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1. 发明申请

US20120316127A1 METHOD OF MANUFACTURING COATING AGENT FOR DRUG RELEASING STENT AND COATING AGENT FOR DRUG RELEASING STENT MANUFACTURED THEREBY 审中-公开
标题翻译：制造用于药物释放的涂层剂的方法和用于药物释放的涂层剂
公开(公告)号：US20120316127A1
公开(公告)日：2012-12-13
申请号：US13491145
申请日：2012-06-07
申请人： Kyong-Min SHIN , Kun Na
发明人： Kyong-Min SHIN , Kun Na
IPC分类号： A61K31/7068 , A61P35/00 , B05D5/00
CPC分类号： A61L31/16 , A61L31/10 , A61L2300/416 , A61L2300/608 , A61L2420/02 , C08L75/04 , C08L27/18
摘要： This invention relates to a method of manufacturing a coating agent for a drug releasing stent and to a coating agent for a drug releasing stent manufactured thereby. This method includes (1) dissolving polyurethane in tetrahydrofuran, (2) dissolving pluronic F-127 in tetrahydrofuran, (3) dissolving a gemcitabine compound in ethanol, (4) mixing these three solutions obtained in (1) to (3) thus preparing a solution mixture, (5) applying the solution mixture obtained in (4) on a stent coated with a Teflon film, (6) drying the stent of (5) for a predetermined period of time and then immersing the stent in a polyurethane solution in tetrahydrofuran, and (7) removing the stent immersed in (6) from the polyurethane solution and then drying the stent, so that the rate of release of an anti-cancer drug applied on the stent can be continuously and maximally improved thereby maximizing anti-cancer efficacy.
摘要翻译：本发明涉及一种制造药物释放支架用涂布剂的方法及其制造的药物释放支架用涂布剂。该方法包括（1）将聚氨酯溶于四氢呋喃中，（2）将普鲁尼克F-127溶解在四氢呋喃中，（3）将吉西他滨化合物溶于乙醇中，（4）将（1）至（3）中得到的三种溶液混合，溶液混合物，（5）将（4）中得到的溶液混合物涂布在涂有特氟龙膜的支架上，（6）将（5）的支架干燥规定时间，然后将支架浸渍在聚氨酯溶液在四氢呋喃中，和（7）从聚氨酯溶液中取出浸没在（6）中的支架，然后干燥支架，使得施加在支架上的抗癌药物的释放速率可以连续和最大程度地提高，从而最大化抗 - 功效

2. 发明授权

US08017143B2 Coating agent for drug releasing stent, preparation method thereof and drug releasing stent coated therewith 有权
标题翻译：用于药物释放支架的涂层剂，其制备方法和涂覆的药物释放支架
公开(公告)号：US08017143B2
公开(公告)日：2011-09-13
申请号：US12154864
申请日：2008-05-28
申请人： Kyong-Min Shin , Dong-ki Lee , Don-haeng Lee , Kun Na , Eun-ae Jo
发明人： Kyong-Min Shin , Dong-ki Lee , Don-haeng Lee , Kun Na , Eun-ae Jo
IPC分类号： A61K31/337 , A61K47/36 , A61K47/34
CPC分类号： A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/606 , C08L5/00 , C08L75/04
摘要： Disclosed are a coating agent for drug releasing stents, a method for preparing the same and a drug releasing stent coated therewith. The coating agent comprises a biologically active material and a coating material selected from among pullulan acetate, represented by the following Chemical Formula 1, and a polyurethane-surfactant mixture.
摘要翻译：公开了用于药物释放支架的包衣剂，其制备方法和涂覆有药物释放支架的药物释放支架。涂层剂包括生物活性材料和选自下列化学式1表示的醋酸支链淀粉中的涂料和聚氨酯 - 表面活性剂混合物。

