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1. 发明授权

US06245790B1 Oxazole compounds useful as PGE2 agonists and antagonists 失效
标题翻译：可用作PGE2激动剂和拮抗剂的恶唑化合物
公开(公告)号：US06245790B1
公开(公告)日：2001-06-12
申请号：US09424253
申请日：2000-03-08
申请人： Kouji Hattori , Osamu Okitsu , Naoaki Fujii , Akira Tanaka , Kiyoshi Taniguchi , Satoshi Koyama , Mie Nishio
发明人： Kouji Hattori , Osamu Okitsu , Naoaki Fujii , Akira Tanaka , Kiyoshi Taniguchi , Satoshi Koyama , Mie Nishio
IPC分类号： A61K31426
CPC分类号： C07D413/10 , C07D263/32
摘要： Azole compounds of the formula: wherein R1 is lower alkyl substituted with carboxy, etc., R2 is hydrogen or lower alkyl, R3 is aryl, etc. R4 is aryl, etc. Q is etc., and X is O, NH or S, and its salt, which are useful as medicament.
摘要翻译：下式的唑类化合物：其中R1是被羧基取代的低级烷基等，R2是氢或低级烷基，R3是芳基等.R4是芳基等，Q是等等，X是O，NH或S，及其盐，可用作药物。

2. 发明申请

US20070142638A1 Ornithine derivatives as prostaglandin e2 agonists or antagonists 审中-公开
标题翻译：鸟氨酸衍生物作为前列腺素e2激动剂或拮抗剂
公开(公告)号：US20070142638A1
公开(公告)日：2007-06-21
申请号：US10584146
申请日：2004-12-17
申请人： Kouji Hattori , Naoaki Fujii , Akira Tanaka , Kenichi Washizuka , Minoru Sakurai
发明人： Kouji Hattori , Naoaki Fujii , Akira Tanaka , Kenichi Washizuka , Minoru Sakurai
IPC分类号： C07D215/38 , C07D209/42
CPC分类号： C07D215/48 , C07D209/42 , C07D307/85 , C07D471/04
摘要： Ornithine derivatives of the formula (I): wherein X is —CO— or —(CH2)k— (wherein k is 1, 2 or 3); Y is Z-(CH2)n—, and the like; {wherein Z is R1—CO—NR4—, and the like, (wherein R1 is aryl, and the like; and R4 is hydrogen, or lower alkyl); and n is 1, 2, 3, 4, 5 or 6}; R2 is aryl-(lower alkyl), and the like; R3 is -Q-R7, [wherein Q is —CO— or —SO2—, R is heterocyclyl], and the like; and R5 and R6 are independently hydrogen or lower alkyl; or a pharmaceutically acceptable salt thereof, which are useful as medicament.
摘要翻译：式（I）的鸟氨酸衍生物：其中X是-CO-或 - （CH 2 CH 2）n - （其中k是1,2或3）; Y是Z-（CH 2）n - 等等; {其中Z是R 1 -CO-NR 4 - 等，（其中R 1是芳基等）和 R 4是氢或低级烷基）; n为1,2,3,4,5或6}; R 2是芳基 - （低级烷基）等; R 3是-Q-R 7，[其中Q是-CO-或-SO 2 - ，R是杂环基]等; R 5和R 6独立地是氢或低级烷基; 或其药学上可接受的盐，其可用作药物。

