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1. 发明申请

US20100197727A1 Quinoline Derivatives as Antibacterial Agents 审中-公开
标题翻译：喹啉衍生物作为抗菌剂
公开(公告)号：US20100197727A1
公开(公告)日：2010-08-05
申请号：US11917091
申请日：2006-06-26
申请人： Koenraad Jozef Lodewijk Marcel Andries , Anil Koul , David Francis Alain Lancois , Magali Madeleine Simone Motte , Jérôme Emile Georges Guillemont
发明人： Koenraad Jozef Lodewijk Marcel Andries , Anil Koul , David Francis Alain Lancois , Magali Madeleine Simone Motte , Jérôme Emile Georges Guillemont
IPC分类号： A61K31/47 , C07D215/227 , C07D409/06 , A61K31/4709 , C07D401/06 , C07D215/36 , A61P31/04
CPC分类号： C07D409/06 , A61K31/47 , A61K31/4709 , C07D215/227 , C07D215/36 , C07D401/06
摘要： Use of a compound for the manufacture of a medicament for the treatment of a bacterial infection provided that the bacterial infection is other than a Mycobacterial infection, said compound being a compound of formula (Ia) or (Ib) a N-oxide, a tautomeric form or a stereochemically isomeric form thereof wherein A− is a counter ion; R1 is hydrogen, halo, haloalkyl, cyano, hydroxy, Ar, Het, alkyl, alkyloxy, alkylthio, alkyloxyalkyl, alkylthioalkyl, Ar-alkyl or di(Ar)alkyl; p is 1 to 4; R2 is hydrogen, hydroxy, mercapto, alkyloxy, alkyloxyalkyloxy, alkylthio, mono or di(alkyl)amino or wherein Y is CH2, O, S, NH or N-alkyl; R3 is alkyl, Ar, Ar-alkyl, Het or Het-alkyl; q is 0 to 4; R4 and R5 each independently are hydrogen, alkyl or benzyl; or R4 and R5 may be taken together including the N to which they are attached; R6 is hydrogen, halo, haloalkyl, hydroxy, Ar, alkyl, alkyloxy, alkylthio, alkyloxyalkyl, alkylthioalkyl, Ar-alkyl or di(Ar)alkyl; or two vicinal R6 radicals may be taken together to form —CH═CH—CH═CH—; r is 1 to 5; R7 is hydrogen, alkyl, Ar or Het; R8 is hydrogen or alkyl; R9 is oxo; or R8 and R9 taken together form —CH═CH—N═; R10 is alkyl, alkylcarbonyl, Ar, Ar-alkyl, Ar-carbonyl, Het1-alkyl or Het1-carbonyl.
摘要翻译：使用化合物制造用于治疗细菌感染的药物，只要细菌感染不是分枝杆菌感染，所述化合物是式（Ia）或（Ib）的化合物，N-氧化物，互变异构体形式或其立体化学异构体形式，其中A-是抗衡离子; R 1是氢，卤素，卤代烷基，氰基，羟基，Ar，Het，烷基，烷氧基，烷硫基，烷氧基烷基，烷硫基烷基，芳烷基或二（Ar） p为1〜4; R2是氢，羟基，巯基，烷氧基，烷氧基烷氧基，烷硫基，一或二（烷基）氨基或其中Y是CH2，O，S，NH或N-烷基; R3是烷基，Ar，Ar-烷基，Het或Het-烷基; q为0〜4; R4和R5各自独立地为氢，烷基或苄基; 或R4和R5可以一起包括它们所连接的N; R 6是氢，卤素，卤代烷基，羟基，Ar，烷基，烷氧基，烷硫基，烷氧基烷基，烷硫基烷基，芳烷基或二（Ar）或两个连位的R6基团可以一起形成-CH = CH-CH = CH-; r为1〜5; R7是氢，烷基，Ar或Het; R8是氢或烷基; R9是氧代; 或R8和R9一起形成-CH = CH-N =; R10是烷基，烷基羰基，Ar，Ar-烷基，Ar-羰基，Het1-烷基或Het1-羰基。

2. 发明申请

US20100204270A1 Quinoline Derivatives as Antibacterial Agents 审中-公开
标题翻译：喹啉衍生物作为抗菌剂
公开(公告)号：US20100204270A1
公开(公告)日：2010-08-12
申请号：US11917923
申请日：2006-06-26
申请人： Koenraad Jozef Lodewijk Marcel Andries , Anil Koul , Jérôme Emile Georges Guillemont , Magali Madeleine Simone Motte
发明人： Koenraad Jozef Lodewijk Marcel Andries , Anil Koul , Jérôme Emile Georges Guillemont , Magali Madeleine Simone Motte
IPC分类号： A61K31/47 , C07D215/16 , A61P31/04
CPC分类号： C07D215/227 , A61K31/4353 , A61K45/06 , C07D215/36 , A61K2300/00
摘要： Use of a compound for the manufacture of a medicament for the treatment of a bacterial infection provided that the bacterial infection is other than a Mycobacterial infection, said compound being a compound of formula (Ia) or (Ib) a pharmaceutically acceptable acid or base addition salt thereof, a stereochemically isomeric form thereof, a tautomeric form thereof or a N-oxide form thereof. Several of these compounds are also claimed as such. Further the combination of the above compounds with other antibacterial agents is described
摘要翻译：使用化合物制造用于治疗细菌感染的药物，只要细菌感染不是分枝杆菌感染，所述化合物是式（Ia）或（Ib）的化合物，其药学上可接受的酸或碱加成其盐，其立体化学异构形式，其互变异构形式或其N-氧化物形式。这些化合物中的几种也是这样声称的。此外，还描述了上述化合物与其它抗菌剂的组合

