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1. 发明申请

US20080075712A1 Double Specific Antibodies Substituting For Functional Proteins 审中-公开
标题翻译：双功能抗体替代功能蛋白
公开(公告)号：US20080075712A1
公开(公告)日：2008-03-27
申请号：US10575905
申请日：2003-10-14
申请人： Kunihiro Hattori , Tetsuo Kojima , Taro Miyazaki , Tetsuhiro Soeda , Chiaki Senoo , Osamu Natori , Keiko Kasutani , Shinya Ishii
发明人： Kunihiro Hattori , Tetsuo Kojima , Taro Miyazaki , Tetsuhiro Soeda , Chiaki Senoo , Osamu Natori , Keiko Kasutani , Shinya Ishii
IPC分类号： A61K39/395 , A61P31/12 , A61P35/00 , A61P37/00 , A61P7/00 , C07K16/00 , C07K16/36
CPC分类号： C07K16/36 , C07K16/2866 , C07K2317/31 , C07K2317/622
摘要： The present inventors succeeded in separating bispecific antibodies that functionally substitute for ligands of type I interferon receptors comprising two types of molecules: AR1 chain and AR2 chain. Furthermore, the present inventors succeeded in producing bispecific antibodies that substitute for the enzyme reaction-accelerating function of blood coagulation factor VIII/activated blood coagulation factor VIII, which bind to both blood coagulation factor IX/activated blood coagulation factor IX and blood coagulation factor X.
摘要翻译：本发明人成功地分离了功能上代替包含两种类型的分子：AR1链和AR2链的I型干扰素受体的配体的双特异性抗体。此外，本发明人成功地制备了代替凝血因子VIII /活化凝血因子VIII的酶反应促进功能的双特异性抗体，其结合凝血因子IX /活化凝血因子IX和凝血因子X 。

2. 发明申请

US20060204496A1 Agonist antibody against heteroreceptor 审中-公开
标题翻译：抗异种受体的激动剂抗体
公开(公告)号：US20060204496A1
公开(公告)日：2006-09-14
申请号：US10540643
申请日：2003-11-28
申请人： Tetsuo Kojima , Chiaki Senoo , Osamu Natori , Keiko Kasutani , Shiny Ishi
发明人： Tetsuo Kojima , Chiaki Senoo , Osamu Natori , Keiko Kasutani , Shiny Ishi
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K16/2866 , C07K2317/31 , C07K2317/622
摘要： Animals were immunized with either the A or B chain of a receptor, and then mRNA was extracted from the spleen cells of the animals, and the variable regions of the L and H chains were isolated by RT-PCR using primers for variable regions comprising CDRs. Single-chain Fv was synthesized by assembly PCR to construct a phage library. Clones for antigen-bound antibodies were concentrated and cloned by panning. An expression vector for scFv-CH1-Fc was prepared by inserting a single-chain variable region between CH1-hinge-CH2-CH3 and the signal sequence for animal cells. Various combinations of such expression vectors were introduced into cells to express antibodies, and antibody clones exhibiting ligand-like activity were selected.
摘要翻译：用受体的A或B链免疫动物，然后从动物的脾细胞中提取mRNA，并且通过RT-PCR分离L和H链的可变区，使用包含CDR的可变区的引物。通过装配PCR合成单链Fv构建噬菌体文库。通过淘选浓缩抗原结合抗体的克隆并克隆。通过在CH1铰链-CH2-CH3和动物细胞的信号序列之间插入单链可变区来制备scFv-CH1-Fc的表达载体。将这些表达载体的各种组合引入细胞中以表达抗体，并选择显示配体样活性的抗体克隆。

