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1. 发明授权

US08518958B2 Pyrido [2,3-D] pyrimidines and their use as kinase inhibitors 有权
标题翻译：吡啶并[2,3-D]嘧啶及其作为激酶抑制剂的用途
公开(公告)号：US08518958B2
公开(公告)日：2013-08-27
申请号：US12311843
申请日：2007-10-16
申请人： Krishna K. Murthi , Rebecca Casaubon , Arthur F. Kluge , Chase C. Smith , Joachim Vogt
发明人： Krishna K. Murthi , Rebecca Casaubon , Arthur F. Kluge , Chase C. Smith , Joachim Vogt
IPC分类号： A01N43/90 , A61K31/519 , C07D487/00
CPC分类号： C07D471/04
摘要： The present invention provides derivatives of pyrido[2,3-d]pyrimidin-7-one. These compounds are kinase inhibitors, including compounds that show anti-proliferative activity, including against tumor cells, and are useful in the treatment of diseases including cancer.
摘要翻译：本发明提供吡啶并[2,3-d]嘧啶-7-酮的衍生物。这些化合物是激酶抑制剂，包括显示抗增殖活性的化合物，包括抗肿瘤细胞，并且可用于治疗包括癌症在内的疾病。

2. 发明授权

US07230101B1 Synthesis of methotrexate-containing heterodimeric molecules 失效
标题翻译：含甲氨蝶呤的异二聚体分子的合成
公开(公告)号：US07230101B1
公开(公告)日：2007-06-12
申请号：US10651340
申请日：2003-08-28
申请人： Krishna K. Murthi , Chase C. Smith
发明人： Krishna K. Murthi , Chase C. Smith
IPC分类号： C07D475/00 , A01N43/58
CPC分类号： C07D475/08
摘要： The present invention relates to novel compositions of methotrexate-containing heterodimeric probe molecules, also known as chemical inducers of dimerization (CID), useful in three-hybrid assays. The invention further relates to synthesis of said compositions and their intermediates. Another aspect of the invention is a method for using the heterodimeric probe molecules described herein in drug screens to identify potential protein targets to a given ligand, optimize protein-ligand interactions, or identify potential ligands for a given protein target. In certain embodiments, the invention contemplates the synthesis of the following methotrexate-containing heterodimeric probe:
摘要翻译：本发明涉及含有甲氨蝶呤的异二聚体探针分子的新型组合物，也称为二聚化学化学诱导剂（CID），可用于三杂交测定。本发明还涉及所述组合物及其中间体的合成。本发明的另一方面是使用本文所述的异二聚体探针分子在药物筛选中鉴定给定配体的潜在蛋白质靶标，优化蛋白质 - 配体相互作用或鉴定给定蛋白质靶标的潜在配体的方法。在某些实施方案中，本发明涵盖了以下含有甲氨喋呤的异二聚体探针的合成：

3. 发明授权

US09169209B2 Compounds and compositions for the inhibition of NAMPT 有权
标题翻译：用于抑制NAMPT的化合物和组合物
公开(公告)号：US09169209B2
公开(公告)日：2015-10-27
申请号：US14115623
申请日：2011-09-02
申请人： Kenneth W. Bair , Timm Baumeister , Alexandre J. Buckmelter , Karl H. Clodfelter , Bingsong Han , Jian Lin , Dominic J. Reynolds , Chase C. Smith , Zhongguo Wang , Xiaozhang Zheng
发明人： Kenneth W. Bair , Timm Baumeister , Alexandre J. Buckmelter , Karl H. Clodfelter , Bingsong Han , Jian Lin , Dominic J. Reynolds , Chase C. Smith , Zhongguo Wang , Xiaozhang Zheng
IPC分类号： A61K31/535 , C07D213/46 , C07D213/56 , C07D213/34 , C07D401/12 , C07D405/12 , C07D491/08 , A61K31/4406 , A61K31/4439 , A61K31/444 , A61K31/4709 , A61K31/5377 , A61K31/5386 , A61K45/06 , C07D401/14 , C07D451/04
CPC分类号： C07D213/56 , A61K31/4406 , A61K31/4439 , A61K31/444 , A61K31/4709 , A61K31/5377 , A61K31/5386 , A61K45/06 , C07D213/34 , C07D401/12 , C07D401/14 , C07D405/12 , C07D451/04 , C07D491/08
摘要： The present invention relates to compounds and composition for inhibition of NAMPT, their synthesis, applications and antidotes. An illustrative compound of the invention is shown below.
摘要翻译：本发明涉及抑制NAMPT，其合成，应用和解毒剂的化合物和组合物。本发明的说明性化合物如下所示。

