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1. 发明授权

US07364885B2 Process for producing isoprenoid compounds by microorganisms and a method for screening compounds with antibiotic or weeding activity 失效
标题翻译：通过微生物生产类异戊二烯化合物的方法和用抗生素或除草活性筛选化合物的方法
公开(公告)号：US07364885B2
公开(公告)日：2008-04-29
申请号：US11695320
申请日：2007-04-02
申请人： Koichiro Miyake , Shinichi Hashimoto , Hiroaki Motoyama , Akio Ozaki , Haruo Seto , Tomohisa Kuzuyama , Shunji Takahashi
发明人： Koichiro Miyake , Shinichi Hashimoto , Hiroaki Motoyama , Akio Ozaki , Haruo Seto , Tomohisa Kuzuyama , Shunji Takahashi
IPC分类号： C12P5/00
CPC分类号： C12N9/1085 , A01N63/02 , C12N9/0006 , C12N9/1022 , C12N15/52 , C12P7/66 , C12P23/00 , C12Q1/18 , C12Y202/01007 , G01N2430/20
摘要： The present invention provides a process for producing isoprenoid compounds or proteins encoded by DNA using DNA that contains one or more of the DNA encoding proteins having activity to improve efficiency in the biosynthesis of isoprenoid compounds effective in pharmaceuticals for cardiac diseases, osteoporosis, homeostasis, prevention of cancer, and immunopotentiation, health food and anti-fouling paint products against barnacles; the DNA; the protein; and a method for screening a substance with antibiotic and weeding activities comprising screening a substance inhibiting enzymatic reaction on the non-mevalonate pathway.
摘要翻译：本发明提供了使用含有一种或多种编码DNA的蛋白质来生产类异戊二烯化合物或由DNA编码的蛋白质的方法，所述DNA编码蛋白质具有提高有效用于心脏疾病，骨质疏松症，体内平衡，预防的药物中类异戊二烯化合物的生物合成的效率的活性的癌症，免疫增强，保健食品和防腐漆产品针对藤壶; DNA; 蛋白质; 以及用抗生素和除草活性筛选物质的方法，其包括在非甲羟戊酸途径上筛选抑制酶反应的物质。

2. 发明授权

US06806076B1 Process for producing isoprenoid compounds by microorganisms and a method for screening compounds with antibiotic or weeding activity 失效
标题翻译：通过微生物生产类异戊二烯化合物的方法和用抗生素或除草活性筛选化合物的方法
公开(公告)号：US06806076B1
公开(公告)日：2004-10-19
申请号：US09673198
申请日：2000-10-12
申请人： Koichiro Miyake , Shinichi Hashimoto , Hiroaki Motoyama , Akio Ozaki , Haruo Seto , Tomohisa Kuzuyama , Shunji Takahashi
发明人： Koichiro Miyake , Shinichi Hashimoto , Hiroaki Motoyama , Akio Ozaki , Haruo Seto , Tomohisa Kuzuyama , Shunji Takahashi
IPC分类号： C12N988
CPC分类号： C12N9/1085 , A01N63/02 , C12N9/0006 , C12N9/1022 , C12N15/52 , C12P7/66 , C12P23/00 , C12Q1/18 , C12Y202/01007 , G01N2430/20
摘要： The present invention provides a process for producing isoprenoid compounds or proteins encoded by DNA using DNA that contains one or more of the DNA encoding proteins having activity to improve efficiency in the biosynthesis of isoprenoid compounds effective in pharmaceuticals for cardiac diseases, osteoporosis, homeostasis, prevention of cancer, and immunopotentiation, health food and anti-fouling paint products against barnacles the DNA; the protein; and a method for screening a substance with antibiotic and weeding activities comprising screening a substance inhibiting enzymatic reaction on the non-mevalonate pathway.
摘要翻译：本发明提供了使用含有一种或多种编码DNA的蛋白质来生产类异戊二烯化合物或由DNA编码的蛋白质的方法，所述DNA编码蛋白质具有提高有效用于心脏疾病，骨质疏松症，体内平衡，预防的药物中类异戊二烯化合物的生物合成的效率的活性的癌症和免疫增强，保健食品和防污漆产品针对藤壶的DNA; 蛋白质; 以及用抗生素和除草活性筛选物质的方法，其包括在非甲羟戊酸途径上筛选抑制酶反应的物质。

