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1. 发明公开

EP1875273A2 PET/MR SCANNER WITH TIME-OF-FLIGHT CAPABILITY 有权转让
标题翻译： PET / MR扫描仪麻醉飞行时间飞行员
公开(公告)号：EP1875273A2
公开(公告)日：2008-01-09
申请号：EP06727761.6
申请日：2006-03-28
申请人： Koninklijke Philips Electronics N.V. , Philips Intellectual Property & Standards GmbH
发明人： FIEDLER, Klaus , DECKERS, Sjaak , FRACH, Thomas
IPC分类号： G01T1/29
CPC分类号： G01R33/481 , A61B6/037 , A61B6/4417 , G01R33/28 , G01R33/5673 , G06T11/00
摘要： In a combined scanner, a main magnet (20) and magnetic field gradient coils (28) housed in or on a scanner housing (12, 18) acquires spatially encoded magnetic resonances in an imaging region (14). Solid state radiation detectors (50, 50', 50') disposed in or on the scanner housing are arranged to detect gamma rays emitted from the imaging region. Time-of- flight positron emission tomography (TOF-PET) processing (52, 54, 58, 60, 62) determines localized lines of response based on (i) locations of substantially simultaneous gamma ray detections output by the radiation detectors and (ii) a time interval between said substantially simultaneous gamma ray detections. TOF-PET reconstruction processing (64) reconstructs the localized lines of response to produce a TOF-PET image. Magnetic resonance imaging (MRI) reconstruction processing (44) reconstructs the acquired magnetic resonances to produce an MRI image.

2. 发明授权

EP1875273B1 PET/MR SCANNER WITH TIME-OF-FLIGHT CAPABILITY 有权转让
标题翻译： WITH TIME-OF-飞行能力PET / MR扫描器
公开(公告)号：EP1875273B1
公开(公告)日：2011-11-16
申请号：EP06727761.6
申请日：2006-03-28
申请人： Koninklijke Philips Electronics N.V. , Philips Intellectual Property & Standards GmbH
发明人： FIEDLER, Klaus , DECKERS, Sjaak , FRACH, Thomas
IPC分类号： G01T1/29
CPC分类号： G01R33/481 , A61B6/037 , A61B6/4417 , G01R33/28 , G01R33/5673 , G06T11/00
摘要： In a combined scanner, a main magnet (20) and magnetic field gradient coils (28) housed in or on a scanner housing (12, 18) acquires spatially encoded magnetic resonances in an imaging region (14). Solid state radiation detectors (50, 50', 50') disposed in or on the scanner housing are arranged to detect gamma rays emitted from the imaging region. Time-of- flight positron emission tomography (TOF-PET) processing (52, 54, 58, 60, 62) determines localized lines of response based on (i) locations of substantially simultaneous gamma ray detections output by the radiation detectors and (ii) a time interval between said substantially simultaneous gamma ray detections. TOF-PET reconstruction processing (64) reconstructs the localized lines of response to produce a TOF-PET image. Magnetic resonance imaging (MRI) reconstruction processing (44) reconstructs the acquired magnetic resonances to produce an MRI image.

3. 发明申请

WO2004098411A1 METHOD AND APPARATUS FOR TRIGGERING IMAGE ACQUISITION IN A C-ARM SYSTEM BY A ROTARY ENCODER 审中-公开
标题翻译：用于通过旋转编码器在C-ARM系统中触发图像获取的方法和装置
公开(公告)号：WO2004098411A1
公开(公告)日：2004-11-18
申请号：PCT/IB2004/001375
申请日：2004-04-26
申请人： PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , KONINKLIJKE PHILIPS ELECTRONICS N. V. , FIEDLER, Klaus , WIEGERT, Jens
发明人： FIEDLER, Klaus , WIEGERT, Jens
IPC分类号： A61B6/00
CPC分类号： A61B6/4441 , A61B6/547
摘要： Method of generating an image of an object by means of an imaging system which has a radiation source that rotates relative to the object about an axis of rotation within a defined rotation angle range, said radiation source projecting radiation onto a radiation detector in order to record projection data, wherein at predefinable relative rotation angle positions of the radiation source a signal which is used to trigger recording of the projection data is generated, and also apparatus for carrying out this method.
摘要翻译：通过成像系统生成物体的图像的方法，所述成像系统具有围绕限定的旋转角度范围内的旋转轴线相对于物体旋转的辐射源，所述辐射源将辐射投射到辐射检测器上以便记录投影数据，其中在辐射源的预定的相对旋转角度位置处产生用于触发投影数据的记录的信号，以及用于执行该方法的装置。