4. 发明授权

US09555039B2 Piperidine derivatives and compositions for the inhibition of nicotinamide phosphoribosyltransferase (NAMPT) 有权
标题翻译：用于抑制烟酰胺磷酸核糖基转移酶（NAMPT）的哌啶衍生物和组合物
公开(公告)号：US09555039B2
公开(公告)日：2017-01-31
申请号：US14115849
申请日：2011-09-02
申请人： Kenneth W. Bair , Timm R. Baumeister , Alexandre J. Buckmelter , Karl H. Clodfelter , Bingsong Han , Judith D. Kuntz , Jian Lin , Dominic J. Reynolds , Chase C. Smith , Zhongguo Wang , Xiaozhang Zheng
发明人： Kenneth W. Bair , Timm R. Baumeister , Alexandre J. Buckmelter , Karl H. Clodfelter , Bingsong Han , Judith D. Kuntz , Jian Lin , Dominic J. Reynolds , Chase C. Smith , Zhongguo Wang , Xiaozhang Zheng
IPC分类号： A61K31/44 , A01N43/42 , A61K31/5377 , C07D215/48 , C07D471/04 , C07D513/04 , C07D519/00 , A61K31/4545 , A61K45/06
CPC分类号： C07D519/00 , A61K31/437 , A61K31/4545 , A61K31/4709 , A61K31/497 , A61K31/5377 , A61K45/06 , C07D215/48 , C07D471/04 , C07D495/04 , C07D513/04
摘要： The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An illustrative compound of the invention is shown below: Formula (I)
摘要翻译：本发明涉及抑制NAMPT，其合成，应用和解毒剂的化合物和组合物。本发明的说明性化合物如下所示：式（I）

5. 发明申请

US20150104384A1 AMIDO-BENZYL SULFONE AND SULFOXIDE DERIVATIVES 审中-公开
标题翻译： AMIDO-苄基硫醚和硫代衍生物
公开(公告)号：US20150104384A1
公开(公告)日：2015-04-16
申请号：US14382141
申请日：2013-03-01
申请人： Kenneth W. Bair , Timm R. Baumeister , Alexandre J. Buckmelter , Karl H. Clodfelter , Peter Dragovich , Francis Gosselin , Janet Gunzner-Toste , Bingsong Han , Jian Lin , Xiongcai Liu , Dominic J. Reynolds , Chase C. Smith , Zhongguo Wang , Mark Zak , Yamin Zhang , Guiling Zao , Xiaozhang Zheng , Po-Wai Yuen
发明人： Kenneth W. Bair , Timm R. Baumeister , Alexandre J. Buckmelter , Karl H. Clodfelter , Peter Dragovich , Francis Gosselin , Janet Gunzner-Toste , Bingsong Han , Jian Lin , Xiongcai Liu , Dominic J. Reynolds , Chase C. Smith , Zhongguo Wang , Mark Zak , Yamin Zhang , Guiling Zao , Xiaozhang Zheng , Po-Wai Yuen
IPC分类号： C07D519/00 , A61K31/454 , A61K31/5386 , C07D491/048 , A61K31/4545 , A61K45/06 , C07D471/04 , C07D495/04 , A61K31/496 , A61K31/5025 , A61K31/46 , A61K31/551 , C07D487/04 , A61K31/5377
摘要： The present invention relates to certain amido-benzyl sulfoxide and sulfone compounds, pharmaceutical compositions comprising such compounds, and methods of treatment using such compounds.
摘要翻译：本发明涉及某些酰氨基 - 苄基亚砜和砜化合物，包含这些化合物的药物组合物和使用这些化合物的治疗方法。

