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1. 发明授权

US08304448B2 Method for the treatment of metabolic disorder containing benzazole derivatives as an active ingredient 有权
标题翻译：用于治疗含有苯并唑衍生物作为活性成分的代谢紊乱的方法
公开(公告)号：US08304448B2
公开(公告)日：2012-11-06
申请号：US12442895
申请日：2007-09-27
申请人： Hyun Sun Lee , Kyeong Lee , Jung Joon Lee , Young Kook Kim , Mun-Chual Rho , Jeong Hyung Lee , Young Soo Hong , Hye-Ran Park , Chul-Ho Lee , Yongseok Choi
发明人： Hyun Sun Lee , Kyeong Lee , Jung Joon Lee , Young Kook Kim , Mun-Chual Rho , Jeong Hyung Lee , Young Soo Hong , Hye-Ran Park , Chul-Ho Lee , Yongseok Choi
IPC分类号： A61K31/40 , A61K31/405
CPC分类号： A61K31/423
摘要： Disclosed is a composition for the prevention and treatment of metabolic diseases, which comprises a benzazole derivative as an active ingredient. The benzazole derivative has inhibitory activity against DGAT (diacylglycerol acyltransferase), which causes metabolic diseases such as obesity and diabetes in the process of lipid metabolism. With the ability to effectively control lipid metabolism and energy metabolism, thus, the composition is useful in the prevention and treatment of metabolic diseases, such as obesity and diabetes.
摘要翻译：公开了用于预防和治疗代谢疾病的组合物，其包含作为有效成分的苯并唑衍生物。苯并唑衍生物对脂质代谢过程中引起代谢性疾病如肥胖和糖尿病的DGAT（二酰基甘油酰基转移酶）具有抑制活性。具有有效控制脂质代谢和能量代谢的能力，因此，该组合物可用于预防和治疗诸如肥胖症和糖尿病的代谢疾病。

2. 发明授权

US07902190B2 Indol derivatives, the method for preparing thereof and composition for the prevention and treatment of metabolic disorder containing the same as an active ingredient 有权
标题翻译：吲哚衍生物，其制备方法和用于预防和治疗含有其作为活性成分的代谢紊乱的组合物
公开(公告)号：US07902190B2
公开(公告)日：2011-03-08
申请号：US12442930
申请日：2007-09-27
申请人： Kyeong Lee , Hyun Sun Lee , Jung Joon Lee , Young Kook Kim , Mun-Chual Rho , Jeong Hyung Lee , Hye-Ran Park , Chul-Ho Lee , Yongseok Choi
发明人： Kyeong Lee , Hyun Sun Lee , Jung Joon Lee , Young Kook Kim , Mun-Chual Rho , Jeong Hyung Lee , Hye-Ran Park , Chul-Ho Lee , Yongseok Choi
IPC分类号： A61K31/535
CPC分类号： C07D209/18 , C07D405/12 , C07D409/14
摘要： Disclosed are indole derivatives, a preparation method thereof, and a composition for the prevention and treatment of metabolic diseases, containing the same as an active ingredient. The indole derivatives have inhibitory activity against DGAT (diacylglycerol acyltransferase), which causes metabolic diseases such as obesity and diabetes in the process of lipid metabolism. With the ability to effectively control lipid metabolism and energy metabolism, the composition is thus useful in the prevention and treatment of metabolic diseases, such as obesity and diabetes.
摘要翻译：公开了吲哚衍生物，其制备方法和用于预防和治疗代谢疾病的组合物，其含有活性成分。吲哚衍生物对DGAT（二酰基甘油酰基转移酶）具有抑制作用，其在脂质代谢过程中引起诸如肥胖症和糖尿病等代谢疾病。具有有效控制脂质代谢和能量代谢的能力，因此该组合物可用于预防和治疗诸如肥胖症和糖尿病等代谢疾病。

