专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20080311107A1 Novel Gene Disruptions, Compositions and Methods Relating Thereto 审中-公开
标题翻译：新型基因中断，组成和方法
公开(公告)号：US20080311107A1
公开(公告)日：2008-12-18
申请号：US11814136
申请日：2007-02-09
申请人： Kristi Rae Bollinger , Katherin E. Combs , Jaime-Jo Cunningham , Ling Ling Culbertson , Frederic J. de Sauvage , Joel A. Edwards , Leslie Jane Green , Rosemary Girgis , Allison Anne Byers Horner , Dina Rebecca McLain , Charles Montgomery , Laurie Jeanette Minze , Bobby Joe Payne , Heidi Phillips , Trac Ellen Willis Sevaux , Zheng-Zheng Shi , Mary Jean Sparks , Joy Anne Stala , Tracy Tzu-Ling Tang , Teresa Gail Townsend , Peter Vogel
发明人： Kristi Rae Bollinger , Katherin E. Combs , Jaime-Jo Cunningham , Ling Ling Culbertson , Frederic J. de Sauvage , Joel A. Edwards , Leslie Jane Green , Rosemary Girgis , Allison Anne Byers Horner , Dina Rebecca McLain , Charles Montgomery , Laurie Jeanette Minze , Bobby Joe Payne , Heidi Phillips , Trac Ellen Willis Sevaux , Zheng-Zheng Shi , Mary Jean Sparks , Joy Anne Stala , Tracy Tzu-Ling Tang , Teresa Gail Townsend , Peter Vogel
IPC分类号： A61K39/395 , A61K51/00 , C12N5/06 , A61P25/00 , A61P27/12 , C07K16/00
CPC分类号： A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/03 , C12N15/8509
摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO188, PRO235, PRO266, PRO337, PRO361, PRO539, PRO698, PRO717, PRO846, PRO874, PRO98346, PRO1082, PRO1097, PRO1192, PRO1268, PRO1278, PRO1303, PRO1308, PRO1338, PRO1378, PRO1415, PRO1867, PRO1890, PRO3438, PRO19835, PRO36915, PRO36029, PRO4999, PRO5778, PRO5997, PRO6079, PRO6090, PRO7178, PRO21184, PRO7434, PRO9822, PRO9833, PRO9836, PRO9854, PRO9862, PRO10284, PRO37510, PRO35444, PRO20473, PRO21054 or PRO35246 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.
摘要翻译：本发明涉及转基因动物，以及与基因功能表征相关的组合物和方法。具体地，本发明提供转基因小鼠，其包括在PRO188，PRO235，PRO266，PRO337，PRO361，PRO539，PRO698，PRO717，PRO846，PRO874，PRO98346，PRO1082，PRO1097，PRO1192，PRO1268，PRO1278，PRO1303，PRO1308，PRO1338，PRO1378中的中断，PRO1415，PRO1867，PRO1890，PRO3438，PRO19835，PRO36915，PRO36029，PRO4999，PRO5778，PRO5997，PRO6079，PRO6090，PRO7178，PRO21184，PRO7434，PRO9822，PRO9833，PRO9836，PRO9854，PRO9862，PRO10284，PRO37510，PRO35444，PRO20473，PRO21054 或PRO35246基因。这样的体内研究和表征可以提供有用的识别和发现治疗和/或治疗用于预防，改善或矫正与基因中断相关的疾病或功能障碍如神经障碍; 心血管，内皮或血管生成障碍; 眼睛异常; 免疫学障碍; 肿瘤疾病; 骨代谢异常或障碍; 脂代谢紊乱或发育异常。