6. 发明申请

US20140294805A1 NOVEL COMPOUNDS AND COMPOSITIONS FOR THE INHIBITION OF NAMPT 审中-公开
标题翻译：新型化合物和组合物抑制NAMPT
公开(公告)号：US20140294805A1
公开(公告)日：2014-10-02
申请号：US13820497
申请日：2011-09-02
申请人： Kenneth W. Bair , Timm R. Baumeister , Alexandre J. Buckmelter , Karl H. Clodfelter , Peter Dragovich , Francis Gosselin , Bingsong Han , Jian Lin , Dominic J. Reynolds , Bruce Roth , Chase C. Smith , Zhongguo Wang , Po-Wai Yuen , Xiaozhang Zheng
发明人： Kenneth W. Bair , Timm R. Baumeister , Alexandre J. Buckmelter , Karl H. Clodfelter , Peter Dragovich , Francis Gosselin , Bingsong Han , Jian Lin , Dominic J. Reynolds , Bruce Roth , Chase C. Smith , Zhongguo Wang , Po-Wai Yuen , Xiaozhang Zheng
IPC分类号： C07D495/04 , A61K31/437 , C07D471/04 , C07D487/04 , A61K31/519 , A61K31/55 , C07D491/048 , A61K31/4355 , A61K31/4365 , A61K31/496 , A61K31/5377 , A61K45/06 , A61K31/497
CPC分类号： A61K31/4355 , A61K31/4365 , A61K31/437 , A61K31/496 , A61K31/497 , A61K31/519 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D471/04 , C07D487/04 , C07D491/04 , C07D491/048 , C07D495/04
摘要： The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An illustrative compound of the invention is shown below:
摘要翻译：本发明涉及抑制NAMPT，其合成，应用和解毒剂的化合物和组合物。本发明的说明性化合物如下所示：

7. 发明申请

US20130295051A1 NOVEL COMPOUNDS AND COMPOSITIONS FOR THE INHIBITION OF NAMPT 审中-公开
标题翻译：新型化合物和组合物抑制NAMPT
公开(公告)号：US20130295051A1
公开(公告)日：2013-11-07
申请号：US13820489
申请日：2011-09-02
申请人： Kenneth W. Bair , Alexandre J. Buckmelter , Bingsong Han , Jian Lin , Dominic J. Reynolds , Chase C. Smith , Zhongguo Wang , Xiaozhang Zheng
发明人： Kenneth W. Bair , Alexandre J. Buckmelter , Bingsong Han , Jian Lin , Dominic J. Reynolds , Chase C. Smith , Zhongguo Wang , Xiaozhang Zheng
IPC分类号： C07D213/75 , A61K45/06 , A61K31/437 , A61K31/4409 , C07D471/04 , A61K31/4406
CPC分类号： C07D213/75 , A61K31/437 , A61K31/4406 , A61K31/4409 , A61K45/06 , C07D213/74 , C07D401/04 , C07D471/04
摘要： The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An illustrative compound of the invention is shown below.
摘要翻译：本发明涉及抑制NAMPT，其合成，应用和解毒剂的化合物和组合物。本发明的说明性化合物如下所示。