3. 发明授权

US07732149B2 Methods of screening agonistic antibodies 有权
标题翻译：筛选激动性抗体的方法
公开(公告)号：US07732149B2
公开(公告)日：2010-06-08
申请号：US10511993
申请日：2003-04-25
申请人： Tetsuo Kojima , Chiaki Senoo
发明人： Tetsuo Kojima , Chiaki Senoo
IPC分类号： G01N33/53
CPC分类号： C40B30/04 , G01N33/5008
摘要： Cell strains with ligand-dependent (factor-dependent) proliferation are super-infected with antibody libraries against each of the various receptor chains. Antibody genes are recovered from strains that autonomously grow by the autocrine stimulation by agonistic antibodies formed by appropriate combinations, enabling effective screening of agonistic antibodies. In this method, effective screening can be carried out using antibodies as libraries. Furthermore, the manipulations are simple, and there is no need for complicated operations.
摘要翻译：具有配体依赖性（因子依赖性）增殖的细胞株通过针对各种受体链的抗体文库进行超感染。从通过自分泌刺激通过适当组合形成的激动性抗体自主生长的菌株回收抗体基因，能够有效筛选激动性抗体。在该方法中，可以使用抗体作为文库进行有效的筛选。此外，操作简单，不需要复杂的操作。

4. 发明申请

US20050164307A1 Methods of screening agonistic antibody 有权
标题翻译：筛选激素抗体的方法
公开(公告)号：US20050164307A1
公开(公告)日：2005-07-28
申请号：US10511993
申请日：2003-04-25
申请人： Tetsuo Kojima , Chiaki Senoo
发明人： Tetsuo Kojima , Chiaki Senoo
IPC分类号： A61P25/00 , A61P37/00 , C12P21/08 , C40B30/04 , G01N33/50 , G01N33/68 , G01N33/53 , G01N33/567
CPC分类号： C40B30/04 , G01N33/5008
摘要： Cell strains with ligand-dependent (factor-dependent) proliferation are super-infected with antibody libraries against each of the various receptor chains. Antibody genes are recovered from strains that autonomously grow by the autocrine stimulation by agonistic antibodies formed by appropriate combinations, enabling effective screening of agonistic antibodies. In this method, effective screening can be carried out using antibodies as libraries. Furthermore, the manipulations are simple, and there is no need for complicated operations.
摘要翻译：具有配体依赖性（因子依赖性）增殖的细胞株通过针对各种受体链的抗体文库进行超感染。从通过自分泌刺激通过适当组合形成的激动性抗体自主生长的菌株回收抗体基因，能够有效筛选激动性抗体。在该方法中，可以使用抗体作为文库进行有效的筛选。此外，操作简单，不需要复杂的操作。

5. 发明授权

US5800982A Antigenic peptides for growing hepatitis C virus, kit comprising the same and methods for its grouping using the same 失效
标题翻译：用于生长丙型肝炎病毒的抗原肽，包含其的试剂盒以及使用其组合的方法
公开(公告)号：US5800982A
公开(公告)日：1998-09-01
申请号：US685764
申请日：1996-07-24
申请人： Akira Hasegawa , Noboru Maki , Shintaro Yagi , Tomiko Kashiwakuma , Kenjiro Yamaguchi , Naoko Ikeguchi , Tomoko Kobayashi , Chiaki Senoo
发明人： Akira Hasegawa , Noboru Maki , Shintaro Yagi , Tomiko Kashiwakuma , Kenjiro Yamaguchi , Naoko Ikeguchi , Tomoko Kobayashi , Chiaki Senoo
IPC分类号： C07K14/18 , C12N15/51 , C12Q1/70 , A61K39/29
CPC分类号： C07K14/005 , C12N2770/24222
摘要： The present invention relates to an NS4-related antigenic peptide capable of reacting specifically with antibodies directed against Group I of hepatitis C virus (HCV); to an NS4-related antigenic peptide capable of reacting specifically with antibodies directed against Group II of HCV; to a kit for identifying HCV Groups I or II which comprises said peptides in separate sections; and to methods for grouping HCV. The peptides of the present invention can be used to detect HCV Groups I or II specifically as well as the detection of patients having the mixed infection, by which HCV Group II-infected patients can receive early interferon treatment effectively. The peptides are also useful for diagnosis of HCV infection.
摘要翻译：本发明涉及能够特异性地针对丙型肝炎病毒（HCV）I组抗体的NS4相关抗原肽; 涉及能够与针对HCV II组的抗体特异性反应的NS4相关抗原肽; 用于鉴定HCV组I或II的试剂盒，其包含分开部分中的所述肽; 以及HCV分组方法。本发明的肽可用于特异性检测HCV组I或II，以及检测具有混合感染的患者，由此可以有效地接受HCV II类感染患者的早期干扰素治疗。这些肽也可用于诊断HCV感染。

