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1. 发明授权

US08797527B2 Biologic fluid sample analysis cartridge 有权
标题翻译：生物液样品分析盒
公开(公告)号：US08797527B2
公开(公告)日：2014-08-05
申请号：US13594439
申请日：2012-08-24
申请人： Kyle Hukari , Igor Nikonorov , Ralph W. Dowdell , Douglas Olson , Niten V. Lalpuria , Darryn Unfricht , Benjamin Ports , Vu Phan , Robin A. Levy , John W. Roche
发明人： Kyle Hukari , Igor Nikonorov , Ralph W. Dowdell , Douglas Olson , Niten V. Lalpuria , Darryn Unfricht , Benjamin Ports , Vu Phan , Robin A. Levy , John W. Roche
IPC分类号： G01N21/01 , G01N33/50
CPC分类号： G01N21/01 , B01L3/502715 , B01L3/502738 , B01L9/527 , B01L2200/025 , B01L2200/027 , B01L2200/04 , B01L2200/0652 , B01L2200/0684 , B01L2200/142 , B01L2300/042 , B01L2300/044 , B01L2300/0654 , B01L2300/0672 , B01L2300/0816 , B01L2300/0858 , B01L2300/0867 , B01L2300/087 , B01L2300/0877 , B01L2300/0883 , B01L2300/089 , B01L2300/161 , B01L2400/024 , B01L2400/0406 , B01L2400/0457 , B01L2400/086 , B01L2400/088
摘要： A biological fluid sample analysis cartridge, analysis system, and method for analyzing a biologic fluid sample are provided. The cartridge includes a collection port, at least one channel within the cartridge in fluid communication with the collection port, a passage in fluid communication with the at least one channel, and an analysis chamber mounted on a tray. The tray is mounted relative to the cartridge and selectively positionable relative to the passage in a first position where the analysis chamber will engage a bolus of sample extending out from the passage to permit selective transfer of sample from the bolus to the analysis chamber.
摘要翻译：提供了生物流体样品分析盒，分析系统和分析生物流体样品的方法。所述盒包括收集端口，所述盒内的至少一个通道与所述收集端口流体连通，与所述至少一个通道流体连通的通道以及安装在托盘上的分析室。托盘相对于盒被安装并且在第一位置中相对于通道可选择性地定位，其中分析室将与从通道延伸出来的样品推注接合，以允许样品从推注到分析室的选择性转移。

2. 发明申请

US20130114075A1 BIOLOGIC FLUID SAMPLE ANALYSIS CARTRIDGE 有权
标题翻译：生物流体样品分析盒
公开(公告)号：US20130114075A1
公开(公告)日：2013-05-09
申请号：US13594439
申请日：2012-08-24
申请人： Kyle Hukari , Igor Nikonorov , Ralph W. Dowdell , Douglas Olson , Niten V. Lalpuria , Darryn Unfricht , Benjamin Ports , Vu Phan , Robin A. Levy , John W. Roche
发明人： Kyle Hukari , Igor Nikonorov , Ralph W. Dowdell , Douglas Olson , Niten V. Lalpuria , Darryn Unfricht , Benjamin Ports , Vu Phan , Robin A. Levy , John W. Roche
IPC分类号： G01N21/01
CPC分类号： G01N21/01 , B01L3/502715 , B01L3/502738 , B01L9/527 , B01L2200/025 , B01L2200/027 , B01L2200/04 , B01L2200/0652 , B01L2200/0684 , B01L2200/142 , B01L2300/042 , B01L2300/044 , B01L2300/0654 , B01L2300/0672 , B01L2300/0816 , B01L2300/0858 , B01L2300/0867 , B01L2300/087 , B01L2300/0877 , B01L2300/0883 , B01L2300/089 , B01L2300/161 , B01L2400/024 , B01L2400/0406 , B01L2400/0457 , B01L2400/086 , B01L2400/088
摘要： A biological fluid sample analysis cartridge, analysis system, and method for analyzing a biologic fluid sample are provided. The cartridge includes a collection port, at least one channel within the cartridge in fluid communication with the collection port, a passage in fluid communication with the at least one channel, and an analysis chamber mounted on a tray. The tray is mounted relative to the cartridge and selectively positionable relative to the passage in a first position where the analysis chamber will engage a bolus of sample extending out from the passage to permit selective transfer of sample from the bolus to the analysis chamber.
摘要翻译：提供了生物流体样品分析盒，分析系统和分析生物流体样品的方法。所述盒包括收集端口，所述盒内的至少一个通道与所述收集端口流体连通，与所述至少一个通道流体连通的通道以及安装在托盘上的分析室。托盘相对于盒被安装并且在第一位置中相对于通道可选择性地定位，其中分析室将与从通道延伸出来的样品推注接合，以允许样品从推注到分析室的选择性转移。

