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1. 发明申请

US20110263018A1 CORE-SHELL STRUCTURED DELIVERY SYSTEM FOR GROWTH FACTORS, A PREPARATION METHOD THEREOF, AND USE THEREOF FOR THE DIFFERENTIATION OR PROLIFERATION OF CELLS 审中-公开
标题翻译：用于生长因子的核心结构输送系统，其制备方法及其用于细胞分化或增殖的用途
公开(公告)号：US20110263018A1
公开(公告)日：2011-10-27
申请号：US12902537
申请日：2010-10-12
申请人： Kwideok PARK , Dong Keun Han , Dong Hoon Choi , Jae-Jin Kim , Hee Joong Kim , Heung Jae Chun
发明人： Kwideok PARK , Dong Keun Han , Dong Hoon Choi , Jae-Jin Kim , Hee Joong Kim , Heung Jae Chun
IPC分类号： C12N5/02 , C12N5/00
CPC分类号： C12N5/0075 , A61K9/1647 , A61K9/5036 , C12N2533/40
摘要： The present invention relates to a method of preparing a delivery system capable of loading bioactive growth factors that are essential for the differentiation and proliferation of cells and is characterized as loading at least two types of components comprising growth factors in a single carrier, whereby the release of each of the plurality of growth factors can be temporally controlled. Specifically, the method of preparing a microcapsule type growth factor delivery system according to the present invention includes: (1) preparing a polymeric microsphere comprising a first component, and then encapsulating the microspheres by electrodropping the polymer microsphere into another polymer comprising a second component, thereby manufacturing a core-shell structured, microcapsule type delivery system, or (2) encapsulating a polymer solution comprising a first component by electrodropping the polymer solution into another polymer comprising a second component, thereby manufacturing a core-shell structured microcapsule type delivery system. The present invention also provides a stem cell differentiation method involving bringing a microcapsule type delivery system loaded with multiple growth factors according to the present invention into contact with stem cells.
摘要翻译：本发明涉及一种制备能够载入对细胞分化和增殖至关重要的生物活性生长因子的递送系统的方法，其特征在于将至少两种包含生长因子的组分装载在单个载体中，由此释放可以暂时控制多个生长因子中的每一个。具体而言，本发明的微胶囊型生长因子递送系统的制备方法包括：（1）制备包含第一成分的聚合物微球体，然后通过将聚合物微球体电渗入另一种包含第二组分的聚合物中来包封微球体，从而制造芯壳结构的微胶囊型输送系统，或（2）通过将聚合物溶液电渗到另一种包含第二组分的聚合物中，将包含第一组分的聚合物溶液包封，由此制造核 - 壳结构的微胶囊型递送系统。本发明还提供一种干细胞分化方法，其包括使根据本发明的负载有多种生长因子的微胶囊型递送系统与干细胞接触。

2. 发明申请

US20100267143A1 Method for Surface Modification of Polymeric Scaffold for Stem Cell Transplantation Using Decellularized Extracellular Matrix 审中-公开
标题翻译：用于使用脱细胞细胞外基质进行干细胞移植的聚合物支架的表面改性方法
公开(公告)号：US20100267143A1
公开(公告)日：2010-10-21
申请号：US12607793
申请日：2009-10-28
申请人： Kwi Deok Park , Hee Joong Kim , Dong Keun Han , Yu Jin Hong , Heung Jae Chun , Ju Woong Jang
发明人： Kwi Deok Park , Hee Joong Kim , Dong Keun Han , Yu Jin Hong , Heung Jae Chun , Ju Woong Jang
IPC分类号： C12N5/071
CPC分类号： C12N5/0068 , C12N2533/18 , C12N2533/40
摘要： The present invention relates to a method for the surface modification of a polymeric scaffold for stem cell transplantation using a decellularized extracellular matrix. The method for the surface modification of the polymeric scaffold according to the present invention can embody a biomimetic surface environment that is effective for initial cell attachment, cell growth and differentiation of stem cells by modifying the surface of the polymeric scaffold using the decellularized extracellular matrix directly derived from specific tissue cells.
摘要翻译：本发明涉及使用脱细胞的细胞外基质进行干细胞移植的聚合物支架的表面改性的方法。根据本发明的用于表面改性的聚合物支架的方法可以体现通过使用脱细胞的细胞外基质直接修饰聚合物支架的表面来实现对初始细胞附着，细胞生长和干细胞分化有效的仿生表面环境衍生自特定组织细胞。