3. 发明授权

US06297267B1 4,5-diaryloxazole compounds 失效
标题翻译： 4,5-二碘唑化合物
公开(公告)号：US06297267B1
公开(公告)日：2001-10-02
申请号：US09529405
申请日：2000-04-26
申请人： Kouji Hattori , Naoaki Fujii , Akira Tanaka , Fujiko Takamura
发明人： Kouji Hattori , Naoaki Fujii , Akira Tanaka , Fujiko Takamura
IPC分类号： A61K3142
CPC分类号： C07D413/04 , C07D263/32 , Y02P20/55
摘要： A compound of the formula: wherein R1 is a hydrogen atom or a carboxy protective group, R2, R5, R6 and R7 are each a hydrogen atom or a hydroxy group, R3 and R4 are each a hydrogen atom, or are combined together to form an epoxy group or a single bond. R8 and R9 are each an optionally substituted aryl group, and X is a single bond or a methylene group, in addition to the above definitions. R2 and R3 may be combined together to form a single bond; provided that when R2, R5, R6 and R7 are each a hydrogen atom, then R3 and R4 are combined together to form an epoxy group; when R3 and R4 are combined together to form a single bond, then at least one of R2, R5, R6 and R7 is a hydroxy group and the others are hydrogen; and when R3 and R4 are each a hydrogen atom, then at least one of R2, R5, R6 and R7 is a hydroxy group and the others are hydrogen, and X is a methylene group, or its salt.
摘要翻译：下式的化合物：其中R 1是氢原子或羧基保护基，R 2，R 5，R 6和R 7各自是氢原子或羟基，R 3和R 4各自是氢原子，或者组合在一起形成环氧基或单键。除上述定义之外，R 8和R 9各自为任选取代的芳基，X为单键或亚甲基。 R2和R3可以组合在一起形成单键; 条件是当R 2，R 5，R 6和R 7各自为氢原子时，则R 3和R 4组合在一起形成环氧基; 当R3和R4组合在一起形成单键时，R 2，R 5，R 6和R 7中的至少一个是羟基，而其余的是氢; 当R 3和R 4各自为氢原子时，R 2，R 5，R 6和R 7中的至少一个为羟基，其余为氢，X为亚甲基或其盐。

4. 发明授权

US06437146B1 Oxazole compounds as prostaglandin e2 agonists or antagonists 有权
标题翻译：恶唑化合物作为前列腺素e2激动剂或拮抗剂
公开(公告)号：US06437146B1
公开(公告)日：2002-08-20
申请号：US09787433
申请日：2001-04-20
申请人： Kouji Hattori , Akira Tanaka , Yutaka Kono , Shoko Nakazato
发明人： Kouji Hattori , Akira Tanaka , Yutaka Kono , Shoko Nakazato
IPC分类号： C07D26336
CPC分类号： C07D413/12 , C07D263/32 , C07D413/10
摘要： Oxazole compounds of formula (I), wherein R1 is aryl which may be substituted with halogen(s), R2 is aryl which may be substituted with halogen(s), X is single bond, (a) or SO2, R3 and R4 are independently hydrogen or suitable substituent, (wherein X is (a), neither R3 nor R4 is hydrogen), R3 and R4 may be linked together to form (b), (b) is N-containing heterocyclic group which may be substituted with one or more suitable substituent(s), R5 is hydrogen, etc., A1 is lower alkylene or single bond, (c) is cyclo(C3-C9)alkane or cyclo(C5-C9)alkene, or a pro-drug thereof, or a pharmaceutically acceptable salt thereof, which are useful as medicament.
摘要翻译：式（I）的恶唑化合物，其中R 1为可被卤素取代的芳基，R 2为可被卤素取代的芳基，X为单键，（a）或SO 2，R 3和R 4为（其中X是（a），R3和R4都不是氢），R3和R4可以连接在一起形成（b），（b）是可以被一个取代的含氮杂环基或更合适的取代基，R5是氢等，A1是低级亚烷基或单键，（c）是环（C 3 -C 9）烷烃或环（C 5 -C 9）烯烃或其前药，或其药学上可接受的盐，其可用作药物。