3. 发明授权

US07994213B2 Coating agent for drug releasing stent, preparation method thereof and drug releasing stent coated therewith 有权
标题翻译：用于药物释放支架的涂层剂，其制备方法和涂覆的药物释放支架
公开(公告)号：US07994213B2
公开(公告)日：2011-08-09
申请号：US12154863
申请日：2008-05-28
申请人： Kyong-Min Shin , Dong-ki Lee , Don-haeng Lee , Kun Na , Eun-ae Jo
发明人： Kyong-Min Shin , Dong-ki Lee , Don-haeng Lee , Kun Na , Eun-ae Jo
IPC分类号： A61K31/337 , A61K9/14 , A61K47/48 , A61K31/56 , A61K31/131 , A01N43/02 , A61F2/82 , A61F13/00
CPC分类号： A61L31/16 , A61L31/10 , A61L2300/416 , A61L2300/624 , A61L2400/12 , C08L79/02
摘要： Disclosed are a coating agent for drug releasing stents, a method for preparing the same and a drug releasing stent coated therewith. The coating agent for drug releasing stents comprises nanoparticles with a biologically active material entrapped therein, wherein the particles are formed of a polyethyleneimine (PEI)-deoxycholic acid (DOCA) polymer (PDo) in which 1˜8 moles of DOCA are grafted per mole of PEI.
摘要翻译：公开了用于药物释放支架的包衣剂，其制备方法和涂覆有药物释放支架的药物释放支架。用于药物释放支架的包衣剂包含其中包含生物活性物质的纳米颗粒，其中所述颗粒由聚乙烯亚胺（PEI） - 脱氧胆酸（DOC）聚合物（PDo）形成，其中每摩尔接枝1〜8摩尔DOCA 的PEI。

4. 发明申请

US20090286864A1 Coating agent for drug releasing stent, preparation method thereof and drug releasing stent coated therewith 有权
标题翻译：用于药物释放支架的涂层剂，其制备方法和涂覆的药物释放支架
公开(公告)号：US20090286864A1
公开(公告)日：2009-11-19
申请号：US12154863
申请日：2008-05-28
申请人： Kyong-Min Shin , Dong-ki Lee , Don-haeng Lee , Kun Na , Eun-ae Jo
发明人： Kyong-Min Shin , Dong-ki Lee , Don-haeng Lee , Kun Na , Eun-ae Jo
IPC分类号： A61K31/337
CPC分类号： A61L31/16 , A61L31/10 , A61L2300/416 , A61L2300/624 , A61L2400/12 , C08L79/02
摘要： Disclosed are a coating agent for drug releasing stents, a method for preparing the same and a drug releasing stent coated therewith. The coating agent for drug releasing stents comprises nanoparticles with a biologically active material entrapped therein, wherein the particles are formed of a polyethyleneimine (PEI)-deoxycholic acid (DOCA) polymer (PDo) in which 1˜8 moles of DOCA are grafted per mole of PEI.
摘要翻译：公开了用于药物释放支架的包衣剂，其制备方法和涂覆有药物释放支架的药物释放支架。用于药物释放支架的包衣剂包含其中包含生物活性物质的纳米颗粒，其中所述颗粒由聚乙烯亚胺（PEI） - 脱氧胆酸（DOC）聚合物（PDo）形成，其中每摩尔接枝1〜8摩尔DOCA 的PEI。

5. 发明申请

US20080300296A1 Coating agent for drug releasing stent, preparation method thereof and drug releasing stent coated therewith 有权
标题翻译：用于药物释放支架的涂层剂，其制备方法和涂覆的药物释放支架
公开(公告)号：US20080300296A1
公开(公告)日：2008-12-04
申请号：US12154864
申请日：2008-05-28
申请人： Kyong-Min Shin , Dong-ki Lee , Don-haeng Lee , Kun Na , Eun-ae Jo
发明人： Kyong-Min Shin , Dong-ki Lee , Don-haeng Lee , Kun Na , Eun-ae Jo
IPC分类号： A61K31/337 , A61K47/36 , A61K47/34
CPC分类号： A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/606 , C08L5/00 , C08L75/04
摘要： Disclosed are a coating agent for drug releasing stents, a method for preparing the same and a drug releasing stent coated therewith. The coating agent comprises a biologically active material and a coating material selected from among pullulan acetate, represented by the following Chemical Formula 1, and a polyurethane-surfactant mixture.
摘要翻译：公开了用于药物释放支架的包衣剂，其制备方法和涂覆有药物释放支架的药物释放支架。涂层剂包括生物活性材料和选自下列化学式1表示的醋酸支链淀粉中的涂料和聚氨酯 - 表面活性剂混合物。

