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1. 发明授权

US5270339A Phenoxybenzene derivative 失效
标题翻译：苯氧基苯衍生物
公开(公告)号：US5270339A
公开(公告)日：1993-12-14
申请号：US938164
申请日：1992-12-03
申请人： Kozo Yamamoto , Yoshihide Fuse , Hideyuki Kishida , Naoko Yasuhara , Toshiaki Miwa , Ikuo Katsumi , Takayoshi Hidaka
发明人： Kozo Yamamoto , Yoshihide Fuse , Hideyuki Kishida , Naoko Yasuhara , Toshiaki Miwa , Ikuo Katsumi , Takayoshi Hidaka
IPC分类号： C07D207/08 , C07D207/20 , C07D207/24 , C07D207/26 , C07D207/36 , C07D405/12 , C07D207/06
CPC分类号： C07D207/26 , C07D207/08 , C07D207/20 , C07D207/24 , C07D207/36 , C07D405/12
摘要： There are described a phenoxybenzene derivative having the formula (I): ##STR1## wherein R.sup.1 is hydrogen atom; an alkyl group having 1 to 3 carbon atoms; --OR.sup.6 or a halogen atom,R.sup.2 is hydrogen atom, nitro group or amino group,R.sup.3 is hydrogen atom, an alkyl group having 1 to 8 carbon atoms, a cycloalkyl group having 3 to 5 carbon atoms, allyl group, vinyl group or --(CH.sub.2)n.sup.1 R.sup.7R.sup.4 is hydrogen atom, an alkyl group having 1 to 3 carbon atoms or --(CH.sub.2)n.sup.3 R.sup.25R.sup.5 hydrogen atom; an alkyl group having 1 to 3 carbon atoms; or phenyl group,X is ##STR2## wherein Y is oxygen atom or sulfur atom; or --CHR.sup.27 -- and line means a single bond or a double bond provided that n is 2 in case that the line means a single bond and n is 1 in case that the line means a double bond, ora pharmacologically acceptable salt thereof,a cognition enhancer comprising the same as an effective ingredient andan antidepressant comprising the same as an effective ingredient.
摘要翻译： PCT No.PCT / JP92 / 00410 Sec。 371日期1992年12月3日 102（e）日期1992年12月3日PCT提交1992年4月2日PCT公布。 WO92 / 17447 PCT出版物描述了具有式（I）的苯氧基苯衍生物：其中R 1是氢原子;（I）其中R 1是氢原子; 具有1至3个碳原子的烷基; -OR 6或卤原子，R 2为氢原子，硝基或氨基，R 3为氢原子，碳原子数1〜8的烷基，碳原子数3〜5的环烷基，烯丙基，乙烯基或 - （CH2）n1R7 R4为氢原子，碳原子数1〜3的烷基或 - （CH2）n3R25 R5氢原子; 具有1至3个碳原子的烷基; 或苯基，X是其中Y是氧原子或硫原子; 或-CHR27-，并且线表示单键或双键，条件是在线表示单键的情况下n为2，并且在该线表示双键的情况下n为1，或其药理学上可接受的盐，包含与有效成分相同的认知增强剂和包含其作为有效成分的抗抑郁药。

2. 发明授权

US5494917A Cognition enhancing quinuclidine compound 失效
标题翻译：认知增强奎宁环化合物
公开(公告)号：US5494917A
公开(公告)日：1996-02-27
申请号：US313118
申请日：1994-10-12
申请人： Yoshihide Fuse , Kozo Yamamoto , Hideyuki Kishida , Toshiaki Miwa , Takayoshi Hidaka , Ikuo Katsumi
发明人： Yoshihide Fuse , Kozo Yamamoto , Hideyuki Kishida , Toshiaki Miwa , Takayoshi Hidaka , Ikuo Katsumi
IPC分类号： A61K31/435 , A61K31/55 , A61P25/28 , C07D453/02 , C07D471/08 , C07D487/08 , A61K31/44 , C07D211/72
CPC分类号： C07D453/02
摘要： A cognition enhancer comprising, as an effective ingredient, a bicyclic compound containing nitrogen atom having the general formula (I): ##STR1## or a physiologically acceptable salt thereof.
摘要翻译： PCT No.PCT / JP94 / 00218 Sec。 371日期：1994年10月12日 102（e）日期1994年10月12日PCT 1994年2月4日PCT PCT。 WO94 / 19348 PCT公开号 1994年9月1日。一种认知增强剂，其包含作为有效成分的含有通式（I）的氮原子的双环化合物或其生理学上可接受的盐。