5. 发明授权

US06384072B1 Benzocycloheptene derivatives 失效
标题翻译：苯并环庚烯衍生物
公开(公告)号：US06384072B1
公开(公告)日：2002-05-07
申请号：US09529412
申请日：2000-04-27
申请人： Kouji Hattori , Akira Tanaka
发明人： Kouji Hattori , Akira Tanaka
IPC分类号： A61K31335
CPC分类号： C07D303/16 , C07C271/28 , C07C2602/12 , C07C2603/30
摘要： This invention relates to benzocycloheptene derivatives having novel structure. More particularly, it relates to new benzocycloheptene derivatives and pharmaceutically acceptable salts thereof, their production processes, a pharmaceutical composition containing the same and a use thereof for the manufacture of medicaments.
摘要翻译：本发明涉及具有新结构的苯并环庚烯衍生物。更具体地说，本发明涉及新的苯并环庚烯衍生物及其药学上可接受的盐，它们的制备方法，含有它们的药物组合物及其制备药物的用途。

6. 发明授权

US06660759B1 4.5-diaryloxazole compounds with prostaglandin I2 (PGI2) agonistic activity 失效
标题翻译：具有前列腺素I2（PGI2）激动活性的4.5-二碘唑化合物
公开(公告)号：US06660759B1
公开(公告)日：2003-12-09
申请号：US10049654
申请日：2002-02-26
申请人： Kouji Hattori , Akira Tanaka
发明人： Kouji Hattori , Akira Tanaka
IPC分类号： A61K3142
CPC分类号： C07D413/04
摘要： Heterocyclic compounds of formula (I), wherein R1 is carboxy or protected carboxy, R2 is aryl which may have suitable sustituent(s), R3 is aryl which may have suitable substituent(s), R4 is hydrogen, lower alkyl, hydroxy or aryl, A1 is lower alkylene, (a) is (b), etc., —A3— is (c), etc. and n is 0 or 1, and pharmaceutically acceptable salts thereof which are useful as a medicament.
摘要翻译：式（I）的杂环化合物，其中R 1为羧基或被保护的羧基，R 2为可具有合适取代基的芳基，R 3为可具有合适取代基的芳基，R 低级烷基，羟基或芳基，A 1为低级亚烷基，（a）为（b）等，-A 3 - 为（c）等，n为0或 1及其药学上可接受的盐，其可用作药物。

7. 发明授权

US06303649B1 Naphthalene derivatives 失效
标题翻译：萘衍生物
公开(公告)号：US06303649B1
公开(公告)日：2001-10-16
申请号：US09582173
申请日：2000-08-04
申请人： Kouji Hattori , Hiromichi Itani , Akira Tanaka , Toshifumi Shiraga
发明人： Kouji Hattori , Hiromichi Itani , Akira Tanaka , Toshifumi Shiraga
IPC分类号： A61K3127
CPC分类号： C07C271/28 , C07C2602/10
摘要： A compound of formula (I), wherein R1 is carboxy or protected carboxy, R2 and R3 are each independently hydrogen, hydroxy, or protected hydroxy, R4 is hydrogen or halogen, R5 is aryl substituted with halogen, amino, hydroxy or protected hydroxy, R6 is aryl optionally substituted with halogen, amino, hydroxy or protected hydroxy, A1 and A2 are each independently lower alkylene, and (II) is (III), (IV), (V) or (VI) or its salt, process for preparing it, a pharmaceutical composition including it, and a use thereof.
摘要翻译：式（I）化合物，其中R 1为羧基或保护的羧基，R 2和R 3各自独立地为氢，羟基或被保护的羟基，R 4为氢或卤素，R 5为被卤素，氨基，羟基或保护的羟基取代的芳基， R6是任选被卤素，氨基，羟基或保护的羟基取代的芳基，A1和A2各自独立地是低级亚烷基，和（II）是（III），（IV），（V）或（VI）或其盐，制备它，包括它的药物组合物及其用途。