3. 发明申请

US20110244581A1 BIOLOGIC FLUID ANALYSIS SYSTEM WITH SAMPLE MOTION 审中-公开
标题翻译：具有样本运动的生物流体分析系统
公开(公告)号：US20110244581A1
公开(公告)日：2011-10-06
申请号：US13077476
申请日：2011-03-31
申请人： Igor Nikonorov , Niten V. Lalpuria , Jeremy Hill , John Wieners , Anil S. Patil , Robert Levine , Benjamin Ports , Darryn Unfricht
发明人： Igor Nikonorov , Niten V. Lalpuria , Jeremy Hill , John Wieners , Anil S. Patil , Robert Levine , Benjamin Ports , Darryn Unfricht
IPC分类号： G01N21/75
CPC分类号： G01N35/08 , B01L3/50273 , B01L2300/123 , B01L2400/0439 , B01L2400/0481 , B01L2400/0655 , F04B19/006 , G01N2035/00158 , Y10T436/11 , Y10T436/118339
摘要： An apparatus for and method of analyzing a biologic fluid sample is provided. The method includes the steps of: a) providing a sample cartridge having at least one channel for fluid sample passage; b) providing an analysis device having imaging hardware, a programmable analyzer, and a sample motion system, which sample motion system includes a bidirectional fluid actuator operable to selectively move a bolus of sample axially within the channel, and to cycle the bolus back and forth within the channel; and c) cycling the bolus of sample disposed within the channel at a predetermined frequency until constituents within the sample are substantially uniformly distributed, using the bidirectional fluid actuator.
摘要翻译：提供了一种分析生物流体样品的方法和方法。该方法包括以下步骤：a）提供具有用于流体样品通道的至少一个通道的样品盒; b）提供具有成像硬件，可编程分析器和样本运动系统的分析装置，所述采样运动系统包括双向流体致动器，所述双向流体致动器可操作以在所述通道内轴向选择性地移动样品，并使所述弹丸周转在渠道内以及c）使用所述双向流体致动器，以预定的频率循环设置在所述通道内的样品的推注，直到所述样品内的组分基本上均匀分布。

4. 发明申请

US20120219457A1 BIOLOGIC FLUID ANALYSIS CARTRIDGE WITH SAMPLE HANDLING PORTION AND ANALYSIS CHAMBER PORTION 有权
标题翻译：生物流体分析盒与样品处理部分和分析室部分
公开(公告)号：US20120219457A1
公开(公告)日：2012-08-30
申请号：US13341618
申请日：2011-12-30
申请人： John A. Verrant , Niten V. Lalpuria , Igor Nikonorov , Darryn W. Unfricht , Benjamin Ports , Stephen C. Wardlaw , Robert A. Levine , Robert Holt , Kyle Hukari
发明人： John A. Verrant , Niten V. Lalpuria , Igor Nikonorov , Darryn W. Unfricht , Benjamin Ports , Stephen C. Wardlaw , Robert A. Levine , Robert Holt , Kyle Hukari
IPC分类号： B01L3/00 , G01N33/48
CPC分类号： B01L3/502707 , B01L3/5027 , B01L3/50273 , B01L2200/027 , B01L2300/0861
摘要： A biological fluid analysis cartridge is provided. In certain embodiments, the cartridge includes a base plate extending between a sample handling portion and an analysis chamber portion. A handling upper panel is attached to the base plate within the sample handling portion. A collection port is at least partially formed with the handling upper panel. An initial channel and a secondary channel are formed between the handling upper panel and the base plate. The collection port and initial and secondary channels are in fluid communication with one another. A chamber upper panel is attached to the base plate within the analysis chamber portion. At least one analysis chamber is formed between the chamber upper panel and the base plate. The secondary channel and the analysis chamber are in fluid communication with one another.
摘要翻译：提供生物流体分析盒。在某些实施例中，盒包括在样品处理部分和分析室部分之间延伸的基板。处理上面板附接到样品处理部分中的基板。收集口至少部分地形成有处理上面板。在处理上板和基板之间形成初始通道和次通道。收集口和初始和次要通道彼此流体连通。腔室上面板在分析室部分内连接到基板。在室上板和基板之间形成至少一个分析室。第二通道和分析室彼此流体连通。