3. 发明授权

US06613780B2 Heat shock factor activity inhibitor 失效
标题翻译：热休克因子活性抑制剂
公开(公告)号：US06613780B2
公开(公告)日：2003-09-02
申请号：US09939901
申请日：2001-08-27
申请人： Shin-ichi Yokota , Kozo Yamamoto , Souichi Morikawa , Yoshihide Fuse , Mikio Kitahara
发明人： Shin-ichi Yokota , Kozo Yamamoto , Souichi Morikawa , Yoshihide Fuse , Mikio Kitahara
IPC分类号： A61K31445
CPC分类号： C07D405/06
摘要： A disease treatment is provided by controlling the expression of a protein induced by a heat shock factor. The novel compound benzo-1,3-dioxole provides an inhibitor of HSF activity or an inhibitor of inducing the production of a protein regulated by HSF, which inhibits the activity of a heat shock factor, a transcriptional regulatory factor, thereby in turn inhibiting transcription of a structural gene having a heat shock element sequence in the gene region for transcriptional regulation into RNA, and thus inhibiting translation of the gene into a protein, and resulting in inhibition of inducing production of RNA or protein encoded by the gene. It also provides a drug for treating or preventing cancer through thermotherapy and a drug for treating or preventing stress diseases such as depression.
摘要翻译：通过控制由热休克因子诱导的蛋白质的表达来提供疾病治疗。新化合物苯并-1,3-二氧杂环戊烷提供HSF活性的抑制剂或诱导由HSF调节的蛋白质的产生的抑制剂，其中抑制热休克因子的活性，转录调节因子，从而进一步抑制基因区域中具有热休克元件序列的结构基因的转录，用于转录调节成RNA，从而抑制基因转化为蛋白质，并导致抑制由该基因编码的RNA或蛋白质的产生。它还提供通过热疗治疗或预防癌症的药物和用于治疗或预防压力疾病如抑郁症的药物。

4. 发明授权

US06281229B1 Heat shock factor activity inhibitors 失效
标题翻译：热休克因子活性抑制剂
公开(公告)号：US06281229B1
公开(公告)日：2001-08-28
申请号：US09446286
申请日：2000-03-27
申请人： Shin-ichi Yokota , Kozo Yamamoto , Souichi Morikawa , Yoshihide Fuse , Mikio Kitahara
发明人： Shin-ichi Yokota , Kozo Yamamoto , Souichi Morikawa , Yoshihide Fuse , Mikio Kitahara
IPC分类号： A61K31445
CPC分类号： C07D405/06
摘要： A disease treatment is provided by controlling the expression of a protein induced by a heat shock factor. The novel compound benzo-1,3-dioxole provides an inhibitor of HSF activity or an inhibitor of inducing the production of a protein regulated by HSF, which inhibits the activity of a heat shock factor, a transcriptional regulatory factor, thereby in turn inhibiting transcription of a structural gene having a heat shock element sequence in the gene region for transcriptional regulation into RNA, and thus inhibiting translation of the gene into a protein, and resulting in inhibition of inducing production of RNA or protein encoded by the gene. It also provides a drug for treating or preventing cancer through thermotherapy and a drug for treating or preventing stress diseases such as depression.
摘要翻译：通过控制由热休克因子诱导的蛋白质的表达来提供疾病治疗。新化合物苯并-1,3-二氧杂环戊烷提供HSF活性的抑制剂或诱导由HSF调节的蛋白质的产生的抑制剂，其中抑制热休克因子的活性，转录调节因子，从而进一步抑制基因区域中具有热休克元件序列的结构基因的转录，用于转录调节成RNA，从而抑制基因转化为蛋白质，并导致抑制由该基因编码的RNA或蛋白质的产生。它还提供通过热疗治疗或预防癌症的药物和用于治疗或预防压力疾病如抑郁症的药物。

