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1. 发明申请

US20110166203A1 ANTI-HEPATITIS C VIRUS COMPOSITION 失效
标题翻译：抗生素C病毒组合物
公开(公告)号：US20110166203A1
公开(公告)日：2011-07-07
申请号：US13060474
申请日：2009-08-28
申请人： Kohji Moriishi , Yoshiharu Matsuura
发明人： Kohji Moriishi , Yoshiharu Matsuura
IPC分类号： A61K31/7088 , C07H21/02
CPC分类号： A61K31/7088 , A61K31/7105 , A61K31/7115 , C12N15/1131 , C12N2310/14 , G01N33/5767 , G01N2500/04
摘要： The present invention provides an anti-hepatitis C virus composition that includes a substance that suppresses the expression or function of a PA28γ gene, a method for preventing hepatitis C viral infection or suppressing hepatitis C virus growth that includes the step of administering the composition to a subject, and a method for screening an effective component of an anti-hepatitis C virus composition that includes the step of selecting a substance that inhibits the expression or function of a PA28γ gene.
摘要翻译：本发明提供一种抗丙型肝炎病毒组合物，其包含抑制PA28γ基因的表达或功能的物质，预防丙型肝炎病毒感染或抑制丙型肝炎病毒生长的方法，其包括将组合物施用于受试者和筛选抗丙型肝炎病毒组合物的有效成分的方法，其包括选择抑制PA28γ基因的表达或功能的物质的步骤。

2. 发明授权

US08580759B2 Anti-hepatitis C virus composition 失效
标题翻译：抗丙型肝炎病毒组成
公开(公告)号：US08580759B2
公开(公告)日：2013-11-12
申请号：US13060474
申请日：2009-08-28
申请人： Kohji Moriishi , Yoshiharu Matsuura
发明人： Kohji Moriishi , Yoshiharu Matsuura
IPC分类号： C12N15/113 , C07H21/04
CPC分类号： A61K31/7088 , A61K31/7105 , A61K31/7115 , C12N15/1131 , C12N2310/14 , G01N33/5767 , G01N2500/04
摘要： The present invention provides an anti-hepatitis C virus composition that includes a substance that suppresses the expression or function of a PA28γ gene, a method for preventing hepatitis C viral infection or suppressing hepatitis C virus growth that includes the step of administering the composition to a subject, and a method for screening an effective component of an anti-hepatitis C virus composition that includes the step of selecting a substance that inhibits the expression or function of a PA28γ gene.
摘要翻译：本发明提供一种抗丙型肝炎病毒组合物，其包含抑制PA28γ基因的表达或功能的物质，预防丙型肝炎病毒感染或抑制丙型肝炎病毒生长的方法，其包括将组合物施用于受试者和筛选抗丙型肝炎病毒组合物的有效成分的方法，其包括选择抑制PA28γ基因表达或功能的物质的步骤。

