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1. 发明授权

EP2380600B1 POLYMER SLIDING MATERIAL, ARTIFICIAL JOINT MEMBER, MEDICAL APPLIANCE, AND MANUFACTURING METHOD THEREFOR 有权转让
标题翻译：聚合物滑动材料，人造关节部件，医疗器械及其制造方法
公开(公告)号：EP2380600B1
公开(公告)日：2018-04-18
申请号：EP09835034.1
申请日：2009-12-25
申请人： Kyocera Corporation , The University of Tokyo
发明人： KYOMOTO, Masayuki , ISHIHARA, Kazuhiko
IPC分类号： A61L27/00
CPC分类号： A61L27/18 , C08F2/48 , C08F291/18 , Y10T428/31855 , C08L71/00
摘要： Disclosed is a sliding member with excellent durability and capable of maintaining wear resistance over a long period of time. Further disclosed is an artificial joint member for which the film thickness of the polymer base material is reduced. Further disclosed is an artificial joint which is capable of demonstrating high lubricity, biocompatibility, and resistance to dislocation after introduction into the body. Further disclosed are a medical appliance material and a medical appliance which demonstrate excellent biocompatibility. The sliding material or the medical appliance material is formed by a polymer layer or a biocompatible material layer (B) being provided by coating at least a portion of the surface of a polymer base material (A), the surface of which has a ketone group, and the polymer layer or biocompatible layer (B) is characterized by being formed by surface graft polymerization, wherein the polymer base material (A) is immersed in a reaction system which contains a monomer (C), the polymer base material (A) is exposed to light, and polymerization of the monomer is initiated from the surface of the polymer base material (A). Using the sliding material or medical appliance material, an artificial joint member, an artificial joint, a medical appliance material, and a medical appliance are manufactured.

3. 发明授权

EP3266803B1 POLYMER AND CROSSLINKED BODY THEREOF 有权
公开(公告)号：EP3266803B1
公开(公告)日：2020-01-01
申请号：EP16758952.2
申请日：2016-03-02
申请人： The University of Tokyo , NOF Corporation
发明人： ISHIHARA, Kazuhiko , INOUE, Yuuki , FUKAZAWA, Kyoko , MATSUDA, Masaru , YAMADA, Satoshi , NODA, Tomozumi
IPC分类号： C08F230/02 , A61L27/16 , A61L27/50 , C09D143/02

4. 发明授权

EP2233159B1 MEDICAL DEVICE AND METHOD FOR MANUFACTURE THEREOF 有权
标题翻译：医疗器械及其制备方法
公开(公告)号：EP2233159B1
公开(公告)日：2014-05-14
申请号：EP08865567.5
申请日：2008-12-19
申请人： Kyocera Medical Corporation , The University of Tokyo
发明人： KYOMOTO, Masayuki , ISHIHARA, Kazuhiko , NAKAMURA, Kozo , TAKATORI, Yoshio , KAWAGUCHI, Hiroshi , MORO, Toru
IPC分类号： A61K6/04 , A61L27/34 , A61L31/10 , A61L33/00 , A61K6/00 , A61K6/033
CPC分类号： A61L33/0076 , A61K6/033 , A61K6/04 , A61L27/34 , A61L31/10 , Y10T428/31667 , A61K6/0023 , C08L33/08 , C08L33/10

5. 发明公开

EP2226075A1 MATERIAL FOR PREVENTING TISSUE ADHESION AND MATERIAL FOR PREVENTING JOINT CONTRACTURE 审中-公开
标题翻译：材料关节挛缩的预防和材料组织粘连防止
公开(公告)号：EP2226075A1
公开(公告)日：2010-09-08
申请号：EP08852570.4
申请日：2008-11-14
申请人： The University of Tokyo , KAKEN PHARMACEUTICAL CO., LTD.
发明人： MORO, Toru , NAKAMURA, Kozo , KAWAGUCHI, Hiroshi , ISHIYAMA, Noriyuki , ISHIHARA, Kazuhiko , KONNO, Tomohiro , OHYAMA, Tadashi , YOSHIKAWA, Mizuna
IPC分类号： A61K31/80 , A61K31/715 , A61K31/765 , A61P41/00 , A61P43/00
CPC分类号： A61K31/715 , A61K31/765 , A61K31/80
摘要： The present invention provides a tissue adhesion prevention material preparable at an affected area at the time of surgical procedure by producing a three-dimensional polymeric structure having a flexible structure and high solute permeability in a medium comprising water as the main component under mild conditions appropriate for body tissue components (i.e., at ordinary temperature and pressure) without conducting a chemical reaction or employing a physical procedure such as heating or light or radiation irradiation. This makes it possible to provide a tissue adhesion prevention material and a joint contracture prevention materials, which can effectively prevent postoperative adhesion of a tissue in the affected area to the surrounding tissue and contracture of the movable part of a joint.
The tissue adhesion prevention material and/or the joint contracture prevention material of the present invention comprise, as the main component, a composition comprising a compound having a polyvalent hydroxyl group and a polymer containing phosphorylcholine groups and phenylboronic acid groups.
摘要翻译：本发明通过产生具有包含水作为适合在温和条件下的主要成分在培养基中的柔性结构和高溶质透过性的三维聚合物结构提供在受影响的区域中的组织粘连防止材料制备的在外科手术过程的时间体的组织成分（即，在普通的温度和压力）不进行化学反应或物理用人过程：如加热或光或放射线照射。这使得可以提供一种组织粘连防止材料和关节挛缩预防材料，可有效地防止在患处的关节的可动部的周围组织和挛缩的组织的术后粘连。的组织粘连防止材料和/或本发明的关节挛缩预防材料包括，作为主要成分，其包括具有多价羟基和聚合物含磷酸胆碱基团和苯基硼酸基团的化合物的组合物。