5. 发明授权

US06903116B2 Methods of treating cancer using a heat shock factor activity inhibitor 失效
标题翻译：使用热休克因子活性抑制剂治疗癌症的方法
公开(公告)号：US06903116B2
公开(公告)日：2005-06-07
申请号：US10339063
申请日：2003-01-09
申请人： Shin-ichi Yokota , Kozo Yamamoto , Souichi Morikawa , Yoshihide Fuse , Mikio Kitahara
发明人： Shin-ichi Yokota , Kozo Yamamoto , Souichi Morikawa , Yoshihide Fuse , Mikio Kitahara
IPC分类号： C07D405/06 , A61K31/445 , A61K31/40
CPC分类号： C07D405/06
摘要： A disease treatment is provided by controlling the expression of a protein induced by a heat shock factor.The novel compound benzo-1,3-dioxole provides an inhibitor of HSF activity or an inhibitor of inducing the production of a protein regulated by HSF, which inhibits the activity of a heat shock factor, a transcriptional regulatory factor, thereby in turn inhibiting transcription of a structural gene having a heat shock element sequenc in the gene region for transcriptional regulation into RNA, and thus inhibiting translation of the gene into a protein, and resulting in inhibition of inducing production of RNA or protein encoded by the gene. It also provides a drug for treating or preventing cancer through thermotherapy and a drug for treating or preventing stress diseases such as depression.
摘要翻译：通过控制由热休克因子诱导的蛋白质的表达来提供疾病治疗。新型化合物苯并-1,3-二氧杂环戊烷提供HSF活性的抑制剂或诱导由HSF调节的蛋白质产生的抑制剂，其抑制热休克因子（转录调节因子）的活性，从而进而抑制转录在基因区域中具有用于转录调节RNA的热休克元件的结构基因的结构基因，从而抑制基因翻译成蛋白质，并导致抑制由该基因编码的RNA或蛋白质的产生。它还提供通过热疗治疗或预防癌症的药物和用于治疗或预防压力疾病如抑郁症的药物。

6. 发明授权

US5635486A Ophthalmic composition comprising a sleep adjusting substance 失效
标题翻译：包含睡眠调节物质的眼用组合物
公开(公告)号：US5635486A
公开(公告)日：1997-06-03
申请号：US302236
申请日：1994-09-07
申请人： Kozo Yamamoto , Takayoshi Hidaka
发明人： Kozo Yamamoto , Takayoshi Hidaka
IPC分类号： A61K31/495 , A61K31/70
CPC分类号： A61K31/7068 , Y10S514/912
摘要： The present invention provides an ophthalmic composition comprising a sleep inducing substance or a sleep inhibiting substance, and the sleep inducing substance or the sleep inhibiting substance is derived from an organism. Thus, the invention provides an ophthalmic composition comprising a sleep adjusting substance which normalizes irregularity of the rhythm of sleep and a liquid ophthalmic medicament comprising the composition, the composition and the medicament being safe and obtainable by anyone, and a method for regulating the rhythm of sleep comprising instilling the ophthalmic medicament including the sleep adjusting substance to an individual.
摘要翻译：本发明提供一种眼科组合物，其包含睡眠诱导物质或睡眠抑制物质，并且所述睡眠诱导物质或所述睡眠抑制物质来源于生物体。因此，本发明提供了一种眼用组合物，其包含睡眠调节物质，其使睡眠节律的不规则正常化，以及包含组合物，组合物和药物是安全的并且可由任何人获得的液体眼药物，以及调节睡眠调节物质的节律的方法睡眠包括将包括睡眠调节物质的眼科药物滴注到个体。

7. 发明授权

US08568243B2 Flywheel assembly 有权
标题翻译：飞轮总成
公开(公告)号：US08568243B2
公开(公告)日：2013-10-29
申请号：US13059017
申请日：2009-08-06
申请人： Kozo Yamamoto , Keisuke Fujioka , Tomoki Hada
发明人： Kozo Yamamoto , Keisuke Fujioka , Tomoki Hada
IPC分类号： F16D3/14
CPC分类号： F16F15/1343 , F16F15/13469
摘要： A first flywheel assembly a first flywheel, a second flywheel, a first spring set, a first spring seat, and a second spring set. The first spring set is arranged between the first flywheel and the second flywheel in a pre-compressed state. The first spring seat is a member that supports an end portion of the first spring set and is pushed in a radially outward direction against the first flywheel. The second spring set is a member having a lower stiffness than a stiffness of the first spring set and is arranged between the second flywheel and the first spring set in a pre-compressed state such that it acts in series with the first spring set.
摘要翻译：第一飞轮组件，第一飞轮，第二飞轮，第一弹簧组，第一弹簧座和第二弹簧组。第一弹簧组以预压缩状态布置在第一飞轮和第二飞轮之间。第一弹簧座是支撑第一弹簧组件的端部并且朝向第一飞轮沿径向向外的方向推动的构件。第二弹簧组是具有比第一弹簧组的刚度低的刚度的构件，并且以预压缩状态布置在第二飞轮和第一弹簧组之间，使得其与第一弹簧组串联起来。