6. 发明申请

US20050250144A1 Novel genes encoding protein kinase/protein phosphatase 审中-公开
标题翻译：编码蛋白激酶/蛋白磷酸酶的新基因
公开(公告)号：US20050250144A1
公开(公告)日：2005-11-10
申请号：US11109156
申请日：2005-04-19
申请人： Toshio Ota , Takao Isogai , Tetsuo Nishikawa , Koji Hayashi , Kaoru Otsuka , Jun-Ichi Yamamoto , Shizuko Ishii , Tomoyasu Sugiyama , Ai Wakamatsu , Keiichi Nagai , Tetsuji Otsuki , Shin-Ichi Funahashi , Chiaki Senoo , Jin-Ichi Nezu
发明人： Toshio Ota , Takao Isogai , Tetsuo Nishikawa , Koji Hayashi , Kaoru Otsuka , Jun-Ichi Yamamoto , Shizuko Ishii , Tomoyasu Sugiyama , Ai Wakamatsu , Keiichi Nagai , Tetsuji Otsuki , Shin-Ichi Funahashi , Chiaki Senoo , Jin-Ichi Nezu
IPC分类号： A61K38/00 , C07K14/47 , C12N1/15 , C12N1/19 , C12N1/21 , C12N15/12 , C12Q1/68 , C07H21/04 , C12N9/12 , C12N9/16 , C12N15/09 , C12P21/06
CPC分类号： C07K14/4702 , A61K38/00 , A61K2039/505 , A61K2039/53 , C07K14/47 , C12N2799/021
摘要： Selection of clones having the kinase and/or phosphatase-like structure from clones which had been isolated and the structures thereof had been determined in the Helix Research Institute (helix clones; Japanese Patent Application No. 2000-183767) was conducted. Two novel genes were provided by carrying out homology search for all the helix clones by using the amino acid sequences of known kinases and phosphatases as queries. The genes are expected to be involved in intracellular signal transduction. The physiological functions of the inventive genes can be tested by using reporter gene assay systems capable of detecting signal transduction. The proteins of the present invention are useful as target molecules in drug discovery and in the development of new pharmaceuticals.
摘要翻译：已经在螺旋研究所（螺旋克隆，日本专利申请2000-183767）中确定了已经分离的克隆的克隆和/或磷酸酶样结构的克隆及其结构的选择。通过使用已知的激酶和磷酸酶的氨基酸序列作为查询，通过对所有螺旋克隆进行同源性检索来提供两个新基因。这些基因预期参与细胞内信号转导。可以通过使用能够检测信号转导的报告基因测定系统来测试本发明基因的生理功能。本发明的蛋白质可用作药物发现和开发新药物中的靶分子。