2. 发明申请

US20120005766A1 Methods of identifying agents that modulate phenotypes related to disruptions, of a gene encoding PRO235 polypeptide 审中-公开
标题翻译：确定调节与破坏有关的表型的试剂的方法，编码PRO235多肽的基因
公开(公告)号：US20120005766A1
公开(公告)日：2012-01-05
申请号：US13205917
申请日：2011-08-09
申请人： Kristi Rae Bollinger , Katherin E. Combs , Jaime-Jo Cunningham , Ling Ling Culbertson , Frederic J. de Sauvage , Joel Edwards , Leslie Jane Green , Rosemary Girgis , Allison Anne Byers Horner , Dina Rebecca McLain , Charles Montgomery , Laurie Jeanette Minze , Bobby Joe Payne , Heidi Phillips , Tracy Ellen Willis Sevaux , Zheng-Zheng Shi , Mary Jean Sparks , Joy Anne Stala , Tracy Tzu-Ling Tang , Teresa Gail Townsend , Peter Vogel
发明人： Kristi Rae Bollinger , Katherin E. Combs , Jaime-Jo Cunningham , Ling Ling Culbertson , Frederic J. de Sauvage , Joel Edwards , Leslie Jane Green , Rosemary Girgis , Allison Anne Byers Horner , Dina Rebecca McLain , Charles Montgomery , Laurie Jeanette Minze , Bobby Joe Payne , Heidi Phillips , Tracy Ellen Willis Sevaux , Zheng-Zheng Shi , Mary Jean Sparks , Joy Anne Stala , Tracy Tzu-Ling Tang , Teresa Gail Townsend , Peter Vogel
IPC分类号： A61K49/00 , C12Q1/68 , C40B30/04 , C12Q1/02
CPC分类号： A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/03 , C12N15/8509
摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO188, PRO235, PRO266, PRO337, PRO361, PRO539, PRO698, PRO717, PRO846, PRO874, PRO98346, PRO1082, PRO1097, PRO1192, PRO1268, PRO1278, PRO1303, PRO1308, PRO1338, PRO1378, PRO1415, PRO1867, PRO1890, PRO3438, PRO19835, PRO36915, PRO36029, PRO4999, PRO5778, PRO5997, PRO6079, PRO6090, PRO7178, PRO21184, PRO7434, PRO9822, PRO9833, PRO9836, PRO9854, PRO9862, PRO10284, PRO37510, PRO35444, PRO20473, PRO21054 or PRO35246 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; cyc abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.
摘要翻译：本发明涉及转基因动物，以及与基因功能表征相关的组合物和方法。具体地，本发明提供转基因小鼠，其包括在PRO188，PRO235，PRO266，PRO337，PRO361，PRO539，PRO698，PRO717，PRO846，PRO874，PRO98346，PRO1082，PRO1097，PRO1192，PRO1268，PRO1278，PRO1303，PRO1308，PRO1338，PRO1378中的中断，PRO1415，PRO1867，PRO1890，PRO3438，PRO19835，PRO36915，PRO36029，PRO4999，PRO5778，PRO5997，PRO6079，PRO6090，PRO7178，PRO21184，PRO7434，PRO9822，PRO9833，PRO9836，PRO9854，PRO9862，PRO10284，PRO37510，PRO35444，PRO20473，PRO21054 或PRO35246基因。这样的体内研究和表征可以提供有用的识别和发现治疗和/或治疗用于预防，改善或矫正与基因中断相关的疾病或功能障碍如神经障碍; 心血管，内皮或血管生成障碍; 循环异常; 免疫学障碍; 肿瘤疾病; 骨代谢异常或障碍; 脂代谢紊乱或发育异常。

