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1. 再颁专利

USRE31550E N-(2-Chloro-4-pyridyl) ureas 失效
标题翻译： N-（2-氯-4-吡啶基）脲
公开(公告)号：USRE31550E
公开(公告)日：1984-04-10
申请号：US305768
申请日：1981-09-25
申请人： Koichi Shudo , Toshihiko Okamoto , Yo Isogai , Soshiro Takahashi
发明人： Koichi Shudo , Toshihiko Okamoto , Yo Isogai , Soshiro Takahashi
IPC分类号： A01N47/36 , C07D213/75
CPC分类号： C07D213/75 , A01N47/36
摘要： N-(2-Chloro-4-pyridyl)ureas represented by the formula (I): ##STR1## wherein R.sub.1 represents hydrogen or alkyl, R.sub.2 represents an aromatic group, especially phenyl, which may be substituted by alkyl, alkoxyl, hydroxyl or halogen, and X is oxygen or sulfur, and acid addition salts thereof, useful as plant growth regulators, are disclosed. Method of making and using same and agricultural compositions thereof are also disclosed.

2. 发明授权

US4308054A N-(2,6-Disubstituted-4-pyridyl)-N'-phenylureas 失效
标题翻译： N-（2,6-二取代-4-吡啶基）-N'-苯基脲
公开(公告)号：US4308054A
公开(公告)日：1981-12-29
申请号：US200352
申请日：1980-10-24
申请人： Yo Isogai , Soshiro Takahashi , Koichi Shudo , Toshihiko Okamoto
发明人： Yo Isogai , Soshiro Takahashi , Koichi Shudo , Toshihiko Okamoto
IPC分类号： A01N47/36 , C07D213/75 , A01N47/30
CPC分类号： C07D213/75 , A01N47/36
摘要： N-(2,6-disubstituted 4-pyridyl)-N'-phenylurea compounds are plant growth regulators having potent cytokinin activity. N-(2,6-dichloro-4-pyridyl)-N'-phenylurea is useful for regulating plant growth.
摘要翻译： N-（2,6-二取代的4-吡啶基）-N'-苯脲化合物是具有强的细胞分裂素活性的植物生长调节剂。 N-（2,6-二氯-4-吡啶基）-N'-苯基脲可用于调节植物生长。

3. 发明授权

US4193788A N-(2-Chloro-4-pyridyl)ureas 失效
标题翻译： N-（2-氯-4-吡啶基）脲
公开(公告)号：US4193788A
公开(公告)日：1980-03-18
申请号：US947468
申请日：1978-10-02
申请人： Koichi Shudo , Toshihiko Okamoto , Yo Isogai , Soshiro Takahashi
发明人： Koichi Shudo , Toshihiko Okamoto , Yo Isogai , Soshiro Takahashi
IPC分类号： A01N47/36 , C07D213/75 , A01N9/22 , C07D213/46 , C07D213/52 , C07D401/12
CPC分类号： C07D213/75 , A01N47/36
摘要： N-(2-Chloro-4-pyridyl)ureas represented by the formula (I): ##STR1## wherein R.sub.1 represents hydrogen or alkyl, R.sub.2 represents an aromatic group, especially phenyl, which may be substituted by alkyl, alkoxyl, hydroxyl or halogen, and X is oxygen or sulfur, and acid addition salts thereof, useful as plant growth regulators, are disclosed. Method of making and using same and agricultural compositions thereof are also disclosed.
摘要翻译：由式（I）表示的N-（2-氯-4-吡啶基）脲：其中R 1表示氢或烷基，R 2表示芳基，特别是可被烷基取代的苯基，烷氧基，羟基或卤素，X是氧或硫，及其酸加成盐，可用作植物生长调节剂。还公开了制备和使用它们的方法及其农业组合物。

4. 发明授权

US4397678A Plant growth regulators 失效
标题翻译：植物生长调节剂
公开(公告)号：US4397678A
公开(公告)日：1983-08-09
申请号：US343090
申请日：1982-01-27
申请人： Toshihiko Okamoto , Yo Isogai , Koichi Shudo , Soshiro Takahashi
发明人： Toshihiko Okamoto , Yo Isogai , Koichi Shudo , Soshiro Takahashi
IPC分类号： A01N47/36 , C07D237/20 , C07D237/22 , C07D237/24 , A01N43/58
CPC分类号： A01N47/36 , C07D237/20
摘要： Plant growth regulators of the N-(4-pyridazinyl)urea and thiourea type are disclosed which exhibit excellent cytokinin-like activities and are useful for regulating plant growth in various manners, such as acceleration and suppression.
摘要翻译：公开了N-（4-哒嗪基）脲和硫脲类的植物生长调节剂，其表现出优异的细胞分裂素样活性，并且可用于以各种方式调节植物生长，例如加速和抑制。