7. 发明授权

US07485714B2 Transcription factor having zinc finger domain 失效
标题翻译：具有锌指结构域的转录因子
公开(公告)号：US07485714B2
公开(公告)日：2009-02-03
申请号：US10312680
申请日：2001-06-14
申请人： Chiaki Senoo , Mariko Numata
发明人： Chiaki Senoo , Mariko Numata
IPC分类号： C07H21/04 , C12N15/63 , C12N15/85 , C12N15/86 , C12P21/00
CPC分类号： C07K14/4705
摘要： Using an undifferentiated mouse CL6 cell line, DMSO was added to induce its differentiation into cardiac muscular cells in order to obtain gene fragments whose expression elevated upon the induction. The isolated gene had zinc finger domains and showed a significant homology to the Sp1 family genes. Furthermore, a human gene corresponding to this mouse gene was isolated. The protein encoded by this gene existed in the nucleus and bonded to a GC-box. The protein was revealed to repress the transcription regulatory activity of the CMV promoter and thus serves as a transcription factor.
摘要翻译：使用未分化的小鼠CL6细胞系，加入DMSO以诱导其分化为心肌细胞，以获得其诱导表达升高的基因片段。分离的基因具有锌指结构域，并显示与Sp1家族基因的显着同源性。此外，分离与该小鼠基因相对应的人类基因。由该基因编码的蛋白质存在于细胞核中并结合到GC盒上。显示蛋白质以抑制CMV启动子的转录调节活性，从而作为转录因子。

8. 发明授权

US08058408B2 Transcription factor having zinc finger domains 失效
标题翻译：具有锌指结构域的转录因子
公开(公告)号：US08058408B2
公开(公告)日：2011-11-15
申请号：US12363650
申请日：2009-01-30
申请人： Chiaki Senoo , Mariko Numata
发明人： Chiaki Senoo , Mariko Numata
IPC分类号： C07K14/47 , C07K14/00
CPC分类号： C07K14/4705
摘要： Using an undifferentiated mouse CL6 cell line, DMSO was added to induce its differentiation into cardiac muscular cells in order to obtain gene fragments whose expression elevated upon the induction. The isolated gene had zinc finger domains and showed a significant homology to the Sp1 family genes. Furthermore, a human gene corresponding to this mouse gene was isolated. The protein encoded by this gene existed in the nucleus and bonded to a GC-box. The protein was revealed to repress the transcription regulatory activity of the CMV promoter and thus serves as a transcription factor.
摘要翻译：使用未分化的小鼠CL6细胞系，加入DMSO以诱导其分化为心肌细胞，以获得其诱导表达升高的基因片段。分离的基因具有锌指结构域，并显示与Sp1家族基因的显着同源性。此外，分离与该小鼠基因相对应的人类基因。由该基因编码的蛋白质存在于细胞核中并结合到GC盒上。显示蛋白质以抑制CMV启动子的转录调节活性，从而作为转录因子。

9. 发明申请

US20090182124A1 NOVEL TRANSCRIPTION FACTOR HAVING ZINC FINGER DOMAINS 失效
标题翻译：具有ZINC指纹域的新型转录因子
公开(公告)号：US20090182124A1
公开(公告)日：2009-07-16
申请号：US12363650
申请日：2009-01-30
申请人： Chiaki Senoo , Mariko Numata
发明人： Chiaki Senoo , Mariko Numata
IPC分类号： C07K14/47 , C07H21/04
CPC分类号： C07K14/4705
摘要： Using an undifferentiated mouse CL6 cell line, DMSO was added to induce its differentiation into cardiac muscular cells in order to obtain gene fragments whose expression elevated upon the induction. The isolated gene had zinc finger domains and showed a significant homology to the Sp1 family genes. Furthermore, a human gene corresponding to this mouse gene was isolated. The protein encoded by this gene existed in the nucleus and bonded to a GC-box. The protein was revealed to repress the transcription regulatory activity of the CMV promoter and thus serves as a transcription factor.
摘要翻译：使用未分化的小鼠CL6细胞系，加入DMSO以诱导其分化为心肌细胞，以获得其诱导表达升高的基因片段。分离的基因具有锌指结构域，并显示与Sp1家族基因的显着同源性。此外，分离与该小鼠基因相对应的人类基因。由该基因编码的蛋白质存在于细胞核中并结合到GC盒上。显示蛋白质以抑制CMV启动子的转录调节活性，从而作为转录因子。

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