3. 发明申请

US20090288176A1 Novel Gene Disruptions, Compositions and Methods Relating Thereto 审中-公开
标题翻译：新型基因中断，组成和方法
公开(公告)号：US20090288176A1
公开(公告)日：2009-11-19
申请号：US11814025
申请日：2007-04-18
申请人： Kristi Rae Bollinger , Frederic J. de Sauvage , Joel Edwards , Rosemary Girgis , Leslie Jane Green , Laurie Jeanette Minze , Bobby Joe Payne , Carolina Rangel , Zheng-Zheng Shi , Mary Jean Sparks , Tracy Tzu-Ling Tang , Peter Vogel
发明人： Kristi Rae Bollinger , Frederic J. de Sauvage , Joel Edwards , Rosemary Girgis , Leslie Jane Green , Laurie Jeanette Minze , Bobby Joe Payne , Carolina Rangel , Zheng-Zheng Shi , Mary Jean Sparks , Tracy Tzu-Ling Tang , Peter Vogel
IPC分类号： G01N33/00 , A61K39/395 , C12N5/10 , C07K16/00 , A01K67/00
CPC分类号： C12Q1/6883 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/0375 , C07K14/705 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158
摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO286, PRO706, PRO1800, PRO4354, PRO6029, PRO9739, PRO20044, PRO28631 or PRO34128 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.
摘要翻译：本发明涉及转基因动物，以及与基因功能表征相关的组合物和方法。具体地说，本发明提供包含PRO286，PRO706，PRO1800，PRO4354，PRO6029，PRO9739，PRO20044，PRO28631或PRO34128基因中断的转基因小鼠。这样的体内研究和表征可以提供有用的识别和发现治疗和/或治疗用于预防，改善或矫正与基因中断相关的疾病或功能障碍如神经障碍; 心血管，内皮或血管生成障碍; 眼睛异常; 免疫学障碍; 肿瘤疾病; 骨代谢异常或障碍; 脂代谢紊乱或发育异常。

4. 发明申请

US20090313707A1 Novel Gene Disruptions, Compositions and Methods Relating Thereto 失效
标题翻译：新型基因中断，组成和方法
公开(公告)号：US20090313707A1
公开(公告)日：2009-12-17
申请号：US11814361
申请日：2006-05-18
申请人： Katherin E. Combs , Ling Ling Culbertson , Frederic J. de Sauvage , Zhiyong Ding , Joel Edwards , Rosemary Girgis , Allison A. B. Horner , Harald Junge , Jagath Reddy Junutula , Erin Marie Massey , Dina R. McLain , Charles Montgomery , Bobby Joe Payne , Heidi Phillips , Ni Nancy Qian , Carolina Rangel , Tracy E. W. Sevaux , Zheng-Zheng Shi , Mary Jean Sparks , Joy Anne Stala , Peter Vogel , Weilan Ye
发明人： Katherin E. Combs , Ling Ling Culbertson , Frederic J. de Sauvage , Zhiyong Ding , Joel Edwards , Rosemary Girgis , Allison A. B. Horner , Harald Junge , Jagath Reddy Junutula , Erin Marie Massey , Dina R. McLain , Charles Montgomery , Bobby Joe Payne , Heidi Phillips , Ni Nancy Qian , Carolina Rangel , Tracy E. W. Sevaux , Zheng-Zheng Shi , Mary Jean Sparks , Joy Anne Stala , Peter Vogel , Weilan Ye
IPC分类号： G01N33/00 , C12N5/06 , C12Q1/02
CPC分类号： A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/03 , C12N15/8509
摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO69122, PRO204, PRO214, PRO222, PRO234, PRO265, PRO309, PRO332, PRO342, PRO356, PRO540, PRO618, PRO944, PRO994, PRO1079, PRO1110, PRO1122, PRO1138, PRO1190, PRO1272, PRO1286, PRO1295, PRO1309, PRO1316, PRO1383, PRO1384, PRO1431, PRO1434, PRO1475, PRO1481, PRO1568, PRO1573, PRO1599, PRO1604, PRO1605, PRO1693, PRO1753, PRO1755, PRO1777, PRO1788, PRO1864, PRO1925, PRO1926, PRO3566, PRO4330, PRO4423, PRO36935, PRO4977, PRO4979, PRO4980, PRO4981, PRO5801, PRO5995, PRO6001, PRO6095, PRO6182, PRO7170, PRO7171, PRO7436, PRO9912, PRO9917, PRO37337, PRO37496, PRO19646, PRO21718, PRO19820, PRO21201, PRO20026, PRO20110, PRO23203 or PRO35250 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.
摘要翻译：本发明涉及转基因动物，以及与基因功能表征相关的组合物和方法。具体地，本发明提供转基因小鼠，其包括PRO69122，PRO204，PRO214，PRO222，PRO234，PRO265，PRO309，PRO332，PRO342，PRO356，PRO540，PRO618，PRO944，PRO994，PRO1079，PRO1110，PRO1122，PRO1138，PRO1190，PRO1272中的中断，PRO1286，PRO1295，PRO1309，PRO1316，PRO1383，PRO1384，PRO1431，PRO1434，PRO1475，PRO1481，PRO1568，PRO1573，PRO1599，PRO1604，PRO1605，PRO1693，PRO1753，PRO1755，PRO1777，PRO1788，PRO1864，PRO1925，PRO1926，PRO3566，PRO4330。，PRO4423，PRO36935，PRO4977，PRO4979，PRO4980，PRO4981，PRO5801，PRO5995，PRO6001，PRO6095，PRO6182，PRO7170，PRO7171，PRO7436，PRO9912，PRO9917，PRO37337，PRO37496，PRO19646，PRO21718，PRO19820，PRO21201，PRO20026，PRO20110，PRO23203 或PRO35250基因。这样的体内研究和表征可以提供有用的识别和发现治疗和/或治疗用于预防，改善或矫正与基因中断相关的疾病或功能障碍如神经障碍; 心血管，内皮或血管生成障碍; 眼睛异常; 免疫学障碍; 肿瘤疾病; 骨代谢异常或障碍; 脂代谢紊乱或发育异常。

