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1. 发明申请

US20080278682A1 Systems and methods For Improving Visual Discrimination 有权
标题翻译：改善视觉歧视的系统和方法
公开(公告)号：US20080278682A1
公开(公告)日：2008-11-13
申请号：US11794883
申请日：2006-01-06
申请人： Krystel R. Huxlin , Mary M. Hayhoe , Jeff B. Pelz
发明人： Krystel R. Huxlin , Mary M. Hayhoe , Jeff B. Pelz
IPC分类号： A61B3/024 , A61B3/00 , A61H5/00 , A61B3/113
CPC分类号： A61H5/00
摘要： A system and method for retraining the visual system of a subject with damage to the striate and/or extrastriate visual cortex includes displaying a visual stimulus within a first location of an impaired visual field of the subject; and detecting the subject's perception of an attribute of the visual stimulus. The system and method are believed to effectively recruit undamaged higher level structures in the visual system to assume the functions of the damaged structures.
摘要翻译：一种用于对受试者的视觉系统进行再训练的系统和方法，所述系统和方法损伤所述条纹和/或激进视觉皮层，包括在受试者的受损视野的第一位置内显示视觉刺激; 并检测受试者对视觉刺激的属性的感知。该系统和方法被认为有效地在视觉系统中招募未损坏的较高级别的结构，以承担损坏结构的功能。

2. 发明授权

US07549743B2 Systems and methods for improving visual discrimination 有权
标题翻译：改善视觉辨别的系统和方法
公开(公告)号：US07549743B2
公开(公告)日：2009-06-23
申请号：US11794883
申请日：2006-01-06
申请人： Krystel R. Huxlin , Mary M. Hayhoe , Jeff B. Pelz
发明人： Krystel R. Huxlin , Mary M. Hayhoe , Jeff B. Pelz
IPC分类号： A61B3/00
CPC分类号： A61H5/00
摘要： A system and method for retraining the visual system of a subject with damage to the striate and/or extrastriate visual cortex includes displaying a visual stimulus within a first location of an impaired visual field of the subject; and detecting the subject's perception of an attribute of the visual stimulus. The system and method are believed to effectively recruit undamaged higher level structures in the visual system to assume the functions of the damaged structures.
摘要翻译：一种用于对受试者的视觉系统进行再训练的系统和方法，所述系统和方法损伤所述条纹和/或激进视觉皮层，包括在受试者的受损视野的第一位置内显示视觉刺激; 并检测受试者对视觉刺激的属性的感知。该系统和方法被认为有效地在视觉系统中招募未损坏的较高级别的结构，以承担损坏结构的功能。

3. 发明授权

US08617147B2 Method for modifying the refractive index of ocular tissues 有权
$Method for modifying the refractive index of ocular tissues$
标题翻译：改变眼组织折射率的方法
公开(公告)号：US08617147B2
公开(公告)日：2013-12-31
申请号：US12895978
申请日：2010-10-01
申请人： Wayne H. Knox , Krystel R. Huxlin
发明人： Wayne H. Knox , Krystel R. Huxlin
IPC分类号： A61B18/18
CPC分类号： A61F9/00829 , A61F9/008 , A61F9/00827 , A61F2009/00842 , A61F2009/00851 , A61F2009/0087 , A61F2009/00872 , A61F2009/00897
摘要： A method for providing vision correction to a patient. The method includes: (a) measuring the degree of vision correction needed by the patient and determining the location and shape of refractive structures that need to be positioned within the cornea to partially correct a patient's vision; (b) directing and focusing femtosecond laser pulses in the blue spectral region within the cornea at an intensity high enough to change the refractive index of the cornea within a focal region, but not high enough to damage the cornea or to affect cornea tissue outside of the focal region; and (c) scanning the laser pulses across a volume of the cornea or the lens to provide the focal region with refractive structures in the cornea or the lens. Again, the refractive structures are characterized by a change in refractive index, and exhibit little or no scattering loss.
摘要翻译：一种用于向患者提供视力矫正的方法。该方法包括：（a）测量患者所需的视力矫正度，并确定需要定位在角膜内的折射结构的位置和形状，以部分校正患者的视力; （b）以足够高的强度将飞秒激光脉冲引导和聚焦在角膜内的蓝色光谱区域，以改变焦点区域内的角膜的折射率，但不足以破坏角膜或影响角膜外部的角膜组织焦点区域; 和（c）扫描角膜或透镜体积上的激光脉冲，以在角膜或透镜中提供焦点区域的折射结构。此外，折射结构的特征在于折射率的变化，并且表现出很少或没有散射损失。