8. 发明授权

US07438166B2 Flywheel assembly 失效
标题翻译：飞轮总成
公开(公告)号：US07438166B2
公开(公告)日：2008-10-21
申请号：US11373236
申请日：2006-03-13
申请人： Hiroyoshi Tsuruta , Hiroshi Uehara , Kozo Yamamoto
发明人： Hiroyoshi Tsuruta , Hiroshi Uehara , Kozo Yamamoto
IPC分类号： F16D13/68
CPC分类号： F16F15/139 , Y10T74/2131
摘要： A flywheel assembly that receives torque from a crankshaft of an engine includes a flywheel, a damper mechanism, and a frictional resistance generation mechanism. The damper mechanism elastically connects the flywheel to the crankshaft in a rotational direction. The damper mechanism includes an input member, an output member, elastic members to connect elastically the input member and the output member in the rotational direction. The frictional resistance generation mechanism is located functionally in parallel with the damper mechanism in the rotational direction. The frictional resistance generation mechanism utilizes a portion of the flywheel as a friction surface.
摘要翻译：从发动机的曲轴接收扭矩的飞轮组件包括飞轮，阻尼机构和摩擦阻力产生机构。阻尼器机构沿旋转方向将飞轮弹性地连接到曲轴。阻尼机构包括输入构件，输出构件，用于沿旋转方向弹性地连接输入构件和输出构件的弹性构件。摩擦阻力发生机构在功能上与减震机构沿旋转方向平行。摩擦阻力产生机构利用飞轮的一部分作为摩擦面。

9. 发明申请

US20070099710A1 Flexible flywheel 审中-公开
标题翻译：柔性飞轮
公开(公告)号：US20070099710A1
公开(公告)日：2007-05-03
申请号：US10571894
申请日：2004-09-07
申请人： Kozo Yamamoto , Hiroyoshi Tsuruta , Hiroshi Uehara
发明人： Kozo Yamamoto , Hiroyoshi Tsuruta , Hiroshi Uehara
IPC分类号： F16F15/121
CPC分类号： F16F15/1315 , F16F15/13107
摘要： A flexible flywheel is a member to which torque is input from a crankshaft 91 of the engine and includes a first flywheel 2 and a damper mechanism 4. The first flywheel 2 includes an inertia member 13, and a flexible plate 11 for connecting the inertia member 13 with the crankshaft 91. The flexible plate is flexibly deformable in the bending direction. The damper mechanism 4 includes an input-side disc-like plate 20 to which torque is input from the crankshaft 91, output plates 32 and 33 located rotatable relative to the input-side disc-like plate 20, and coil springs 34, 35, and 36 to be compressed in the rotational direction when both the plates rotate relative to each other. The first flywheel 2 can move relative to the damper mechanism 4 in the bending direction with a limited range.
摘要翻译：柔性飞轮是从发动机的曲轴91输入扭矩的构件，其包括第一飞轮2和减震机构4.第一飞轮2包括惯性构件13和用于将惯性构件柔性板在弯曲方向上可挠曲地变形。阻尼机构4包括输入侧盘状板20，从曲轴91输入转矩，相对于输入侧盘状板20可旋转的输出板32,33，以及螺旋弹簧34,35，并且当两个板相对于彼此旋转时，在旋转方向上被压缩。第一飞轮2可以在有限的范围内相对于阻尼机构4在弯曲方向上移动。

10. 发明授权

US06488139B1 Damper mechanism 失效
标题翻译：阻尼机制
公开(公告)号：US06488139B1
公开(公告)日：2002-12-03
申请号：US09273540
申请日：1999-03-22
申请人： Kozo Yamamoto
发明人： Kozo Yamamoto
IPC分类号： F16D4702
CPC分类号： F16F15/1238
摘要： An input rotary member 2 and an output rotary member 3 are circumferentially and elastically coupled together via first and second damper mechanisms 4 and 5 arranged in parallel. The first damper mechanism 4 includes first springs 8. The first springs 8 are arranged between the input and output rotary members 2 and 3 for transmitting torque therebetween. Compression of the first springs 8 does not start before a torsion angle reaches a first torsion angle 1. The second damper mechanism 5 includes second springs 13 and a high hysteresis torque generating mechanism 15 arranged in series. The second springs 13 can be compressed only within a range of a torsion angle &thgr;AC smaller than the first torsion angle &thgr;1.
摘要翻译：输入旋转构件2和输出旋转构件3通过平行布置的第一和第二阻尼器机构4和5周向地弹性地联接在一起。第一阻尼机构4包括第一弹簧8.第一弹簧8布置在输入和输出旋转构件2和3之间，用于在它们之间传递扭矩。第一弹簧8的压缩在扭转角达到第一扭转角1之前不开始。第二阻尼机构5包括串联布置的第二弹簧13和高滞后扭矩产生机构15。第二弹簧13只能在小于第一扭转角θ1的扭转角度θAC的范围内被压缩。

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