5. 发明申请

US20090293137A1 Novel Gene Disruptions, Compositions and Methods Relating Thereto 审中-公开
标题翻译：新型基因中断，组成和方法
公开(公告)号：US20090293137A1
公开(公告)日：2009-11-26
申请号：US11814413
申请日：2006-11-16
申请人： Katherin E. Combs , Frederic J. de Sauvage , Liangfen Fan , Ellen Filvaroff , Allison A. B. Horner , Bryan Irving , Jagath Reddy Juntula , Erin Marie Massey , Dina Rebecca McLain , Laurie Jeanette Minze , Charles Montgomery , Bobby Joe Payne , Heidi Philips , Carolina Rangel , Tracy E. W. Sevaux , Zheng-Zheng Shi , Mary Jean Sparks , Joy Anne Stala , Teresa G. Townsend , Peter Vogel
发明人： Katherin E. Combs , Frederic J. de Sauvage , Liangfen Fan , Ellen Filvaroff , Allison A. B. Horner , Bryan Irving , Jagath Reddy Juntula , Erin Marie Massey , Dina Rebecca McLain , Laurie Jeanette Minze , Charles Montgomery , Bobby Joe Payne , Heidi Philips , Carolina Rangel , Tracy E. W. Sevaux , Zheng-Zheng Shi , Mary Jean Sparks , Joy Anne Stala , Teresa G. Townsend , Peter Vogel
IPC分类号： A01K67/027 , C12N5/06 , C07K16/18 , C12Q1/02 , A61K39/395
CPC分类号： C12Q1/6883 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A61K49/0008 , C12N15/8509 , C12Q2600/158
摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO218, PRO228, PRO271, PRO273, PRO295, PRO302, PRO305, PRO326, PRO386, PRO655, PRO162, PRO788, PRO792, PRO940, PRO941, PRO1004, PRO1012, PRO 1016, PRO474, PRO5238, PRO1069, PRO1111, PRO1113, PRO1130, PRO1195, PRO1271, PRO1865, PRO1879, PRO3446, PRO3543, PRO4329, PRO4352, PRO5733, PRO9859, PRO9864, PRO9904, PRO9907, PRO10013, PRO90948, PRO28694, PRO16089, PRO19563, PRO19675, PRO20084, PRO21434, PRO50332, PRO38465 or PRO346 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.
摘要翻译：本发明涉及转基因动物，以及与基因功能表征相关的组合物和方法。具体地，本发明提供转基因小鼠，其包括在PRO218，PRO228，PRO271，PRO273，PRO295，PRO302，PRO305，PRO326，PRO386，PRO655，PRO162，PRO788，PRO792，PRO940，PRO941，PRO1004，PRO1012，PRO1016，PRO474， PRO5238，PRO1069，PRO1111，PRO1113，PRO1130，PRO1195，PRO1271，PRO1865，PRO1879，PRO3446，PRO3543，PRO4329，PRO4352，PRO5733，PRO9859，PRO9864，PRO9904，PRO9907，PRO10013，PRO90948，PRO28694，PRO16089，PRO19563，PRO19675，PRO20084， PRO21434，PRO50332，PRO38465或PRO346基因。这样的体内研究和表征可以提供有用的识别和发现治疗和/或治疗用于预防，改善或矫正与基因中断相关的疾病或功能障碍如神经障碍; 心血管，内皮或血管生成障碍; 眼睛异常; 免疫学障碍; 肿瘤疾病; 骨代谢异常或障碍; 脂代谢紊乱或发育异常。

