明涉及用于保护含有月桂酰-L-精氨酸乙酯钠盐（LAE）的口腔和牙齿的组合物的用途，相应的组合物和相应的保护牙齿的方法。由于牙齿侵蚀发生几乎流行，因此继续需要提供防止牙齿侵蚀的改良产品。因此，本发明的目的是保护牙齿免受牙齿侵蚀。令人惊讶的是，已经发现乙基 - 月桂酰-L-精氨酸盐酸盐（LAE）及其盐附着在牙齿上，并且保护牙齿免受侵蚀，特别是由于酸在食品和饮料中的作用引起的，例如口香糖和锭剂组合物本发明的特殊优点是：（a）通过LAE及其同系物持续涂覆牙齿; （b）涂层剂通过提供持续的碱形成提供中和斑块酸源。这是因为LAE中的精氨酸被口腔中的牙齿上的细菌降解以产生氨。因此，这种化学不仅提供了涂层保护，而且还产生了基础，以持续地维持pH平衡; 和（c）避免使用磨料清洁剂进行刷牙。

3. 发明申请

WO2009080563A1 USE OF CATIONIC SURFACTANTS AGAINST FISH PARASITES 审中-公开
标题翻译：使用阳离子表面活性剂对鱼类寄生虫
公开(公告)号：WO2009080563A1
公开(公告)日：2009-07-02
申请号：PCT/EP2008/067425
申请日：2008-12-12
申请人： LABORATORIOS MIRET, S.A. , ROCABAYERA BONVILA, Xavier , FIGUERAS ROCA, Sergi , SEGRET PONS, Roger , PIERA EROLES, Eva
发明人： ROCABAYERA BONVILA, Xavier , FIGUERAS ROCA, Sergi , SEGRET PONS, Roger , PIERA EROLES, Eva
IPC分类号： A23B4/20 , A23L3/3526 , A23L3/3544
CPC分类号： A23L3/3526 , A23B4/20 , A23L3/3544
摘要： Cationic surfactants derived from the condensation of fatty acids and esterified dibasic amino acids, such as from lauric acid and arginine, in particular the ethyl ester of the lauramide of the arginine monohydrochloride (LAE), may be used for the treatment of fish which is infected with parasites. The cationic surfactants of this type are effective against the larvae of parasites such as Anisakis.
摘要翻译：衍生自脂肪酸和酯化二元氨基酸如月桂酸和精氨酸，特别是精氨酸一盐酸盐（LAE）的月桂酰胺的乙酯的缩合产生的阳离子表面活性剂可用于治疗感染的鱼与寄生虫。这种阳离子表面活性剂对寄生虫如Anisakis的幼虫有效。

4. 发明申请

WO2009033508A2 COMBINATIONS OF POLYENE FUNGICIDE WITH CATIONIC SURFACTANTS 审中-公开
标题翻译：聚苯乙烯杀菌剂与阳离子表面活性剂的组合
公开(公告)号：WO2009033508A2
公开(公告)日：2009-03-19
申请号：PCT/EP2007/060598
申请日：2007-10-05
申请人： LABORATORIOS MIRET, S.A. , ROCABAYERA BONVILA, Xavier , FIGUERAS ROCA, Sergi , SEGRET PONS, Roger , PIERA EROLES, Eva
发明人： ROCABAYERA BONVILA, Xavier , FIGUERAS ROCA, Sergi , SEGRET PONS, Roger , PIERA EROLES, Eva
IPC分类号： A01N43/90 , A01N47/44 , A01N25/30 , A01P1/00 , A01P3/00 , A23C19/11 , A23L3/3463
CPC分类号： A23B4/22 , A01N43/90 , A23B4/20 , A23C19/11 , A23L3/3463 , A23L3/34635 , A01N2300/00
摘要： A solid composition comprising a cationic surfactant, such as the ethyl ester of the lauramide of the arginine monohydrochloride (LAE) and a polyene fungicide such as natamycin is provided. The solid composition is the basis for providing solutions of natamycin of increased concentration. The solid composition may be used for providing a dispersion of natamycin in a suitable liquid, such as tap water or an organic solvent. The dispersion may be further diluted with water. This leads to a solution of natamycin in water. The combination of the cationic surfactant and the polyene fungicide displays a biological effect which is stronger than the effect of each of the two components alone.
摘要翻译：提供了包含阳离子表面活性剂（例如精氨酸一盐酸盐（LAE）的月桂酰胺的乙酯和多烯杀真菌剂如游霉素）的固体组合物。固体组合物是提供浓度增加的那他霉素溶液的基础。该固体组合物可用于提供纳他霉素在合适液体例如自来水或有机溶剂中的分散体。分散体可以进一步用水稀释。这导致纳他霉素在水中的溶液。阳离子表面活性剂和多烯杀真菌剂的组合显示比单独的两种组分中的每一种的效果更强的生物效应。