3. 发明授权

US07208298B2 Process for producing isoprenoid compounds by microorganisms and a method for screening compounds with antibiotic or weeding activity 有权
标题翻译：通过微生物生产类异戊二烯化合物的方法和用抗生素或除草活性筛选化合物的方法
公开(公告)号：US07208298B2
公开(公告)日：2007-04-24
申请号：US11439162
申请日：2006-05-24
申请人： Koichiro Miyake , Shinichi Hashimoto , Hiroaki Motoyama , Akio Ozaki , Haruo Seto , Tomohisa Kuzuyama , Shunji Takahashi
发明人： Koichiro Miyake , Shinichi Hashimoto , Hiroaki Motoyama , Akio Ozaki , Haruo Seto , Tomohisa Kuzuyama , Shunji Takahashi
IPC分类号： C12P5/00 , C12N9/02
CPC分类号： C12N9/1085 , A01N63/02 , C12N9/0006 , C12N9/1022 , C12N15/52 , C12P7/66 , C12P23/00 , C12Q1/18 , C12Y202/01007 , G01N2430/20
摘要： The present invention provides a process for producing isoprenoid compounds or proteins encoded by DNA using DNA that contains one or more of the DNA encoding proteins having activity to improve efficiency in the biosynthesis of isoprenoid compounds effective in pharmaceuticals for cardiac diseases, osteoporosis, homeostasis, prevention of cancer, and immunopotentiation, health food and anti-fouling paint products against barnacles; the DNA; the protein; and a method for screening a substance with antibiotic and weeding activities comprising screening a substance inhibiting enzymatic reaction on the non-mevalonate pathway.
摘要翻译：本发明提供了使用含有一种或多种编码DNA的蛋白质来生产类异戊二烯化合物或由DNA编码的蛋白质的方法，所述DNA编码蛋白质具有提高有效用于心脏疾病，骨质疏松症，体内平衡，预防的药物中类异戊二烯化合物的生物合成的效率的活性的癌症，免疫增强，保健食品和防腐漆产品针对藤壶; DNA; 蛋白质; 以及用抗生素和除草活性筛选物质的方法，其包括在非甲羟戊酸途径上筛选抑制酶反应的物质。

4. 发明申请

US20070004000A1 Process for producing isoprenoid compounds by microorganisms and a method for screening compounds with antibiotic or weeding activity 有权
公开(公告)号：US20070004000A1
公开(公告)日：2007-01-04
申请号：US11439162
申请日：2006-05-24
申请人： Koichiro Miyake , Shinichi Hashimoto , Hiroaki Motoyama , Akio Ozaki , Haruo Seto , Tomohisa Kuzuyama , Shunji Takahashi
发明人： Koichiro Miyake , Shinichi Hashimoto , Hiroaki Motoyama , Akio Ozaki , Haruo Seto , Tomohisa Kuzuyama , Shunji Takahashi
IPC分类号： C12P23/00 , C07H21/04 , C12P21/06 , A01N25/00 , C12P7/66 , C12N1/21 , C12N9/10 , C12N15/74
CPC分类号： C12N9/1085 , A01N63/02 , C12N9/0006 , C12N9/1022 , C12N15/52 , C12P7/66 , C12P23/00 , C12Q1/18 , C12Y202/01007 , G01N2430/20
摘要： The present invention provides a process for producing isoprenoid compounds or proteins encoded by DNA using DNA that contains one or more of the DNA encoding proteins having activity to improve efficiency in the biosynthesis of isoprenoid compounds effective in pharmaceuticals for cardiac diseases, osteoporosis, homeostasis, prevention of cancer, and immunopotentiation, health food and anti-fouling paint products against barnacles; the DNA; the protein; and a method for screening a substance with antibiotic and weeding activities comprising screening a substance inhibiting enzymatic reaction on the non-mevalonate pathway.