6. 发明申请

US20110097330A1 Novel Gene Disruptions, Compostitions and Methods Relating Thereto 审中-公开
标题翻译：新型基因破坏，组合和方法相关
公开(公告)号：US20110097330A1
公开(公告)日：2011-04-28
申请号：US11722967
申请日：2006-02-27
申请人： Allison Anne Byers Horner , Catherine Batac Clarke , Katherin E. Combs , Frederic J. de Sauvage , Joel Edwards , Paul Godowski , Deanna Grant Wilson , Wenhu Huang , Lorelei Diane Ketcherside , Erin Marie Massey , Charles Montgomery , Bobby Joe Payne , Andrew Peterson , Ni Nancy Qian , Jeffrey J. Schrick , Zheng-Zheng Shi , Mary Jean Sparks , Joy Anne Stala , Colleen M. Viator , Peter Vogel , Weilan Ye , Jung-Hua Yeh , Zhiyong Ding
发明人： Allison Anne Byers Horner , Catherine Batac Clarke , Katherin E. Combs , Frederic J. de Sauvage , Joel Edwards , Paul Godowski , Deanna Grant Wilson , Wenhu Huang , Lorelei Diane Ketcherside , Erin Marie Massey , Charles Montgomery , Bobby Joe Payne , Andrew Peterson , Ni Nancy Qian , Jeffrey J. Schrick , Zheng-Zheng Shi , Mary Jean Sparks , Joy Anne Stala , Colleen M. Viator , Peter Vogel , Weilan Ye , Jung-Hua Yeh , Zhiyong Ding
IPC分类号： A61K49/00 , C07K16/18 , A61K39/00 , A61P25/00 , A61P9/00 , A61P37/00 , A61P27/02 , A61P25/24 , A61P25/22 , A61P25/18 , A61P27/06 , A61P27/12 , A61P9/10 , A61P19/02 , A61P19/10 , C12Q1/68 , C12N5/071 , C12N5/0735 , C12Q1/02
CPC分类号： C07K14/47 , A01K2217/075 , A61K2039/505 , G01N2500/00
摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO179, PRO181, PRO244, PRO247, PRO269, PRO293, PRO298, PRO339, PRO341, PRO347, PRO531, PRO537, PRO718, PRO773, PRO860, PRO871, PRO872, PRO813, PRO828, PRO1100, PRO1114, PRO115, PRO1126, PRO1133, PRO1154, PRO1185, PRO1194, PRO1287, PRO1291, PRO1293, PRO1310, PRO1312, PRO1335, PRO1339, PRO2155, PRO1356, PRO1385, PRO1412, PRO1487, PRO1758, PRO1779, PRO1785, PRO1889, PRO90318, PRO3434, PRO3579, PRO4322, PRO4343, PRO4347, PRO4403, PRO4976, PRO260, PRO6014, PRO6027, PRO6181, PRO6714, PRO9922, PRO7179, PRO7476, PRO9824, PRO19814, PRO19836, PRO20088, PRO70789, PRO50298, PRO51592, PRO1757, PRO4421, PRO9903, PRO1106, PRO1411, PRO1486, PRO1565, PRO4399 or PRO4404 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.
摘要翻译：本发明涉及转基因动物，以及与基因功能表征相关的组合物和方法。具体地说，本发明提供转基因小鼠，其包括PRO179，PRO181，PRO244，PRO247，PRO269，PRO293，PRO298，PRO339，PRO341，PRO347，PRO531，PRO537，PRO718，PRO773，PRO860，PRO871，PRO872，PRO813，PRO828，PRO1100中的中断，PRO1114，PRO115，PRO1126，PRO1133，PRO1154，PRO1185，PRO1194，PRO1287，PRO1291，PRO1293，PRO1310，PRO1312，PRO1335，PRO1339，PRO2155，PRO1356，PRO1385，PRO1412，PRO1487，PRO1758，PRO1779，PRO1785，PRO1889，PRO90318，PRO3434 ，PRO3579，PRO4322，PRO4343，PRO4347，PRO4403，PRO4976，PRO260，PRO6014，PRO6027，PRO6181，PRO6714，PRO9922，PRO7179，PRO7476，PRO9824，PRO19814，PRO19836，PRO20088，PRO70789，PRO50298，PRO51592，PRO1757，PRO4421，PRO9903，PRO1106 ，PRO1411，PRO1486，PRO1565，PRO4399或PRO4404基因。这样的体内研究和表征可以提供有用的识别和发现治疗和/或治疗用于预防，改善或矫正与基因中断相关的疾病或功能障碍如神经障碍; 心血管，内皮或血管生成障碍; 眼睛异常; 免疫学障碍; 肿瘤疾病; 骨代谢异常或障碍; 脂代谢紊乱或发育异常。

