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1. 发明公开

EP1826218A1 ANTIHUMAN BAFF ANTIBODY 有权
标题翻译：抗菌素抗菌素
公开(公告)号：EP1826218A1
公开(公告)日：2007-08-29
申请号：EP05776879.8
申请日：2005-08-30
申请人： Kowa Company, Ltd. , Takeuchi, Tsutomu , Yoshimoto, Keiko
发明人： TAKEUCHI, Tsutomu , YOSHIMOTO, Keiko
IPC分类号： C07K16/24 , C12N15/02 , C12P21/08 , A61K39/395 , A61P37/00 , A61P3/10 , A61P29/00 , A61P19/02 , G01N33/53 , G01N33/15
CPC分类号： G01N33/68 , A61K2039/505 , C07K14/70575 , C07K16/241 , G01N33/564 , G01N33/74 , G01N2500/00
摘要： An antibody against a peptide having an amino acid sequence AVQGPEETVT QDC (expressed in single letter amino acid code) corresponding to the 134-to 146-positions in human BAFF (B cell activating factor belonging to the TNF family) protein which is preferably a monoclonal antibody; a method of producing the above antibody; a medicinal composition containing the antibody; utilization of the antibody; and a method of screening an inhibitory effect or an activating effect on BAFF with the use of the antibody.
摘要翻译：具有对应于人BAFF（属于TNF家族的B细胞活化因子）中的134位至146位的氨基酸序列AVQGPEETVT QDC（以单字母氨基酸编码表示）的肽的抗体，其优选为单克隆抗体抗体; 制备上述抗体的方法; 含有抗体的药物组合物; 抗体的利用; 以及使用抗体筛选对BAFF的抑制作用或活化作用的方法。

2. 发明授权

EP1826218B1 ANTIHUMAN BAFF ANTIBODY 有权
标题翻译：抗人BAFF抗体
公开(公告)号：EP1826218B1
公开(公告)日：2014-01-01
申请号：EP05776879.8
申请日：2005-08-30
申请人： Kowa Company, Ltd. , Takeuchi, Tsutomu , Yoshimoto, Keiko
发明人： TAKEUCHI, Tsutomu , YOSHIMOTO, Keiko
IPC分类号： C07K16/24 , C12N15/02 , C12P21/08 , A61K39/395 , A61P37/00 , A61P3/10 , A61P29/00 , A61P19/02 , G01N33/53 , G01N33/15 , C07K14/705 , G01N33/564 , G01N33/74
CPC分类号： G01N33/68 , A61K2039/505 , C07K14/70575 , C07K16/241 , G01N33/564 , G01N33/74 , G01N2500/00

3. 发明授权

EP1801231B1 METHOD OF SCREENING BAFF SUPPRESSOR OR INHIBITOR 有权转让
标题翻译：一种筛选BAFF抑制器或抑制剂
公开(公告)号：EP1801231B1
公开(公告)日：2011-11-30
申请号：EP05783483.0
申请日：2005-09-14
申请人： Kowa Co., Ltd. , Takeuchi, Tsutomu , Tsuzaka, Kensei , Yoshimoto, Keiko
发明人： TAKEUCHI, Tsutomu , TSUZAKA, Kensei , YOSHIMOTO, Keiko
IPC分类号： C12Q1/02 , C12Q1/68 , A61K39/395 , A61K31/341 , A61P43/00
CPC分类号： C07K16/2875 , A61K31/341 , G01N33/5008 , G01N33/5023 , G01N33/505 , G01N33/5052 , G01N33/6863 , G01N2500/00
摘要： A method of screening a novel BAFF suppressor or inhibitor. More specifically speaking, a method which comprises adding a combination of TPA with ionomycin and/or an anti-CD3 antibody to a cultured human cell to thereby induce the production of BAFF by the cell; a method of screening a substance capable of suppressing the expression or activity of BAFF which comprises adding a test substance to a BAFF-production system prepared by adding a combination of TPA with ionomycin and/or an anti-CD3 antibody to a cultured human cell and measuring the expression amount and/or the activity of BAFF in the BAFF-production system; and a BAFF production inducer for a BAFF-producing cell which contains a combination of TPA with ionomycin and/or an anti-CD3 antibody.

4. 发明公开

EP1801231A1 METHOD OF SCREENING BAFF SUPPRESSOR OR INHIBITOR 有权转让
标题翻译：一种筛选BAFF抑制器或抑制剂
公开(公告)号：EP1801231A1
公开(公告)日：2007-06-27
申请号：EP05783483.0
申请日：2005-09-14
申请人： Kowa Co., Ltd. , Takeuchi, Tsutomu , Tsuzaka, Kensei , Yoshimoto, Keiko
发明人： TAKEUCHI, Tsutomu , TZUSAKA, Kensei , YOSHIMOTO, Keiko
IPC分类号： C12Q1/02 , C12Q1/68 , A61K39/395 , A61K31/341 , A61P43/00
CPC分类号： C07K16/2875 , A61K31/341 , G01N33/5008 , G01N33/5023 , G01N33/505 , G01N33/5052 , G01N33/6863 , G01N2500/00
摘要： A method of screening a novel BAFF suppressor or inhibitor. More specifically speaking, a method which comprises adding a combination of TPA with ionomycin and/or an anti-CD3 antibody to a cultured human cell to thereby induce the production of BAFF by the cell; a method of screening a substance capable of suppressing the expression or activity of BAFF which comprises adding a test substance to a BAFF-production system prepared by adding a combination of TPA with ionomycin and/or an anti-CD3 antibody to a cultured human cell and measuring the expression amount and/or the activity of BAFF in the BAFF-production system; and a BAFF production inducer for a BAFF-producing cell which contains a combination of TPA with ionomycin and/or an anti-CD3 antibody.