3. 发明授权

US08080370B2 Screening method for prophylactic and/or therapeutic agent for disease accompanied by hepatitis C 有权
标题翻译：用于丙型肝炎伴随疾病的预防和/或治疗剂的筛选方法
公开(公告)号：US08080370B2
公开(公告)日：2011-12-20
申请号：US12311333
申请日：2007-09-25
申请人： Yoshiharu Matsuura , Kohji Moriishi
发明人： Yoshiharu Matsuura , Kohji Moriishi
IPC分类号： C12Q1/70 , C12Q1/18 , C12Q1/68
CPC分类号： G01N33/5767 , A61K31/7088 , A61K31/7105 , C07K14/005 , C12N2770/24222 , C12Q1/707 , G01N2333/18 , G01N2500/02
摘要： An easy and efficient screening method for an agent useful for prevention and/or treatment of hepatitis C virus-related disease, and a prophylactic and/or therapeutic agent for hepatitis C virus-related disease obtained by the method. The screening method comprises a step of examining the inhibitory activity of an test substance on the protein-protein interaction between hepatitis C virus core protein and PA28.gamma,. The method can be carried out by using transcriptional activity of a lipid metabolism-control factor as indicator. The test substance used in the method may have an activity to inhibit expression or function of the PA28.gamma. gene. The hepatitis C virus-related diseases include fatty liver, acute hepatitis, chronic hepatitis, liver cirrhosis, liver cancer, and insulin-resistant diseases. The method is extremely useful as a method of obtaining an agent superior in preventive and therapeutic activity particularly to diseases such as fatty liver and liver cancer.
摘要翻译：用于预防和/或治疗丙型肝炎病毒相关疾病的药剂的简便有效的筛选方法，以及通过该方法获得的用于丙型肝炎病毒相关疾病的预防和/或治疗剂。筛选方法包括检查测试物质对丙型肝炎病毒核心蛋白和PA28.gamma之间的蛋白质 - 蛋白质相互作用的抑制活性的步骤。该方法可以通过使用脂质代谢控制因子的转录活性作为指标进行。该方法中使用的测试物质可能具有抑制PA28.gamma表达或功能的活性。基因。丙型肝炎病毒相关疾病包括脂肪肝，急性肝炎，慢性肝炎，肝硬化，肝癌和胰岛素抵抗疾病。该方法作为获得预防和治疗活性优异的药物，特别是脂肪肝和肝癌等疾病的方法是非常有用的。

4. 发明申请

US20100297605A1 Screening method for prophylactic and/or therapeutic agent for disease accompanied by hepatitis c 有权
标题翻译：丙型肝炎病毒预防和/或治疗剂的筛选方法
公开(公告)号：US20100297605A1
公开(公告)日：2010-11-25
申请号：US12311333
申请日：2007-09-25
申请人： Yoshiharu Matsuura , Kohji Moriishi
发明人： Yoshiharu Matsuura , Kohji Moriishi
IPC分类号： C12Q1/70 , C07H21/04
CPC分类号： G01N33/5767 , A61K31/7088 , A61K31/7105 , C07K14/005 , C12N2770/24222 , C12Q1/707 , G01N2333/18 , G01N2500/02
摘要： Provided is a screening method being able to screen an agent useful for prevention and/or treatment of hepatitis C virus-related disease easily and efficiently and a prophylactic and/or therapeutic agent for hepatitis C virus-related disease obtained by the method.The screening method for a prophylactic and/or therapeutic agent for hepatitis C virus-related disease according to the present invention is characterized by comprising a a step of examining the inhibitory activity of an test substance on the protein-protein interaction between hepatitis C virus core protein and PA28γ. The method can be carried out, for example, by using transcriptional activity of a lipid metabolism-control factor as indicator. The test substance used in the method may have an activity to inhibit expression or function of the PA28γ gene. The hepatitis C virus-related diseases include hepatitis C, fatty liver, acute hepatitis, chronic hepatitis, liver cirrhosis, liver cancer, insulin-resistant diseases, and the like. The method according to the present invention is extremely useful as a method of obtaining an agent superior in preventive and therapeutic activity particularly to diseases such as fatty liver and liver cancer.
摘要翻译：本发明提供一种筛选方法，其能够容易且有效地筛选用于预防和/或治疗丙型肝炎病毒相关疾病的药剂，以及通过该方法获得的用于丙型肝炎病毒相关疾病的预防和/或治疗剂。根据本发明的用于丙型肝炎病毒相关疾病的预防和/或治疗剂的筛选方法的特征在于包括检查测试物质对丙型肝炎病毒核心蛋白质之间的蛋白质 - 蛋白质相互作用的抑制活性的步骤和PA28γ。该方法可以例如通过使用脂质代谢控制因子的转录活性作为指标进行。该方法中使用的测试物质可能具有抑制PA28γ基因表达或功能的活性。丙型肝炎病毒相关疾病包括丙型肝炎，脂肪肝，急性肝炎，慢性肝炎，肝硬化，肝癌，胰岛素抵抗疾病等。根据本发明的方法作为获得在预防和治疗活性方面特别是脂肪肝和肝癌等疾病优异的药剂的方法是非常有用的。

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