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    • 4. 发明授权
    • Pharmaceutical compositions for inhibiting angiogenesis
    • 用于抑制血管生成的药物组合物
    • US08450502B2
    • 2013-05-28
    • US12865356
    • 2009-01-30
    • Ho Jeong KwonHye Jin Jung
    • Ho Jeong KwonHye Jin Jung
    • C07D333/50A61P35/00
    • A61K31/381
    • Provided is a pharmaceutical composition for inhibiting angiogenesis, comprising a therapeutically effective amount of a compound represented by Formula 1: (I) wherein R1 through R13 and X are as defined in the specification. Compounds used as an active ingredient in the pharmaceutical composition of the present invention bind to QP-C to provide effective prevention of angiogenesis and can be effectively used for prevention and/or treatment of angiogenesis-related diseases or disorders. Further, the active compounds of the present invention inhibit biological functions of QP-C, which consequently leads to inhibition of angiogenic responses without the risk of cellular apoptosis, thus significantly improving safety of the drug.
    • 本发明提供一种抑制血管生成的药物组合物,其含有治疗有效量的式1表示的化合物:(Ⅰ)其中R1至R13和X如说明书中所定义。 在本发明的药物组合物中用作活性成分的化合物与QP-C结合以提供有效的血管发生预防,并可有效地用于预防和/或治疗血管发生相关疾病或病症。 此外,本发明的活性化合物抑制QP-C的生物学功能,其结果导致血管生成反应的抑制而没有细胞凋亡的风险,因此显着提高了药物的安全性。