5. 发明申请

WO2008095534A1 NEW COMBINATION OF CATIONIC PRESERVATIVES WITH TASTE-MASKING COMPONENTS 审中-公开
标题翻译：具有吸收组分的阳离子防腐剂的新组合
公开(公告)号：WO2008095534A1
公开(公告)日：2008-08-14
申请号：PCT/EP2007/051168
申请日：2007-02-07
申请人： LABORATORIOS MIRET, S.A. , ROCABAYERA BONVILA, Xavier , FIGUERAS ROCA, Sergi , SEGRET PONS, Roger , PIERA EROLES, Eva
发明人： ROCABAYERA BONVILA, Xavier , FIGUERAS ROCA, Sergi , SEGRET PONS, Roger , PIERA EROLES, Eva
IPC分类号： A23L2/44 , A23L3/3526 , A61K8/44 , A61Q11/00 , A23L1/226 , A23L1/227 , A23L1/229 , A23L1/236 , A23L1/22
CPC分类号： A61K8/44 , A23L2/44 , A23L2/56 , A23L2/60 , A23L3/3526 , A23L3/3544 , A23L27/20 , A23L27/30 , A23L27/84 , A23L27/86 , A23V2002/00 , A61K2800/524 , A61Q11/00 , A23V2200/16 , A23V2250/264 , A23V2200/10 , A23V2250/06 , A23V2250/24
摘要： Use of cationic surfactants, derived from the condensation of fatty acids and esterified dibasic amino acids, of the formula (I): occasionally leads to a bitter taste, when the compound is present in a large concentration. The bitter taste can be masked by combination with a second component selected from the list consisting of sucralose, neohespiridin (NHDC), β-cyclodextrin, mono ammonium glycyrrhizinate (MAG), banana, mentholyptus, sodium dodecyl sulphate (SDS), anetol, menthol, thaumatin, adenosine monophosphate (AMP), aloten, arginine, sodium acetate, arilic acids (ferulic acid, caffeic acid), sclareolide, maltol, anane, phosphatidic acid, eucalyptol, lactisole, lysozyme, lactoglobulin, timol, borneol, acetol, phosphothreonine, phosphotyrosine, phosphoserine, Masking flavour 501521T, Masking flavour 501522, saccharine, aspartame, MK22 N&A FL for masking #25682, MM24 Prosweet N&A FL Enhancer, neodiosmin, xylitol, stevia and Natural and Functional Flavour (NAF ® ).
摘要翻译：衍生自式（I）的脂肪酸和酯化的二元氨基酸的缩合的阳离子表面活性剂的使用：当化合物以大的浓度存在时，偶尔会导致苦味。可以通过与选自三氯蔗糖，新西兰白藜芦素（NHDC），β-环糊精，甘草酸甘草酸（MAG），香蕉，薄荷醇，十二烷基硫酸钠（SDS），茴香醚，薄荷醇的列表组合的第二组分的组合掩蔽苦味，马齿苋，阿魏酸，磷脂酸，桉油醇，乳清蛋白，溶菌酶，乳球蛋白，酪醇，冰片，丙酮醇，磷酸苏氨酸（阿司匹林），磷酸肌酸，磷酸酪氨酸，磷酸丝氨酸，掩蔽风味501521T，掩蔽风味501522，糖精，阿斯巴甜，MK22 N＆A FL用于掩蔽＃25682，MM24 Prosweet N＆A FL Enhancer，neodiosmin，木糖醇，甜菊和天然和功能性风味（NAF ）。