3. 发明申请

US20100076039A1 COMPOSITION FOR THE PREVENTION AND TREATMENT OF METABOLIC DISORDER CONTAINING BENZAZOLE DERIVATIVES AS AN ACTIVE INGREDIENT 有权
标题翻译：用于预防和治疗含有苯扎唑衍生物作为活性成分的代谢性疾病的组合物
公开(公告)号：US20100076039A1
公开(公告)日：2010-03-25
申请号：US12442895
申请日：2007-09-27
申请人： Hyun Sun Lee , Kyeong Lee , Jung Joon Lee , Young Kook Kim , Mun-Chual Rho , Jeong Hyung Lee , Young Soo Hong , Hye-Ran Park , Chul-Ho Lee , Yongseok Choi
发明人： Hyun Sun Lee , Kyeong Lee , Jung Joon Lee , Young Kook Kim , Mun-Chual Rho , Jeong Hyung Lee , Young Soo Hong , Hye-Ran Park , Chul-Ho Lee , Yongseok Choi
IPC分类号： A61K31/421 , A61P3/00
CPC分类号： A61K31/423
摘要： Disclosed is a composition for the prevention and treatment of metabolic diseases, which comprises a benzazole derivative as an active ingredient. The benzazole derivative has inhibitory activity against DGAT (diacylglycerol acyltransferase), which causes metabolic diseases such as obesity and diabetes in the process of lipid metabolism. With the ability to effectively control lipid metabolism and energy metabolism, thus, the composition is useful in the prevention and treatment of metabolic diseases, such as obesity and diabetes.
摘要翻译：公开了用于预防和治疗代谢疾病的组合物，其包含作为有效成分的苯并唑衍生物。苯并唑衍生物对脂质代谢过程中引起代谢性疾病如肥胖和糖尿病的DGAT（二酰基甘油酰基转移酶）具有抑制活性。具有有效控制脂质代谢和能量代谢的能力，因此，该组合物可用于预防和治疗诸如肥胖症和糖尿病的代谢疾病。

4. 发明申请

US20100075962A1 INDOL DERIVATIVES, THE METHOD FOR PREPARING THEREOF AND COMPOSITION FOR THE PREVENTION AND TREATMENT OF METABOLIC DISORDER CONTAINING THE SAME AS AN ACTIVE INGREDIENT 有权
标题翻译：吲哚衍生物，其制备方法和组合物，用于预防和治疗含有其作为活性成分的代谢异常
公开(公告)号：US20100075962A1
公开(公告)日：2010-03-25
申请号：US12442930
申请日：2007-09-27
申请人： Kyeong Lee , Hyun Sun Lee , Jung Joon Lee , Young Kook Kim , Mun-Chual Roh , Jeong Hyung Lee , Hye-Ran Park , Chul-Ho Lee , Yongseok Choi
发明人： Kyeong Lee , Hyun Sun Lee , Jung Joon Lee , Young Kook Kim , Mun-Chual Roh , Jeong Hyung Lee , Hye-Ran Park , Chul-Ho Lee , Yongseok Choi
IPC分类号： A61K31/5377 , C07D209/04 , C07D401/02 , C07D413/02 , A61K31/405 , A61K31/454 , A61P3/04 , A61P3/10
CPC分类号： C07D209/18 , C07D405/12 , C07D409/14
摘要： Disclosed are indole derivatives a preparation method thereof, and a composition for the prevention and treatment of metabolic diseases, containing the same as an active ingredient. The indole derivatives have inhibitory activity against DGAT (diacylglycerol acyltransferase), which causes metabolic diseases such as obesity and diabetes in the process of lipid metabolism. With the ability to effectively control lipid metabolism and energy metabolism, the composition is thus useful in the prevention and treatment of metabolic diseases, such as obesity and diabetes.
摘要翻译：公开了吲哚衍生物及其制备方法，以及用于预防和治疗代谢疾病的组合物，其含有活性成分。吲哚衍生物对DGAT（二酰基甘油酰基转移酶）具有抑制作用，其在脂质代谢过程中引起诸如肥胖症和糖尿病等代谢疾病。具有有效控制脂质代谢和能量代谢的能力，因此该组合物可用于预防和治疗诸如肥胖症和糖尿病的代谢疾病。

