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1. 发明授权

US5731293A Esculetin derivatives, method for manufacture thereof, and pharmaceutical composition 失效
标题翻译： Esculetin衍生物，其制备方法和药物组合物
公开(公告)号：US5731293A
公开(公告)日：1998-03-24
申请号：US580364
申请日：1995-12-28
申请人： Koju Watanabe , Koichi Niimura , Toru Yamazaki , Hiroshi Maruoka
发明人： Koju Watanabe , Koichi Niimura , Toru Yamazaki , Hiroshi Maruoka
IPC分类号： C12N9/99 , A61K31/365 , A61K31/535 , A61K31/70 , A61K31/7042 , A61K31/7048 , A61P1/02 , A61P11/00 , A61P13/02 , A61P15/00 , A61P17/00 , A61P27/02 , A61P29/00 , A61P43/00 , C07D311/16 , C07H1/00 , C07H17/075 , A61K31/35 , C07D313/06 , C07H15/24
CPC分类号： C07H17/075 , C07D311/16
摘要： A compound of the formula (I): ##STR1## wherein R.sup.1 and R.sup.2 are, independently, --CON(R.sup.4)R.sup.5, or a monosaccharide, or acylated monosaccharide group, with the proviso that at least one of R.sup.1 and R.sup.2 is --CON(R.sup.4)R.sup.5, and R.sup.4 and R.sup.5 are, independently, a hydrogen atom, or a hydroxyl, alkyl, aryl, or aralkyl group, or R.sup.4 and R.sup.5 together with the nitrogen atom attached thereto form a 3- to 7-membered saturated cycloaliphatic amino group, and R.sup.3 is a hydrogen atom, or a hydroxyl, alkyl, aryl, aralkyl, or --COOR.sup.8 group, and R.sup.3 is at 3- or 4-position, and R.sup.8 is a hydrogen atom or an alkyl group, or a salt thereof is disclosed. The compound has a function to inhibit a matrix metalloproteinase.
摘要翻译：式（I）的化合物：其中R 1和R 2独立地为-CON（R 4）R 5，或单糖或酰化单糖基团，条件是R 1和R 2中的至少一个是-CON（R4）R5，R4和R5独立地是氢原子或羟基，烷基，芳基或芳烷基，或R4和R5与连接的氮原子一起形成3-至7- R 3为氢原子或羟基，烷基，芳基，芳烷基或-COOR 8基，R 3为3-或4-位，R 8为氢原子或烷基，或其盐。该化合物具有抑制基质金属蛋白酶的功能。

2. 发明授权

US07098215B2 Nitrogenous compounds and antiviral drugs containing the same 失效
标题翻译：含氮化合物和含有相同的抗病毒药物
公开(公告)号：US07098215B2
公开(公告)日：2006-08-29
申请号：US10257340
申请日：2001-04-11
申请人： Toru Yamazaki , Hiroshi Maruoka , Shigeru Suzuki , Tsutomu Mukade , Kunitaka Hirose , Mikiro Yanaka , Naoki Yamamoto
发明人： Toru Yamazaki , Hiroshi Maruoka , Shigeru Suzuki , Tsutomu Mukade , Kunitaka Hirose , Mikiro Yanaka , Naoki Yamamoto
IPC分类号： A61K31/495 , C07D24/36
CPC分类号： C07D207/335 , A61K31/4155 , A61K31/4164 , A61K31/4184 , A61K31/427 , A61K31/4402 , A61K31/4406 , A61K31/4436 , A61K31/4439 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/497 , A61K31/502 , A61K31/506 , A61K31/5377 , C07D213/38 , C07D215/40 , C07D233/48 , C07D233/64 , C07D235/14 , C07D307/79 , C07D311/70 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D417/12
摘要： The present invention provides novel compounds having antiviral activities and antiviral drugs containing the compounds as the active ingredient. The compounds are shown by the following general formula (1), wherein typically A1 and A2 are each guanidine or a group of the general formula (ia); A3 is a mono- or poly-cyclic heteroaromatic ring containing 1 or 2 heteroatoms; B1 is a single bond or alkylene group; R1 is hydrogen or alkyl group; W is an alkylene having 2-3 carbons, a cycloalkylene having 5-10 carbons, aromatic ring having 6-10 carbons, or a heteroaromatic ring having 5-10 carbons; y is C(═O)—; x is —C(═O)—NH—; n1 is an integer of 1-2; n2 is an integer of 2-3; D is a substituent selected from among various groups
摘要翻译：本发明提供具有抗病毒活性的新化合物和含有该化合物作为活性成分的抗病毒药物。所述化合物由以下通式（1）表示，其中通常A 1和A 2各自为胍或通式（ia）的基团。 A 3是含有1或2个杂原子的单环或多环杂芳环; B 1是单键或亚烷基; R 1是氢或烷基; W是具有2-3个碳的亚烷基，具有5-10个碳的亚环烷基，具有6-10个碳的芳族环，或具有5-10个碳的杂芳族环; y为C（-O） - ; x是-C（-O）-NH-; n 1是1-2的整数; n≥2是2-3的整数; D是选自不同组的取代基