5. 发明授权

US09873118B2 Biologic fluid analysis cartridge with sample handling portion and analysis chamber portion 有权
公开(公告)号：US09873118B2
公开(公告)日：2018-01-23
申请号：US13341618
申请日：2011-12-30
申请人： John A. Verrant , Niten V. Lalpuria , Igor Nikonorov , Darryn W. Unfricht , Benjamin Ports , Stephen C. Wardlaw , Robert A. Levine , Robert Holt , Kyle Hukari
发明人： John A. Verrant , Niten V. Lalpuria , Igor Nikonorov , Darryn W. Unfricht , Benjamin Ports , Stephen C. Wardlaw , Robert A. Levine , Robert Holt , Kyle Hukari
IPC分类号： A61J1/06 , B01L3/00
CPC分类号： B01L3/502707 , B01L3/5027 , B01L3/50273 , B01L2200/027 , B01L2300/0861
摘要： A biological fluid analysis cartridge is provided. In certain embodiments, the cartridge includes a base plate extending between a sample handling portion and an analysis chamber portion. A handling upper panel is attached to the base plate within the sample handling portion. A collection port is at least partially formed with the handling upper panel. An initial channel and a secondary channel are formed between the handling upper panel and the base plate. The collection port and initial and secondary channels are in fluid communication with one another. A chamber upper panel is attached to the base plate within the analysis chamber portion. At least one analysis chamber is formed between the chamber upper panel and the base plate. The secondary channel and the analysis chamber are in fluid communication with one another.

6. 发明授权

US08753890B2 Apparatus and method using anti-adsorption agent to facilitate sample mixing and analysis 有权
标题翻译：使用抗吸附剂的装置和方法来促进样品混合和分析
公开(公告)号：US08753890B2
公开(公告)日：2014-06-17
申请号：US13314959
申请日：2011-12-08
申请人： Niten V. Lalpuria , Darryn W. Unfricht , Igor Nikonorov , Benjamin Ports , Douglas R. Olson
发明人： Niten V. Lalpuria , Darryn W. Unfricht , Igor Nikonorov , Benjamin Ports , Douglas R. Olson
IPC分类号： G01N33/48 , G01N21/05 , B01L3/00 , G01N33/487 , G01N21/03 , G01N15/14
CPC分类号： B01L3/5027 , B01F11/0071 , B01F13/0059 , B01L3/502707 , B01L2200/14 , B01L2300/0816 , B01L2300/161 , B01L2300/165 , G01N15/1463 , G01N15/1484 , G01N21/0303 , G01N21/05 , G01N33/48 , G01N33/487 , Y10T436/2575
摘要： An apparatus and method for analyzing a biological fluid sample is provided. The method includes the steps of: a) providing an analysis cartridge having a channel and an analysis chamber, wherein the channel is in fluid communication with the analysis chamber and includes at least one hydrophobic interior wall surface; b) admixing one or more anti-adsorption agents with fluid sample disposed within the channel, wherein the anti-adsorption agents are operable to inhibit adsorption of fluid sample onto the interior wall surface of the channel; c) moving the fluid sample into the analysis chamber; and d) analyzing the sample within the analysis chamber.
摘要翻译：提供了用于分析生物流体样品的装置和方法。该方法包括以下步骤：a）提供具有通道和分析室的分析盒，其中所述通道与分析室流体连通并且包括至少一个疏水性内壁表面; b）将一种或多种抗吸附剂与设置在通道内的流体样品混合，其中所述抗吸附剂可操作以抑制流体样品吸附到通道的内壁表面上; c）将流体样品移入分析室; 和d）分析分析室内的样品。

7. 发明申请

US20120149118A1 APPARATUS AND METHOD USING ANTI-ADSORPTION AGENT TO FACILITATE SAMPLE MIXING AND ANALYSIS 有权
标题翻译：使用抗吸收剂进行样品混合和分析的装置和方法
公开(公告)号：US20120149118A1
公开(公告)日：2012-06-14
申请号：US13314959
申请日：2011-12-08
申请人： Niten V. Lalpuria , Darryn W. Unfricht , Igor Nikonorov , Benjamin Ports , Douglas R. Olson
发明人： Niten V. Lalpuria , Darryn W. Unfricht , Igor Nikonorov , Benjamin Ports , Douglas R. Olson
IPC分类号： G01N33/68 , B01L3/00
CPC分类号： B01L3/5027 , B01F11/0071 , B01F13/0059 , B01L3/502707 , B01L2200/14 , B01L2300/0816 , B01L2300/161 , B01L2300/165 , G01N15/1463 , G01N15/1484 , G01N21/0303 , G01N21/05 , G01N33/48 , G01N33/487 , Y10T436/2575
摘要： An apparatus and method for analyzing a biological fluid sample is provided. The method includes the steps of: a) providing an analysis cartridge having a channel and an analysis chamber, wherein the channel is in fluid communication with the analysis chamber and includes at least one hydrophobic interior wall surface; b) admixing one or more anti-adsorption agents with fluid sample disposed within the channel, wherein the anti-adsorption agents are operable to inhibit adsorption of fluid sample onto the interior wall surface of the channel; c) moving the fluid sample into the analysis chamber; and d) analyzing the sample within the analysis chamber.
摘要翻译：提供了用于分析生物流体样品的装置和方法。该方法包括以下步骤：a）提供具有通道和分析室的分析盒，其中所述通道与分析室流体连通并且包括至少一个疏水性内壁表面; b）将一种或多种抗吸附剂与设置在通道内的流体样品混合，其中所述抗吸附剂可操作以抑制流体样品吸附到通道的内壁表面上; c）将流体样品移入分析室; 和d）分析分析室内的样品。