6. 发明申请

US20130095186A1 TEMPERATURE-SENSITIVE CARRIER FOR CARRYING A PHYSIOLOGICALLY ACTIVE SUBSTANCE AND PREPARATION METHOD THEREOF 审中-公开
标题翻译：用于携带生理活性物质的温度敏感载体及其制备方法
公开(公告)号：US20130095186A1
公开(公告)日：2013-04-18
申请号：US13319306
申请日：2011-06-29
申请人： Kun Na , Young Seok Jung
发明人： Kun Na , Young Seok Jung
IPC分类号： A61K9/48 , A61K38/47
CPC分类号： A61K9/4816 , A61K38/47 , A61K41/0028 , A61K47/36 , A61K47/593 , A61K47/61 , A61L27/26 , A61L27/48 , A61L27/54 , A61L2300/252 , A61L2300/258 , A61L2300/62 , C08L67/04 , C08L5/08
摘要： The present invention relates to a temperature-sensitive carrier for carrying a physiologically active substance and a preparation method thereof. Specifically, the temperature-sensitive carrier according to the present invention comprises an amphiphilic biodegradable block copolymer containing polysaccharide or polysaccharide and succinic anhydride as a hydrophilic block and polylactide as a non-ionic block. A hydrophilic polymer-polylactide copolymer according to the present invention forms a stable complex with a physiologically active substance such as protein, polynucleotide and the like in vivo via ionic bonding and temperature-sensitive hydrophobic bonding. Therefore, a copolymer according to the present invention can facilitate in vivo delivery of a physiologically active substance and used as an in vivo drug delivery system.
摘要翻译：本发明涉及一种携带生理活性物质的感温载体及其制备方法。具体而言，本发明的感温载体包含含有多糖或多糖的两亲性生物可降解嵌段共聚物和作为亲水性嵌段的琥珀酸酐和作为非离子嵌段的聚交酯。根据本发明的亲水性聚合物 - 聚丙交酯共聚物通过离子键合和温度敏感性疏水键合在体内与生理活性物质如蛋白质，多核苷酸等形成稳定的复合物。因此，根据本发明的共聚物可以促进生理活性物质的体内递送并用作体内药物递送系统。

7. 发明授权

US07371781B2 Tumor environment-induced ligand-expressing nanocarrier system 有权
公开(公告)号：US07371781B2
公开(公告)日：2008-05-13
申请号：US10948078
申请日：2004-09-22
申请人： You Han Bae , Kun Na , Eun Seong Lee
发明人： You Han Bae , Kun Na , Eun Seong Lee
IPC分类号： A61K47/00
CPC分类号： A61K9/1075
摘要： Drug delivery compositions for specific delivery of a drug to a tumor are described. These compositions include a core for sequestering the drug and a shell to which a ligand is attached for delivery of a drug to target cells. Since normal cells may also be targeted by the ligand, the compositions embed the ligand in the shell until the localized conditions surrounding the tumor cause the ligand to be displayed on the surface of the shell. One composition exhibits shrinkage of the shell at tumor pH, whereas another composition exhibits extension of the ligand at tumor pH. Still another composition causes the ligand to be exhibited at an elevated temperature.

8. 发明申请

US20050070721A1 PH-sensitive polymeric micelles for drug delivery 有权
标题翻译： PH敏感聚合物胶束用于药物递送
公开(公告)号：US20050070721A1
公开(公告)日：2005-03-31
申请号：US10640739
申请日：2003-05-19
申请人： You Bae , Kun Na , Eun Lee
发明人： You Bae , Kun Na , Eun Lee
IPC分类号： A01N43/64 , A61K9/00 , A61K9/107 , A61K9/127 , A61K31/41 , C07D233/54 , C07D233/61 , C07D413/06 , C08F8/30
CPC分类号： C07D233/64 , A61K9/0019 , A61K9/1075 , C07D413/06 , C08F8/30
摘要： Mixed micelles containing poly(L-histidine)-poly(ethylene glycol) block copolymer and poly(L-lactic acid)-poly(ethylene glycol) block copolymer are a pH-sensitive drug carrier that release the drug in an acidic microenvironment, but not in the blood. Since the microenvironment of solid tumors is acidic, these mixed micelles are useful for treating cancer, including those cancers exhibiting multidrug resistance. Targeting ligands, such as folate, can also be attached to the mixed micelles for enhancing drug delivery into cells. Methods of making poly(L-histidine), synthetic intermediates, and block copolymers are also described.
摘要翻译：含有聚（L-组氨酸） - 聚（乙二醇）嵌段共聚物和聚（L-乳酸） - 聚（乙二醇）嵌段共聚物的混合胶束是在酸性微环境中释放药物的pH敏感药物载体，但是不在血中由于实体瘤的微环境是酸性的，所以这些混合胶束可用于治疗癌症，包括那些显示出多药耐药性的癌症。靶向配体如叶酸也可以连接到混合的胶束上，以增强药物递送到细胞中。还描述了制备聚（L-组氨酸），合成中间体和嵌段共聚物的方法。

