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    • 5. 发明授权
    • Method for dissolving arginineamides and pharmaceutical compositions
containing them
    • 溶解精氨酸酰胺和含有它们的药物组合物的方法
    • US5214052A
    • 1993-05-25
    • US851248
    • 1992-03-13
    • Kunihiko OfuchiTatsuo Nomura
    • Kunihiko OfuchiTatsuo Nomura
    • A61K9/00A61K31/445A61K31/47A61K38/04A61K47/10A61K47/26
    • A61K9/0019A61K31/445A61K31/47A61K38/04A61K47/10A61K47/26
    • A method for dissolving an arginineamide of the invention comprising dissolving N.sup.2 -arylsulfonyl-L-arginineamide having the general formula (I) ##STR1## wherein R.sup.1 represents a (2R, 4R)-4-alkyl-2-carboxypiperizino group and R.sup.2 represents a phenyl group or a condensed polycyclic compound residue which may be substituted with one or more substituents selected from lower alkyl groups, lower alkoxy groups and lower alkyl-substituted amino groups, said condensed polycyclic compound residue including a benzene ring which binds to sulfur atom of the sulfonyl group in the general formula (I) and is condensed with one or more other rings which may be heterocyclic and having 7 to 14 carbon atoms as the ring-constituent atoms;and/or its salt in a solvent of alcohol and water is disclosed herein.And, the pharmaceutical composition comprising N.sup.2 -arylsulfonyl-L-arginineamide having the general formula (I), an alcohol and water is disclosed herein.
    • 一种溶解本发明精氨酸酰胺的方法,其包括将通式(I)的N-芳基磺酰基-L-精氨酸酰胺(Ⅰ)溶解在其中R1表示(2R,4R)-4-烷基-2-羧基哌啶子基和 R2表示可被一个或多个选自低级烷基,低级烷氧基和低级烷基取代氨基的取代基取代的苯基或稠合多环化合物残基,所述缩合多环化合物残基包括与硫结合的苯环 通式(I)中的磺酰基的原子,并与一个或多个其它可以是杂环并且具有7-14个碳原子的环作为环组成原子缩合; 和/或其盐在醇和水的溶剂中公开。 并且,本文公开了包含具有通式(I)的N-芳基磺酰基-L-精氨酸酰胺,醇和水的药物组合物。