8. 发明授权

US08481282B2 Method for detecting the presence of anisotropic crystals in undiluted whole blood 失效
标题翻译：检测未稀释全血中各向异性晶体存在的方法
公开(公告)号：US08481282B2
公开(公告)日：2013-07-09
申请号：US13190242
申请日：2011-07-25
申请人： Robert A. Levine , Darryn W. Unfricht , Stephen C. Wardlaw , Benjamin Ports
发明人： Robert A. Levine , Darryn W. Unfricht , Stephen C. Wardlaw , Benjamin Ports
IPC分类号： C12Q1/04
CPC分类号： G01N21/23 , G01N21/6458
摘要： An apparatus and method for detecting the presence of anisotropic crystals within a biologic fluid sample is provided. The method includes the steps of: a) disposing the sample within a sample chamber in a sample layer having a height not greater than about fifteen microns (15μ); b) disposing the sample layer within the sample chamber between a polarizing filter and an analyzing filter; c) disposing the polarizing filter, sample chamber, and analyzing filter in a configuration relative to a light source such that polarized light passes through the sample, and subsequently impinges on the analyzing filter; and d) wherein polar orientations of the polarizing filter and the analyzing filter are such that the polarized light will not pass through the analyzing filter, and light passing through an anisotropic crystal disposed within the sample will pass through the analyzing filter and appear as a point of light.
摘要翻译：提供了一种用于检测生物液体样品中各向异性晶体的存在的装置和方法。该方法包括以下步骤：a）将样品置于具有不大于约15微米（15mu）的高度的样品层中的样品室内; b）将样品层置于样品室内，在偏振滤光片和分析滤光片之间; c）将偏振滤光器，样品室和分析滤光片相对于光源配置成使得偏振光通过样品，随后撞击在分析滤光片上; 和d）其中偏振滤光器和分析滤光器的极性取向使得偏振光不会通过分析滤光器，并且穿过设置在样品内的各向异性晶体的光将通过分析滤光器并显现为点的光。

9. 发明申请

US20120021456A1 METHOD AND APPARATUS FOR DETECTING THE PRESENCE OF ANISOTROPIC CRYSTALS AND HEMOZOIN PRODUCING PARASITES IN LIQUID BLOOD 失效
标题翻译：用于检测液体血液中各向异性晶体和HEMOZOIN生产PARASITE的存在的方法和装置
公开(公告)号：US20120021456A1
公开(公告)日：2012-01-26
申请号：US13190242
申请日：2011-07-25
申请人： Robert A. Levine , Darryn W. Unfricht , Stephen C. Wardlaw , Benjamin Ports
发明人： Robert A. Levine , Darryn W. Unfricht , Stephen C. Wardlaw , Benjamin Ports
IPC分类号： C12Q1/04 , G01N33/48 , B01L3/00 , G01N21/21
CPC分类号： G01N21/23 , G01N21/6458
摘要： An apparatus and method for detecting the presence of anisotropic crystals within a biologic fluid sample is provided. The method includes the steps of: a) disposing the sample within a sample chamber in a sample layer having a height riot greater than about fifteen microns (15μ); b) disposing the sample layer within the sample chamber between a polarizing filter and an analyzing filter; a) disposing the polarizing filter, sample chamber, and analyzing filter in a configuration relative to a light source such that polarized light passes through the sample, and subsequently impinges on the analyzing filter; and d) wherein polar orientations of the polarizing filter and the analyzing filter are such that the polarized light will not pass through the analyzing filter, and light passing through an anisotropic crystal disposed within the sample will pass through the analyzing filter and appear as a point of light.
摘要翻译：提供了一种用于检测生物液体样品中各向异性晶体的存在的装置和方法。该方法包括以下步骤：a）将样品置于具有高于约十五微米（15μ）的高度骚乱的样品层中的样品室内; b）将样品层置于样品室内，在偏振滤光片和分析滤光片之间; a）将偏振滤光器，样品室和分析滤光片相对于光源配置成使得偏振光通过样品，随后撞击在分析滤光片上; 和d）其中偏振滤光器和分析滤光器的极性取向使得偏振光不会通过分析滤光器，并且通过设置在样品内的各向异性晶体的光将通过分析滤光器并显现为点的光。

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