5. 发明授权

US09180138B2 2′-fluoronucleosides 有权
标题翻译： 2'-核糖核苷
公开(公告)号：US09180138B2
公开(公告)日：2015-11-10
申请号：US13437676
申请日：2012-04-02
申请人： Raymond F. Schinazi , Dennis C. Liotta , Chung K. Chu , J. Jeffrey McAtee , Junxing Shi , Yongseok Choi , Kyeong Lee , Joon H. Hong
发明人： Raymond F. Schinazi , Dennis C. Liotta , Chung K. Chu , J. Jeffrey McAtee , Junxing Shi , Yongseok Choi , Kyeong Lee , Joon H. Hong
IPC分类号： A01N61/00 , A61K48/00 , A61K31/708 , C07D405/04 , C07D473/00 , C07H19/06 , C07H19/10 , C07H19/16 , A61K31/706 , A61K31/7064 , A61K31/7068 , A61K31/7072 , A61K31/7076 , C07H1/00 , C07G3/00
CPC分类号： A61K31/7076 , A61K31/706 , A61K31/7064 , A61K31/7068 , A61K31/7072 , A61K31/708 , C07D405/04 , C07D473/00 , C07H19/06 , C07H19/10 , C07H19/16
摘要： 2′-Fluoro-nucleoside compounds are disclosed which are useful in the treatment of hepatitis B infection, hepatitis C infection, HIV and abnormal cellular proliferation, including tumors and cancer. The compounds have the general formulae: wherein Base is a purine or pyrimidine base; R1 is OH, H, OR3, N3, CN, halogen, CF3, lower alkyl, amino, loweralkylamino, di(lower)alkylamino, or alkoxy; R2 is H, phosphate, or a stabilized phosphate prodrug; acyl, or other pharmaceutically acceptable leaving benzyl, a lipid, an amino acid, peptide, or cholesterol; and R3 is acyl, alkyl, phosphate, or other pharmaceutically acceptable leaving group; or a pharmaceutically acceptable salt thereof.
摘要翻译：公开了可用于治疗乙型肝炎感染，丙型肝炎感染，HIV和异常细胞增殖（包括肿瘤和癌症）的2'-氟 - 核苷化合物。所述化合物具有以下通式：其中碱是嘌呤或嘧啶碱; R 1是OH，H，OR 3，N 3，CN，卤素，CF 3，低级烷基，氨基，低级烷基氨基，二（低级）烷基氨基或烷氧基; R2是H，磷酸盐或稳定的磷酸盐前药; 酰基或其它药学上可接受的苄基，脂质，氨基酸，肽或胆固醇; 烷基，磷酸酯或其它药学上可接受的离去基团; 或其药学上可接受的盐。

6. 发明授权

US07307065B2 2′-Fluoronucleosides 有权
标题翻译： 2'-氟核苷
公开(公告)号：US07307065B2
公开(公告)日：2007-12-11
申请号：US10796529
申请日：2004-03-08
申请人： Raymond F. Schinazi , Dennis C. Liotta , Chung K. Chu , J. Jeffrey McAtee , Junxing Shi , Yongseok Choi , Kyeong Lee , Joon H. Hong
发明人： Raymond F. Schinazi , Dennis C. Liotta , Chung K. Chu , J. Jeffrey McAtee , Junxing Shi , Yongseok Choi , Kyeong Lee , Joon H. Hong
IPC分类号： A61K38/00 , A01N61/00 , C07H1/00 , C07G3/00
CPC分类号： A61K31/7076 , A61K31/706 , A61K31/7064 , A61K31/7068 , A61K31/7072 , A61K31/708 , C07D405/04 , C07D473/00 , C07H19/06 , C07H19/10 , C07H19/16
摘要： A class of 2′-fluoro-nucleoside compounds are disclosed which are useful in the treatment of hepatitis B infection, hepatitis C infection, HIV and abnormal cellular proliferation, including tumors and cancer. The compounds have the general formulae: wherein Base is a purine or pyrimidine base; R1 is OH, H, OR3, N3, CN, halogen, including F, or CF3, lower alkyl, amino, loweralkylamino, di(lower)alkylamino, or alkoxy, and base refers to a purine or pyrimidine base; R2 is H, phosphate, including monophosphate, diphosphate, triphosphate, or a stabilized phosphate prodrug; acyl, or other pharmaceutically acceptable leaving group which when administered in vivo, is capable of providing a compound wherein R2 is H or phosphate; sulfonate ester including alkyl or arylalkyl sulfonyl including methanesulfonyl, benzyl, wherein the phenyl group is optionally substituted with one or more substituents as described in the definition of aryl given above, a lipid, an amino acid, peptide, or cholesterol; and R3 is acyl, alkyl, phosphate, or other pharmaceutically acceptable leaving group which when administered in vivo, is capable of being cleaved to the parent compound, or a pharmaceutically acceptable salt thereof.
摘要翻译：公开了一类可用于治疗乙型肝炎感染，丙型肝炎感染，HIV和异常细胞增殖（包括肿瘤和癌症）的2'-氟 - 核苷化合物。所述化合物具有以下通式：其中碱是嘌呤或嘧啶碱; R 1是OH，H，OR 3，N 3，CN，卤素，包括F或CF 3 N ，低级烷基，氨基，低级烷基氨基，二（低级）烷基氨基或烷氧基，碱是指嘌呤或嘧啶碱基; R 2是H，磷酸盐，包括单磷酸盐，二磷酸盐，三磷酸盐或稳定化的磷酸盐前药; 酰基或其它药学上可接受的离去基团，其当在体内施用时能够提供其中R 2是H或磷酸酯的化合物; 磺酸酯，包括烷基或芳基烷基磺酰基，包括甲磺酰基，苄基，其中苯基任选被一个或多个取代基取代，如上述芳基定义中所述，脂质，氨基酸，肽或胆固醇; 并且R 3是酰基，烷基，磷酸酯或其它药学上可接受的离去基团，当其在体内施用时，其能够被切割成母体化合物或其药学上可接受的盐。