6. 发明申请

WO2008014824A1 ANTIVIRAL USE OF CATIONIC SURFACTANT 审中-公开
标题翻译：阳离子表面活性剂的有害使用
公开(公告)号：WO2008014824A1
公开(公告)日：2008-02-07
申请号：PCT/EP2006/065035
申请日：2006-08-03
申请人： LABORATORIOS MIRET, S.A. , ROCABAYERA BONVILA, Xavier , FIGUERAS ROCA, Sergi , SEGRET PONS, Roger
发明人： ROCABAYERA BONVILA, Xavier , FIGUERAS ROCA, Sergi , SEGRET PONS, Roger
IPC分类号： A61K31/16 , A61P31/12
CPC分类号： A61K31/16
摘要： Cationic surfactants derived from the condensation of fatty acids and esterified dibasic amino acids, such as from lauric acid and arginine, in particular the ethyl ester of the lauramide of the arginine monohydrochloride (LAE), may be used for the protection against the growth of the microorganisms. The cationic surfactants of this type are also effective against virus infections. Addition of LAE to cultures of Herpes virus type 1 Vaccinia virus and bovine parainfluenzae 3 virus leads to nearly complete reduction of the virus organisms in these cultures, such effects being observed after 5 and 60 minutes.
摘要翻译：衍生自脂肪酸和酯化的二元氨基酸（例如月桂酸和精氨酸），特别是精氨酸一盐酸盐（LAE）的月桂酰胺的乙酯的缩合产生的阳离子表面活性剂可用于防止生长微生物。这种阳离子表面活性剂对于病毒感染也是有效的。在1型疱疹病毒和牛副流感病毒3病毒的培养物中添加LAE导致这些培养物中病毒生物体的几乎完全减少，在5和60分钟后观察到这种效应。

7. 发明申请

WO2010136405A1 NOVEL METHOD FOR THE TREATMENT OF FOOD PRODUCTS 审中-公开
标题翻译：用于治疗食品的新方法
公开(公告)号：WO2010136405A1
公开(公告)日：2010-12-02
申请号：PCT/EP2010/057059
申请日：2010-05-21
申请人： LABORATORIOS MIRET, S.A. , ROCABAYERA BONVILA, Xavier , FIGUERAS ROCA, Sergi , CARPINTERO CORDERO, Eloy , PIERA EROLES, Eva
发明人： ROCABAYERA BONVILA, Xavier , FIGUERAS ROCA, Sergi , CARPINTERO CORDERO, Eloy , PIERA EROLES, Eva
IPC分类号： A23B4/20 , A23B4/30 , A23B5/12 , A23B5/20 , A23B7/158 , A23B7/16 , A23B9/26 , A23B9/32 , A23L3/3454 , A23L3/3526 , A23L3/3589
CPC分类号： A23L3/3526 , A23B4/10 , A23B4/20 , A23B4/30 , A23L3/3454 , A23L3/3589
摘要： The invention is a method for the treatment of food products, wherein the food product is cut in slices or in cubes, and the slices or cubes are treated with an antimicrobial solution in the form of a cloud of droplets, characterized in that the treatment with the antimicrobial solution is conducted during the cutting of the slices or the cubes. The invention is also a cutting device for conducting the method of the invention. This cutting device contains at least one nozzle or system of spray dosage for the simultaneous treatment of the slices of the food product and the cutting blade.
摘要翻译：本发明是用于处理食品的方法，其中食品以切片或立方体切割，切片或立方体用微滴形式的抗微生物溶液处理，其特征在于用抗微生物溶液在切片或立方体时进行。本发明也是用于实施本发明的方法的切割装置。该切割装置包含用于同时处理食品和切割刀片的至少一个喷嘴或喷雾剂系统。

8. 发明申请

WO2010000744A3 USE OF CATIONIC SURFACTANTS AS SPORICIDAL AGENTS 审中-公开
公开(公告)号：WO2010000744A3
公开(公告)日：2010-01-07
申请号：PCT/EP2009/058197
申请日：2009-06-30
申请人： LABORATORIOS MIRET, S.A. , ROCABAYERA BONVILA, Xavier , FIGUERAS ROCA, Sergi , SEGRET PONS, Roger , PIERA EROLES, Eva
发明人： ROCABAYERA BONVILA, Xavier , FIGUERAS ROCA, Sergi , SEGRET PONS, Roger , PIERA EROLES, Eva
IPC分类号： A01N37/46 , A01N43/50 , A23B4/20 , A61L2/00 , A61L2/16 , A61L12/14 , C11D3/00 , A01P3/00 , A01P15/00
摘要： Cationic surfactants derived from the condensation of fatty acids and esterified dibasic amino acids, such as from lauric acid and arginine, in particular the ethyl ester of the laurarnide of the arginine monohydrochloride (LAE), may be used for the treatment of objects which are infected with spores. The spores may originate from bacteria or fungi.