3. 发明授权

US09233187B2 Biodegradable suture type cell delivery system for improving stem cell engraftment rate 有权
标题翻译：可生物降解缝合型细胞递送系统，用于改善干细胞移植率
公开(公告)号：US09233187B2
公开(公告)日：2016-01-12
申请号：US13266677
申请日：2009-11-18
申请人： Heung Jae Chun , Su Jung You , Ki Dong Yoo , Kyu Nam Park , Gue Tae Chae , Seok Whan Moon , Han Joon Kim , Jung Hee Wee
发明人： Heung Jae Chun , Su Jung You , Ki Dong Yoo , Kyu Nam Park , Gue Tae Chae , Seok Whan Moon , Han Joon Kim , Jung Hee Wee
IPC分类号： A61B17/04 , A61L17/06 , A61L17/00 , A61L17/10 , A61L17/12 , A61L17/14
CPC分类号： A61L17/06 , A61L17/005 , A61L17/105 , A61L17/12 , A61L17/145 , A61L2300/252
摘要： The present invention relates to a biodegradable suture-type cell delivery system, a preparation method thereof and a biodegradable suture comprising the same. The biodegradable suture-type cell delivery system has improved cell compatibility as a result of depositing a hydrophilic functional group-containing compound on the surface of a biodegradable suture yarn made of a biodegradable polymer, a portion of which has partially a bulky structure beneficial for the proliferation of cells or living tissue, so as to hydrophilically modify the surface, and then bonding a cell compatible material to the surface, and also functions as a cell culture scaffold, because the bulky structure is beneficial for the proliferation of cells. Accordingly, the biodegradable suture-type cell delivery system can improve the rate of engraftment of stem cells in vivo.
摘要翻译：本发明涉及可生物降解缝合线型细胞递送系统，其制备方法和包含该方法的生物可降解缝合线。可生物降解的缝合型细胞递送系统由于在由可生物降解的聚合物制成的可生物降解的缝合线的表面上沉积含亲水性官能团的化合物的结果而具有改善的细胞相容性，其一部分具有有利于细胞或活组织的增殖，从而亲水地改变表面，然后将细胞相容的材料粘合到表面，并且还起到细胞培养支架的作用，因为体积大的结构有利于细胞的增殖。因此，可生物降解的缝合线型细胞递送系统可以提高体内干细胞的移植速度。

4. 发明申请

US20120078297A1 BIODEGRADABLE SUTURE TYPE CELL DELIVERY SYSTEM FOR IMPROVING STEM CELL ENGRAFTMENT RATE 有权
标题翻译：用于改善干细胞增殖率的生物可降解型细胞递送系统
公开(公告)号：US20120078297A1
公开(公告)日：2012-03-29
申请号：US13266677
申请日：2009-11-18
申请人： Heung Jae Chun , Su Jung You , Ki Dong Yoo , Kyu Nam Park , Gue Tae Chae , Seok Whan Moon , Han Joon Kim , Jung Hee Wee
发明人： Heung Jae Chun , Su Jung You , Ki Dong Yoo , Kyu Nam Park , Gue Tae Chae , Seok Whan Moon , Han Joon Kim , Jung Hee Wee
IPC分类号： A61B17/04 , D06P7/00 , D02G3/02
CPC分类号： A61L17/06 , A61L17/005 , A61L17/105 , A61L17/12 , A61L17/145 , A61L2300/252
摘要： The present invention relates to a biodegradable suture-type cell delivery system, a preparation method thereof and a biodegradable suture comprising the same. The biodegradable suture-type cell delivery system has improved cell compatibility as a result of depositing a hydrophilic functional group-containing compound on the surface of a biodegradable suture yarn made of a biodegradable polymer, a portion of which has partially a bulky structure beneficial for the proliferation of cells or living tissue, so as to hydrophilically modify the surface, and then bonding a cell compatible material to the surface, and also functions as a cell culture scaffold, because the bulky structure is beneficial for the proliferation of cells. Accordingly, the biodegradable suture-type cell delivery system can improve the rate of engraftment of stem cells in vivo.
摘要翻译：本发明涉及可生物降解缝合线型细胞递送系统，其制备方法和包含该方法的生物可降解缝合线。可生物降解的缝合型细胞递送系统由于在由可生物降解的聚合物制成的可生物降解的缝合线的表面上沉积含亲水性官能团的化合物的结果而具有改善的细胞相容性，其一部分具有有利于细胞或活组织的增殖，从而亲水地改变表面，然后将细胞相容的材料粘合到表面，并且还起到细胞培养支架的作用，因为体积大的结构有利于细胞的增殖。因此，可生物降解的缝合线型细胞递送系统可以提高体内干细胞的移植速度。

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