4. 发明申请

WO2006018766A2 TIMING CALIBRATION FOR A TOF-PET SCANNER 审中-公开
标题翻译： TOF-PET扫描仪的时序校准
公开(公告)号：WO2006018766A2
公开(公告)日：2006-02-23
申请号：PCT/IB2005/052587
申请日：2005-08-02
申请人： KONINKLIJKE PHILIPS ELECTRONICS, N.V. , FIEDLER, Klaus , GEAGAN, Michael , MUEHLLEHNER, Gerd , RUETTEN, Walter , THON, Andreas
发明人： FIEDLER, Klaus , GEAGAN, Michael , MUEHLLEHNER, Gerd , RUETTEN, Walter , THON, Andreas
IPC分类号： G01T1/40 , G01T1/208
CPC分类号： G01T1/40 , A61B6/037 , G01T1/208
摘要： A time-of-flight PET nuclear imaging device (A) includes radiation detectors (20, 22, 24), electronic circuits (26, 28, 30, 32) for processing output signals from each of detectors (20), a coincidence detector (34), a time-of-flight calculator (38) and image processing circuitry (40). A calibration system (48) includes an energy source (50, 150) which generates an electrical or optical calibration pulse. The electrical calibration pulse is applied at an input to the electronics at an output of the detector and the optical calibration pulse is applied to a preselected point adjacent a face of each optical sensor (20) of the detectors. A calibration processor (52) measures the time differences between the generation of the calibration pulse and the receipt of a trigger signal from the electronic circuitry by the coincidence detector (34) and adjusts adjustable delay circuits (44, 46) to minimize these time differences.
摘要翻译：飞行时间PET核成像装置（A）包括用于处理来自每个检测器（20）的输出信号的辐射检测器（20,22,24），电子电路（26,28,30,32），重合检测器（34），飞行时间计算器（38）和图像处理电路（40）。校准系统（48）包括产生电或光学校准脉冲的能量源（50,150）。电校准脉冲在检测器的输出处的电子器件的输入处施加，并且光学校准脉冲被施加到与检测器的每个光学传感器（20）的面相邻的预选点。校准处理器（52）通过重合检测器（34）测量校准脉冲的产生和来自电子电路的触发信号的接收之间的时间差，并且调节可调延迟电路（44,46）以最小化这些时间差。