5. 发明授权

US07531333B2 Process for producing isoprenoid compounds by microorganisms and a method for screening compounds with antibiotic or weeding activity 失效
标题翻译：通过微生物生产类异戊二烯化合物的方法和用抗生素或除草活性筛选化合物的方法
公开(公告)号：US07531333B2
公开(公告)日：2009-05-12
申请号：US11837645
申请日：2007-08-13
申请人： Koichiro Miyake , Shinichi Hashimoto , Hiroaki Motoyama , Akio Ozaki , Haruo Seto , Tomohisa Kuzuyama , Shunji Takahashi
发明人： Koichiro Miyake , Shinichi Hashimoto , Hiroaki Motoyama , Akio Ozaki , Haruo Seto , Tomohisa Kuzuyama , Shunji Takahashi
IPC分类号： C12P5/00
CPC分类号： C12N9/1085 , A01N63/02 , C12N9/0006 , C12N9/1022 , C12N15/52 , C12P7/66 , C12P23/00 , C12Q1/18 , C12Y202/01007 , G01N2430/20
摘要： The present invention provides a process for producing isoprenoid compounds or proteins encoded by DNA using DNA that contains one or more of the DNA encoding proteins having activity to improve efficiency in the biosynthesis of isoprenoid compounds effective in pharmaceuticals for cardiac diseases, osteoporosis, homeostasis, prevention of cancer, and immunopotentiation, health food and anti-fouling paint products against barnacles; the DNA; the protein; and a method for screening a substance with antibiotic and weeding activities comprising screening a substance inhibiting enzymatic reaction on the non-mevalonate pathway.
摘要翻译：本发明提供了使用含有一种或多种编码DNA的蛋白质来生产类异戊二烯化合物或由DNA编码的蛋白质的方法，所述DNA编码蛋白质具有提高有效用于心脏疾病，骨质疏松症，体内平衡，预防的药物中类异戊二烯化合物的生物合成的效率的活性的癌症，免疫增强，保健食品和防腐漆产品针对藤壶; DNA; 蛋白质; 以及用抗生素和除草活性筛选物质的方法，其包括在非甲羟戊酸途径上筛选抑制酶反应的物质。

6. 发明申请

US20080227141A1 PROCESS FOR PRODUCING ISOPRENOID COMPOUNDS BY MICROORGANISMS AND A METHOD FOR SCREENING COMPOUNDS WITH ANTIBIOTIC OR WEEDING ACTIVITY 审中-公开
公开(公告)号：US20080227141A1
公开(公告)日：2008-09-18
申请号：US12045792
申请日：2008-03-11
申请人： Koichiro Miyake , Shinichi Hashimoto , Hiroaki Motoyama , Akio Ozaki , Haruo Seto , Tomohisa Kuzuyama , Shunji Takahashi
发明人： Koichiro Miyake , Shinichi Hashimoto , Hiroaki Motoyama , Akio Ozaki , Haruo Seto , Tomohisa Kuzuyama , Shunji Takahashi
IPC分类号： C12Q1/18
CPC分类号： C12N9/1085 , A01N63/02 , C12N9/0006 , C12N9/1022 , C12N15/52 , C12P7/66 , C12P23/00 , C12Q1/18 , C12Y202/01007 , G01N2430/20
摘要： The present invention provides a process for producing isoprenoid compounds or proteins encoded by DNA using DNA that contains one or more of the DNA encoding proteins having activity to improve efficiency in the biosynthesis of isoprenoid compounds effective in pharmaceuticals for cardiac diseases, osteoporosis, homeostasis, prevention of cancer, and immunopotentiation, health food and anti-fouling paint products against barnacles; the DNA; the protein; and a method for screening a substance with antibiotic and weeding activities comprising screening a substance inhibiting enzymatic reaction on the non-mevalonate pathway.