9. 发明申请

WO2012164061A2 COSMETIC PREPARATIONS AGAINST DANDRUFF 审中-公开
标题翻译：化妆品制剂反对丹麦
公开(公告)号：WO2012164061A2
公开(公告)日：2012-12-06
申请号：PCT/EP2012/060343
申请日：2012-06-01
申请人： LABORATORIOS MIRET, S.A. , BELTRÁN, Pina Maria Teresa , ROCABAYERA BONVILA, Xavier , MINGUET BONVEHÍ, Maria
发明人： BELTRÁN, Pina Maria Teresa , ROCABAYERA BONVILA, Xavier , MINGUET BONVEHÍ, Maria
IPC分类号： A61K8/44
CPC分类号： A61K8/44 , A61K8/368 , A61K8/4926 , A61K8/4933 , A61Q5/006 , A61Q5/02 , A61Q5/12
摘要： Cosmetic preparations for the treatment of dandruff contain Ethyl LauroyI Arginate HCI (LAE ) in combination with a further active ingredient which is effective against dandruff. Such a further active ingredient may be at least one selected from the group consisting of zinc pyrithione, salicylic acid and piroctone olamine.
摘要翻译：用于治疗头皮屑的化妆品制剂含有L-赖氨酸精氨酸盐酸盐（LAE）和与头皮屑有效的其它活性成分的组合。这种另外的活性成分可以是选自吡啶硫酮锌，水杨酸和吡罗酮醇胺中的至少一种。

10. 发明申请

WO2003064669A1 ENZYMATIC SYNTHESIS OF Nα-ACYL-L-ARGININE ESTERS 审中-公开
标题翻译： Nα-乙酰-L-阿魏酸酯的酶促合成
公开(公告)号：WO2003064669A1
公开(公告)日：2003-08-07
申请号：PCT/EP2002/001070
申请日：2002-02-01
申请人： LAMIRSA (LABORATORIOS MIRET, S.A.) , ROCABAYERA BONVILA, Xavier , SEGUER BONAVENTURA, Joan
发明人： ROCABAYERA BONVILA, Xavier , SEGUER BONAVENTURA, Joan
IPC分类号： C12P13/04
CPC分类号： C12P13/08 , C12P13/04 , C12P13/10 , C12P13/24
摘要： The invention relates to a process for preparing a Na-acyl-L-arginine ester, derived from fatty acids and esterified dibasic amino acids, according to the following formula (I), where:X- is Br-, Cl-, or HSO4- R1: is linear alkyl chain from an saturated fatty acid, or hydroxy-acid from 8 to 14 atoms of carbon bonded to the ∝- amino acid group through amidic bond. R2: is a linear or branched alkyl chain from 1 to 18 carbon atoms or aromatic. R3: is formula (II), where n can be from 0 to 4, from the appropriate organic acid and alcohol. The process is catalyzed by a hydrolase, more in particular a protease, the protease papain from Carica papaya being highly suitable . In order for the esterification reaction to run as wanted, the process is performed in a low-water-content organic medium. When the highly suitable papain from Carica papaya is used, a water activity of between 0,03 and 0,5 is selected.
摘要翻译：本发明涉及根据下式（I）制备衍生自脂肪酸和酯化二元氨基酸的酰基-L-精氨酸酯的方法，其中：X-是Br-，Cl-或HSO 4 R1是来自饱和脂肪酸的直链烷基链，或通过酰胺键键合到丙氨酸基团的8-14个碳原子的羟基酸。 R2：是1至18个碳原子或芳族的直链或支链烷基链。 R3：由适当的有机酸和醇组成的式（II），其中n可为0至4。该方法由水解酶，更特别是蛋白酶催化，来自木瓜木瓜的蛋白酶木瓜蛋白酶是非常适合的。为了使酯化反应按需要运行，该方法在低含水量的有机介质中进行。当使用来自番木瓜的高度适宜的木瓜蛋白酶时，选择0.03-0.5的水分活度。

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