5. 发明授权

US4279639A N-(2-Substituted-4-pyridyl)ureas and thioureas as well as plant growth regulators containing same, and method for using compounds as plant growth regulators 失效
标题翻译： N-（2-取代-4-吡啶基）脲和硫脲以及含有它们的植物生长调节剂以及使用化合物作为植物生长调节剂的方法
公开(公告)号：US4279639A
公开(公告)日：1981-07-21
申请号：US62850
申请日：1979-08-01
申请人： Toshihiko Okamoto , Yo Isogai , Koichi Shudo , Soshiro Takahashi
发明人： Toshihiko Okamoto , Yo Isogai , Koichi Shudo , Soshiro Takahashi
IPC分类号： A01N47/36 , A01N57/00 , C07D213/75 , C07D213/79 , C07D213/84 , A01N43/40
CPC分类号： C07D213/75 , A01N47/36 , C07D213/79
摘要： Plant growth and suppression regulators of the N-(2-substituted-4-pyridyl)urea and thiourea type are provided, which exhibit excellent cytokinin-like activities and are thus useful for regulating plant growth in various fashions, such as acceleration of growth when used in flowering or fruiting at a controlled time when used in small amounts, and controlling compositions such as sugar, alkaloids, etc. of plants, or suppression of plant growth when used in an amount higher than optimal for growth acceleration, etc.
摘要翻译：提供N-（2-取代-4-吡啶基）脲和硫脲类的植物生长和抑制调节剂，其表现出优异的细胞分裂素样活性，因此可用于调节各种时尚中的植物生长，例如加速生长用于少量使用的控制时间的开花或果实，并且控制植物的组合物，例如植物的糖，生物碱等，或当以高于生长加速的最佳量的量使用时抑制植物生长。

6. 发明授权

US4331807A Pyridazine urea plant growth regulators 失效
标题翻译：哒嗪脲植物生长调节剂
公开(公告)号：US4331807A
公开(公告)日：1982-05-25
申请号：US154664
申请日：1980-05-30
申请人： Toshihiko Okamoto , Yo Isogai , Koichi Shudo , Soshiro Takahashi
发明人： Toshihiko Okamoto , Yo Isogai , Koichi Shudo , Soshiro Takahashi
IPC分类号： A01N47/36 , C07D237/20 , C07D237/22 , C07D237/24
CPC分类号： A01N47/36 , C07D237/20
摘要： Plant growth regulators of the N-(4-pyridazinyl)urea and thiourea type are disclosed which exhibit excellent cytokinin-like activities and are useful for regulating plant growth in various manners, such as acceleration and suppression.
摘要翻译：公开了N-（4-哒嗪基）脲和硫脲类的植物生长调节剂，其表现出优异的细胞分裂素样活性，并且可用于以各种方式调节植物生长，例如加速和抑制。

7. 发明授权

US08785625B2 Compound having heterocyclic ring 失效
标题翻译：具有杂环的化合物
公开(公告)号：US08785625B2
公开(公告)日：2014-07-22
申请号：US13372848
申请日：2012-02-14
申请人： Hideyuki Suzuki , Shoji Hizatate , Iwao Utsunomiya , Koichi Shudo
发明人： Hideyuki Suzuki , Shoji Hizatate , Iwao Utsunomiya , Koichi Shudo
IPC分类号： C07D255/02 , C07D273/06
CPC分类号： C07D273/06 , C07D255/02 , C07D413/10 , C07D413/14 , C07D417/14 , C07D471/14 , Y02P20/55
摘要： The invention provides a novel oxazolidinone derivative represented by the formula (I): wherein Ring A, X1, Ring B and R1 are as described in the description, and an antibacterial agent containing the same.
摘要翻译：本发明提供由式（I）表示的新型恶唑烷酮衍生物：其中环A，X1，环B和R1如说明书所述，以及含有该恶唑烷酮衍生物的抗菌剂。

8. 发明授权

US08431613B2 Memory fixation accelerator 有权
标题翻译：记忆固定加速器
公开(公告)号：US08431613B2
公开(公告)日：2013-04-30
申请号：US13459959
申请日：2012-04-30
申请人： Koichi Shudo , Hiroyuki Kagechika
发明人： Koichi Shudo , Hiroyuki Kagechika
IPC分类号： A01N37/00 , A01N55/00 , A61K31/185 , A61K31/695
CPC分类号： A61K31/192 , A61K31/695
摘要： A medicament for promoting memory consolidation, which comprises, as an active ingredient, a non-natural retinoid, preferably a retinoid having a basic skeleton comprising an aromatic ring bound with an aromatic carboxylic acid or tropolone by means of a bridging group, more preferably 4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbamoyl]benzoic acid or 4-[(3,5-bis-trimethylsilylphenyl)-carboxamido]benzoic acid.
摘要翻译：一种用于促进记忆巩固的药物，其包含作为活性成分的非天然类视黄醇，优选具有基本骨架的类视黄醇，所述基本骨架包含通过桥连基团与芳族羧酸或托洛替林结合的芳环，更优选4 - [（5,6,7,8-四氢-5,5,8,8-四甲基-2-萘基）氨基甲酰基]苯甲酸或4 - [（3,5-双三甲基甲硅烷基苯基） - 甲酰胺基]苯甲酸。

