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1. 发明申请

US20100004203A1 MEDICAMENT FOR PREVENTIVE AND/OR THERAPEUTIC TREATMENT OF BOWEL DISEASE 失效
标题翻译：用于预防和/或治疗BOWEL疾病的药物
公开(公告)号：US20100004203A1
公开(公告)日：2010-01-07
申请号：US12559268
申请日：2009-09-14
申请人： Koichi SHUDO , Hiroyuki KAGECHIKA , Hiroshi FUKASAWA , Tetsuro MATSUISHI , Naoko KATSUMURA , Miwako ISHIDO
发明人： Koichi SHUDO , Hiroyuki KAGECHIKA , Hiroshi FUKASAWA , Tetsuro MATSUISHI , Naoko KATSUMURA , Miwako ISHIDO
IPC分类号： A61K31/695 , A61K31/195 , A61P1/00
CPC分类号： A61K31/192
摘要： A medicament for preventive and/or therapeutic treatment of a bowel diseases such as inflammatory bowel diseases including Crohn's disease, which comprises as an active ingredient a retinoid such as, for example, 4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbamoyl]benzoic acid.
摘要翻译：一种用于预防和/或治疗诸如包括克罗恩病在内的肠疾病的肠疾病的药物，其包含类视黄醇作为活性成分，例如4 - [（5,6,7,8-四氢 - 5,5,8,8-四甲基-2-萘基）氨基甲酰基]苯甲酸。

2. 发明申请

US20100324134A1 MEDICAMENT FOR PREVENTIVE AND/OR THERAPEUTIC TREATMENT OF BOWEL DISEASE 失效
公开(公告)号：US20100324134A1
公开(公告)日：2010-12-23
申请号：US12872171
申请日：2010-08-31
申请人： Koichi SHUDO , Hiroyuki KAGECHIKA , Hiroshi FUKASAWA , Tetsuro MATSUISHI , Naoko KATSUMURA , Miwako ISHIDO
发明人： Koichi SHUDO , Hiroyuki KAGECHIKA , Hiroshi FUKASAWA , Tetsuro MATSUISHI , Naoko KATSUMURA , Miwako ISHIDO
IPC分类号： A61K31/27 , A61P1/00
CPC分类号： A61K31/192
摘要： A medicament for preventive and/or therapeutic treatment of a bowel diseases such as inflammatory bowel diseases including Crohn's disease, which comprises as an active ingredient a retinoid such as, for example, 4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbamoyl]benzoic acid.

3. 发明申请

US20080139842A1 Medicament for preventive and/or therapeutic treatment of diseases with secretory disorder 审中-公开
标题翻译：用于预防和/或治疗分泌性疾病疾病的药物
公开(公告)号：US20080139842A1
公开(公告)日：2008-06-12
申请号：US11854697
申请日：2007-09-13
申请人： Koichi SHUDO , Tetsuro MATSUISHI , Miwako ISHIDO
发明人： Koichi SHUDO , Tetsuro MATSUISHI , Miwako ISHIDO
IPC分类号： C07C229/00
CPC分类号： A61K31/192
摘要： A medicament for preventive and/or therapeutic treatment of a secretory dysfunctional disease associated with lymphocyte infiltration into a gland such as type I diabetes or Sjogren's syndrome, which comprises as an active ingredient a retinoid such as, for example, 4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbamoyl]benzoic acid.
摘要翻译：用于预防和/或治疗与淋巴细胞浸润相关的分泌功能障碍性疾病的药物，所述分泌功能障碍性疾病包括作为活性成分的类视黄醇例如4 - [（5， 6,7,8-四氢-5,5,8,8-四甲基-2-萘基）氨基甲酰基]苯甲酸。

4. 发明申请

US20080207768A1 MEDICAMENT FOR PREVENTIVE AND/OR THERAPEUTIC TREATMENT OF LOWER URINARY TRACT SYMPTOM 失效
标题翻译：用于预防和/或治疗下尿路症状的药物
公开(公告)号：US20080207768A1
公开(公告)日：2008-08-28
申请号：US11693082
申请日：2007-03-29
申请人： Koichi SHUDO , Tetsuji ASAO , Miwako ISHIDO
发明人： Koichi SHUDO , Tetsuji ASAO , Miwako ISHIDO
IPC分类号： A61K31/07 , A61P13/02
CPC分类号： A61K31/07 , A61K31/203
摘要： A medicament for preventive and/or therapeutic treatment of a lower urinary tract symptom caused by a lower urinary tract disorder, which comprises as an active ingredient a retinoid such as, for example, 4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbamoyl]benzoic acid
摘要翻译：一种用于预防和/或治疗由下泌尿道疾病引起的下尿路症状的药物，其包含类视黄醇作为活性成分，例如4 - [（5,6,7,8-四氢 -5,5,8,8-四甲基-2-萘基）氨基甲酰基]苯甲酸