7. 发明申请

US20080160034A1 Novel Gene Disruptions, Compositions and Methods Relating Thereto 失效
标题翻译：新型基因中断，组成和方法
公开(公告)号：US20080160034A1
公开(公告)日：2008-07-03
申请号：US11572702
申请日：2005-08-23
申请人： Jane Brennan , Frederic J. de Sauvage , Weilan Ye , Joel A. Edwards , Wenhu Huang , Charles Montgomery , Bobby Joe Payne , Zheng-Zheng Shi , Mary Jean Sparks , Peter Vogel
发明人： Jane Brennan , Frederic J. de Sauvage , Weilan Ye , Joel A. Edwards , Wenhu Huang , Charles Montgomery , Bobby Joe Payne , Zheng-Zheng Shi , Mary Jean Sparks , Peter Vogel
IPC分类号： A61K39/395 , A01K67/00 , C12N5/06 , A61P27/02 , C07K16/18 , G01N33/567
CPC分类号： A01K67/0276 , A01K2217/05 , A01K2227/105 , A01K2267/02 , A01K2267/03 , C12N15/8509
摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO196, PRO217, PRO231, PRO236, PRO245, PRO246, PRO258, PRO287, PRO328, PRO344, PRO357, PRO526, PRO724, PRO731, PRO732, PRO1003, PRO1104, PRO1151, PRO1244, PRO1298, PRO1313, PRO1570, PRO1886, PRO1891, PRO4409, PRO5725, PRO5994, PRO6097, PRO7425, PRO10102, PRO10282, PRO61709 or PRO779 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.
摘要翻译：本发明涉及转基因动物，以及与基因功能表征相关的组合物和方法。具体地说，本发明提供转基因小鼠，其包括PRO196，PRO217，PRO231，PRO236，PRO245，PRO246，PRO258，PRO287，PRO328，PRO344，PRO357，PRO526，PRO724，PRO731，PRO732，PRO1003，PRO1104，PRO1151，PRO1244，PRO1298中的中断，PRO1313，PRO1570，PRO1886，PRO1891，PRO4409，PRO5725，PRO5994，PRO6097，PRO7425，PRO10102，PRO10282，PRO61709或PRO779基因。这样的体内研究和表征可以提供有用的识别和发现治疗和/或治疗用于预防，改善或矫正与基因中断相关的疾病或功能障碍如神经障碍; 心血管，内皮或血管生成障碍; 眼睛异常; 免疫学障碍; 肿瘤疾病; 骨代谢异常或障碍; 脂代谢紊乱或发育异常。