4. 发明授权

US10813791B2 Method for modifying the refractive index of ocular tissues and applications thereof 有权
$Method for modifying the refractive index of ocular tissues and applications thereof$
公开(公告)号：US10813791B2
公开(公告)日：2020-10-27
申请号：US13326403
申请日：2011-12-15
申请人： Wayne H. Knox , Krystel R. Huxlin
发明人： Wayne H. Knox , Krystel R. Huxlin
IPC分类号： A61F9/008
摘要： A method for modifying a refractive property of ocular tissue in an eye by creating at least one optically-modified gradient index (GRIN) layer in the corneal stroma and/or the crystalline by continuously scanning a continuous stream of laser pulses having a focal volume from a laser having a known average power along a continuous line having a smoothly changing refractive index within the tissue, and varying either or both of the scan speed and the laser average power during the scan. The method may further involve determining a desired vision correction adjustment, and determining a position, number, and design parameters of gradient index (GRIN) layers to be created within the ocular tissue to provide the desired vision correction.

5. 发明授权

US08486055B2 Method for modifying the refractive index of ocular tissues 有权
$Method for modifying the refractive index of ocular tissues$
标题翻译：改变眼组织折射率的方法
公开(公告)号：US08486055B2
公开(公告)日：2013-07-16
申请号：US12146976
申请日：2008-06-26
申请人： Wayne H. Knox , Li Ding , Krystel R. Huxlin , Jay F. Kunzler
发明人： Wayne H. Knox , Li Ding , Krystel R. Huxlin , Jay F. Kunzler
IPC分类号： A61B18/18
CPC分类号： A61F9/00804 , A61F9/008 , A61F9/00829 , A61F2009/00842 , A61F2009/00848 , A61F2009/0087 , A61F2009/00872 , A61F2009/0088
摘要： A method for modifying the refractive index of ocular tissues. The method comprises irradiating select regions of ocular tissue with a visible or near-IR laser. The irradiation results in the formation of structures in the ocular tissue, characterized by a change in refractive index, and which exhibit little or no scattering loss.
摘要翻译：一种改变眼组织折射率的方法。该方法包括用可见光或近红外激光照射眼组织的选择区域。照射导致眼组织中的结构的形成，其特征在于折射率的变化，并且表现出很少或没有散射损失。

6. 发明授权

US09545340B1 Multi-photon absorption for femtosecond micromachining and refractive index modification of tissues 有权
$Multi-photon absorption for femtosecond micromachining and refractive index modification of tissues$
标题翻译：用于飞秒微加工和组织折射率修改的多光子吸收
公开(公告)号：US09545340B1
公开(公告)日：2017-01-17
申请号：US12207137
申请日：2008-09-09
申请人： Wayne H. Knox , Krystel R. Huxlin , Li Ding
发明人： Wayne H. Knox , Krystel R. Huxlin , Li Ding
IPC分类号： A61F9/008
CPC分类号： A61F9/00827 , A61F9/008 , A61F9/00804 , A61F9/00829 , A61F2009/00842 , A61F2009/00846 , A61F2009/00848 , A61F2009/0087 , A61F2009/00872 , A61F2009/0088
摘要： By adapting femtosecond micromachining approaches developed in hydrogels, we can perform Intra-tissue Refractive Index Shaping (IRIS) in biological tissues. We reduced femtosecond laser pulse energies below the optical breakdown thresholds to create grating patterns that are associated with a change in the refractive index of the tissue. To increase two-photon absorption, we used a two (or more)-photon-absorbing chromophore.
摘要翻译：通过适应在水凝胶中开发的飞秒微加工方法，我们可以在生物组织中进行组织内折射指数整形（IRIS）。我们将飞秒激光脉冲能量降低到光学击穿阈值以下，以产生与组织的折射率变化相关联的光栅图案。为了增加双光子吸收，我们使用了两个（或更多）光子吸收发色团。

