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1. 发明授权

US4957114A Diagnostic apparatus for intrinsic fluorescence of malignant tumor 失效
标题翻译：恶性肿瘤内在荧光诊断仪
公开(公告)号：US4957114A
公开(公告)日：1990-09-18
申请号：US212630
申请日：1988-06-28
申请人： Kun Zeng , Jinrong Wu , Sen Yang , Zhenfen Yu , Jiude Zhu
发明人： Kun Zeng , Jinrong Wu , Sen Yang , Zhenfen Yu , Jiude Zhu
IPC分类号： A61B5/00 , A61B10/00
CPC分类号： A61B5/0059
摘要： This invention relates to a diagnostic apparatus and particularly to an apparatus for the diagnosis of malignant tumor and the method of using the apparatus for diagnosis. The apparatus employs an ultraviolet light source with an emitting waveband of 3000A-4000A. Light from the light source is transmitted through a bundle of quartz optic fibers to the surface of the tumor, whether benign or malignant, to stimulate it, which then generates a specific intrinsic fluorescence spectrum. The intrinsic fluorescence spectrum reflected from the surface of the tumor is transmitted by a second bundles of glass fibers placed near it to a color resolution means, then processed by a scanning means and a circuit means, and displayed recorded by a display recording means. The display may be a graphic presentation of the intrinsic fluorescence spectrum of the tumor that is tested. If the graphic presentation displayed includes a single peak within the range of the blue color band, it indicates that the tumor being tested is benign. If however, a second peak appears within the range of the red color band of the graphic presentation it is a characteristic peak of malignancy, indicating the existence of a malignant tumor. The presence of the red color can be established by eye rather than a complex color resolution system.
摘要翻译：本发明涉及一种诊断装置，特别涉及诊断恶性肿瘤的装置以及使用该诊断装置的方法。该装置采用发射波段为3000A-4000A的紫外光源。来自光源的光通过一束石英光纤传播到肿瘤的表面，无论是良性还是恶性的，以刺激它，其然后产生特定的内在荧光光谱。从肿瘤表面反射的固有荧光光谱通过放置在其附近的第二束玻璃纤维传输到颜色分辨装置，然后由扫描装置和电路装置处理，并由显示记录装置记录。显示可以是被测试的肿瘤的固有荧光光谱的图形呈现。如果显示的图形显示包括蓝色区域范围内的单个峰值，则表示正在测试的肿瘤是良性的。然而，如果第二个峰出现在图形呈现的红色区域的范围内，则它是恶性肿瘤的特征峰，表明存在恶性肿瘤。红色的存在可以通过眼睛而不是复杂的颜色分辨率系统建立。

2. 发明授权

US10952618B2 Optical observation equipment and endoscope for identifying forming process of malignant tumor 有权
公开(公告)号：US10952618B2
公开(公告)日：2021-03-23
申请号：US15312476
申请日：2015-05-14
申请人： Kun Zeng , Guozheng Yan , Zhenfen Yu
发明人： Kun Zeng , Guozheng Yan , Zhenfen Yu , Wen Liu , Xiuzhang Wang , Zhiwu Wang , Dasheng Liu , Pingping Jiang
IPC分类号： A61B5/00 , G16H30/20 , A61B1/00 , A61B1/04
摘要： Disclosed is optical observation equipment for identifying the forming process of a malignant tumor, which is provided with a receiving space and a transparent front end. The optical observation equipment comprises: a light-guide fiber, a laser emitter, a focusing device, a white light emitter, an image sensor, a high gain amplifier and an encoding and emitting device, wherein the light-guide fiber extends to the transparent front end from the receiving space; the laser emitter emits laser with a wavelength of 340 nm±20 nm and an energy of 0.3˜0.5 mj/m2 in a pulsing mode; the focusing device is coupled to the output end of the laser emitter and used for focusing the laser to the input end of the light-guide fiber; the white light emitter is used for emitting white light, and the white light is guided into the input end of the light-guide fiber, wherein the laser emitter and the white light emitter are alternately turned on; the image sensor is used for acquiring an image of an area irradiated by light emitted from the output end of the light-guide fiber and converting a light signal into an electric signal; the high gain amplifier is coupled to the image sensor and is used for amplifying the electric signal generated by the image sensor; and the encoding and emitting device is coupled to the high gain amplifier and is used for encoding the signal output by the high gain amplifier and emitting the encoded signal.

3. 发明申请

US20080161699A1 OPTICAL BIOPSY METHOD FOR PRECANCEROUS LESION DIAGNOSIS AND AN ENDOSCOPE APPARATUS THEREOF 审中-公开
标题翻译：用于前列腺切除术的光学生物学方法及其内窥镜装置
公开(公告)号：US20080161699A1
公开(公告)日：2008-07-03
申请号：US11935155
申请日：2007-11-05
申请人： Kun ZENG , Zhenfen Yu , Hao Huang , Cailin Zhu
发明人： Kun ZENG , Zhenfen Yu , Hao Huang , Cailin Zhu
IPC分类号： A61B1/06 , A61B6/00
CPC分类号： A61B5/0084 , A61B5/0071
摘要： A optical Biopsy method and an apparatus are used in the diagnosis of precancerous lesion for locating the place and determining the level of malignant tumor. The apparatus comprises light source (1, 10) a light channel system, an endoscope (21) and a circuit system. The light sources include an excited light (1) and a cold light source (10). The cold light source and the excited light in the light channel system go through the end of the light guide of the endoscope via optical fiber bundle and irradiate the tested living tissue (22). The white light image signal and the intrinsic fluorescence image signal reflected from the tested living tissue (22) are received by a weak fluorescence CCD (6) that tightly connects to the end of the endoscope (21) and then transmit to the circuit system via a signal wire (9) to produce the image in the display (17). The weak fluorescence signal reflected from the tested living tissue (22) is transmitted to the circuit system via the weak fluorescence fiber bundle (4) protruding from the forceps hole of the endoscope to produce the spectrum image (16).
摘要翻译：光学活检方法和装置用于诊断癌前病变以确定位置并确定恶性肿瘤的水平。该装置包括光源（1,10），光通道系统，内窥镜（21）和电路系统。光源包括激发光（1）和冷光源（10）。光通道系统中的冷光源和激发光经由光纤束穿过内窥镜的光导的端部并照射测试的活体组织（22）。从被测活体组织（22）反射的白光图像信号和固有荧光图像信号被紧密连接到内窥镜（21）的端部的弱荧光CCD（6）接收，然后通过用于在显示器（17）中产生图像的信号线（9）。从被检测的活体组织（22）反射的弱荧光信号通过从内窥镜的镊子孔突出的弱荧光纤维束（4）传输到电路系统，产生光谱图像（16）。

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