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1. 发明授权

US4539403A Process for the preparation of a 2-alkyl-4-amino-5-aminomethylpyrimidine 失效
标题翻译：制备2-烷基-4-氨基-5-氨基甲基嘧啶的方法
公开(公告)号：US4539403A
公开(公告)日：1985-09-03
申请号：US461163
申请日：1983-01-26
申请人： Kozo Fujii , Keigo Nishihira , Hiroyuki Sawada , Shuji Tanaka , Mamoru Nakai , Hiroshi Yoshida , Teruhiko Inoue , Kiyosi Oomori
发明人： Kozo Fujii , Keigo Nishihira , Hiroyuki Sawada , Shuji Tanaka , Mamoru Nakai , Hiroshi Yoshida , Teruhiko Inoue , Kiyosi Oomori
IPC分类号： C07D239/42 , C07D239/02
CPC分类号： C07D239/42
摘要： There is disclosed a process for the preparation of a 2-alkyl-4-amino-5-aminomethylpyrimidine, which comprises subjecting a 2-alkyl-4-amino-5-formylpyrimidine to catalytic reaction with hydrogen and ammonia in the presence of a reduction catalyst.According to the process of this invention, the desired product can be obtained in much higher yield as compared with the processes known to the art.
摘要翻译：公开了2-烷基-4-氨基-5-氨基甲基嘧啶的制备方法，该方法包括使2-烷基-4-氨基-5-甲酰基嘧啶在还原反应的存在下与氢和氨进行催化反应催化剂。根据本发明的方法，与本领域已知的方法相比，可以以更高的收率获得所需产物。

2. 发明授权

US4492792A Process for preparing 4-amino-5-dialkoxy-methylpyrimidine derivatives 失效
标题翻译： 4-氨基-5-二烷氧基 - 甲基嘧啶衍生物的制备方法
公开(公告)号：US4492792A
公开(公告)日：1985-01-08
申请号：US461191
申请日：1983-01-26
申请人： Kozo Fujii , Keigo Nishihira , Hiroyuki Sawada , Shuji Tanaka , Mamoru Nakai , Hiroshi Yoshida , Teruhiko Inoue
发明人： Kozo Fujii , Keigo Nishihira , Hiroyuki Sawada , Shuji Tanaka , Mamoru Nakai , Hiroshi Yoshida , Teruhiko Inoue
IPC分类号： C07D239/42 , C07D317/32 , C07D239/02
CPC分类号： C07D239/42 , C07C255/00
摘要： A process for preparing a 4-amino-5-dialkoxymethylpyrimidine derivative of the formula: ##STR1## which comprises reacting a propanenitrile derivative represented by the formula (I) or the novel compound represented by formula (II): ##STR2## with an amidine of the formula: ##STR3## wherein R.sup.1 to R.sup.6 are as defined in the specification. Also disclosed is a process for making the novel compounds of formula (II).
摘要翻译：制备下式的4-氨基-5-二烷氧基甲基嘧啶衍生物的方法：包括使由式（I）表示的丙腈衍生物或由式（II）表示的新化合物：（I）（II），其具有下式的脒：其中R 1至R 6如说明书中所定义。还公开了制备式（II）的新型化合物的方法。

3. 发明授权

US4514571A Process for the preparation of urea derivatives 失效
标题翻译：尿素衍生物的制备方法
公开(公告)号：US4514571A
公开(公告)日：1985-04-30
申请号：US496179
申请日：1983-05-19
申请人： Mamoru Nakai , Fumio Iwata , Teruhiko Inoue
发明人： Mamoru Nakai , Fumio Iwata , Teruhiko Inoue
IPC分类号： C07C67/00 , C07C239/00 , C07C273/02 , C07C275/06 , C07C275/26 , C07C275/28 , C07D213/75 , C07D261/14 , C07B29/00 , C07C126/00 , C07D213/89 , C07D263/48
CPC分类号： C07D213/75 , C07C275/06 , C07C275/28 , C07D261/14
摘要： A process for the preparation of a urea derivative having the formula: ##STR1## in which A represents a straight- or branched-chain alkyl group having 1-20 carbon atoms, an aryl group, or a heterocyclic group, and each of R.sup.1 and R.sup.2 represents hydrogen, a straight- or branched-chain alkyl group having 1-20 carbon atoms, an alicyclic group, or an aryl groups, which comprises:reacting sodium salt of an N-halogenamide with a quaternary ammonium salt to obtain its addition salt and then,reacting said addition salt with an amine derivative in the absence or presence of an organic solvent.
摘要翻译：一种制备具有下式的脲衍生物的方法：其中A表示具有1-20个碳原子的直链或支链烷基，芳基或杂环基，R1和 R2表示氢，具有1-20个碳原子的直链或支链烷基，脂环基或芳基，其包括：使N-卤代酰胺的钠盐与季铵盐反应以获得其加成盐然后在不存在或存在有机溶剂的情况下使所述加成盐与胺衍生物反应。