6. 发明公开

EP2204197A1 BIOCOMPATIBLE AND LOW-WEAR MATERIAL, ARTIFICIAL JOINT USING THE SAME AND METHOD OF PRODUCING THE SAME 有权
标题翻译： BIOVERTRÄGLICHESVERSCHLEISSARMES材料，KÜNSTLICHESGELENK DAMIT UND HERSTELLUNGSVERFAHRENDAFÜR
公开(公告)号：EP2204197A1
公开(公告)日：2010-07-07
申请号：EP08836671.1
申请日：2008-10-02
申请人： Japan Medical Materials Corporation , The University of Tokyo
发明人： KYOMOTO, Masayuki , ISHIHARA, Kazuhiko , NAKAMURA, Kozo , TAKATORI, Yoshio , KAWAGUCHI, Hiroshi , MORO, Toru
IPC分类号： A61L27/00 , A61F2/30 , A61F2/32 , A61F2/38 , A61F2/40 , A61F2/42 , A61F2/44
CPC分类号： A61L27/34 , A61F2/32 , A61F2/38 , A61F2/40 , A61F2/42 , A61F2/44 , A61F2002/30003 , A61F2002/30026 , A61F2002/30065 , A61F2002/30673 , A61F2002/30685 , A61F2002/30934 , A61F2002/30971 , A61F2310/00011 , A61F2310/00023 , A61F2310/00029 , A61F2310/00179 , A61F2310/00389 , A61F2310/00916 , A61F2310/00976 , A61L27/50 , A61L2400/18 , A61L2430/24
摘要： The object of the present invention is to provide a sliding member, a prosthesis and a method of producing the sliding member, which can suppress production of abrasive wear debris by suppressing friction of the sliding section, and also can maintain satisfactory mechanical characteristics in vivo. A sliding member comprising: a substrate 1 capable of forming hydroxyl groups; and a biocompatible material layer 4 laminated on appropriate sections of the substrate 1, wherein hydroxyl groups are formed on at least a required section of a surface of the substrate 1 by surface treating to form a surface-treated layer 2, while the biocompatible material layer 4 is formed from a polymer containing phosphorylcholine groups, and wherein the substrate 1 and the biocompatible material layer 4 are joined via a binder layer 3 formed from silica being covalently bonded with the hydroxyl groups and the biocompatible material, respectively.
摘要翻译：本发明的目的是提供一种滑动构件，假体和制造滑动构件的方法，其可以通过抑制滑动部分的摩擦来抑制磨损碎屑的产生，并且还可以在体内保持令人满意的机械特性。一种滑动构件，包括：能够形成羟基的基底1; 以及层叠在基板1的适当部分上的生物相容性材料层4，其中通过表面处理在基材1的表面的至少所需部分上形成羟基以形成表面处理层2，同时生物相容性材料层 4由含有磷酸胆碱基团的聚合物形成，并且其中基底1和生物相容性材料层4分别经由由与由羟基和生物相容性材料共价键合的二氧化硅形成的粘合剂层3连接。