5. 发明申请

WO2006111883A2 DIGITAL SILICON PHOTOMULTIPLIER FOR TOF-PET 审中-公开
标题翻译：用于TOF-PET的数字硅光电倍增管
公开(公告)号：WO2006111883A2
公开(公告)日：2006-10-26
申请号：PCT/IB2006/051089
申请日：2006-04-10
申请人： KONINKLIJKE PHILIPS ELECTRONICS, N.V. , U.S. PHILIPS CORPORATION , FRACH, Thomas , FIEDLER, Klaus
发明人： FRACH, Thomas , FIEDLER, Klaus
IPC分类号： G01T1/164
CPC分类号： G01T1/2018 , A61B6/037 , G01T1/1642 , G01T1/248 , G01T1/2985 , G01T7/005
摘要： A radiation detector (10) includes an array of detector pixels (22) each including an array of detector cells (50, 50', 50"). Each detector cell includes a photodiode (52) biased in a breakdown region and digital circuitry (54, 54', 54") coupled with the photodiode and configured to output a first digital value in a quiescent state and a second digital value responsive to photon detection by the photodiode. Digital triggering circuitry (60, 60', 60", 84) is configured to output a trigger signal indicative of a start of an integration time period responsive to a selected number of one or more of the detector cells transitioning from the first digital value to the second digital value. Readout digital circuitry (66, 82) accumulates a count of a number of transitions of detector cells of the array of detector cells from the first digital state to the second digital state over the integration time period.
摘要翻译：辐射检测器（10）包括检测器像素阵列（22），每个检测器像素包括检测器单元阵列（50,50'，50“），每个检测器单元包括偏置在击穿区域中的光电二极管（52）和数字电路 54,54'，54“），其耦合到光电二极管并被配置为输出静止状态的第一数字值和响应于光电二极管的光子检测的第二数字值。数字触发电路（60,60'，60“，84）被配置为响应于选定数量的一个或多个检测器单元从第一数字值转换到第一数字值，输出指示积分时间周期开始的触发信号第二数字值读出数字电路（66,82）在积分时间段内累积检测器单元阵列的检测器单元从第一数字状态到第二数字状态的转移次数的计数。

6. 发明申请

WO2006111869A2 PET/MR SCANNER WITH TIME-OF-FLIGHT CAPABILITY 审中-公开
标题翻译：具有时间飞行能力的PET / MR扫描仪
公开(公告)号：WO2006111869A2
公开(公告)日：2006-10-26
申请号：PCT/IB2006/050944
申请日：2006-03-28
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , U.S. PHILIPS CORPORATION , FIEDLER, Klaus , DECKERS, Sjaak , FRACH, Thomas
发明人： FIEDLER, Klaus , DECKERS, Sjaak , FRACH, Thomas
IPC分类号： G01T1/29
CPC分类号： G01R33/481 , A61B6/037 , A61B6/4417 , G01R33/28 , G01R33/5673 , G06T11/00
摘要： In a combined scanner, a main magnet (20) and magnetic field gradient coils (28) housed in or on a scanner housing (12, 18) acquires spatially encoded magnetic resonances in an imaging region (14). Solid state radiation detectors (50, 50', 50") disposed in or on the scanner housing are arranged to detect gamma rays emitted from the imaging region. Time-of- flight positron emission tomography (TOF-PET) processing (52, 54, 58, 60, 62) determines localized lines of response based on (i) locations of substantially simultaneous gamma ray detections output by the radiation detectors and (ii) a time interval between said substantially simultaneous gamma ray detections. TOF-PET reconstruction processing (64) reconstructs the localized lines of response to produce a TOF-PET image. Magnetic resonance imaging (MRI) reconstruction processing (44) reconstructs the acquired magnetic resonances to produce an MRI image.
摘要翻译：在组合扫描器中，容纳在扫描仪外壳（12,18）中或扫描仪外壳（12,18）上的主磁体（20）和磁场梯度线圈（28）在成像区域（14）中获取空间编码的磁共振。布置在扫描仪外壳中或扫描仪外壳上的固态辐射检测器（50,50'，50“）布置成用于检测从成像区域发射的伽马射线。飞行时间正电子发射断层扫描（TOF-PET）处理（52,54 ，58,60,62）基于（i）由辐射检测器输出的基本上同时的伽马射线检测的位置确定局部的响应线，以及（ii）所述基本上同时的伽马射线检测之间的时间间隔TOF-PET重建处理磁共振成像（MRI）重建处理（44）重建获取的磁共振以产生MRI图像。

