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1. 发明申请

US20050070550A1 Benzoimidazole compounds 有权
标题翻译：苯并咪唑化合物
公开(公告)号：US20050070550A1
公开(公告)日：2005-03-31
申请号：US10952989
申请日：2004-09-29
申请人： Kristen Arienti , J. Breitenbucher , Daniel Buzard , James Edwards , Michael Hack , Haripada Khatuya , David Kindrachuk , Alice Lee , Jennifer Venable
发明人： Kristen Arienti , J. Breitenbucher , Daniel Buzard , James Edwards , Michael Hack , Haripada Khatuya , David Kindrachuk , Alice Lee , Jennifer Venable
IPC分类号： A61K31/454 , A61K31/4545 , A61K31/496 , C07D235/18 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D43/02 , C07D43/14
CPC分类号： C07D235/18 , C04B35/632 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07K16/00 , C07K2317/50 , C07K2317/53 , C07K2318/10
摘要： Benzoimidazole compounds, compositions, and methods of using them in leukocyte recruitment inhibition, in modulating H4 receptor, and in treating conditions such as inflammation, H4 receptor-mediated conditions, and related conditions.
摘要翻译：苯并咪唑化合物，组合物及其在白细胞募集抑制中的用途，调节H4受体以及治疗诸如炎症，H4受体介导的病症和相关病症的病症的方法。

2. 发明申请

US20080009493A1 Substituted Benzimidazoles and Imidazo-[4,5]-Pyridines 有权
标题翻译：取代的苯并咪唑和咪唑并[4,5] - 吡啶
公开(公告)号：US20080009493A1
公开(公告)日：2008-01-10
申请号：US11832789
申请日：2007-08-02
申请人： Kristen Arienti , Frank Axe , J. Breitenbucher , Liming Huang , Alice Lee , Kelly McClure
发明人： Kristen Arienti , Frank Axe , J. Breitenbucher , Liming Huang , Alice Lee , Kelly McClure
IPC分类号： A61K31/4184 , A61K31/4439 , A61K31/496 , A61K31/5377 , A61P35/00 , C07D235/16 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D413/12
CPC分类号： C07D235/18 , C07D401/04 , C07D401/10 , C07D401/12 , C07D405/12 , C07D471/04
摘要： 2-Aryl substituted benzimidazoles and imidazo[4,5]pyridines are disclosed as inhibitors of Cds1 and useful as adjuvants to chemotherapy or radiation therapy in the treatment of cancer.
摘要翻译：公开了2-芳基取代的苯并咪唑和咪唑并[4,5]吡啶作为Cds1的抑制剂，并且可用作治疗癌症的化疗或放射治疗的佐剂。

3. 发明授权

US07504414B2 Substituted benzimidazoles and imidazo-[4,5]-pyridines 有权
标题翻译：取代的苯并咪唑和咪唑并[4,5] - 吡啶
公开(公告)号：US07504414B2
公开(公告)日：2009-03-17
申请号：US11832789
申请日：2007-08-02
申请人： Kristen L. Arienti , Frank U. Axe , J. Guy Breitenbucher , Liming Huang , Alice Lee , Kelly J. McClure
发明人： Kristen L. Arienti , Frank U. Axe , J. Guy Breitenbucher , Liming Huang , Alice Lee , Kelly J. McClure
IPC分类号： C07D487/04 , A61K31/4188
CPC分类号： C07D235/18 , C07D401/04 , C07D401/10 , C07D401/12 , C07D405/12 , C07D471/04
摘要： 2-Aryl substituted benzimidazoles and imidazo[4,5]pyridines are disclosed as inhibitors of Cds1 and useful as adjuvants to chemotherapy or radiation therapy in the treatment of cancer.
摘要翻译：公开了2-芳基取代的苯并咪唑和咪唑并[4,5]吡啶作为Cds1的抑制剂，并且可用作治疗癌症的化疗或放射治疗的佐剂。

4. 发明授权

US08741291B2 Multifunctional antibody conjugates 有权
标题翻译：多功能抗体缀合物
公开(公告)号：US08741291B2
公开(公告)日：2014-06-03
申请号：US13305354
申请日：2011-11-28
申请人： Abhijit Suresh Bhat , Curt William Bradshaw , Olivier Alexandre Laurent , Alice Lee , Richard Ryan Preston , David Tumelty , Lauren Diane Wood , Wei Hong Yu
发明人： Abhijit Suresh Bhat , Curt William Bradshaw , Olivier Alexandre Laurent , Alice Lee , Richard Ryan Preston , David Tumelty , Lauren Diane Wood , Wei Hong Yu
IPC分类号： A61K38/00
CPC分类号： C07K16/2863 , A61K47/6811 , A61K47/6849 , A61K2039/505 , C07K2317/52 , C07K2317/55 , C07K2317/76 , C07K2317/90
摘要： The present invention relates to Multifunctional Antibody Conjugates, comprising an antibody or antigen binding portion thereof, comprising at least a fragment of a light chain constant kappa region (CLκ) comprising K188 according to Kabat numbering; a linker comprising the formula X-Y-Z, wherein Z is a group is covalently connected to the antibody through the side chain of K188, Y is a linear or branched biologically compatible connecting chain, and X is a group covalently connected to at least one Effector Moiety.The invention further provides specific MAC compounds and compositions of the invention.
摘要翻译：本发明涉及多功能抗体缀合物，其包含抗体或其抗原结合部分，其至少包含根据Kabat编号的包含K188的轻链恒定κ区域（CL＆amp; Kgr）的片段; 包含式X-Y-Z的接头，其中Z是一个基团，通过K188的侧链与抗体共价连接，Y是直链或支链的生物相容的连接链，X是与至少一个效应子部分共价连接的基团。本发明还提供了本发明的具体的MAC化合物和组合物。