3. 发明授权

US5863913A Aromatic compound and pharmaceutical composition 失效
标题翻译：芳香族化合物和药物组成
公开(公告)号：US5863913A
公开(公告)日：1999-01-26
申请号：US857206
申请日：1997-05-15
申请人： Mikiro Yanaka , Hiroyuki Enari , Toru Yamazaki , Hiroshi Maruoka , Toshikazu Dewa , Fuyuhiko Nishijima , Hiroshi Takahashi , Michihito Ise
发明人： Mikiro Yanaka , Hiroyuki Enari , Toru Yamazaki , Hiroshi Maruoka , Toshikazu Dewa , Fuyuhiko Nishijima , Hiroshi Takahashi , Michihito Ise
IPC分类号： C07D295/18 , A61K31/195 , A61K31/24 , A61K31/44 , A61K31/495 , A61K31/535 , A61K31/5375 , A61P9/12 , A61P13/02 , A61P15/00 , A61P43/00 , C07C229/38 , C07C233/54 , C07C237/42 , C07C243/22 , C07D213/72 , C07D213/89 , C07D295/192 , C07D411/06
CPC分类号： C07D295/192 , C07C237/42
摘要： An aromatic compound of the formula (I): ##STR1## specifically, for example, 3-��(4-carboxyphenyl)methyl!valeramido!-4-dimethylaminobenzoic acid 4'-methylpiperazide, or a salt thereof, and a pharmaceutical composition comprising said aromatic compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier or diluent which provides sufficiently effective alleviation of renal dysfunction without affecting blood pressure at a low blood concentration.
摘要翻译：式（I）的芳族化合物：其中特别是例如3 - [[（4-羧基苯基）甲基]戊酰氨基] -4-二甲基氨基苯甲酸4'-甲基哌嗪或其盐，和包含所述芳族化合物或其药学上可接受的盐的药物组合物，以及药学上可接受的载体或稀释剂，其提供足够有效的肾功能障碍减轻而不影响低血药浓度的血压。

4. 发明授权

US06242445B1 Benzimidazole derivative 失效
标题翻译：苯并咪唑衍生物
公开(公告)号：US06242445B1
公开(公告)日：2001-06-05
申请号：US09622788
申请日：2000-08-23
申请人： Mikiro Yanaka , Shigeru Suzuki , Fuyuhiko Nishijima , Hiroshi Takahashi , Mikio Sugano , Hiroshi Maruoka , Toru Yamazaki , Toshikazu Dewa , Hiroyuki Enari , Michihito Ise
发明人： Mikiro Yanaka , Shigeru Suzuki , Fuyuhiko Nishijima , Hiroshi Takahashi , Mikio Sugano , Hiroshi Maruoka , Toru Yamazaki , Toshikazu Dewa , Hiroyuki Enari , Michihito Ise
IPC分类号： A61K315377
CPC分类号： C07D235/26 , C07D235/30
摘要： A novel benzimidazole derivative [specifically, for example, 2-ethoxy-1-[{4′-(2″-N,N-dimethylaminoethoxycarbonyl)phenyl}methyl]-1H-benzimidazole-6-carboxylic acid morpholide] represented by formula (I) and a salt thereof. The compound exhibits satisfactory curative effects for cardiac and nephric diseases, although having little action on blood-pressure.
摘要翻译：一种新的苯并咪唑衍生物[具体地，例如2-乙氧基-1 - [{4' - （2“ - N，N-二甲基氨基乙氧基羰基）苯基}甲基] -1H-苯并咪唑-6-羧酸吗啉代] （I）化合物及其盐。该化合物对心脏和肾脏疾病表现出令人满意的治疗效果，尽管对血压几乎没有作用。