7. 发明公开

EP1779142A2 TIMING CALIBRATION FOR A TOF-PET SCANNER 失效转让
标题翻译： TOF-PET扫描仪的定时校准
公开(公告)号：EP1779142A2
公开(公告)日：2007-05-02
申请号：EP05773345.3
申请日：2005-08-02
申请人： Koninklijke Philips Electronics N.V.
发明人： FIEDLER, Klaus , GEAGAN, Michael , MUEHLLEHNER, Gerd , RUETTEN, Walter , THON, Andreas
IPC分类号： G01T1/40 , G01T1/208
CPC分类号： G01T1/40 , A61B6/037 , G01T1/208
摘要： A time-of-flight PET nuclear imaging device (A) includes radiation detectors (20, 22, 24), electronic circuits (26, 28, 30, 32) for processing output signals from each of detectors (20), a coincidence detector (34), a time-of-flight calculator (38) and image processing circuitry (40). A calibration system (48) includes an energy source (50, 150) which generates an electrical or optical calibration pulse. The electrical calibration pulse is applied at an input to the electronics at an output of the detector and the optical calibration pulse is applied to a preselected point adjacent a face of each optical sensor (20) of the detectors. A calibration processor (52) measures the time differences between the generation of the calibration pulse and the receipt of a trigger signal from the electronic circuitry by the coincidence detector (34) and adjusts adjustable delay circuits (44, 46) to minimize these time differences.
摘要翻译：飞行时间PET核成像设备（A）包括辐射探测器（20,22,24），用于处理来自每个探测器（20）的输出信号的电子电路（26,28,30,32），重合检测器（34），飞行时间计算器（38）和图像处理电路（40）。校准系统（48）包括产生电或光学校准脉冲的能量源（50,150）。电校准脉冲在检测器的输出处被施加到电子器件的输入处，并且光学校准脉冲被施加到与检测器的每个光学传感器（20）的面相邻的预选点。校准处理器（52）测量校准脉冲的产生和由重合检测器（34）接收来自电子电路的触发信号之间的时间差并调整可调延迟电路（44,46）以使这些时间差最小化。

8. 发明授权

EP1875271B1 DIGITAL SILICON PHOTOMULTIPLIER FOR TOF-PET 有权转让
标题翻译：数字硅用于光电倍增TOF-PET
公开(公告)号：EP1875271B1
公开(公告)日：2011-06-22
申请号：EP06727868.9
申请日：2006-04-10
申请人： Koninklijke Philips Electronics N.V.
发明人： FRACH, Thomas , FIEDLER, Klaus
IPC分类号： G01T1/164
CPC分类号： G01T1/2018 , A61B6/037 , G01T1/1642 , G01T1/248 , G01T1/2985 , G01T7/005
摘要： A radiation detector includes an array of detector pixels each including an array of detector cells. Each detector cell includes a photodiode biased in a breakdown region and digital circuitry coupled with the photodiode and configured to output a first digital value in a quiescent state and a second digital value responsive to photon detection by the photodiode. Digital triggering circuitry is configured to output a trigger signal indicative of a start of an integration time period responsive to a selected number of one or more of the detector cells tranisitioning from the first digital value to the second digital value. Readout digital circuitry accumulates a count of a number of transitions of detector cells of the array of detector cells from the first digital state to the second digital state over the integration time period.

9. 发明公开

EP1875271A2 DIGITAL SILICON PHOTOMULTIPLIER FOR TOF-PET 有权转让
标题翻译：数字硅用于光电倍增TOF-PET
公开(公告)号：EP1875271A2
公开(公告)日：2008-01-09
申请号：EP06727868.9
申请日：2006-04-10
申请人： Koninklijke Philips Electronics N.V.
发明人： FRACH, Thomas , FIEDLER, Klaus
IPC分类号： G01T1/164
CPC分类号： G01T1/2018 , A61B6/037 , G01T1/1642 , G01T1/248 , G01T1/2985 , G01T7/005
摘要： A radiation detector includes an array of detector pixels each including an array of detector cells. Each detector cell includes a photodiode biased in a breakdown region and digital circuitry coupled with the photodiode and configured to output a first digital value in a quiescent state and a second digital value responsive to photon detection by the photodiode. Digital triggering circuitry is configured to output a trigger signal indicative of a start of an integration time period responsive to a selected number of one or more of the detector cells tranisitioning from the first digital value to the second digital value. Readout digital circuitry accumulates a count of a number of transitions of detector cells of the array of detector cells from the first digital state to the second digital state over the integration time period.

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