7. 发明授权

US06911424B2 2′-fluoronucleosides 有权
标题翻译： 2'-核糖核苷
公开(公告)号：US06911424B2
公开(公告)日：2005-06-28
申请号：US10061128
申请日：2002-01-30
申请人： Raymond F. Schinazi , Dennis C. Liotta , Chung K. Chu , J. Jeffrey McAtee , Junxing Shi , Yongseok Choi , Kyeong Lee , Joon H. Hong
发明人： Raymond F. Schinazi , Dennis C. Liotta , Chung K. Chu , J. Jeffrey McAtee , Junxing Shi , Yongseok Choi , Kyeong Lee , Joon H. Hong
IPC分类号： C07D239/47 , A61K31/505 , A61K31/506 , A61K31/52 , A61K31/522 , A61K31/7042 , A61K31/7052 , A61K31/7064 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61P31/20 , A61P35/00 , C07D405/04 , C07D473/00 , C07D473/18 , C07D473/34 , C07F7/18 , C07F9/547 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H19/207 , A01N61/00 , A01N43/04 , C07H1/00 , C07H11/00 , C07H19/00
CPC分类号： A61K31/7076 , A61K31/706 , A61K31/7064 , A61K31/7068 , A61K31/7072 , A61K31/708 , C07D405/04 , C07D473/00 , C07H19/06 , C07H19/10 , C07H19/16
摘要： A class of 2′-fluoro-nucleoside compounds are disclosed which are useful in the treatment of hepatitis B infection, hepatitis C infection, HIV and abnormal cellular proliferation, including tumors and cancer. The compounds have the general formulae: wherein Base is a purine or pyrimidine base; R1 is OH, H, OR3, N3, CN, halogen, including F, or CF3, lower alkyl, amino, loweralkylamino, di(lower)alkylamino, or alkoxy, and base refers to a purine or pyrimidine base; R2 is H, phosphate, including monophosphate, diphosphate, triphosphate, or a stabilized phosphate prodrug; acyl, or other pharmaceutically acceptable leaving group which when administered in vivo, is capable of providing a compound wherein R2 is H or phosphate; sulfonate ester including alkyl or arylalkyl sulfonyl including methanesulfonyl, benzyl, wherein the phenyl group is optionally substituted with one or more substituents as described in the definition of aryl given above, a lipid, an amino acid, peptide, or cholesterol; and R3 is acyl, alkyl, phosphate, or other pharmaceutically acceptable leaving group which when administered in vivo, is capable of being cleaved to the parent compound, or a pharmaceutically acceptable salt thereof.
摘要翻译：公开了一类可用于治疗乙型肝炎感染，丙型肝炎感染，HIV和异常细胞增殖（包括肿瘤和癌症）的2'-氟 - 核苷化合物。所述化合物具有以下通式：其中碱是嘌呤或嘧啶碱; R 1是OH，H，OR 3，N 3，CN，卤素，包括F或CF 3 N ，低级烷基，氨基，低级烷基氨基，二（低级）烷基氨基或烷氧基，碱是指嘌呤或嘧啶碱基; R 2是H，磷酸盐，包括单磷酸盐，二磷酸盐，三磷酸盐或稳定化的磷酸盐前药; 酰基或其它药学上可接受的离去基团，其当在体内施用时能够提供其中R 2是H或磷酸酯的化合物; 磺酸酯，包括烷基或芳基烷基磺酰基，包括甲磺酰基，苄基，其中苯基任选被一个或多个取代基取代，如上述芳基定义中所述，脂质，氨基酸，肽或胆固醇; 并且R 3是酰基，烷基，磷酸酯或其它药学上可接受的离去基团，当其在体内施用时，其能够被切割成母体化合物或其药学上可接受的盐。