5. 发明申请

US20120201809A1 MULTIFUNCTIONAL ANTIBODY CONJUGATES 有权
标题翻译：多功能抗体结合
公开(公告)号：US20120201809A1
公开(公告)日：2012-08-09
申请号：US13305354
申请日：2011-11-28
申请人： Abhijit Suresh Bhat , Curt William Bradshaw , Olivier Alexandre Laurent , Alice Lee , Richard Ryan Preston , David Tumelty , Lauren Diane Wood , Wei Hong Yu
发明人： Abhijit Suresh Bhat , Curt William Bradshaw , Olivier Alexandre Laurent , Alice Lee , Richard Ryan Preston , David Tumelty , Lauren Diane Wood , Wei Hong Yu
IPC分类号： A61K39/395 , A61P9/00 , A61P35/00 , C07K16/00
CPC分类号： C07K16/2863 , A61K47/6811 , A61K47/6849 , A61K2039/505 , C07K2317/52 , C07K2317/55 , C07K2317/76 , C07K2317/90
摘要： The present invention relates to Multifunctional Antibody Conjugates, comprising an antibody or antigen binding portion thereof, comprising at least a fragment of a light chain constant kappa region (CLκ) comprising K188 according to Kabat numbering; a linker comprising the formula X-Y-Z, wherein Z is a group is covalently connected to the antibody through the side chain of K188, Y is a linear or branched biologically compatible connecting chain, and X is a group covalently connected to at least one Effector Moiety.The invention further provides specific MAC compounds and compositions of the invention.
摘要翻译：本发明涉及多功能抗体缀合物，其包含抗体或其抗原结合部分，其至少包含根据Kabat编号的包含K188的轻链恒定κ区域（CL＆amp; Kgr）的片段; 包含式X-Y-Z的接头，其中Z是一个基团，通过K188的侧链与抗体共价连接，Y是直链或支链的生物相容的连接链，X是与至少一个效应子部分共价连接的基团。本发明还提供了本发明的具体的MAC化合物和组合物。

6. 发明授权

US07271261B2 Substituted benzimidazoles and imidazo-[4,5]-pyridines 有权
标题翻译：取代的苯并咪唑和咪唑并[4,5] - 吡啶
公开(公告)号：US07271261B2
公开(公告)日：2007-09-18
申请号：US10273487
申请日：2002-10-18
申请人： Kristen L. Arienti , Frank U. Axe , J. Guy Breitenbucher , Liming Huang , Alice Lee , Kelly J. McClure
发明人： Kristen L. Arienti , Frank U. Axe , J. Guy Breitenbucher , Liming Huang , Alice Lee , Kelly J. McClure
IPC分类号： C07D235/18 , C07D471/04 , C07D401/04 , A61K31/4184
CPC分类号： C07D235/18 , C07D401/04 , C07D401/10 , C07D401/12 , C07D405/12 , C07D471/04
摘要： 2-Aryl substituted benzimidazoles and imidazo[4,5]pyridines are disclosed as inhibitors of Cds1 and useful as adjuvants to chemotherapy or radiation therapy in the treatment of cancer.
摘要翻译：公开了2-芳基取代的苯并咪唑和咪唑并[4,5]吡啶作为Cds1的抑制剂，并且可用作治疗癌症的化疗或放射治疗的佐剂。

7. 发明授权

US09083753B1 Secure network access control 有权
标题翻译：安全的网络访问控制
公开(公告)号：US09083753B1
公开(公告)日：2015-07-14
申请号：US14175687
申请日：2014-02-07
申请人： Alice Lee , Stacey Lum
发明人： Alice Lee , Stacey Lum
IPC分类号： H04L9/00 , H04L9/32 , H04L29/06
CPC分类号： H04L63/0876 , H04L63/20
摘要： A new approach to network security includes manipulating an access point (215) such that an initial communication from an external device (230) is passed to a restricted subset (205) of a computing network (200) including a gatekeeper (225). The gatekeeper is configured to enforce a security policy (330A) against the external device before granting access to a less-restricted subset (210) of the computing network. If requirements of the security policy are satisfied, then the gatekeeper reconfigures the access point such that further communication from the external device may be received by elements of the less-restricted subset. Enforcement of the security policy optionally includes performing a security audit of the external device.
摘要翻译：新的网络安全方法包括操纵接入点（215），使得来自外部设备（230）的初始通信传递到包括关守（225）的计算网络（200）的受限子集（205）。网守被配置为在授予对计算网络的较不受限制的子集（210）的访问之前对外部设备执行安全策略（330A）。如果满足安全策略的要求，则网守重新配置接入点，使得来自外部设备的进一步通信可以被较少限制子集的元素接收。安全策略的执行可选地包括执行外部设备的安全审核。

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