专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20110237462A1 IMMOBILIZATION SUBSTRATE AND METHOD FOR PRODUCING THE SAME 审中-公开
标题翻译：固定基材及其制造方法
公开(公告)号：US20110237462A1
公开(公告)日：2011-09-29
申请号：US13132834
申请日：2009-12-04
申请人： Koichi Minami , Hirohiko Tsuzuki , Hiroshi Ueda , Masaki Ihara
发明人： Koichi Minami , Hirohiko Tsuzuki , Hiroshi Ueda , Masaki Ihara
IPC分类号： C40B40/10 , C40B50/14
CPC分类号： G01N33/54353
摘要： An antibody-fragment-immobilizing substrate includes a substrate and at least one set of antibody fragments, wherein antibody fragments of each set include at least two types of separate antibody fragments, the at least two types of separate antibody fragments include at least one type of labeled antibody fragment having a labeled site labeled with a luminescent substance and at least one type of acceptor antibody fragment having an acceptor site for accepting emission from the labeled antibody fragment, and the at least one type of labeled antibody fragment and the at least one type of acceptor antibody fragment are capable of cooperatively recognizing one type of antigen in combination and are independently immobilized on the substrate in a positional relationship that allows each of the antibody fragments in one set to bind to the same antigen.
摘要翻译：抗体片段固定的底物包括底物和至少一组抗体片段，其中每组的抗体片段包括至少两种类型的分离的抗体片段，所述至少两种类型的分离的抗体片段包括至少一种类型的具有用发光物质标记的标记位点的标记抗体片段和至少一种具有用于接受来自标记抗体片段的发射的受体位点的受体抗体片段，以及至少一种类型的标记抗体片段和至少一种类型的受体抗体片段能够组合地协同识别一种类型的抗原，并以允许一组中的每个抗体片段结合相同抗原的位置关系独立地固定在底物上。

2. 发明授权

US09487592B2 Immobilization substrate and method for producing the same 有权
标题翻译：固定基质及其制备方法
公开(公告)号：US09487592B2
公开(公告)日：2016-11-08
申请号：US13125478
申请日：2009-10-23
申请人： Koichi Minami , Hirohiko Tsuzuki , Hiroshi Ueda , Masaki Ihara
发明人： Koichi Minami , Hirohiko Tsuzuki , Hiroshi Ueda , Masaki Ihara
IPC分类号： C07K16/18 , C07K16/40
CPC分类号： C07K16/40 , C07K16/18 , C07K2317/56 , Y10T428/269
摘要： An antibody-fragment-immobilizing substrate includes a substrate and at least one set of antibody fragments, wherein the antibody fragments of each set includes at least two types of separate antibody fragments that are capable of recognizing one type of antigen and that are independently immobilized on the substrate in a positional relationship that allows each of the antibody fragments in one set to bind to the same antigen.
摘要翻译：抗体片段固定底物包括底物和至少一组抗体片段，其中每组的抗体片段包含能够识别一种类型的抗原并且独立地固定在其上的至少两种类型的分离的抗体片段位置关系的底物允许一组中的每个抗体片段与相同的抗原结合。

3. 发明申请

US20110236679A1 IMMOBILIZATION SUBSTRATE AND METHOD FOR PRODUCING THE SAME 有权
标题翻译：固定基材及其制造方法
公开(公告)号：US20110236679A1
公开(公告)日：2011-09-29
申请号：US13125478
申请日：2009-10-23
申请人： Koichi Minami , Hirohiko Tsuzuki , Hiroshi Ueda , Masaki Ihara
发明人： Koichi Minami , Hirohiko Tsuzuki , Hiroshi Ueda , Masaki Ihara
IPC分类号： B32B27/00 , C07K16/00 , C08F301/00
CPC分类号： C07K16/40 , C07K16/18 , C07K2317/56 , Y10T428/269
摘要： An antibody-fragment-immobilizing substrate includes a substrate and at least one set of antibody fragments, wherein the antibody fragments of each set includes at least two types of separate antibody fragments that are capable of recognizing one type of antigen and that are independently immobilized on the substrate in a positional relationship that allows each of the antibody fragments in one set to bind to the same antigen.
摘要翻译：抗体片段固定底物包括底物和至少一组抗体片段，其中每组的抗体片段包含能够识别一种类型的抗原并且独立地固定在其上的至少两种类型的分离的抗体片段位置关系的底物允许一组中的每个抗体片段与相同的抗原结合。