8. 发明申请

US20100173863A1 2-Fluoronucleosides 有权
标题翻译： 2-氟核苷
公开(公告)号：US20100173863A1
公开(公告)日：2010-07-08
申请号：US12510083
申请日：2009-07-27
申请人： Raymond F. Schinazi , Dennis C. Liotta , Chung K. Chu , J. Jeffrey McAtee , Junxing Shi , Yongseok Choi , Kyeong Lee , Joon H. Hong
发明人： Raymond F. Schinazi , Dennis C. Liotta , Chung K. Chu , J. Jeffrey McAtee , Junxing Shi , Yongseok Choi , Kyeong Lee , Joon H. Hong
IPC分类号： A61K31/7052 , A61K31/7064 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61P31/14
CPC分类号： A61K31/7076 , A61K31/706 , A61K31/7064 , A61K31/7068 , A61K31/7072 , A61K31/708 , C07D405/04 , C07D473/00 , C07H19/06 , C07H19/10 , C07H19/16
摘要： 2′-Fluoro-nucleoside compounds are disclosed which are useful in the treatment of hepatitis B infection, hepatitis C infection, HIV and abnormal cellular proliferation, including tumors and cancer. The compounds have the general formulae: wherein Base is a purine or pyrimidine base; R1 is OH, H, OR3, N3, CN, halogen, CF3, lower alkyl, amino, loweralkylamino, di(lower)alkylamino, or alkoxy; R2 is H, phosphate, or a stabilized phosphate prodrug; acyl, or other pharmaceutically acceptable leaving benzyl, a lipid, an amino acid, peptide, or cholesterol; and R3 is acyl, alkyl, phosphate, or other pharmaceutically acceptable leaving group; or a pharmaceutically acceptable salt thereof.
摘要翻译：公开了可用于治疗乙型肝炎感染，丙型肝炎感染，HIV和异常细胞增殖（包括肿瘤和癌症）的2'-氟 - 核苷化合物。所述化合物具有以下通式：其中碱是嘌呤或嘧啶碱; R 1是OH，H，OR 3，N 3，CN，卤素，CF 3，低级烷基，氨基，低级烷基氨基，二（低级）烷基氨基或烷氧基; R2是H，磷酸盐或稳定的磷酸盐前药; 酰基或其它药学上可接受的苄基，脂质，氨基酸，肽或胆固醇; 烷基，磷酸酯或其它药学上可接受的离去基团; 或其药学上可接受的盐。

9. 发明授权

US08168583B2 2-fluoronucleosides 有权
标题翻译： 2-氟核苷
公开(公告)号：US08168583B2
公开(公告)日：2012-05-01
申请号：US12510083
申请日：2009-07-27
申请人： Raymond F. Schinazi , Dennis C. Liotta , Chung K. Chu , J. Jeffrey McAtee , Junxing Shi , Yongseok Choi , Kyeong Lee , Joon H. Hong
发明人： Raymond F. Schinazi , Dennis C. Liotta , Chung K. Chu , J. Jeffrey McAtee , Junxing Shi , Yongseok Choi , Kyeong Lee , Joon H. Hong
IPC分类号： A01N61/00 , A61K48/00 , C07H1/00 , C07G3/00
CPC分类号： A61K31/7076 , A61K31/706 , A61K31/7064 , A61K31/7068 , A61K31/7072 , A61K31/708 , C07D405/04 , C07D473/00 , C07H19/06 , C07H19/10 , C07H19/16
摘要： 2′-Fluoro-nucleoside compounds are disclosed which are useful in the treatment of hepatitis B infection, hepatitis C infection, HIV and abnormal cellular proliferation, including tumors and cancer. The compounds have the general formulae: wherein Base is a purine or pyrimidine base; R1 is OH, H, OR3, N3, CN, halogen, CF3, lower alkyl, amino, loweralkylamino, di(lower)alkylamino, or alkoxy; R2 is H, phosphate, or a stabilized phosphate prodrug; acyl, or other pharmaceutically acceptable leaving benzyl, a lipid, an amino acid, peptide, or cholesterol; and R3 is acyl, alkyl, phosphate, or other pharmaceutically acceptable leaving group; or a pharmaceutically acceptable salt thereof.
摘要翻译：公开了可用于治疗乙型肝炎感染，丙型肝炎感染，HIV和异常细胞增殖（包括肿瘤和癌症）的2'-氟 - 核苷化合物。所述化合物具有以下通式：其中碱是嘌呤或嘧啶碱; R 1是OH，H，OR 3，N 3，CN，卤素，CF 3，低级烷基，氨基，低级烷基氨基，二（低级）烷基氨基或烷氧基; R2是H，磷酸盐或稳定的磷酸盐前药; 酰基或其它药学上可接受的苄基，脂质，氨基酸，肽或胆固醇; 烷基，磷酸酯或其它药学上可接受的离去基团; 或其药学上可接受的盐。

