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1. 发明授权

US08858768B2 Electrochemical sensor and method for manufacturing same 有权
标题翻译：电化学传感器及其制造方法
公开(公告)号：US08858768B2
公开(公告)日：2014-10-14
申请号：US13148465
申请日：2010-02-04
申请人： Koji Katsuki , Yoshiaki Fujinawa , Masashi Tsukada , Yosuke Murase
发明人： Koji Katsuki , Yoshiaki Fujinawa , Masashi Tsukada , Yosuke Murase
IPC分类号： G01N27/327 , C12Q1/32 , C12Q1/00 , A61B5/05
CPC分类号： C12Q1/006 , C12Q1/32 , G01N2333/902
摘要： The present invention provides an electrochemical sensor comprising a substrate, an electrically conductive layer made of carbon particles which is disposed on the substrate, a cell membrane mimetic structure layer containing an enzyme at least one of inside the cell membrane mimetic structure layer and on the interface of the cell membrane mimetic structure layer which is disposed on the electrically conductive layer.
摘要翻译：本发明提供了一种电化学传感器，其包括基板，由设置在基板上的碳颗粒制成的导电层，包含细胞膜模拟结构层内部和界面上至少一个的酶的细胞膜模拟结构层的细胞膜模拟结构层，其设置在导电层上。

2. 发明申请

US20120029332A1 Method of Continuously Measuring Substrate Concentration 审中-公开
标题翻译：连续测量底物浓度的方法
公开(公告)号：US20120029332A1
公开(公告)日：2012-02-02
申请号：US13256525
申请日：2010-03-15
申请人： Koji Katsuki , Masashi Tsukada
发明人： Koji Katsuki , Masashi Tsukada
IPC分类号： A61B5/1468 , C12Q1/54 , G01N27/00
CPC分类号： C12Q1/006 , A61B5/14532 , A61B5/14865 , A61B5/1495 , A61B5/4839 , A61B5/6849
摘要： Analysis equipment is provided, which is capable of fulfilling a demand for miniaturization and ensuring high sensitivity, and which can be produced easily. The present invention relates to a method of continuously measuring a substrate concentration based on a response when a voltage is applied to a sensor. The present invention includes a response voltage application step of applying a response voltage E2 at which a response attributed to a substrate is obtained and a non-response voltage application step of applying a non-response voltage E1 at which the response attributed to the substrate is not obtained or is not substantially obtained. Preferably, the response voltage application step and the non-response voltage application step are repeated alternately.
摘要翻译：提供分析设备，其能够满足小型化的需求并确保高灵敏度，并且可以容易地制造。本发明涉及一种当将电压施加到传感器时基于响应连续测量衬底浓度的方法。本发明包括：响应电压施加步骤，其施加响应电压E2，在该响应电压E2处获得归因于基板的响应;以及非响应电压施加步骤，施加响应归因于该基板的非响应电压E1 未获得或基本不获得。优选地，交替地重复响应电压施加步骤和非响应电压施加步骤。

3. 发明申请

US20110308944A1 Electrochemical Sensor and Method for Manufacturing Same 有权
标题翻译：电化学传感器及其制造方法
公开(公告)号：US20110308944A1
公开(公告)日：2011-12-22
申请号：US13148465
申请日：2010-02-04
申请人： Koji Katsuki , Yoshiaki Fujinawa , Masashi Tsukada , Yosuke Murase
发明人： Koji Katsuki , Yoshiaki Fujinawa , Masashi Tsukada , Yosuke Murase
IPC分类号： C12Q1/00 , B41F31/00 , B05D5/12
CPC分类号： C12Q1/006 , C12Q1/32 , G01N2333/902
摘要： The present invention provides an electrochemical sensor comprising a substrate, an electrically conductive layer made of carbon particles which is disposed on the substrate, a cell membrane mimetic structure layer containing an enzyme at least one of inside the cell membrane mimetic structure layer and on the interface of the cell membrane mimetic structure layer which is disposed on the electrically conductive layer.
摘要翻译：本发明提供了一种电化学传感器，其包括基板，由设置在基板上的碳颗粒制成的导电层，包含细胞膜模拟结构层内部和界面上至少一个的酶的细胞膜模拟结构层的细胞膜模拟结构层，其设置在导电层上。