5. 发明授权

US09253983B2 Triazole compound and use thereof 有权
标题翻译：三唑化合物及其用途
公开(公告)号：US09253983B2
公开(公告)日：2016-02-09
申请号：US14122944
申请日：2012-05-30
申请人： Taiji Miyake , Nobuyuki Araki , Toru Yamazaki
发明人： Taiji Miyake , Nobuyuki Araki , Toru Yamazaki
IPC分类号： A01N43/653 , C07B57/00 , C07D249/08
CPC分类号： A01N43/653 , C07B57/00 , C07D249/08 , A01N25/00
摘要： In order to provide a compound that shows a strong effect on controlling a plant disease, a triazole compound of the present invention (i) is a compound in which —OH group, —R2 group, and CH2—Ar group are bonded in cis configuration with a cyclopentane, (ii) is (−)-enantiomer or (+) enantiomer, and (iii) is represented by Formula (I): (wherein R1 represents an alkyl group; R2 represents a haloalkyl group; and Ar represents a substituted/unsubstituted aromatic hydrocarbon group or a substituted/unsubstituted aromatic heterocyclic group.
摘要翻译：为了提供对控制植物病害具有强效果的化合物，本发明的三唑化合物（i）是其中-OH基，-R2基和CH2-Ar基以顺式结构键合的化合物（ii）为（ - ） - 对映体或（+）对映异构体，（iii）由式（I）表示：（其中R 1表示烷基; R 2表示卤代烷基; Ar表示取代基 /未取代的芳香族烃基或取代/未取代的芳香族杂环基。

6. 发明授权

US08722719B2 Amine compound and use for same 失效
标题翻译：胺化合物和用途相同
公开(公告)号：US08722719B2
公开(公告)日：2014-05-13
申请号：US13878131
申请日：2011-09-30
申请人： Ryo Matsui , Toru Yamazaki , Shigeyuki Kikumoto
发明人： Ryo Matsui , Toru Yamazaki , Shigeyuki Kikumoto
IPC分类号： A61K31/4178 , C07D403/12
CPC分类号： C07D233/64
摘要： Provided is an ester of 3-[(4-dipropylamino-butyl)(4-{[(1H-imidazole-2-ylmethyl)(1-methyl-1H-imidazole-2-ylmethyl)amino]methyl}benzyl)amino]propionic acid which is easily hydrolyzed in serum. The amine compound of the present invention is an ester compound represented by general formula (1). (In general formula (1), n is 1-4, and R1 and R2 represent an alkyl group having 1-3 carbon atoms.)
摘要翻译：提供了3 - [（4-二丙基氨基 - 丁基）（4 - {[（1H-咪唑-2-基甲基）（1-甲基-1H-咪唑-2-基甲基）氨基]甲基}苄基）氨基] 在血清中容易水解的丙酸。本发明的胺化合物是由通式（1）表示的酯化合物。（通式（1）中，n为1-4，R 1和R 2表示碳原子数1〜3的烷基。）

7. 发明申请

US20110158643A1 Optical transmission module and wavelength control method of optical transmission module 审中-公开
标题翻译：光传输模块和光传输模块的波长控制方法
公开(公告)号：US20110158643A1
公开(公告)日：2011-06-30
申请号：US12926866
申请日：2010-12-14
申请人： Toru Yamazaki
发明人： Toru Yamazaki
IPC分类号： H04B10/08
CPC分类号： H04B10/572
摘要： An optical transmission module includes a variable wavelength light source; an alternating current adding unit that adds an alternating current to a drive current to the variable wavelength light source; a first detector to detect optical power of an output light; a filter to input the output light from the variable wavelength light source in which transmission wavelength periodically increases and decreases; a second detector to detect optical power of transmitted light transmitted through the filter; an extraction unit to extract a wavelength fluctuation component of the output light based on the optical power of the output light and the optical power of the transmitted light; a phase comparison unit to compare a phase of the wavelength fluctuation component with a phase of the alternating current; and a wavelength controller to control a wavelength of the output light by controlling a temperature of the variable wavelength light source.
摘要翻译：光传输模块包括可变波长光源; 交流电加法单元，其向所述可变波长光源添加与驱动电流的交流电流; 检测输出光的光功率的第一检测器; 输入来自可变波长光源的输出光的滤波器，其中透射波长周期性地增加和减少; 第二检测器，用于检测透射过滤器的透射光的光功率; 提取单元，用于基于输出光的光功率和透射光的光功率来提取输出光的波长变动分量; 相位比较单元，用于将波长波动分量的相位与交流电的相位进行比较; 以及波长控制器，通过控制可变波长光源的温度来控制输出光的波长。