4. 发明授权

US08236575B2 Carrier for analysis of an analyte and process for producing the same 有权
标题翻译：用于分析分析物的载体和用于制备分析物的方法
公开(公告)号：US08236575B2
公开(公告)日：2012-08-07
申请号：US12744311
申请日：2008-11-21
申请人： Koichi Minami , Hirohiko Tsuzuki
发明人： Koichi Minami , Hirohiko Tsuzuki
IPC分类号： G01N33/543
CPC分类号： G01N33/542 , G01N21/6428
摘要： A first reactant, which is provided with a reaction site for specific binding with an analyte, and a fluorescent label site, and a second reactant, which is provided with a reaction site for specific binding with the analyte, and a fluorescence recognition site for recognizing fluorescence produced by the fluorescent label site of the first reactant, are respectively fixed onto a support such that the first reactant and the second reactant have a positional relationship adapted for the binding with the analyte.
摘要翻译：提供有用于与分析物特异性结合的反应位点的第一反应物和荧光标记位点，以及第二反应物，其具有用于与分析物特异性结合的反应位点和用于识别的荧光识别位点由第一反应物的荧光标记位点产生的荧光分别固定在载体上，使得第一反应物和第二反应物具有适于与分析物结合的位置关系。

5. 发明申请

US20100290954A1 CARRIER FOR ANALYSIS OF AN ANALYTE AND PROCESS FOR PRODUCING THE SAME 有权
标题翻译：分析仪的分析仪器及其生产方法
公开(公告)号：US20100290954A1
公开(公告)日：2010-11-18
申请号：US12744311
申请日：2008-11-21
申请人： Koichi Minami , Hirohiko Tsuzuki
发明人： Koichi Minami , Hirohiko Tsuzuki
IPC分类号： G01N21/64 , G01N33/543
CPC分类号： G01N33/542 , G01N21/6428
摘要： A first reactant, which is provided with a reaction site for specific binding with an analyte, and a fluorescent label site, and a second reactant, which is provided with a reaction site for specific binding with the analyte, and a fluorescence recognition site for recognizing fluorescence produced by the fluorescent label site of the first reactant, are respectively fixed onto a support such that the first reactant and the second reactant have a positional relationship adapted for the binding with the analyte.
摘要翻译：提供有用于与分析物特异性结合的反应位点的第一反应物和荧光标记位点，以及第二反应物，其具有用于与分析物特异性结合的反应位点和用于识别的荧光识别位点由第一反应物的荧光标记位点产生的荧光分别固定在载体上，使得第一反应物和第二反应物具有适于与分析物结合的位置关系。

6. 发明授权

US08137733B2 Process for producing a carrier 有权
标题翻译：制造载体的方法
公开(公告)号：US08137733B2
公开(公告)日：2012-03-20
申请号：US12276004
申请日：2008-11-21
申请人： Koichi Minami , Hirohiko Tsuzuki
发明人： Koichi Minami , Hirohiko Tsuzuki
IPC分类号： G01N1/31
CPC分类号： C07K17/00 , G01N21/553
摘要： A complex, which has been formed by at least two pieces of a ligand and a first metal ion, is bound with a carrier. A second metal ion is then added onto the carrier, a new complex being thereby formed. A substance that contains a Group-15 or Group-16 atom, which has metal coordinating capability, is then fixed to the first metal ion and the second metal ion.
摘要翻译：由至少两个配体和第一金属离子形成的络合物与载体结合。然后将第二金属离子加入到载体上，从而形成新的络合物。含有具有金属配位能力的第15族或第16族原子的物质然后固定在第一金属离子和第二金属离子上。

7. 发明申请

US20090042745A1 BIOSENSOR CHIP 审中-公开
标题翻译：生物传感器芯片
公开(公告)号：US20090042745A1
公开(公告)日：2009-02-12
申请号：US12188508
申请日：2008-08-08
申请人： Koichi MINAMI , Yohsuke Takeuchi , Hirohiko Tsuzuki
发明人： Koichi MINAMI , Yohsuke Takeuchi , Hirohiko Tsuzuki
IPC分类号： C40B60/12
CPC分类号： G01N33/54353 , G01N33/54393 , G01N33/553 , G01N2610/00
摘要： A biosensor chip is constituted by: a substrate; a metal film which is physically attached to the substrate; and a self assembled monolayer constituted by alkyl chains, which is physically attached to the metal film. Ligands and at least one functional group, selected from a group consisting of a hydroxyl group, a carboxyl group, an alkoxy group, a methyl group, and hydrogen atoms are physically attached to the self assembled monolayer. The ratio between the total number of alkyl chains physically attached to the metal film and the number of alkyl chains which are covalently bonded with the ligands is within a range of 0.40 to 0.99.
摘要翻译：生物传感器芯片由以下部分构成：基板; 物理地附接到基底的金属膜; 以及由金属膜物理附着的烷基链构成的自组装单层。配体和选自羟基，羧基，烷氧基，甲基和氢原子的至少一个官能团物理连接到自组装单层。与金属膜物理连接的烷基链的总数与与配体共价键合的烷基链的数量之间的比例在0.40至0.99的范围内。