7. 发明申请

US20120310223A1 METHOD FOR MODIFYING THE REFRACTIVE INDEX OF OCULAR TISSUES AND APPLICATIONS THEREOF 审中-公开
标题翻译：用于修改眼科组织折射指数的方法及其应用
公开(公告)号：US20120310223A1
公开(公告)日：2012-12-06
申请号：US13326403
申请日：2011-12-15
申请人： Wayne H. Knox , Krystel R. Huxlin
发明人： Wayne H. Knox , Krystel R. Huxlin
IPC分类号： A61F9/01
CPC分类号： A61F9/00827 , A61F9/00834 , A61F2009/00842 , A61F2009/00846 , A61F2009/0087 , A61F2009/00872 , A61F2009/0088
摘要： A method for modifying a refractive property of ocular tissue in an eye by creating at least one optically-modified gradient index (GRIN) layer in the corneal stroma and/or the crystalline by continuously scanning a continuous stream of laser pulses having a focal volume from a laser having a known average power along a continuous line having a smoothly changing refractive index within the tissue, and varying either or both of the scan speed and the laser average power during the scan. The method may further involve determining a desired vision correction adjustment, and determining a position, number, and design parameters of gradient index (GRIN) layers to be created within the ocular tissue to provide the desired vision correction.
摘要翻译：一种通过在角膜基质和/或晶体中产生至少一个光学修饰的梯度指数（GRIN）层来连续地扫描具有聚焦体积的激光脉冲的流量来修改眼睛中眼组织的折射特性的方法，具有在组织内具有平滑变化的折射率的连续线具有已知平均功率的激光，并且在扫描期间改变扫描速度和激光平均功率中的任一者或两者。该方法还可以包括确定期望的视力矫正调整，以及确定要在眼组织内产生的梯度指数（GRIN）层的位置，数量和设计参数，以提供期望的视力矫正。

8. 发明申请

US20110071509A1 METHOD FOR MODIFYING THE REFRACTIVE INDEX OF OCULAR TISSUES 有权
标题翻译：修饰眼科组织折射指数的方法
公开(公告)号：US20110071509A1
公开(公告)日：2011-03-24
申请号：US12895978
申请日：2010-10-01
申请人： Wayne H. Knox , Krystel R. Huxlin
发明人： Wayne H. Knox , Krystel R. Huxlin
IPC分类号： A61F9/01
CPC分类号： A61F9/00829 , A61F9/008 , A61F9/00827 , A61F2009/00842 , A61F2009/00851 , A61F2009/0087 , A61F2009/00872 , A61F2009/00897
摘要： A method for providing vision correction to a patient. The method includes: (a) measuring the degree of vision correction needed by the patient and determining the location and shape of refractive structures that need to be positioned within the cornea to partially correct a patient's vision; (b) directing and focusing femtosecond laser pulses in the blue spectral region within the cornea at an intensity high enough to change the refractive index of the cornea within a focal region, but not high enough to damage the cornea or to affect cornea tissue outside of the focal region; and (c) scanning the laser pulses across a volume of the cornea or the lens to provide the focal region with refractive structures in the cornea or the lens. Again, the refractive structures are characterized by a change in refractive index, and exhibit little or no scattering loss.
摘要翻译：一种用于向患者提供视力矫正的方法。该方法包括：（a）测量患者所需的视力矫正度，并确定需要定位在角膜内的折射结构的位置和形状，以部分校正患者的视力; （b）以足够高的强度将飞秒激光脉冲引导和聚焦在角膜内的蓝色光谱区域，以改变焦点区域内的角膜的折射率，但不足以破坏角膜或影响角膜外部的角膜组织焦点区域; 和（c）扫描角膜或透镜体积上的激光脉冲，以在角膜或透镜中提供焦点区域的折射结构。此外，折射结构的特征在于折射率的变化，并且表现出很少或没有散射损失。

9. 发明申请

US20090005764A1 Method for Modifying the Refractive Index of Ocular Tissues 有权
$Method for Modifying the Refractive Index of Ocular Tissues$
标题翻译：修改眼组织折射率的方法
公开(公告)号：US20090005764A1
公开(公告)日：2009-01-01
申请号：US12146976
申请日：2008-06-26
申请人： Wayne H. Knox , Li Ding , Krystel R. Huxlin , Jay F. Kunzler
发明人： Wayne H. Knox , Li Ding , Krystel R. Huxlin , Jay F. Kunzler
IPC分类号： A61B18/20
CPC分类号： A61F9/00804 , A61F9/008 , A61F9/00829 , A61F2009/00842 , A61F2009/00848 , A61F2009/0087 , A61F2009/00872 , A61F2009/0088
摘要： A method for modifying the refractive index of ocular tissues. The method comprises irradiating select regions of ocular tissue with a visible or near-IR laser. The irradiation results in the formation of structures in the ocular tissue, characterized by a change in refractive index, and which exhibit little or no scattering loss.
摘要翻译：一种改变眼组织折射率的方法。该方法包括用可见光或近红外激光照射眼组织的选择区域。照射导致眼组织中的结构的形成，其特征在于折射率的变化，并且表现出很少或没有散射损失。

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