10. 发明授权

US07662938B2 2′-fluoronucleosides 有权
标题翻译： 2'-核糖核苷
公开(公告)号：US07662938B2
公开(公告)日：2010-02-16
申请号：US11942551
申请日：2007-11-19
申请人： Raymond F. Schinazi , Dennis C. Liotta , Chung K. Chu , J. Jeffrey McAtee , Junxing Shi , Yongseok Choi , Kyeong Lee , Joon H. Hong
发明人： Raymond F. Schinazi , Dennis C. Liotta , Chung K. Chu , J. Jeffrey McAtee , Junxing Shi , Yongseok Choi , Kyeong Lee , Joon H. Hong
IPC分类号： C07G3/00 , C07H21/00 , C07H21/02 , C12Q1/68
CPC分类号： A61K31/7076 , A61K31/706 , A61K31/7064 , A61K31/7068 , A61K31/7072 , A61K31/708 , C07D405/04 , C07D473/00 , C07H19/06 , C07H19/10 , C07H19/16
摘要： A class of 2′-fluoro-nucleoside compounds are disclosed which are useful in the treatment of hepatitis B infection, hepatitis C infection, HIV and abnormal cellular proliferation, including tumors and cancer. The compounds have the general formula: wherein Base is a purine or pyrimidine base; R1 is OH, H, OR3, N3, CN, halogen, including F, or CF3, lower alkyl, amino, lower alkylamino, di(lower)alkylamino, or alkoxy, and base refers to a purine or pyrimidine base; R2 is H, phosphate, including monophosphate, diphosphate, triphosphate, or a stabilized phosphate prodrug; acyl, or other pharmaceutically acceptable leaving group which when administered in vivo, is capable of providing a compound wherein R2 is H or phosphate; sulfonate ester including alkyl or aryalkyl sulfonyl including methanesulfonyl, benzyl, wherein the phenyl group is optionally substituted with one or more substituents as described in the definition of aryl given above, a lipid, an amino acid, peptide, or cholesterol; and R3 is acyl, alkyl, phosphate, or other pharmaceutically acceptable leaving group which when administered in vivo, is capable of being cleaved to the parent compound, or a pharmaceutically acceptable salt thereof.
摘要翻译：公开了一类可用于治疗乙型肝炎感染，丙型肝炎感染，HIV和异常细胞增殖（包括肿瘤和癌症）的2'-氟 - 核苷化合物。所述化合物具有以下通式：其中碱是嘌呤或嘧啶碱; R 1是OH，H，OR 3，N 3，CN，卤素，包括F或CF 3，低级烷基，氨基，低级烷基氨基，二（低级）烷基氨基或烷氧基，碱是指嘌呤或嘧啶碱基; R2是H，磷酸盐，包括单磷酸盐，二磷酸盐，三磷酸盐或稳定的磷酸盐前体药物; 酰基或其它药学上可接受的离去基团，其在体内施用时能够提供其中R 2为H或磷酸酯的化合物; 磺酸酯，包括烷基或芳烷基磺酰基，包括甲磺酰基，苄基，其中苯基任选被一个或多个取代基取代，如上文给出的芳基的定义，脂质，氨基酸，肽或胆固醇; 并且R3是酰基，烷基，磷酸酯或其它药学上可接受的离去基团，当其在体内施用时，能够被切割成母体化合物或其药学上可接受的盐。

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