5. 发明申请

US20120214763A1 MEMORY FIXATION ACCELERATOR 有权
标题翻译：存储器固定加速器
公开(公告)号：US20120214763A1
公开(公告)日：2012-08-23
申请号：US13459959
申请日：2012-04-30
申请人： Koichi SHUDO , Hiroyuki KAGECHIKA
发明人： Koichi SHUDO , Hiroyuki KAGECHIKA
IPC分类号： A61K31/695 , A61P25/28
CPC分类号： A61K31/192 , A61K31/695
摘要： A medicament for promoting memory consolidation, which comprises, as an active ingredient, a non-natural retinoid, preferably a retinoid having a basic skeleton comprising an aromatic ring bound with an aromatic carboxylic acid or tropolone by means of a bridging group, more preferably 4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbamoyl]benzoic acid or 4-[(3,5-bis-trimethylsilylphenyl)-carboxamido]benzoic acid.
摘要翻译：一种用于促进记忆巩固的药物，其包含作为活性成分的非天然类视黄醇，优选具有基本骨架的类视黄醇，所述基本骨架包含通过桥连基团与芳族羧酸或托洛替林结合的芳环，更优选4 - [（5,6,7,8-四氢-5,5,8,8-四甲基-2-萘基）氨基甲酰基]苯甲酸或4 - [（3,5-双三甲基甲硅烷基苯基） - 甲酰胺基]苯甲酸。

6. 发明申请

US20090291492A1 METHOD FOR FORMING ORGAN 失效
标题翻译：形成有机体的方法
公开(公告)号：US20090291492A1
公开(公告)日：2009-11-26
申请号：US12535576
申请日：2009-08-04
申请人： Makoto ASASHIMA , Tatsuo HAMAZAKI , Hiroyuki KAGECHIKA , Koichi SHUDO
发明人： Makoto ASASHIMA , Tatsuo HAMAZAKI , Hiroyuki KAGECHIKA , Koichi SHUDO
IPC分类号： C12N5/06
CPC分类号： C12N5/0062 , C12N2501/385 , C12N2501/999 , C12N2506/00
摘要： A method for forming an organ and/or tissue from undifferentiated cells derived from a vertebrate animal in vitro, which comprises the step of culturing the undifferentiated cells derived from a vertebrate animal in the presence of a retinoic acid X receptor ligand (e.g., a retinoic acid X receptor agonist or antagonist), and a method for forming a pancreas from undifferentiated cells derived from a vertebrate animal in vitro or a method for forming a tissue having morphology and function of a pancreas from undifferentiated cells derived from a vertebrate in vitro, which comprises the step of culturing the undifferentiated cells derived from a vertebrate animal in the presence of a retinoic acid receptor ligand, together with activin, that does not substantially bind to the retinoic acid receptor subtype γ.
摘要翻译：一种用于从体外衍生自脊椎动物的未分化细胞形成器官和/或组织的方法，其包括在视黄酸X受体配体（例如视黄酸）存在下培养源自脊椎动物的未分化细胞的步骤酸X受体激动剂或拮抗剂）以及从体外衍生自脊椎动物的未分化细胞形成胰腺的方法或用于从体外衍生自脊椎动物的未分化细胞形成具有胰腺形态和功能的组织的方法，其中包括在视黄酸受体配体存在下培养来源于脊椎动物的未分化细胞以及基本上不与维甲酸受体亚型γ结合的激活素的步骤。