8. 发明授权

US09676721B2 Compounds and compositions for the inhibition of NAMPT 有权
公开(公告)号：US09676721B2
公开(公告)日：2017-06-13
申请号：US13820489
申请日：2011-09-02
申请人： Kenneth W. Bair , Alexandre J. Buckmelter , Bingsong Han , Jian Lin , Dominic J. Reynolds , Chase C. Smith , Zhongguo Wang , Xiaozhang Zheng
发明人： Kenneth W. Bair , Alexandre J. Buckmelter , Bingsong Han , Jian Lin , Dominic J. Reynolds , Chase C. Smith , Zhongguo Wang , Xiaozhang Zheng
IPC分类号： C07D213/75 , C07D213/74 , C07D471/04 , A61K31/4406 , A61K31/4409 , C07D401/04 , A61K31/437 , A61K45/06
CPC分类号： C07D213/75 , A61K31/437 , A61K31/4406 , A61K31/4409 , A61K45/06 , C07D213/74 , C07D401/04 , C07D471/04
摘要： The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An illustrative compound of the invention is shown below.

9. 发明申请

US20170137441A1 Piperidine Derivatives And Compositions For the Inhibition Of Nicotinamide Phosphoribosyltransferase (NAMPT) 审中-公开
公开(公告)号：US20170137441A1
公开(公告)日：2017-05-18
申请号：US15419727
申请日：2017-01-30
申请人： Kenneth W. BAIR , Timm BAUMEISTER , Alexandre J. BUCKMELTER , Karl H. CLODFELTER , Bingsong HAN , Judith D. KUNTZ , Jian LIN , Dominic J. Reynolds , Chase C. Smith , Zhongguo WANG , Xiaozhang ZHENG
发明人： Kenneth W. BAIR , Timm BAUMEISTER , Alexandre J. BUCKMELTER , Karl H. CLODFELTER , Bingsong HAN , Judith D. KUNTZ , Jian LIN , Dominic J. Reynolds , Chase C. Smith , Zhongguo WANG , Xiaozhang ZHENG
IPC分类号： C07D519/00 , A61K31/4545 , A61K31/4709 , A61K31/497 , A61K31/437 , C07D495/04 , A61K31/5377 , C07D471/04 , C07D215/48
CPC分类号： C07D519/00 , A61K31/437 , A61K31/4545 , A61K31/4709 , A61K31/497 , A61K31/5377 , A61K45/06 , C07D215/48 , C07D471/04 , C07D495/04 , C07D513/04
摘要： The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An illustrative compound of the invention is shown below:

10. 发明申请

US20140275057A1 NOVEL COMPOUNDS AND COMPOSITIONS FOR THE INHIBITION OF NAMPT 审中-公开
标题翻译：新型化合物和组合物抑制NAMPT
公开(公告)号：US20140275057A1
公开(公告)日：2014-09-18
申请号：US14115623
申请日：2011-09-02
申请人： Kenneth W. Bair , Timm Baumeister , Alexandre J. Buckmelter , Karl H. Clodfelter , Bingsong Han , Jian Lin , Dominic J. Reynolds , Chase C. Smith , Zhongguo Wang , Xiaozhang Zheng
发明人： Kenneth W. Bair , Timm Baumeister , Alexandre J. Buckmelter , Karl H. Clodfelter , Bingsong Han , Jian Lin , Dominic J. Reynolds , Chase C. Smith , Zhongguo Wang , Xiaozhang Zheng
IPC分类号： C07D213/56 , A61K45/06 , C07D401/12 , A61K31/444 , A61K31/4439 , A61K31/5377 , C07D451/04 , A61K31/5386 , C07D401/14 , A61K31/4406 , A61K31/4709
CPC分类号： C07D213/56 , A61K31/4406 , A61K31/4439 , A61K31/444 , A61K31/4709 , A61K31/5377 , A61K31/5386 , A61K45/06 , C07D213/34 , C07D401/12 , C07D401/14 , C07D405/12 , C07D451/04 , C07D491/08
摘要： The present invention relates to compounds and composition for inhibition of NAMPT, their synthesis, applications and antidotes. An illustrative compound of the invention is shown below.
摘要翻译：本发明涉及抑制NAMPT，其合成，应用和解毒剂的化合物和组合物。本发明的说明性化合物如下所示。

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