4. 发明申请

US20120116706A1 Analysis Device and Analysis Method 审中-公开
标题翻译：分析装置与分析方法
公开(公告)号：US20120116706A1
公开(公告)日：2012-05-10
申请号：US13381598
申请日：2010-06-25
申请人： Hiroyuki Nakanishi , Yoshiharu Uehata , Masako Kawanishi , Yosuke Murase , Masashi Tsukada
发明人： Hiroyuki Nakanishi , Yoshiharu Uehata , Masako Kawanishi , Yosuke Murase , Masashi Tsukada
IPC分类号： G06F19/00
CPC分类号： A61B5/14532 , A61B5/14865 , A61B2560/0252 , G01N27/3274
摘要： Provided is an analysis device or an analysis method, by which highly reliable analysis results can be obtained even in the circumstances where environment temperature changes, while reducing load on the user. The analysis device (1) is provided with a determining means (13) which determines whether environmental temperature measured by means of a temperature measuring means (6) is within a predetermined temperature range or not. The determining means (13) is so configured as to determine whether the environmental temperature is within the predetermined temperature range or not, even in the circumstances where information relating to a target substance in a sample cannot be obtained from the analysis device.
摘要翻译：提供了一种分析装置或分析方法，即使在环境温度变化的情况下也可以获得高度可靠的分析结果，同时减轻用户的负担。分析装置（1）具有确定装置（13），其确定通过温度测量装置（6）测量的环境温度是否处于预定温度范围内。即使在从分析装置不能获得与样本中的目标物质有关的信息的情况下，判定装置（13）被配置为确定环境温度是否在预定温度范围内。

5. 发明申请

US20100086989A1 MUTANT GLUCOSE DEHYDROGENASE 有权
公开(公告)号：US20100086989A1
公开(公告)日：2010-04-08
申请号：US12556142
申请日：2009-09-09
申请人： Hideaki Yamaoka , Masashi Tsukada
发明人： Hideaki Yamaoka , Masashi Tsukada
IPC分类号： C07H21/04 , C12N1/21
CPC分类号： C12Q1/32 , C12N9/0006 , C12Q1/54 , C12Y101/01049
摘要： A mutant glucose dehydrogenase having the amino acid sequence of SEQ ID NO: 3 or an amino acid sequence of SEQ ID NO: 3 including substitution, deletion, insertion or addition of one or more amino acid residues other than the amino acid residue at the 365th position and having glucose dehydrogenase activity, wherein an amino acid residue at a position corresponding to the 365th position of, the amino acid sequence is replaced with another amino acid residue, and the mutant glucose dehydrogenase shows an improved substrate specificity to glucose.
摘要翻译：具有SEQ ID NO：3的氨基酸序列或SEQ ID NO：3的氨基酸序列的突变体葡萄糖脱氢酶，包括在第365天除了氨基酸残基之外的一个或多个氨基酸残基的取代，缺失，插入或添加位置并且具有葡萄糖脱氢酶活性，其中与氨基酸序列的第365位相对应的位置的氨基酸残基被另一氨基酸残基替代，并且突变型葡萄糖脱氢酶显示出对葡萄糖的底物特异性改善。

6. 发明申请

US20120273368A1 Analysis Device 有权
标题翻译：分析装置
公开(公告)号：US20120273368A1
公开(公告)日：2012-11-01
申请号：US13455555
申请日：2012-04-25
申请人： Masashi Tsukada
发明人： Masashi Tsukada
IPC分类号： G01N27/30 , G01N27/26 , G01N27/327
CPC分类号： G01N27/3271 , C12Q1/004 , C12Q1/006 , G01N27/3273 , G01N2333/902 , G01N2333/904
摘要： An analysis device is disclosed which includes an electron detection medium to obtain information needed for analyzing an analyte in correlation with an electron transfer level, and a reagent part which is disposed on the electron detection medium and includes an electron transporting substance to transport electrons between the analyte and the electron detection medium, the electron transporting substance including a water-soluble aromatic heterocycle compound, and being free of a metal complex. An analysis method using the analysis device is also disclosed.
摘要翻译：公开了一种分析装置，其包括电子检测介质，以获得与电子转移水平相关的分析物所需的信息;以及试剂部件，其设置在电子检测介质上并且包括电子传输物质以在分析物和电子检测介质，电子传输物质包括水溶性芳族杂环化合物，并且不含金属络合物。还公开了使用分析装置的分析方法。