4. 发明授权

US4025566A Process for preparing monoalkyl ethers of dihydric phenols 失效
标题翻译：制备二元酚单烷基醚的方法
公开(公告)号：US4025566A
公开(公告)日：1977-05-24
申请号：US656938
申请日：1976-02-10
申请人： Shigeki Nagai , Hiroshi Yoshida , Teruhiko Inoue
发明人： Shigeki Nagai , Hiroshi Yoshida , Teruhiko Inoue
IPC分类号： C07C43/23 , B01J21/00 , B01J27/00 , B01J27/18 , C07B61/00 , C07C41/00 , C07C67/00
CPC分类号： B01J27/1802
摘要： Process for preparing monoalkyl ethers of dihydric phenols using a catalyst comprising Al, B and P.
摘要翻译：使用包含Al，B和P的催化剂制备二元酚的单烷基醚的方法。

5. 发明授权

US4675412A Process for preparing 5-mercapto-1,2,3-thiadiazole salts 失效
标题翻译： 5-巯基-1,2,3-噻二唑盐的制备方法
公开(公告)号：US4675412A
公开(公告)日：1987-06-23
申请号：US777834
申请日：1985-09-19
申请人： Hiroshi Yoshida , Teruhiko Inoue
发明人： Hiroshi Yoshida , Teruhiko Inoue
IPC分类号： C07D285/06
CPC分类号： C07D285/06
摘要： There is disclosed a process for preparing 5-mercapto-1,2,3-thiadiazole salts comprising reacting a hydrazone compound represented by the formula:X.sub.3 C--CH.dbd.N--NH--SO.sub.2 Arwherein X represents a halogen atom and Ar represents an aryl group, with a polysulfide compound represented by the formula:M.sub.2 S.sub.xwherein M represents an alkali metal atom or an NH.sub.4 group and x is an integer of 2 to 6.The present invention provides the 5-mercapto-1,2,3-thiadiazole salt with remarkably increased yield as compared with the conventional method.
摘要翻译：公开了一种制备5-巯基-1,2,3-噻二唑盐的方法，包括使由下式表示的腙化合物：X3C-CH = N-NH-SO2Ar，其中X表示卤素原子，Ar表示芳基与由下式表示的多硫化合物：M2Sx其中M表示碱金属原子或NH4基团，x为2-6的整数。本发明提供5-巯基-1,2,3-噻二唑盐与与常规方法相比，产量显着提高。

6. 发明申请

US20090048425A1 PROCESS FOR PRODUCTION OF CYCLOOLEFIN 有权
标题翻译：生产环烯醇的方法
公开(公告)号：US20090048425A1
公开(公告)日：2009-02-19
申请号：US11912575
申请日：2006-08-18
申请人： Mitsuo Konishi , Teruhiko Inoue
发明人： Mitsuo Konishi , Teruhiko Inoue
IPC分类号： C08G61/10
CPC分类号： B01J23/46 , B01J23/60 , B01J23/96 , B01J27/053 , B01J38/64 , C07C5/11 , C07C2523/46 , C07C2527/053 , C07C2601/16 , Y02P20/584
摘要： According to the present invention, when cycloolefins are produced by partially hydrogenating a monocyclic aromatic hydrocarbon with hydrogen in the presence of a ruthenium catalyst, water, and a metal sulfate, the decrease in catalytic activity and cycloolefin selectivity is suppressed by reducing the concentration of chloride ions dissolved in the water in which the catalyst is present to 300 wt ppm or less and regenerating a part or all of the catalyst for reuse. Zinc sulfate is preferably used as the metal sulfate. Further, the raw materials and catalyst to be supplied to the reaction preferably have a reduced chloride ion content. This method can suppress the decrease in long-term catalytic activity and cycloolefin selectivity. Furthermore, the catalytic activity and cycloolefin selectivity after catalyst regeneration can be maintained at a high level. As a result, cycloolefins can be efficiently produced for a long period of time.
摘要翻译：根据本发明，当在钌催化剂，水和金属硫酸盐的存在下，通过氢气使单环芳族烃部分氢化制备环烯烃时，通过降低氯化物的浓度来抑制催化活性和环烯选择性的降低溶解在其中存在催化剂的水中的离子为300重量ppm以下，再生部分或全部催化剂用于再利用。硫酸锌优选用作金属硫酸盐。此外，供给反应的原料和催化剂优选具有减少的氯离子含量。该方法可以抑制长期催化活性和环烯烃选择性的降低。此外，催化剂再生后的催化活性和环烯选择性可以保持在高水平。因此，可以长时间有效地制造环烯烃。

7. 发明授权

US07371760B2 Medicinal compositions containing aspirin 有权
公开(公告)号：US07371760B2
公开(公告)日：2008-05-13
申请号：US10600266
申请日：2003-06-20
申请人： Fumitoshi Asai , Atsuhiro Sugidachi , Taketoshi Ogawa , Teruhiko Inoue
发明人： Fumitoshi Asai , Atsuhiro Sugidachi , Taketoshi Ogawa , Teruhiko Inoue
IPC分类号： A61K31/60 , A61K31/4743
摘要： A combination of 2-acetoxy-5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine or a pharmaceutically acceptable salt thereof, and aspirin, which possess excellent inhibitory activity against platelet aggregation and thrombogenesis, and is useful for preventing or treating diseases caused by thrombus or embolus.