3. 发明申请

US20130030017A1 QUINOLINE DERIVATIVES AS ANTIBACTERIAL AGENTS 审中-公开
标题翻译：喹诺酮衍生物作为抗菌剂
公开(公告)号：US20130030017A1
公开(公告)日：2013-01-31
申请号：US13568597
申请日：2012-08-07
申请人： Koenraad Jozef Lodewijk Marcel ANDRIES , Anil Koul , Jérôme Emile Georges Guillemont , Magali Madeleine Simone Motte
发明人： Koenraad Jozef Lodewijk Marcel ANDRIES , Anil Koul , Jérôme Emile Georges Guillemont , Magali Madeleine Simone Motte
IPC分类号： A61K31/47 , A61P31/04
CPC分类号： C07D215/227 , A61K31/4353 , A61K45/06 , C07D215/36 , A61K2300/00
摘要： Method of treating a bacterial infection other than a Mycobacterial infection, using a compound of formula (Ia) or (Ib) a pharmaceutically acceptable acid or base addition salt thereof, a stereochemically isomeric form thereof, a tautomeric form thereof or a N-oxide form thereof, wherein the substituents R1, R2, R3, R4, R5, R6, R7, R8, and R9 are as defined.
摘要翻译：使用式（Ia）或（Ib）化合物或其药学上可接受的酸或碱加成盐，其立体化学异构形式，其互变异构形式或N-氧化物形式治疗除分枝杆菌感染之外的细菌感染的方法其中取代基R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8和R 9如上所定义。

4. 发明授权

US07998979B2 Antibacterial quinoline derivatives 有权
标题翻译：抗菌喹啉衍生物
公开(公告)号：US07998979B2
公开(公告)日：2011-08-16
申请号：US12516370
申请日：2007-12-04
申请人： Jérôme Emile Georges Guillemont , Magali Madeleine Simone Motte , Koenraad Jozef Lodewijk Marcel Andries , Anil Koul
发明人： Jérôme Emile Georges Guillemont , Magali Madeleine Simone Motte , Koenraad Jozef Lodewijk Marcel Andries , Anil Koul
IPC分类号： A61K31/47 , A61P31/04 , C07D215/00 , C07D401/02
CPC分类号： C07D215/227
摘要： The present invention relates to novel substituted quinoline derivatives according to the general formula (Ia) or formula (Ib): including any stereochemically isomeric form thereof, a pharmaceutically acceptable salt thereof, a N-oxide form thereof or a solvate thereof. The claimed compounds are useful for the treatment of a bacterial infection. Also claimed is a composition comprising a pharmaceutically acceptable carrier and, as active ingredient, a therapeutically effective amount of the claimed compounds, the use of the claimed compounds or compositions for the manufacture of a medicament for the treatment of a bacterial infection and a process for preparing the claimed compounds.
摘要翻译：本发明涉及根据通式（Ia）或式（Ib）的新的取代喹啉衍生物：包括其任何立体化学异构形式，其药学上可接受的盐，其N-氧化物形式或其溶剂化物。所要求保护的化合物可用于治疗细菌感染。还要求保护的是包含药学上可接受的载体和作为活性成分的治疗有效量的要求保护的化合物的组合物，所要求保护的化合物或组合物在制备用于治疗细菌感染的药物中的用途和制备所要求保护的化合物。