7. 发明申请

US20120259192A1 MEASURING APPARATUS AND SENSOR PLACEMENT METHOD 审中-公开
标题翻译：测量装置和传感器放置方法
公开(公告)号：US20120259192A1
公开(公告)日：2012-10-11
申请号：US13518820
申请日：2010-11-25
申请人： Masashi Tsukada , Yasuhide Kusaka , Akihiro Yamamoto
发明人： Masashi Tsukada , Yasuhide Kusaka , Akihiro Yamamoto
IPC分类号： A61B5/145
CPC分类号： A61B5/14532 , A61B5/1486 , A61B5/7207 , A61B2560/063
摘要： Provided are a measurement device, a sensor unit, and a sensor placement method, which enable the suppression of the occurrence of a situation where a measurement carried out with a sensor implanted under the skin, the implanted sensor becomes faulty. A sensor unit is used for measuring numerical information relating to a substance contained in a body fluid in a body. The sensor unit is provided with a sensor a part of which is placed under the skin and generates a signal according to the state of the substance, a base which is disposed on the skin and holds the sensor, a variable mechanism which is attached to the base and enables the position and/or the direction of the sensor with reference to the base to be varied, and an external terminal which is provided in the base and leads the signal generated by the sensor to the outside.
摘要翻译：提供了一种测量装置，传感器单元和传感器放置方法，其能够抑制通过植入在皮肤下的传感器进行的测量的发生的情况，植入的传感器变得有缺陷。传感器单元用于测量与体内体液中所含物质有关的数值信息。传感器单元设置有传感器，其一部分放置在皮肤下面并根据物质的状态产生信号，设置在皮肤上并保持传感器的基座，可变机构，其附接到并且使得能够相对于基座改变传感器的位置和/或方向，以及设置在基座中并将由传感器产生的信号引导到外部的外部端子。

8. 发明授权

US06295883B1 Opening and closing type interior device 有权
标题翻译：开闭式室内装置
公开(公告)号：US06295883B1
公开(公告)日：2001-10-02
申请号：US09417780
申请日：1999-10-14
申请人： Masashi Tsukada , Kenichi Oji
发明人： Masashi Tsukada , Kenichi Oji
IPC分类号： F16H1908
CPC分类号： B60K35/00 , B60K2350/405 , Y10T74/18816 , Y10T74/19623 , Y10T74/19637
摘要： An opening and closing type interior device includes a fixed member, a movable member which is capable of being opened and closed and is movable relative to the fixed member, an actuator including a driving source and a gear mechanism, and a damper coupled to one of the movable member and the fixed member. The opening and closing type interior device includes, for example, a display device for an automobile.
摘要翻译：一种打开和关闭型内部装置，包括固定构件，能够被打开和关闭并且可相对于固定构件移动的可动构件，包括驱动源和齿轮机构的致动器以及耦合到可动构件和固定构件。打开和关闭型内部装置例如包括用于汽车的显示装置。

9. 发明授权

US09588210B2 Analysis apparatus, analysis method and analysis system 有权
标题翻译：分析仪器，分析方法和分析系统
公开(公告)号：US09588210B2
公开(公告)日：2017-03-07
申请号：US13581152
申请日：2011-02-01
申请人： Masashi Tsukada , Yasuhide Kusaka
发明人： Masashi Tsukada , Yasuhide Kusaka
IPC分类号： G01R35/00 , A61B5/1473 , A61B5/1486 , G06F19/10 , A61B5/1495
CPC分类号： G01R35/00 , A61B5/1473 , A61B5/1486 , A61B5/1495 , A61B2560/0242 , G06F19/10
摘要： Provided is an analysis apparatus capable of acquiring a measurement result with high reliability that includes: a signal detection unit; a measuring unit; a first temperature detection unit; a second temperature detection unit; and a calculation unit.
摘要翻译：提供一种能够以高可靠性获取测量结果的分析装置，包括：信号检测单元; 测量单元; 第一温度检测单元; 第二温度检测单元; 和计算单元。

10. 发明授权

US09045790B2 Analysis device 有权
标题翻译：分析装置
公开(公告)号：US09045790B2
公开(公告)日：2015-06-02
申请号：US13455555
申请日：2012-04-25
申请人： Masashi Tsukada
发明人： Masashi Tsukada
IPC分类号： G01N27/30 , G01N27/26 , G01N27/327 , C12Q1/00
CPC分类号： G01N27/3271 , C12Q1/004 , C12Q1/006 , G01N27/3273 , G01N2333/902 , G01N2333/904
摘要： An analysis device is disclosed which includes an electron detection medium to obtain information needed for analyzing an analyte in correlation with an electron transfer level, and a reagent part which is disposed on the electron detection medium and includes an electron transporting substance to transport electrons between the analyte and the electron detection medium, the electron transporting substance including a water-soluble aromatic heterocycle compound, and being free of a metal complex. An analysis method using the analysis device is also disclosed.
摘要翻译：公开了一种分析装置，其包括电子检测介质，以获得与电子转移水平相关的分析物所需的信息;以及试剂部件，其设置在电子检测介质上并且包括电子传输物质以在分析物和电子检测介质，电子传输物质包括水溶性芳族杂环化合物，并且不含金属络合物。还公开了使用分析装置的分析方法。

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