8. 发明授权

US07285572B2 CaSR antagonist 失效
标题翻译： CaSR拮抗剂
公开(公告)号：US07285572B2
公开(公告)日：2007-10-23
申请号：US11286378
申请日：2005-11-25
申请人： Yuko Shinagawa , Teruhiko Inoue , Toshihiro Kiguchi , Taku Ikenogami , Naoki Ogawa , Takashi Nakagawa , Masanori Shindo , Yuki Soejima
发明人： Yuko Shinagawa , Teruhiko Inoue , Toshihiro Kiguchi , Taku Ikenogami , Naoki Ogawa , Takashi Nakagawa , Masanori Shindo , Yuki Soejima
IPC分类号： A61K31/19 , A61K31/195 , A61K31/185 , C07C61/00 , C07C211/00
CPC分类号： C07D257/04 , C07C217/28 , C07C311/51 , C07D277/56 , C07D285/08 , C07D333/38 , C07F9/3834 , C07F9/4021
摘要： The present invention provides a compound having a calcium-sensitive receptor antagonistic action, a pharmaceutical composition containing the compound, particularly a calcium receptor antagonist and a therapeutic drug for osteoporosis. A compound represented by the following formula (1), a pharmaceutically acceptable salt thereof or an optically active form thereof: wherein each symbol is as defined in the description.
摘要翻译：本发明提供具有钙敏感受体拮抗作用的化合物，含有该化合物，特别是钙受体拮抗剂的药物组合物和用于骨质疏松症的治疗药物。由下式（1）表示的化合物，其药学上可接受的盐或其光学活性形式：其中每个符号如说明书中所定义。

9. 发明申请

US20050032796A1 CaSR antagonist 有权
标题翻译： CaSR拮抗剂
公开(公告)号：US20050032796A1
公开(公告)日：2005-02-10
申请号：US10830480
申请日：2004-04-23
申请人： Yuko Shinagawa , Teruhiko Inoue , Toshihiro Kiguchi , Taku Ikenogami , Naoki Ogawa , Kenji Fukuda , Takashi Nakagawa , Masanori Shindo , Yuki Soejima
发明人： Yuko Shinagawa , Teruhiko Inoue , Toshihiro Kiguchi , Taku Ikenogami , Naoki Ogawa , Kenji Fukuda , Takashi Nakagawa , Masanori Shindo , Yuki Soejima
IPC分类号： A61P3/14 , A61P19/02 , A61P19/08 , A61P19/10 , A61P29/00 , A61P43/00 , C07C217/28 , C07C317/44 , C07C323/62 , C07D215/12 , C07D295/155 , C07D307/79 , A61K31/5377 , A61K31/4025 , A61K31/4439 , A61K31/454 , A61K31/4545 , C07D413/14 , C07D43/14
CPC分类号： C07D213/80 , C07C217/28 , C07C317/44 , C07C323/62 , C07C2601/02 , C07D215/12 , C07D295/155 , C07D307/79
摘要： A compound represented by the following formula (1), a pharmaceutically acceptable salt thereof or an optically active form thereof: wherein each symbol is as defined in the specification. A compound having a calcium-sensing receptor antagonistic action, a pharmaceutical composition comprising the compound, particularly a calcium receptor antagonist and a therapeutic drug for osteoporosis are provided.
摘要翻译：由下式（1）表示的化合物，其药学上可接受的盐或其光学活性形式：其中每个符号如说明书中所定义。提供了具有钙敏感受体拮抗作用的化合物，包含该化合物，特别是钙受体拮抗剂和用于骨质疏松症的治疗药物的药物组合物。

10. 发明授权

US5073556A 4-oxoquinoline-3-carboxylic acid derivatives and their use 失效
标题翻译： 4-氧杂环辛烷-3-羧酸衍生物及其用途
公开(公告)号：US5073556A
公开(公告)日：1991-12-17
申请号：US659829
申请日：1991-02-22
申请人： Masayuki Iwata , Tomio Kimura , Teruhiko Inoue , Yoshimi Fujihara , Tetsushi Katsube
发明人： Masayuki Iwata , Tomio Kimura , Teruhiko Inoue , Yoshimi Fujihara , Tetsushi Katsube
IPC分类号： C07D215/56 , C07D401/04 , C07D521/00
CPC分类号： C07D231/12 , C07D215/56 , C07D233/56 , C07D249/08 , C07D401/04 , Y02P20/55
摘要： Compounds of formula (I): ##STR1## (in which: R.sup.1 represents fluorinated methoxy; R.sup.2 represents a nitrogen-containing heterocyclic group and R.sup.3 represents hydrogen or amino) and pharmaceutically acceptable salts, esters and amides thereof are valuable antibacterial agents, which may be prepared by reacting a compound similar to that of formula (I) but in which R.sup.2 is replaced by a halogen atom with a compound providing the required group R.sup.2.

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