7. 发明授权

US07132268B2 Process for producing isoprenoid compounds by microorganisms and a method for screening compounds with antibiotic or weeding activity 有权
公开(公告)号：US07132268B2
公开(公告)日：2006-11-07
申请号：US10938613
申请日：2004-09-13
申请人： Koichiro Miyake , Shinichi Hashimoto , Hiroaki Motoyama , Akio Ozaki , Haruo Seto , Tomohisa Kuzuyama , Shunji Takahashi
发明人： Koichiro Miyake , Shinichi Hashimoto , Hiroaki Motoyama , Akio Ozaki , Haruo Seto , Tomohisa Kuzuyama , Shunji Takahashi
IPC分类号： C12P5/00 , C12N9/02
CPC分类号： C12N9/1085 , A01N63/02 , C12N9/0006 , C12N9/1022 , C12N15/52 , C12P7/66 , C12P23/00 , C12Q1/18 , C12Y202/01007 , G01N2430/20
摘要： The present invention provides a process for producing isoprenoid compounds or proteins encoded by DNA using DNA that contains one or more of the DNA encoding proteins having activity to improve efficiency in the biosynthesis of isoprenoid compounds effective in pharmaceuticals for cardiac diseases, osteoporosis, homeostasis, prevention of cancer, and immunopotentiation, health food and anti-fouling paint products against barnacles; the DNA; the protein; and a method for screening a substance with antibiotic and weeding activities comprising screening a substance inhibiting enzymatic reaction on the non-mevalonate pathway.

8. 发明申请

US20050032169A1 Process for producing isoprenoid compounds by microorganisms and a method for screening compounds with antibiotic or weeding activity 有权
标题翻译：通过微生物生产类异戊二烯化合物的方法和用抗生素或除草活性筛选化合物的方法
公开(公告)号：US20050032169A1
公开(公告)日：2005-02-10
申请号：US10938613
申请日：2004-09-13
申请人： Koichiro Miyake , Shinichi Hashimoto , Hiroaki Motoyama , Akio Ozaki , Haruo Seto , Tomohisa Kuzuyama , Shunji Takahashi
发明人： Koichiro Miyake , Shinichi Hashimoto , Hiroaki Motoyama , Akio Ozaki , Haruo Seto , Tomohisa Kuzuyama , Shunji Takahashi
IPC分类号： C12N9/10 , C12N15/52 , C12P23/00 , C12Q1/18 , C12P7/16 , C12N5/04 , C12P7/02 , C12P7/26
CPC分类号： C12N9/1085 , A01N63/02 , C12N9/0006 , C12N9/1022 , C12N15/52 , C12P7/66 , C12P23/00 , C12Q1/18 , C12Y202/01007 , G01N2430/20
摘要： The present invention provides a process for producing isoprenoid compounds or proteins encoded by DNA using DNA that contains one or more of the DNA encoding proteins having activity to improve efficiency in the biosynthesis of isoprenoid compounds effective in pharmaceuticals for cardiac diseases, osteoporosis, homeostasis, prevention of cancer, and immunopotentiation, health food and anti-fouling paint products against barnacles; the DNA; the protein; and a method for screening a substance with antibiotic and weeding activities comprising screening a substance inhibiting enzymatic reaction on the non-mevalonate pathway.
摘要翻译：本发明提供了使用含有一种或多种编码DNA的蛋白质来生产类异戊二烯化合物或由DNA编码的蛋白质的方法，所述DNA编码蛋白质具有提高有效用于心脏疾病，骨质疏松症，体内平衡，预防的药物中类异戊二烯化合物的生物合成的效率的活性的癌症，免疫增强，保健食品和防腐漆产品针对藤壶; DNA; 蛋白质; 以及用抗生素和除草活性筛选物质的方法，其包括在非甲羟戊酸途径上筛选抑制酶反应的物质。

