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1. 发明授权

US08530504B2 Pyrazolothiazole compound 失效
标题翻译：吡唑并噻唑化合物
公开(公告)号：US08530504B2
公开(公告)日：2013-09-10
申请号：US12900026
申请日：2010-10-07
申请人： Kogyoku Shin , Taro Terauchi , Yoshinori Takahashi , Minako Hashizume , Kunitoshi Takeda , Kodo Shikata , Akira Inomata
发明人： Kogyoku Shin , Taro Terauchi , Yoshinori Takahashi , Minako Hashizume , Kunitoshi Takeda , Kodo Shikata , Akira Inomata
IPC分类号： A61K31/429 , A61P25/24
CPC分类号： C07D513/04
摘要： A compound represented by the formula (I) or pharmacologically acceptable salt thereof exhibits an excellent CRF receptor antagonism wherein X is a nitrogen atom or CH; R1 is -A11-A12; A11 is a single bond or a C1-6 alkylene group; A12 is a hydrogen atom, a C1-6 alkyl group or a C3-6 cycloalkyl group, etc.; R2 is -A21-A22; A21 is a single bond or a C1-6 alkylene group; A22 is a hydrogen atom, a C1-6 alkyl group, a C3-6 cycloalkyl group, a non-aromatic heterocyclic group, or a heteroaryl group, etc.; R3 is a C1-6 alkyl group, a C3-6 cycloalkyl group, a C1-6 alkoxy group, a C3-6 cycloalkoxy C1-6 alkyl group, di-C1-6 alkyl amino group, a halogen atom, a cyano group, a formyl group, or a carboxyl group, etc; R4 is a hydrogen atom or a C1-6 alkoxy group; R5 is a halogen atom, a C1-6 alkyl group, or a C1-6 alkoxy group; R6 is a hydrogen atom, a C1-6 alkyl group, a C1-6 alkoxy group, a C1-6 alkylthio group, or a C1-6 alkyl sulfinyl group etc.; and R7 is a C1-6 alkyl group, a C1-6 alkoxy group, or a C1-6 alkylthio group.
摘要翻译：由式（I）表示的化合物或其药理学上可接受的盐表现出优异的CRF受体拮抗作用，其中X为氮原子或CH; R1为-A11-A12; A11是单键或C1-6亚烷基; A12是氢原子，C1-6烷基或C3-6环烷基等; R2为-A21-A22; A21是单键或C1-6亚烷基; A22为氢原子，C1-6烷基，C3-6环烷基，非芳族杂环基或杂芳基等; R3是C1-6烷基，C3-6环烷基，C1-6烷氧基，C3-6环烷氧基C1-6烷基，二C1-6烷基氨基，卤素原子，氰基，甲酰基或羧基等; R4是氢原子或C1-6烷氧基; R5是卤素原子，C1-6烷基或C1-6烷氧基; R6是氢原子，C1-6烷基，C1-6烷氧基，C1-6烷硫基或C1-6烷基亚磺酰基等; 且R 7为C 1-6烷基，C 1-6烷氧基或C 1-6烷硫基。

2. 发明授权

US08431603B2 3-phenylpyrazolo[5,1-b]thiazole compounds 有权
标题翻译： 3-苯基吡唑并[5,1-b]噻唑化合物
公开(公告)号：US08431603B2
公开(公告)日：2013-04-30
申请号：US12421182
申请日：2009-04-09
申请人： Hisashi Shibata , Kodo Shikata , Akira Inomata , Kogyoku Shin , Taro Terauchi , Yoshinori Takahashi , Minako Hashizume , Kunitoshi Takeda
发明人： Hisashi Shibata , Kodo Shikata , Akira Inomata , Kogyoku Shin , Taro Terauchi , Yoshinori Takahashi , Minako Hashizume , Kunitoshi Takeda
IPC分类号： A61K31/4439 , C07D513/02
CPC分类号： C07D513/04
摘要： A compound represented by the following formula (I), or salt thereof exhibits excellent CRF receptor antagonism, and sufficient pharmacological activity, safety and pharmacokinetic properties as a drug. wherein R1 represents the formula -A11-A12; R2 represents tetrahydrofurylmethyl, tetrahydropyranylmethyl or tetrahydropyranyl; A11 represents a single bond, methylene or 1,2-ethylene; A12 represents C1-6 alkyl, C3-6 cycloalkyl or C3-6 cycloalkyl having methyl; R3 represents methoxy, cyano, cyclobutyloxymethyl, methoxymethyl or ethoxymethyl; and R4 represents methoxy or chlorine.
摘要翻译：由下式（I）表示的化合物或其盐表现出优异的CRF受体拮抗作用，作为药物具有充分的药理活性，安全性和药代动力学性质。其中R1表示式-A11-A12; R2表示四氢呋喃基甲基，四氢吡喃基甲基或四氢吡喃基; A11表示单键，亚甲基或1,2-亚乙基; A12表示C1-6烷基，C3-6环烷基或具有甲基的C3-6环烷基; R3表示甲氧基，氰基，环丁氧基甲基，甲氧基甲基或乙氧基甲基; R4表示甲氧基或氯。