8. 发明授权

US07449343B2 Method for measuring surface plasmon resonance 有权
标题翻译：表面等离子体共振测量方法
公开(公告)号：US07449343B2
公开(公告)日：2008-11-11
申请号：US11218656
申请日：2005-09-06
申请人： Hirohiko Tsuzuki
发明人： Hirohiko Tsuzuki
IPC分类号： G01N33/558 , G01N33/553
CPC分类号： G01N33/54373 , Y10S436/805
摘要： It is an object of the present invention to provide a measurement method which can suppress noise when a specific binding reaction between a physiologically active substance and a test substance is measured using a surface plasmon resonance measurement device. The present invention provides a method for measuring a change in surface plasmon resonance which comprises: using a surface plasmon resonance measurement device comprising a metal film, a light source for generating a light beam, an optical system for allowing the above-described light beam to enter the interface of the metal film so that total reflection conditions can be obtained at the interface thereof and so that various incidence angles can be included, a flow channel system comprising a cell formed on the above-described metal film, and a light-detecting means for detecting the state of surface plasmon resonance by measuring the intensity of the light beam totally reflected at the above interface, and exchanging the liquid contained in the above flow channel system with another liquid, wherein the liquid in the above-described flow channel system is exchanged with another liquid obtained by eliminating insoluble matters from a measurement solvent, and the change in surface plasmon resonance is then measured in a state where the flow of the liquid has been stopped.
摘要翻译：本发明的目的是提供一种测量方法，当使用表面等离子体共振测量装置测量生理活性物质和测试物质之间的特异性结合反应时，可以抑制噪声。本发明提供了一种用于测量表面等离子体共振的变化的方法，包括：使用表面等离子体共振测量装置，其包括金属膜，用于产生光束的光源，用于允许上述光束进入金属膜的界面，使得能够在其界面获得全反射条件，并且可以包括各种入射角，包括形成在上述金属膜上的单元的流路系统和光检测用于通过测量在上述界面全反射的光束强度来检测表面等离子体共振的状态的装置，以及将上述流道系统中所含的液体与另一种液体进行交换，其中上述流道系统与通过从测量溶剂中除去不溶物质而获得的另一种液体以及表面质膜的变化进行交换然后在液体的流动停止的状态下测量单次共振。

9. 发明申请

US20060187460A1 Method for measuring the surface plasmon resonance 审中-公开
标题翻译：测量表面等离子体共振的方法
公开(公告)号：US20060187460A1
公开(公告)日：2006-08-24
申请号：US11354839
申请日：2006-02-16
申请人： Hirohiko Tsuzuki
发明人： Hirohiko Tsuzuki
IPC分类号： G01N21/55
CPC分类号： G01N21/553
摘要： It is an object of the present invention to provide a method for obtaining a chromatogram using the SPR analysis method. The present invention provides a method for measuring the change in the surface plasmon resonance by using a surface plasmon resonance measurement device which comprises a metal film, a light source for generating a light beam, an optical system for allowing such a light beam to enter the interface of the metal film so that total reflection conditions can be obtained at the interface thereof and so that various incidence angles can be included, a flow channel system comprising a cell formed on said metal film, and a light-detecting means for detecting the state of surface plasmon resonance by measuring the intensity of the light beam totally reflected at said interface, and exchanging a liquid contained in the flow channel system; wherein the measurement is carried out by supplying a liquid at a liquid amount such that the absolute amount of molecules adsorbed on the metal film surface is lower than the saturated adsorption amount of said molecules on said metal film surface.
摘要翻译：本发明的目的是提供使用SPR分析方法获得色谱图的方法。本发明提供了一种用于通过使用表面等离子体共振测量装置来测量表面等离子体共振的变化的方法，所述表面等离子体共振测量装置包括金属膜，用于产生光束的光源，用于允许这种光束进入使得能够在其界面处获得全反射条件，并且可以包括各种入射角，包括形成在所述金属膜上的单元的流路系统和用于检测状态的光检测装置通过测量在所述界面处全反射的光束的强度，并且更换包含在所述流道系统中的液体的表面等离子体共振; 其中所述测量是通过以液体量供给液体来进行的，以使吸附在所述金属膜表面上的分子的绝对量低于所述金属膜表面上的所述分子的饱和吸附量。

10. 发明授权

US06274301B1 Photothermographic recording elements 失效
标题翻译：光热记录元件
公开(公告)号：US06274301B1
公开(公告)日：2001-08-14
申请号：US09174011
申请日：1998-10-16
申请人： Hisashi Okamura , Hirohiko Tsuzuki , Itsuo Fujiwara , Yoshiharu Yabuki
发明人： Hisashi Okamura , Hirohiko Tsuzuki , Itsuo Fujiwara , Yoshiharu Yabuki
IPC分类号： G03C1498
CPC分类号： G03C1/49863 , G03C1/002 , G03C1/04 , G03C1/34 , G03C1/49845 , G03C2200/22 , G03C2200/36
摘要： A photothermographic recording element having improved image tone and improved tone stability during storage is provided wherein at least one of constituent layers comprises (a) polymeric microparticulates containing a dyestuff, (b) microcapsules containing a dyestuff, and/or (c) an organic or inorganic pigment.
摘要翻译：提供了具有改善的图像色调并且在存储期间具有改善的色调稳定性的光热记录元件，其中至少一个构成层包含（a）含有染料的聚合物微粒，（b）含有染料的微胶囊和/或（c）有机或无机颜料。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式