9. 发明申请

US20070269857A1 A PROCESS FOR PRODUCING ISOPRENOID COMPOUNDS BY MICROORGANISMS AND A METHOD FOR SCREENING COMPOUNDS WITH ANTIBIOTIC OR WEEDING ACTIVITY 失效
标题翻译：通过微生物生产异噻菌根化合物的方法和用抗生素或加强活性筛选化合物的方法
公开(公告)号：US20070269857A1
公开(公告)日：2007-11-22
申请号：US11695320
申请日：2007-04-02
申请人： Koichiro Miyake , Shinichi Hashimoto , Hiroaki Motoyama , Akio Ozaki , Haruo Seto , Tomohisa Kuzuyama , Shunji Takahashi
发明人： Koichiro Miyake , Shinichi Hashimoto , Hiroaki Motoyama , Akio Ozaki , Haruo Seto , Tomohisa Kuzuyama , Shunji Takahashi
IPC分类号： C12P23/00 , C12P5/02 , C12P7/66
CPC分类号： C12N9/1085 , A01N63/02 , C12N9/0006 , C12N9/1022 , C12N15/52 , C12P7/66 , C12P23/00 , C12Q1/18 , C12Y202/01007 , G01N2430/20
摘要： The present invention provides a process for producing isoprenoid compounds or proteins encoded by DNA using DNA that contains one or more of the DNA encoding proteins having activity to improve efficiency in the biosynthesis of isoprenoid compounds effective in pharmaceuticals for cardiac diseases, osteoporosis, homeostasis, prevention of cancer, and immunopotentiation, health food and anti-fouling paint products against barnacles; the DNA; the protein; and a method for screening a substance with antibiotic and weeding activities comprising screening a substance inhibiting enzymatic reaction on the non-mevalonate pathway.
摘要翻译：本发明提供了使用含有一种或多种编码DNA的蛋白质来生产类异戊二烯化合物或由DNA编码的蛋白质的方法，所述DNA编码蛋白质具有提高有效用于心脏疾病，骨质疏松症，体内平衡，预防的药物中类异戊二烯化合物的生物合成的效率的活性的癌症，免疫增强，保健食品和防腐漆产品针对藤壶; DNA; 蛋白质; 以及用抗生素和除草活性筛选物质的方法，其包括在非甲羟戊酸途径上筛选抑制酶反应的物质。

10. 发明授权

US09050020B2 Ultrasound diagnostic apparatus and image processing method 有权
标题翻译：超声诊断仪及图像处理方法
公开(公告)号：US09050020B2
公开(公告)日：2015-06-09
申请号：US13684722
申请日：2012-11-26
申请人： Yasuhiko Abe , Shinichi Hashimoto
发明人： Yasuhiko Abe , Shinichi Hashimoto
IPC分类号： A61B8/06 , A61B8/00 , A61B8/08
CPC分类号： A61B8/06 , A61B8/0883 , A61B8/461 , A61B8/463 , A61B8/488 , A61B8/5207 , A61B8/5223 , A61B8/5284
摘要： An ultrasound diagnostic apparatus according to an embodiment includes a detector, a determination unit, a retention controller, and a display controller. The detector is configured to detect a peak flow velocity of blood flow velocities acquired from Doppler waveforms collected in a time-serial manner or a peak value of average flow velocities of the blood flow velocities as a representative flow velocity for each predefined period. The determination unit is configured to determine a maximum value in a predefined polarity of a plurality of representative flow velocities. The retention controller is configured to control a memory unit to retain maximum waveform information that is Doppler waveform information of Doppler waveforms collected for a period in which the maximum value was detected. The display controller is configured to control a display unit to display the maximum waveform information with Doppler waveform information having been collected by a present time point.
摘要翻译：根据实施例的超声波诊断装置包括检测器，确定单元，保持控制器和显示控制器。检测器被配置为检测以时间序列方式收集的多普勒波形获取的血流速度的峰值流速或作为每个预定周期的代表性流速的血流速度的平均流速的峰值。确定单元被配置为以多个代表性流速的预定极性来确定最大值。保持控制器被配置为控制存储器单元以保留最大波形信息，其是在检测到最大值的时段中收集的多普勒波形的多普勒波形信息。显示控制器被配置为控制显示单元以当前时间点收集的多普勒波形信息显示最大波形信息。

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