3. 发明申请

US20110086898A1 PYRAZOLOOXAZOLE COMPOUND 审中-公开
标题翻译：吡唑并噻唑化合物
公开(公告)号：US20110086898A1
公开(公告)日：2011-04-14
申请号：US12900046
申请日：2010-10-07
申请人： Kogyoku SHIN , Taro Terauchi , Yoshinori Takahashi , Minako Hashizume , Kunitoshi Takeda , Kodo Shikata , Akira Inomata
发明人： Kogyoku SHIN , Taro Terauchi , Yoshinori Takahashi , Minako Hashizume , Kunitoshi Takeda , Kodo Shikata , Akira Inomata
IPC分类号： A61K31/4162 , C07D487/04 , A61P25/00 , A61P1/00
CPC分类号： C07D498/04
摘要： A compound represented by the formula (I) or pharmacologically acceptable salt thereof exhibits an excellent CRF receptor antagonism. wherein R1 and R2 are the same or different and are a hydrogen atom, a C1-6 alkyl group, a cyclic group selected from a C3-6 cycloalkyl group, a tetrahydropyranyl group, a dihydropyranyl group, a tetrahydrofuryl group, a dioxanyl group, a tetrahydrothienyl group, a dithianyl group and a hexahydrothiepinyl group, a C1-6 alkyl group substituted with a cyclic group selected from a C3-6 cycloalkyl group, a tetrahydropyranyl group, a dihydropyranyl group, a tetrahydrofuryl group, a dioxanyl group, a tetrahydrothienyl group, a dithianyl group and a hexahydrothiepinyl group, etc; R3, R4 and R5 are the same or different and are a hydrogen atom, a C1-6 alkyl group, a C3-6 cycloalkyl group, a C1-6 alkoxy group, a C1-6 alkoxy-C1-6 alkyl group, a C3-6 cycloalkoxy-C1-6 alkyl group or a halogen atom; R6 is a hydrogen atom or a C1-6 alkyl group; and R7 is a C1-6 alkyl group, a C1-6 alkoxy group or a C1-6 alkylthio group.
摘要翻译：由式（I）表示的化合物或其药理学上可接受的盐表现出优异的CRF受体拮抗作用。其中R1和R2相同或不同，为氢原子，C1-6烷基，选自C 3-6环烷基，四氢吡喃基，二氢吡喃基，四氢呋喃基，二氧杂环己烷基，四噻吩基，二噻烷基和六氢硫杂基，被选自C 3-6环烷基，四氢吡喃基，二氢吡喃基，四氢呋喃基，二烷基，四氢噻吩基中的环状基取代的C 1-6烷基二硫代基，六氢噻吩基等; R 3，R 4和R 5相同或不同，为氢原子，C 1-6烷基，C 3-6环烷基，C 1-6烷氧基，C 1-6烷氧基-C 1-6烷基， C 3-6环烷氧基-C 1-6烷基或卤素原子; R6是氢原子或C1-6烷基; 并且R 7是C 1-6烷基，C 1-6烷氧基或C 1-6烷硫基。