7. 发明申请

US20120208997A1 NOVEL COMPOUND HAVING HETEROCYCLIC RING 失效
标题翻译：具有杂环的新型化合物
公开(公告)号：US20120208997A1
公开(公告)日：2012-08-16
申请号：US13372848
申请日：2012-02-14
申请人： Hideyuki SUZUKI , Shoji HIZATATE , Iwao UTSUNOMIYA , Koichi SHUDO
发明人： Hideyuki SUZUKI , Shoji HIZATATE , Iwao UTSUNOMIYA , Koichi SHUDO
IPC分类号： C07D413/10 , C07D413/14 , C07D401/10 , C07D471/14 , C07D487/14 , C07D471/04 , C07D417/14 , C07D487/04
CPC分类号： C07D273/06 , C07D255/02 , C07D413/10 , C07D413/14 , C07D417/14 , C07D471/14 , Y02P20/55
摘要： The invention provides a novel oxazolidinone derivative represented by the formula (I): wherein Ring A, X1, Ring B and R1 are as described in the description, and an antibacterial agent containing the same.
摘要翻译：本发明提供由式（I）表示的新型恶唑烷酮衍生物：其中环A，X1，环B和R1如说明书所述，以及含有该恶唑烷酮衍生物的抗菌剂。

8. 发明申请

US20090118303A1 SEROTONIN 5-HT3 RECEPTOR AGONIST 审中-公开
标题翻译： SEROTONIN 5-HT3受体激动剂
公开(公告)号：US20090118303A1
公开(公告)日：2009-05-07
申请号：US12345417
申请日：2008-12-29
申请人： Tamaki JIKYO , Koichi SHUDO
发明人： Tamaki JIKYO , Koichi SHUDO
IPC分类号： A61K31/495 , C07D295/195 , A61P35/00
CPC分类号： C07D295/215 , A61K31/395 , A61K31/495 , A61K31/551 , C07D243/08
摘要： A serotonin 5-HT3 receptor agonist containing a compound represented by the general formula (1) [R1, R3 and R5 represent hydrogen atom, a lower alkyl group, a lower alkenyl group, a halogen atom, hydroxyl group, amino group, a lower alkoxy group, carboxyl group, carbamoyl group, or nitro group, R2 and R4 represent a halogen atom, hydroxyl group, or amino group, R6 represents hydrogen atom, a lower alkyl group, or a lower alkenyl group, R7 represents hydrogen atom, a lower alkyl group, a lower alkenyl group, or an aralkyl group, and m and n are integers of 1 to 3] or a physiologically acceptable salt thereof as an active ingredient and having both a serotonin 5-HT3 receptor antagonistic action and a serotonin 5-HT3 receptor activating action.
摘要翻译：含有通式（1）表示的化合物的5-羟色胺5-HT 3受体激动剂[R1，R3和R5表示氢原子，低级烷基，低级烯基，卤素原子，羟基，氨基，低级烷氧基，羧基，氨基甲酰基或硝基，R2和R4表示卤素原子，羟基或氨基，R6表示氢原子，低级烷基或低级烯基，R7表示氢原子，低级烷基，低级烯基或芳烷基，m和n为1〜3的整数]或其生理学上可接受的盐作为有效成分，同时具有5-羟色胺5-HT 3受体拮抗作用和5-羟色胺5 -HT3受体激活作用。

9. 发明申请

US20080153781A1 ANTI-WRINKLE AGENT 有权
标题翻译：防皱剂
公开(公告)号：US20080153781A1
公开(公告)日：2008-06-26
申请号：US12040374
申请日：2008-02-29
申请人： Koichi SHUDO , Seishiro FUJII
发明人： Koichi SHUDO , Seishiro FUJII
IPC分类号： A61K31/695 , A61K31/195 , A61P17/00
CPC分类号： A61K31/196 , A61K31/195 , A61K31/695
摘要： A medicament having an anti-wrinkle action, which comprises as an active ingredient a retinoid having a fundamental structure of a phenyl substituted carbamoyl benzoic acid or a phenyl substituted carboxamide benzoic acid (for example, 4-(2,4-bistrimethylsilylphenylcarboxamide) benzoic acid, 4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl) carbamoyl] benzoic acid, or the like).
摘要翻译：具有抗皱作用的药物，其包含作为活性成分的具有苯基取代的氨基甲酰基苯甲酸或苯基取代的甲酰胺苯甲酸的基本结构的类视黄醇（例如，4-（2,4-双三甲基甲硅烷基苯基甲酰胺）苯甲酸，4 - [（5,6,7,8-四氢-5,5,8,8-四甲基-2-萘基）氨基甲酰基]苯甲酸等）。

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