8. 发明授权

US07858843B2 Gene disruptions, compositions and methods relating thereto 失效
标题翻译：基因破坏，组合物和方法
公开(公告)号：US07858843B2
公开(公告)日：2010-12-28
申请号：US11814361
申请日：2006-05-18
申请人： Ling Ling Culbertson , Frederic J. de Sauvage , Charles Montgomery , Zheng-Zheng Shi , Mary Jean Sparks
发明人： Ling Ling Culbertson , Frederic J. de Sauvage , Charles Montgomery , Zheng-Zheng Shi , Mary Jean Sparks
IPC分类号： G01N33/00 , C12N5/06 , C12Q1/02
CPC分类号： A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/03 , C12N15/8509
摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO69122, PRO204, PRO214, PRO222, PRO234, PRO265, PRO309, PRO332, PRO342, PRO356, PRO540, PRO618, PRO944, PRO994, PRO1079, PRO1110, PRO1122, PRO1138, PRO1190, PRO1272, PRO1286, PRO1295, PRO1309, PRO1316, PRO1383, PRO1384, PRO1431, PRO1434, PRO1475, PRO1481, PRO1568, PRO1573, PRO1599, PRO1604, PRO1605, PRO1693, PRO1753, PRO1755, PRO1777, PRO1788, PRO1864, PRO1925, PRO1926, PRO3566, PRO4330, PRO4423, PRO36935, PRO4977, PRO4979, PRO4980, PRO4981, PRO5801, PRO5995, PRO6001, PRO6095, PRO6182, PRO7170, PRO7171, PRO7436, PRO9912, PRO9917, PRO37337, PRO37496, PRO19646, PRO21718, PRO19820, PRO21201, PRO20026, PRO20110, PRO23203 or PRO35250 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.
摘要翻译：本发明涉及转基因动物，以及与基因功能表征相关的组合物和方法。具体地，本发明提供转基因小鼠，其包括PRO69122，PRO204，PRO214，PRO222，PRO234，PRO265，PRO309，PRO332，PRO342，PRO356，PRO540，PRO618，PRO944，PRO994，PRO1079，PRO1110，PRO1122，PRO1138，PRO1190，PRO1272中的中断，PRO1286，PRO1295，PRO1309，PRO1316，PRO1383，PRO1384，PRO1431，PRO1434，PRO1475，PRO1481，PRO1568，PRO1573，PRO1599，PRO1604，PRO1605，PRO1693，PRO1753，PRO1755，PRO1777，PRO1788，PRO1864，PRO1925，PRO1926，PRO3566，PRO4330 ，PRO4423，PRO36935，PRO4977，PRO4979，PRO4980，PRO4981，PRO5801，PRO5995，PRO6001，PRO6095，PRO6182，PRO7170，PRO7171，PRO7436，PRO9912，PRO9917，PRO37337，PRO37496，PRO19646，PRO21718，PRO19820，PRO21201，PRO20026，PRO20110，PRO23203 或PRO35250基因。这样的体内研究和表征可以提供有用的识别和发现治疗和/或治疗用于预防，改善或矫正与基因中断相关的疾病或功能障碍如神经障碍; 心血管，内皮或血管生成障碍; 眼睛异常; 免疫学障碍; 肿瘤疾病; 骨代谢异常或障碍; 脂代谢紊乱或发育异常。