4. 发明申请

US20090259049A1 3-PHENYLPYRAZOLO[5,1-b]THIAZOLE COMPOUNDS 有权
标题翻译： 3-苯基吡唑并[5,1-b]噻唑化合物
公开(公告)号：US20090259049A1
公开(公告)日：2009-10-15
申请号：US12421182
申请日：2009-04-09
申请人： Hisashi Shibata , Kodo Shikata , Akira Inomata , Kogyoku Shin , Taro Terauchi , Yoshinori Takahashi , Minako Hashizume , Kunitoshi Takeda
发明人： Hisashi Shibata , Kodo Shikata , Akira Inomata , Kogyoku Shin , Taro Terauchi , Yoshinori Takahashi , Minako Hashizume , Kunitoshi Takeda
IPC分类号： C07D513/02
CPC分类号： C07D513/04
摘要： A compound represented by the following formula (I), or salt thereof exhibits excellent CRF receptor antagonism, and sufficient pharmacological activity, safety and pharmacokinetic properties as a drug. wherein R1 represents the formula -A11-A12; R2 represents tetrahydrofurylmethyl, tetrahydropyranylmethyl or tetrahydropyranyl; A11 represents a single bond, methylene or 1,2-ethylene; A12 represents C1-6 alkyl, C3-6 cycloalkyl or C3-6 cycloalkyl having methyl; R3 represents methoxy, cyano, cyclobutyloxymethyl, methoxymethyl or ethoxymethyl; and R4 represents methoxy or chlorine.
摘要翻译：由下式（I）表示的化合物或其盐表现出优异的CRF受体拮抗作用，作为药物具有充分的药理活性，安全性和药代动力学性质。其中R1表示式-A11-A12; R2表示四氢呋喃基甲基，四氢吡喃基甲基或四氢吡喃基; A11表示单键，亚甲基或1,2-亚乙基; A12表示C1-6烷基，C3-6环烷基或具有甲基的C3-6环烷基; R3表示甲氧基，氰基，环丁氧基甲基，甲氧基甲基或乙氧基甲基; R4表示甲氧基或氯。

5. 发明授权

US4297730A Magnetic recording and reproducing device 失效
标题翻译：磁记录和再现装置
公开(公告)号：US4297730A
公开(公告)日：1981-10-27
申请号：US174389
申请日：1979-11-01
申请人： Hidetaka Kadowaki , Akira Inomata , Kiyoshi Yanagida , Tsunao Hasegawa , Satoshi Ishii , Yasushi Ohtake
发明人： Hidetaka Kadowaki , Akira Inomata , Kiyoshi Yanagida , Tsunao Hasegawa , Satoshi Ishii , Yasushi Ohtake
IPC分类号： G11B5/02 , H03G3/20 , H03G5/16 , G11B5/47 , G11B15/12
CPC分类号： H03G3/3026 , G11B5/02 , H03G5/165
摘要： This invention relates to a magnetic recording and reproducing device in which automatic settings of optimum recording bias current, optimum recording level and optimum recording equalization characteristic are successively accomplished in this order. The settings of the optimum recording conditions are achieved with high accuracy within short period of time by a computer control using a microprocessor.
摘要翻译：本发明涉及一种磁记录和再现装置，其中以该顺序连续完成最佳记录偏置电流，最佳记录电平和最佳记录均衡特性的自动设置。通过使用微处理器的计算机控制，在短时间内以高精度实现最佳记录条件的设置。

6. 发明授权

US5178194A Multiply connected air core coil winding apparatus 失效
标题翻译：连接空心线圈绕线装置
公开(公告)号：US5178194A
公开(公告)日：1993-01-12
申请号：US810357
申请日：1991-12-18
申请人： Youji Uchino , Akira Inomata
发明人： Youji Uchino , Akira Inomata
IPC分类号： H01F41/06
CPC分类号： H01F41/09 , H01F41/066
摘要： A multiply connected air core coil winding apparatus is provided in which a winding core is protruded and retracted through a first side frame in order to position the winding core between the first side frame and a second side frame, the winding core being rotated when so positioned in order to form a side face of an air core coil. The second side frame is capable of being drawn towards and away from the first side frame. A pocket is provided at one of the side frames for housing the air core coil when the winding material has been completely wound. As a result, multiple air core coils can be wound without cutting the winding material of a first air core coil. In a second embodiment of the present invention, a multiply connected air core coil winding apparatus is provided, comprising a winding core which can be protruded and retracted through a hole of a side frame face so as to be positioned between a pair of side frames, the winding core being rotated for forming a side face of an air core coil, similar to the first embodiment. One side frame is movable so as to be drawn towards and away from the other side frame, and a plurality of side frame faces are provided on one of the side frames which can be rotated in a direction perpendicular to a winding rotation shaft. One side frame is positioned so as to be opposed to the other side frame, and the winding core is protruded and retracted on the rotation shaft of the winding wire.
摘要翻译：提供一种多相连接的空心线圈卷绕装置，其中卷绕芯通过第一侧框架突出和缩回，以便将卷芯定位在第一侧框架和第二侧框架之间，卷绕芯体在如此定位时旋转以形成空芯线圈的侧面。第二侧框架能够被拉向和远离第一侧框架。当卷绕材料已经完全缠绕时，在一个侧框架上设置有用于容纳空芯线圈的口袋。结果，可以在不切割第一空心线圈的卷绕材料的情况下缠绕多个空心线圈。在本发明的第二实施例中，提供了一种多相连接的空心线圈卷绕装置，其包括：卷绕芯，其可以通过侧框架面的孔突出和缩回以位于一对侧框架之间，为了形成空心线圈的侧面而使卷绕芯旋转，与第一实施方式相同。一侧框架是可移动的，以被拉向和远离另一侧框架，并且多个侧框架面设置在能够沿垂直于卷绕旋转轴的方向旋转的一个侧框架上。一侧框架被定位成与另一侧框架相对，并且卷绕芯在绕组线的旋转轴上突出和缩回。