8. 发明申请

US20220326632A1 TONER, DEVELOPING AGENT, TONER HOUSING UNIT, IMAGE FORMING APPARATUS, AND A METHOD OF FORMING IMAGES 有权
公开(公告)号：US20220326632A1
公开(公告)日：2022-10-13
申请号：US17657471
申请日：2022-03-31
申请人： Keiji MAKABE , Akira Tanaka , Hidekazu Kakinuma , Tsukiko Takahashi
发明人： Keiji MAKABE , Akira Tanaka , Hidekazu Kakinuma , Tsukiko Takahashi
IPC分类号： G03G9/097 , G03G15/08 , G03G9/08
摘要： [Object] An object of the invention is to provide a toner that can both achieve a higher level of low temperature fixability and suppression of the toner scattering.
[Means of Achieving the Object]
The disclosure is to provide a toner, including base-particles, and an external-additive, wherein a glass-transition temperature obtained from a DSC-curve at a second-warming of a THF-insoluble component is −50° C. or higher and 10° C. or lower, wherein an average circularity of the toner is 0.975 or more and 0.985 or lower, wherein the toner satisfies the following formula: 1.5≤Bt−0.025−Ct≤3.0, wherein the Bt [m2/g] is a BET-specific-surface area of the toner-particles, and the Ct [%] is a coverage by the external-additive, and, at least a portion of a surface of the external-additive is coated with either an oxide of a metallic element, a hydroxide of the metallic element, or both.

9. 发明授权

US10303072B2 Toner, developer, and image forming device 有权
公开(公告)号：US10303072B2
公开(公告)日：2019-05-28
申请号：US15889461
申请日：2018-02-06
申请人： Akira Tanaka , Hiroyuki Takeda , Junichi Awamura , Hiroshi Yamada , Daichi Hisakuni , Yasuo Kamada
发明人： Akira Tanaka , Hiroyuki Takeda , Junichi Awamura , Hiroshi Yamada , Daichi Hisakuni , Yasuo Kamada
IPC分类号： G03G9/087 , C08G63/42 , C08G63/20 , G03G15/00 , C08G63/195 , C08G63/16 , C08G63/66 , C08G18/75 , C08G18/42
摘要： A toner is provided. The toner contains a polyester resin. The toner has a glass transition temperature (Tg1st) at first temperature rising of differential scanning calorimetry (DSC) of from 45° C. to 65° C. The toner includes a component insoluble in tetrahydrofuran (THF) having two glass transition temperatures (Tga1st and Tgb1st) at the first temperature rising of DSC, where Tga1st is in a range of −45° C. to 5° C. and Tgb1st is in a range of 45° C. to 70° C. The toner includes a component soluble in THF having a glass transition temperature (Tg2nd) at second temperature rising of DSC of from 40° C. to 65° C.

10. 发明授权

US08686398B2 Semiconductor light emitting device 失效
标题翻译：半导体发光器件
公开(公告)号：US08686398B2
公开(公告)日：2014-04-01
申请号：US13599852
申请日：2012-08-30
申请人： Akira Tanaka , Yoko Motojima
发明人： Akira Tanaka , Yoko Motojima
IPC分类号： H01L29/06
CPC分类号： H01L33/06 , H01L33/0079 , H01L33/22 , H01L33/32 , H01L33/38 , H01L33/382 , H01L33/387 , H01L33/405 , H01L33/42 , H01L2924/0002 , H01L2924/00
摘要： A semiconductor light emitting device includes a first conductivity-type first semiconductor layer, a second conductivity-type second semiconductor layer, a semiconductor light emitting layer, and first and second electrodes. The semiconductor light emitting layer is provided between the first semiconductor layer and the second semiconductor layer, and includes a multiple quantum well structure. The quantum well structure includes well layers and barrier layers each laminated alternately, each of the well layers being not less than 6 nm and not more than 10 nm. The first and second electrodes are electrically connected to the first and second semiconductor layers such that current flows in a direction substantially vertical to the main surface.
摘要翻译：半导体发光器件包括第一导电型第一半导体层，第二导电型第二半导体层，半导体发光层以及第一和第二电极。半导体发光层设置在第一半导体层和第二半导体层之间，并且包括多量子阱结构。量子阱结构包括交替层叠的阱层和势垒层，每个阱层不小于6nm且不大于10nm。第一和第二电极电连接到第一和第二半导体层，使得电流在基本垂直于主表面的方向上流动。

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