9. 发明授权

US07931902B2 Gene disruptions, compositions and methods relating thereto 失效
标题翻译：基因破坏，组合物和方法
公开(公告)号：US07931902B2
公开(公告)日：2011-04-26
申请号：US11814549
申请日：2006-07-18
申请人： Frederic J. de Sauvage , Gretchen Frantz , Charles Montgomery , Franklin Peale , Zheng-Zheng Shi , Mary Jean Sparks
发明人： Frederic J. de Sauvage , Gretchen Frantz , Charles Montgomery , Franklin Peale , Zheng-Zheng Shi , Mary Jean Sparks
IPC分类号： A01K67/00 , A61K39/395 , A61P43/00
CPC分类号： C12N15/8509 , A01K2217/075 , A01K2267/0306 , A01K2267/0362 , A01K2267/0375
摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO226, PRO257, PRO268, PRO290, PRO36006, PRO363, PRO365, PRO382, PRO444, PRO705, PRO1071, PRO1125, PRO1134, PRO1155, PRO1281, PRO1343, PRO1379, PRO1380, PRO1387, PRO1419, PRO1433, PRO1474, PRO1550, PRO1571, PRO1572, PRO1759, PRO1904, PRO35193, PRO4341, PRO4348, PRO4369, PRO4381, PRO4407, PRO4425, PRO4985, PRO4989, PRO5737, PRO5800, PRO5993, PRO6017, PRO7174, PRO9744, PRO9821, PRO9852, PRO9873, PRO10196, PRO34778, PRO20233, PRO21956, PRO57290, PRO38465, PRO38683 or PRO85161 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.
摘要翻译：本发明涉及转基因动物，以及与基因功能表征相关的组合物和方法。具体地，本发明提供转基因小鼠，其包括在PRO226，PRO257，PRO268，PRO290，PRO36006，PRO363，PRO365，PRO382，PRO444，PRO705，PRO1071，PRO1125，PRO1134，PRO1155，PRO1281，PRO1343，PRO1379，PRO1380，PRO1387，PRO1419中的中断，PRO1433，PRO1474，PRO1550，PRO1571，PRO1572，PRO1759，PRO1904，PRO35193，PRO4341，PRO4348，PRO4369，PRO4381，PRO4407，PRO4425，PRO4985，PRO4989，PRO5737，PRO5800，PRO5993，PRO6017，PRO7174，PRO9744，PRO9821，PRO9852，PRO9873 ，PRO10196，PRO34778，PRO20233，PRO21956，PRO57290，PRO38465，PRO38683或PRO85161基因。这样的体内研究和表征可以提供有用的识别和发现治疗和/或治疗用于预防，改善或矫正与基因中断相关的疾病或功能障碍如神经障碍; 心血管，内皮或血管生成障碍; 眼睛异常; 免疫学障碍; 肿瘤疾病; 骨代谢异常或障碍; 脂代谢紊乱或发育异常。

10. 发明申请

US20120174239A1 Novel PRO1199 gene disruptions, and methods relating thereto 审中-公开
标题翻译：新型PRO1199基因破坏及其相关方法
公开(公告)号：US20120174239A1
公开(公告)日：2012-07-05
申请号：US13317754
申请日：2011-10-27
申请人： Stephen Jay Anderson , Jane Brennan , Frederic J. de Sauvage , Zhiyong Ding , Joel Edwards , Nelda A. Fikes , Wenhu Huang , Wenjun Ouyang , Carolina Rangel , Mamta Sangha , Zheng-Zheng Shi , Mary Jean Sparks , Joseph Trackey , Melissa Vetter , Ching-Yun Wang , Jessica Woodings
发明人： Stephen Jay Anderson , Jane Brennan , Frederic J. de Sauvage , Zhiyong Ding , Joel Edwards , Nelda A. Fikes , Wenhu Huang , Wenjun Ouyang , Carolina Rangel , Mamta Sangha , Zheng-Zheng Shi , Mary Jean Sparks , Joseph Trackey , Melissa Vetter , Ching-Yun Wang , Jessica Woodings
IPC分类号： G01N21/64 , G01N23/083 , C40B30/04 , G01N33/53
CPC分类号： A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/0306
摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO224, PRO9783, PRO1108, PRO34000, PRO240, PRO943, hu A33, PRO230, PRO178, PRO1199, PRO4333, PRO1336, PRO19598, PRO1083, hu TRPM2 or PRO1801 genes.Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.
摘要翻译：本发明涉及转基因动物，以及与基因功能表征相关的组合物和方法。具体地说，本发明提供包含PRO224，PRO9783，PRO1108，PRO34000，PRO240，PRO943，hu A33，PRO230，PRO178，PRO1199，PRO4333，PRO1336，PRO19598，PRO1083，hu TRPM2或PRO1801基因中的中断的转基因小鼠。这样的体内研究和表征可以提供有用的识别和发现治疗和/或治疗用于预防，改善或矫正与基因中断相关的疾病或功能障碍如神经障碍; 心血管，内皮或血管生成障碍; 眼睛异常; 免疫学障碍; 肿瘤疾病; 骨代谢异常或障碍; 脂代谢紊乱或发育异常。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式