7. 发明公开

EP2002854A2 BIOMATERIAL, ARTIFICIAL JOINT USING THE SAME AND METHOD OF PRODUCING THE SAME 有权
标题翻译：生物学材料，KÜNSTLICHESGELENK DAMIT UND HERSTELLUNGSVERFAHRENDAFÜR
公开(公告)号：EP2002854A2
公开(公告)日：2008-12-17
申请号：EP07739673.7
申请日：2007-03-26
申请人： Japan Medical Materials Corporations , The University of Tokyo , National University Corporation Tokyo Medical and Dental University
发明人： KYOMOTO, Masayuki , ISHIHARA, Kazuhiko , IWASAKI, Yasuhiko , MORO, Toru , NAKAMURA, Kozo , TAKATORI, Yoshio , KAWAGUCHI, Hiroshi , KONNO, Tomohiro , YAMAWAKI, Noboru
IPC分类号： A61L27/42 , A61F2/34 , A61F2/36 , C22C14/00 , C22C19/07
CPC分类号： A61L27/34 , A61F2/30767 , A61F2/32 , A61F2/34 , A61F2002/30685 , A61F2002/30934 , A61F2002/3611 , A61F2310/00011 , A61F2310/00179 , A61L27/42 , B05D1/18 , B05D3/067 , B23K35/3618 , C22F1/11 , C22F1/183 , Y10T428/24917 , Y10T428/24926 , Y10T428/31536
摘要： The object of the present invention is to provide a joint prosthesis, bearing material and a production method threreof, which suppresses wear in a sliding section and suppresses the production of abrasive powder even during repeated daily operation. To achieve the object, there is provided a biomaterial comprising: a substrate made of metal, alloy or ceramic; and a biocompatible material layer laminated on the substrate, wherein hydroxyl groups are formed on the substrate by surface-treating, while the biocompatible material layer comprises a polymer containing phosphorylcholine groups, the substrate and the biocompatible material layer are bound via a binder layer which is combined with the hydroxyl groups of the substrate and with the biocompatible material layer.
摘要翻译：本发明的目的是提供一种抑制滑动部分磨损的关节假体，轴承材料和制造方法，即使在重复的日常操作中也抑制磨料粉末的产生。为了实现该目的，提供了一种生物材料，包括：由金属，合金或陶瓷制成的基底; 以及层叠在基材上的生物相容性材料层，其中通过表面处理在基材上形成羟基，而生物相容性材料层包含含有磷酸胆碱基团的聚合物，基材和生物相容性材料层通过粘合剂层结合，与基底和生物相容性材料层的羟基组合。

8. 发明公开

EP3480283A1 SLIPPERINESS-IMPARTING AGENT AND SLIPPERINESS-IMPARTING METHOD 有权转让
公开(公告)号：EP3480283A1
公开(公告)日：2019-05-08
申请号：EP17820176.0
申请日：2017-06-28
申请人： NOF Corporation , The University Of Tokyo
发明人： ISHIHARA, Kazuhiko , NODA, Tomozumi , MATSUDA, Masaru , YAMADA,Satoshi , SAKAMOTO,Nobuyuki
IPC分类号： C10M107/28 , A61L33/06 , C08F220/30 , C08F220/36 , C08F230/02 , C09D133/10 , C10N20/04 , C10N30/06 , C10N40/00 , C10N50/02
摘要： Provided is a lubricity-imparting agent that can impart durable lubricity (in particular, lubricity at the time of wetting) to a substrate. It has been found that a lubricity-imparting agent including a copolymer containing a constitutional unit (A) based on 2-methacryloyloxyethyl phosphorylcholine and a constitutional unit (B) based on a photoreactive functional group-containing monomer, or a copolymer containing a constitutional unit (A) based on 2-methacryloyloxyethyl phosphorylcholine, a constitutional unit (B) based on a photoreactive functional group-containing monomer, and a constitutional unit (C) based on a hydrophobic group-containing monomer can impart durable lubricity to a substrate surface through a simple approach called photoirradiation.

10. 发明公开

EP2468311A1 HIGHLY LUBRICATING SLIDING MEMBER AND ARTIFICIAL JOINT USING SAME 有权转让
标题翻译：在霍姆斯·马克斯·史密斯·菲利普·杰克逊
公开(公告)号：EP2468311A1
公开(公告)日：2012-06-27
申请号：EP10809983.9
申请日：2010-08-18
申请人： Japan Medical Materials Corporation , The University of Tokyo
发明人： KYOMOTO, Masayuki , ISHIHARA, Kazuhiko
IPC分类号： A61L27/00 , A61F2/34
CPC分类号： A61L27/14 , A61F2/30767 , A61F2/32 , A61F2002/30673 , A61L27/18 , A61L27/34 , A61L27/50 , A61L2400/10 , A61L2430/24 , C08L101/02 , C08L71/00 , C08L33/10
摘要： Disclosed are: a sliding member which is capable of maintaining wear resistance over a long period of time; an artificial joint member in which the polymer base is reduced in thickness; and an artificial joint which exhibits high lubricating properties in the body, biocompatibility and resistance to dislocation. Specifically disclosed is a polymer sliding material which has a coating layer (B) that is composed of a graft polymer containing a phosphorylcholine group and having a density of at least 1.4 g/cm 3 on at least a part of the surface of a polymer base (A) that has a ketone group on the surface. The sliding material can be obtained by immersing the polymer base (A) into a liquid of a monomer (C) that has a phosphorylcholine group, and causing surface graft polymerization by irradiation of light. Also specifically disclosed are an artificial joint member using the polymer sliding material, and an artificial joint.
摘要翻译：公开了一种能够长时间保持耐磨性的滑动构件; 聚合物基材的厚度减小的人造关节部件; 以及在体内表现出高润滑性的人造关节，生物相容性和耐位错性。具体公开了一种聚合物滑动材料，其具有由聚合物基材的至少一部分表面上含有磷酸胆碱基并具有至少1.4g / cm 3的密度的接枝聚合物构成的涂层（B）（A）在表面上具有酮基。滑动材料可以通过将聚合物基体（A）浸渍到具有磷酰胆碱基团的单体（C）的液体中，并通过照射光进行表面接枝聚合来获得。还具体公开了使用聚合物滑动材料的人造关节构件和人造关节。

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