9. 发明授权

US08148362B2 Compound having heterocyclic ring 失效
标题翻译：具有杂环的化合物
公开(公告)号：US08148362B2
公开(公告)日：2012-04-03
申请号：US12225819
申请日：2007-03-30
申请人： Hideyuki Suzuki , Shoji Hizatate , Iwao Utsunomiya , Koichi Shudo
发明人： Hideyuki Suzuki , Shoji Hizatate , Iwao Utsunomiya , Koichi Shudo
IPC分类号： A61K31/00 , C07D255/00
CPC分类号： C07D273/06 , C07D255/02 , C07D413/10 , C07D413/14 , C07D417/14 , C07D471/14 , Y02P20/55
摘要： The invention provides a novel oxazolidinone derivative represented by the formula (I): wherein Ring A is optionally substituted or fused and represents (A-1) at least 7-membered monocyclic hetero ring containing at least three N atoms; (A-2) at least 6-membered monocyclic hetero ring containing at least two N atoms and at least one O atom; or (A-3) at least 7-membered monocyclic hetero ring containing at least two N atoms and at least one S atom; X1 is a single bond, —O—, —S—, —NR2—, —CO—, —CS—, —CONR3—, —NR4CO—, —SO2NR5—, and —NR6SO2— (wherein R2-R6 are independently hydrogen or lower alkyl), or lower alkylene or lower alkenylene in which one of the preceding groups may intervene; Ring B is optionally substituted carbocycle or optionally substituted heterocycle; R1 is hydrogen, or an organic residue which is able to bind to the 5-position of oxazolidinone ring in oxazolidinone antimicrobial agent, and an antibacterial agent containing the same.
摘要翻译：本发明提供由式（I）表示的新型恶唑烷酮衍生物：其中环A任选被取代或稠合并且代表（A-1）含有至少三个N原子的至少七元单环杂环; （A-2）至少含有至少两个N原子和至少一个O原子的6元单环杂环; 或（A-3）至少含有至少两个N原子和至少一个S原子的7元单环杂环; X 1是单键，-O - ， - S - ， - NR 2 - ， - CO - ， - C - ， - CONR 3 - ， - NR 4 CO-，-SO 2 NR 5 - 和-NR 6 SO 2 - 或低级烷基）或其中一个前述基团可以介入的低级亚烷基或低级亚烯基; 环B是任选取代的碳环或任选取代的杂环; R1是氢，或能够与恶唑烷酮抗微生物剂中的恶唑烷酮环的5位结合的有机残基，以及含有该残基的抗菌剂。

10. 发明授权

US08143260B2 Tricyclic amine compound 失效
标题翻译：三环胺化合物
公开(公告)号：US08143260B2
公开(公告)日：2012-03-27
申请号：US12673221
申请日：2008-08-14
申请人： Yohei Amano , Masayuki Noguchi , Koichi Shudo
发明人： Yohei Amano , Masayuki Noguchi , Koichi Shudo
IPC分类号： A01N43/54 , C07D239/42 , C07D401/04
CPC分类号： C07C229/60 , C07C2601/02 , C07C2603/28 , C07C2603/34 , C07D239/42
摘要： A compound represented by the following general formula (I): [wherein R1 represents hydrogen atom or a C1-6 alkyl group, A and B represent —(CH2)2—, —(CH2)3— or —(CH2)4—, X represents —N(R2)— (R2 represents hydrogen atom or a C1-6 alkyl group), —CO—, —C(═N—R3)— (R3 represents hydrogen atom or a C1-6 alkyl group), or —C(═C(R4)(R5))— (R4 and R5 independently represent hydrogen atom or a C1-6 alkyl group), and Ar represents an aryldiyl group or a heteroaryldiyl group], which has an action of controlling physiological activities of retinoids and useful as an active ingredient of a medicament.
摘要翻译：由下列通式（I）表示的化合物：[其中R1表示氢原子或C1-6烷基，A和B表示 - （CH2）2-， - （CH2）3-或 - （CH2）4- ，X表示-N（R 2） - （R 2表示氢原子或C 1-6烷基），-CO-，-C（= N-R 3） - （R 3表示氢原子或C 1-6烷基）或-C（= C（R4）（R5）） - （R4和R5独立地表示氢原子或C1-6烷基），Ar表示芳基二基或杂芳基二基]，其具有控制生理类维生素A的活性并且可用作药物的活性成分。

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