9. 发明授权

US07229973B2 pH-sensitive polymeric micelles for drug delivery 有权
标题翻译：用于药物递送的pH敏感聚合物胶束
公开(公告)号：US07229973B2
公开(公告)日：2007-06-12
申请号：US10640739
申请日：2003-05-19
申请人： You Han Bae , Kun Na , Eun Seung Lee
发明人： You Han Bae , Kun Na , Eun Seung Lee
IPC分类号： A61K31/704
CPC分类号： C07D233/64 , A61K9/0019 , A61K9/1075 , C07D413/06 , C08F8/30
摘要： Mixed micelles containing poly(L-histidine)-poly(ethylene glycol) block copolymer and poly(L-lactic acid)-poly(ethylene glycol) block copolymer are a pH-sensitive drug carrier that release the drug in an acidic microenvironment, but not in the blood. Since the microenvironment of solid tumors is acidic, these mixed micelles are useful for treating cancer, including those cancers exhibiting multidrug resistance. Targeting ligands, such as folate, can also be attached to the mixed micelles for enhancing drug delivery into cells. Methods of making poly(L-histidine), synthetic intermediates, and block copolymers are also described.
摘要翻译：含有聚（L-组氨酸） - 聚（乙二醇）嵌段共聚物和聚（L-乳酸） - 聚（乙二醇）嵌段共聚物的混合胶束是在酸性微环境中释放药物的pH敏感药物载体，但是不在血中由于实体瘤的微环境是酸性的，所以这些混合胶束可用于治疗癌症，包括那些显示出多药耐药性的癌症。靶向配体如叶酸也可以连接到混合的胶束上，以增强药物递送到细胞中。还描述了制备聚（L-组氨酸），合成中间体和嵌段共聚物的方法。

10. 发明申请

US20050186263A1 PH-sensitive polymeric micelles for drug delivery 失效
标题翻译： PH敏感聚合物胶束用于药物递送
公开(公告)号：US20050186263A1
公开(公告)日：2005-08-25
申请号：US10846487
申请日：2004-05-14
申请人： You Bae , Kun Na , Eun Lee
发明人： You Bae , Kun Na , Eun Lee
IPC分类号： A01N43/64 , A61K9/00 , A61K9/107 , A61K9/127 , A61K31/41 , C07D233/54 , C07D233/61 , C07D413/06 , C08F8/30
CPC分类号： A61K9/1075 , A61K9/0019 , A61K31/704 , C07D233/64 , C07D413/06 , C08F8/30
摘要： Mixed micelles containing poly(L-histidine)-poly(ethylene glycol) block copolymer and poly(L-lactic acid)-poly(ethylene glycol) block copolymer are a pH-sensitive drug carrier that release the drug in an acidic microenvironment, but not in the blood. Since the microenvironment of solid tumors is acidic, these mixed micelles are useful for treating cancer, including those cancers exhibiting multidrug resistance. Targeting ligands, such as folate, can also be attached to the mixed micelles for enhancing drug delivery into cells. Methods of treating a warm-blooded animal with such a drug are disclosed.
摘要翻译：含有聚（L-组氨酸） - 聚（乙二醇）嵌段共聚物和聚（L-乳酸） - 聚（乙二醇）嵌段共聚物的混合胶束是在酸性微环境中释放药物的pH敏感药物载体，但是不在血中由于实体瘤的微环境是酸性的，所以这些混合胶束可用于治疗癌症，包括那些显示出多药耐药性的癌症。靶向配体如叶酸也可以连接到混合的胶束上，以增强药物递送到细胞中。公开了用这种药物治疗温血动物的方法。

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