8. 发明申请

US20070218599A1 Method for producing silicon wafer and silicon wafer 审中-公开
标题翻译：硅晶片和硅晶片的制造方法
公开(公告)号：US20070218599A1
公开(公告)日：2007-09-20
申请号：US11700650
申请日：2007-01-30
申请人： Toru Yamazaki
发明人： Toru Yamazaki
IPC分类号： H01L21/84
CPC分类号： H01L21/76251 , H01L21/76243 , H01L29/78603 , H01L29/78654
摘要： A method for producing a silicon wafer, comprising performing a reduction of an interface state by annealing of an SOI wafer having a buried oxide layer at a temperature of 250 to 900° C. for 3 minutes to 8 hours in an atmosphere composed of one or more gases selected from nitrogen, inert gas, and air.
摘要翻译：一种硅晶片的制造方法，其特征在于，在由一个或多个基板构成的气氛中，在250〜900℃的温度下将具有埋入氧化物层的SOI晶片退火3分钟〜8小时，进行界面态的降低，更多的气体选自氮气，惰性气体和空气。

9. 发明授权

US07245837B2 Optical transmitting device 失效
标题翻译：光传输设备
公开(公告)号：US07245837B2
公开(公告)日：2007-07-17
申请号：US10368346
申请日：2003-02-20
申请人： Hisaya Sakamoto , Toru Yamazaki , Rumiko Tashiro
发明人： Hisaya Sakamoto , Toru Yamazaki , Rumiko Tashiro
IPC分类号： H04B10/12
CPC分类号： H04B10/25137 , H04B10/505
摘要： A demultiplex unit demultiplexes the optical output of a Mach-Zehnder optical modulator and inputs the demultiplexed optical output to a wavelength detection unit. The wavelength detection unit detects the wavelength deviations in the ascending or descending part of the optical signal and inputs the wavelength deviations to a detection unit. The detection unit detects the sign and magnitude of chirping in the magnitude of wavelength deviation and inputs the sign and magnitude of chirping to a driving voltage control unit. The driving voltage control unit compares the detected sign and amount of chirping with the target sign and magnitude of chirping, and a driving voltage generation circuit provides the Mach-Zehnder optical modulator with a suitable driving voltage.
摘要翻译：解复用单元解复用马赫 - 曾德尔光调制器的光输出，并将解复用的光输出输入到波长检测单元。波长检测单元检测光信号的上升或下降部分的波长偏差，并将波长偏差输入到检测单元。检测单元在波长偏差的大小中检测啁啾的符号和大小，并将啁啾的符号和幅度输入到驱动电压控制单元。驱动电压控制单元将检测到的啁啾符号和目标符号与啁啾幅度进行比较，驱动电压产生电路为马赫 - 曾德尔光调制器提供合适的驱动电压。

10. 发明申请

US20070146795A1 Signal light processing apparatus 有权
标题翻译：信号灯处理装置
公开(公告)号：US20070146795A1
公开(公告)日：2007-06-28
申请号：US11645712
申请日：2006-12-27
申请人： Hisaya Sakamoto , Toru Yamazaki , Yoshito Anazawa , Hiroshi Kuzukami
发明人： Hisaya Sakamoto , Toru Yamazaki , Yoshito Anazawa , Hiroshi Kuzukami
IPC分类号： G06K15/00
CPC分类号： H04B10/66
摘要： A signal processing apparatus sets a discrimination level most suitably, regardless of whether the apparatus is in the minimum receiving system or the maximum receiving system. The apparatus comprises a light receiving unit converting input signal light to an electric signal, and a level detecting unit for detecting a high level component and a low level component of the electric signal from the light receiving unit, along with peak levels on a high-side and a low-side of the electric signal.
摘要翻译：信号处理装置最适合地设定判别水平，而不管装置是在最小接收系统还是最大接收系统中。该装置包括将输入信号光转换为电信号的光接收单元，以及用于检测来自光接收单元的电信号的高电平分量和低电平分量的电平检测单元，侧和低端的电信号。

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