7. 发明授权

US4405953A Magnetic recording and reproducing device 失效
标题翻译：磁记录和再现装置
公开(公告)号：US4405953A
公开(公告)日：1983-09-20
申请号：US315337
申请日：1981-10-26
申请人： Akira Inomata , Tsunao Hasegawa , Yasushi Ohtake
发明人： Akira Inomata , Tsunao Hasegawa , Yasushi Ohtake
IPC分类号： G11B5/02 , G11B5/027 , G11B5/035 , G11B5/45
CPC分类号： G11B5/027 , G11B5/02 , G11B5/035
摘要： This invention relates to a magnetic recording and reproducing device in which automatic settings of optimum recording bias current, optimum recording level and optimum recording equalization characteristic are successively accomplished in this order. The settings of the optimum recording conditions are achieved with high accuracy within short period of time by a computer control using a microprocessor.
摘要翻译：本发明涉及一种磁记录和再现装置，其中以该顺序连续完成最佳记录偏置电流，最佳记录电平和最佳记录均衡特性的自动设置。通过使用微处理器的计算机控制，在短时间内以高精度实现最佳记录条件的设置。

8. 发明授权

US4202021A Front-loaded cassette tape deck 失效
标题翻译：前装盒式磁带机
公开(公告)号：US4202021A
公开(公告)日：1980-05-06
申请号：US921153
申请日：1978-06-30
申请人： Tetsuo Nagase , Hideo Watanabe , Akira Inomata
发明人： Tetsuo Nagase , Hideo Watanabe , Akira Inomata
IPC分类号： G11B15/675 , G11B15/66 , G11B23/04
CPC分类号： G11B15/67536
摘要： A front-loaded cassette tape deck which moves the cassette a greater relative distance than the distance travelled by the table. A table is normally in the fully projected position because the force provided by a pair of springs is greater than the frictional forces and the damping forces provided by damping pulleys. A cassette is placed in a slider and is held therein by a leaf spring. As the table is moved towards the closed position, the slider is moved by cords and pulleys at a faster rate than the table. Thus, the slider is moved relative to the table. The greater travel of the slider causes it to be moved within a holder by the sliding engagement of a plurality of guide members. During this time, the holder is at an upper position. When the table reaches the closed position, the slider is fully disposed within the holder. The holder with the slider then automatically rotates to a lower position, which puts the cassette into operational engagement with a cassette driving section. The holder remains in the lower position until an eject lever is depressed, which causes the holder with the slider to be moved back to the upper position. The table then automatically returns to the fully projected position because the force provided by a pair of springs is greater than the frictional forces and the damping forces provided by the damping pulleys. As the table moves towards the fully projected position, the slider is moved out of sliding engagement with the holder and into sliding engagement with the table due to the relative movement of the slider with respect to the table provided by the cords and pulleys.
摘要翻译：一个前装盒式磁带机，使磁带盒移动比桌子行驶的距离更大的相对距离。由于一对弹簧提供的力大于由阻尼滑轮提供的摩擦力和阻尼力，所以台面通常处于完全投影位置。盒式磁带放置在滑块中并通过板簧保持在其中。当桌子移动到关闭位置时，滑块以比表更快的速度被绳索和滑轮移动。因此，滑块相对于工作台移动。滑块的较大行程使得其通过多个引导构件的滑动接合而在保持器内移动。在此期间，支架位于上方。当桌子到达关闭位置时，滑块完全设置在支架内。具有滑块的保持器然后自动旋转到较低位置，这使得盒与盒驱动部分操作接合。保持器保持在下部位置，直到弹出杆被压下，这使得具有滑块的保持器被移回到上部位置。然后，由于一对弹簧提供的力大于由阻尼滑轮提供的摩擦力和阻尼力，工作台将自动返回到完全伸出的位置。当桌子朝向完全投影位置移动时，由于滑块相对于由绳索和滑轮提供的工作台的相对运动，滑块移动离开与支架滑动接合并与桌子滑动接合。

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