5. 发明公开

EP1336608A1 DIBENZOSBERANYL PIPERAZINE DERIVATIVES AND DRUG-RESISTANCE OVERCOMING AGENTS CONTAINING THE DERIVATIVES 审中-公开
标题翻译： DIBENZOSUBERANYLPIPERAZINDERIVATE与这些衍生剂含药物来克服阻力
公开(公告)号：EP1336608A1
公开(公告)日：2003-08-20
申请号：EP01982865.6
申请日：2001-11-20
申请人： POLA CHEMICAL INDUSTRIES, INC. , Takeuchi, Tsutomu , Takayanagi, Hiroaki
发明人： TAKEUCHI, Tsutomu , TAKAYANAGI, Hiroaki , KOBAYASHI, Seiki , OSA, Yumiko , SUZUKI, Yumiko , SATO, Yoko , SAKAGUCHI, M, POLA CHEM IND,INC YOKOHAMA KENKYUSHO , MIYATA, Y, POLA CHEM. IND.,INC. YOKOHAMA KENKYUSHO
IPC分类号： C07D295/088 , C07D295/084 , A61K31/495 , A61P43/00 , A61P33/06
CPC分类号： C07D295/088 , A61K31/495 , C07D295/084 , Y02A50/409 , Y02A50/411 , Y02A50/473 , A61K31/00 , A61K2300/00
摘要： Dibenzosuberanyl piperazine derivatives represented by the following formula (I):
wherein R represents an aliphatic hydrocarbon group, which may contain one or more heteroatom-containing substituent groups and may preferably contain 2 to 30 carbon atoms, and physiologically acceptable salts thereof; and medicinal compositions containing these dibenzosuberanyl piperazine derivatives and/or physiologically acceptable salts thereof.
These compounds show effectiveness in allowing resistance-acquired causes of diseases to restore sensitivity to drug, that is, a resistance overcoming effect.
摘要翻译：由下式（I）表示Dibenzosuberanyl哌嗪衍生物： worinřdarstellt至脂族烃基，其可以包含一个或多个含杂原子的取代基，并且可以优选地包含2至30个碳原子，以及它们的生理学可接受的盐; 和药用组合物包含本文dibenzosuberanyl哌嗪衍生物和/或其生理学可接受的盐。这些化合物显示出在允许的疾病的抗性获得性的原因，以灵敏度恢复到药物的有效性，所做的是，电阻克服效果。

6. 发明申请

WO2012114394A1 STEP UNIT 审中-公开
标题翻译：步骤单位
公开(公告)号：WO2012114394A1
公开(公告)日：2012-08-30
申请号：PCT/JP2011/004516
申请日：2011-08-10
申请人： AISIN SEIKI KABUSHIKI KAISHA , SUZUKI, Seiichi , TAKEUCHI, Tsutomu , ISHIDA, Toshihiko
发明人： SUZUKI, Seiichi , TAKEUCHI, Tsutomu , ISHIDA, Toshihiko
IPC分类号： B60R3/02 , B60J5/06 , B60R3/00
CPC分类号： B60R3/002 , B60J5/06 , B60R3/00 , B62D25/025 , E05F15/632 , E05Y2900/531
摘要： A step unit (1) that guides a sliding door (110) of a vehicle includes a step member (3) and a rail plate member (31). The step member includes first and second lower rails (21,22). The first lower rail (21) has two ends that face toward each other to form a cutout portion (21a) in between. The rail plate member is arranged in the cutout portion. The step member includes an insertion hole (23) and an extended portion. The insertion hole is located at a position corresponding to the cutout portion. The extended portion is extended from at least one of the two ends to support the rail plate member against a load received by the rail plate member from the roller (32). The rail plate member is inserted through the insertion hole from above the upper side of the step member and fixed by a fastening member (33) to the step member.
摘要翻译：引导车辆的滑动门（110）的踏板单元（1）包括台阶构件（3）和轨板构件（31）。台阶部件包括第一和第二下部导轨（21,22）。第一下轨道（21）具有彼此面对的两个端部，以在其间形成切口部分（21a）。轨板构件布置在切口部分中。台阶构件包括插入孔（23）和延伸部分。插入孔位于与切口部对应的位置。延伸部分从两个端部中的至少一个延伸，以支撑轨道板构件抵抗由轨道板构件从滚子（32）接收的载荷。轨板构件从台阶构件的上侧从插入孔插入，并通过紧固构件（33）固定到台阶构件。

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