5. 发明授权

US08841321B2 Quinoline derivatives as antibacterial agents 有权
标题翻译：喹啉衍生物作为抗菌剂
公开(公告)号：US08841321B2
公开(公告)日：2014-09-23
申请号：US11993145
申请日：2006-06-26
申请人： Koenraad Jozef Lodewijk Marcel Andries , Anil Koul , Jérôme Emile Georges Guillemont , David Francis Alain Lançois , Magali Madeleine Simone Motte , Ismet Dorange , Leo Jacobus Jozef Backx , Lieven Meerpoel
发明人： Koenraad Jozef Lodewijk Marcel Andries , Anil Koul , Jérôme Emile Georges Guillemont , David Francis Alain Lançois , Magali Madeleine Simone Motte , Ismet Dorange , Leo Jacobus Jozef Backx , Lieven Meerpoel
IPC分类号： A01N43/42 , A61K31/47 , A01N43/40 , A61K31/445 , A61K31/44 , C07D215/227
CPC分类号： A61K31/47 , C07D215/227
摘要： Use of a compound for the manufacture of a medicament for the treatment of a bacterial infection provided that the bacterial infection is other than a Mycobacterial infection, said compound being a compound of formula (Ia) or (Ib) a pharmaceutically acceptable acid or base addition salt thereof, a stereochemically isomeric form thereof, a tautomeric form thereof or a N-oxide form thereof, wherein R1 is hydrogen, halo, haloalkyl, cyano, hydroxy, Ar, Het, alkyl, alkyloxy, alkylthio, alkyloxyalkyl, alkylthioalkyl, Ar-alkyl or di(Ar)alkyl; p is 1, 2, 3 or 4; R2 is hydrogen, hydroxy, mercapto, alkyloxy, alkyloxyalkyloxy, alkylthio, mono or di(alkyl)amino or a radical of formula; R3 is alkyl, Ar, Ar-alkyl, Het or Het-alkyl; q is 1, 2 or 3; R4 and R5 are hydrogen, alkyl or benzyl; or R4 and R5 together and including the N to which they are attached may form a ring; R6 is hydrogen, halo, haloalkyl, hydroxy, Ar, alkyl, alkyloxy, alkylthio, alkyloxyalkyl, alkythioalkyl, Ar-alkyl or di(Ar)alkyl; or two vicinal R6 radicals may be taken together to form a bivalent radical of formula —CH═CH—CH═CH—; r is 1, 2, 3, 4 or 5; R7 is hydrogen, alkyl, Ar or Het; R8 is hydrogen or alkyl; R9 is oxo; or R8 and R9 together form the radical —CH═CH—N═.
摘要翻译：使用化合物制造用于治疗细菌感染的药物，只要细菌感染不是分枝杆菌感染，所述化合物是式（Ia）或（Ib）的化合物，其药学上可接受的酸或碱加成其盐，其立体化学异构形式，其互变异构形式或其N-氧化物形式，其中R 1是氢，卤素，卤代烷基，氰基，羟基，Ar，Het，烷基，烷氧基，烷硫基，烷氧基烷基，烷硫基烷基，烷基或二（Ar）烷基; p为1,2,3或4; R2是氢，羟基，巯基，烷氧基，烷氧基烷氧基，烷硫基，一或二（烷基）氨基或式的基团; R3是烷基，Ar，Ar-烷基，Het或Het-烷基; q为1,2或3; R4和R5是氢，烷基或苄基; 或R 4和R 5一起并包括它们所连接的N可以形成环; R 6是氢，卤素，卤代烷基，羟基，Ar，烷基，烷氧基，烷硫基，烷氧基烷基，链仲烷基，芳烷基或二（Ar）或两个连位的R6基团可以一起形成式-CH = CH-CH = CH-的二价基团; r为1,2,3,4或5; R7是氢，烷基，Ar或Het; R8是氢或烷基; R9是氧代; 或R8和R9一起形成基团-CH = CH-N =。

6. 发明申请

US20100063026A1 ANTIBACTERIAL QUINOLINE DERIVATIVES 审中-公开
标题翻译：抗生素喹啉衍生物
公开(公告)号：US20100063026A1
公开(公告)日：2010-03-11
申请号：US12516420
申请日：2007-12-04
申请人： Jérôme Emile Georges Guillemont , Ismet Dorange , David Francis Alain Lançois , José Manuel Villalgordo-Soto , Yvan René Ferdinand , Magali Madeleine Simone Motte , Koenraad Jozef Lodewijk Marcel Andries , Anil Koul
发明人： Jérôme Emile Georges Guillemont , Ismet Dorange , David Francis Alain Lançois , José Manuel Villalgordo-Soto , Yvan René Ferdinand , Magali Madeleine Simone Motte , Koenraad Jozef Lodewijk Marcel Andries , Anil Koul
IPC分类号： A61K31/4709 , C07D215/227 , C07D401/06 , C07D401/14 , C07D487/04 , C07D417/06 , A61K31/551 , A61K31/541 , A61P31/04
CPC分类号： C07D401/06 , C07D215/227 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/14 , C07D417/06 , C07D487/08
摘要： The present invention relates to novel substituted quinoline derivatives according to the general Formula (Ia) or Formula (Ib): including any stereochemically isomeric form thereof, a pharmaceutically acceptable salt thereof, a N-oxide form thereof or a solvate thereof. The claimed compounds are useful for the treatment of a bacterial infection. Also claimed is a composition comprising a pharmaceutically acceptable carrier and, as active ingredient, a therapeutically effective amount of the claimed compounds, the use of the claimed compounds or compositions for the manufacture of a medicament for the treatment of a bacterial infection and a process for preparing the claimed compounds.
摘要翻译：本发明涉及根据通式（Ia）或式（Ib）的新的取代喹啉衍生物：包括其任何立体化学异构形式，其药学上可接受的盐，其N-氧化物形式或其溶剂合物。所要求保护的化合物可用于治疗细菌感染。还要求保护的是包含药学上可接受的载体和作为活性成分的治疗有效量的要求保护的化合物的组合物，所要求保护的化合物或组合物在制备用于治疗细菌感染的药物中的用途和制备所要求保护的化合物。

7. 发明授权

US08293732B2 Antibacterial quinoline derivatives 有权
标题翻译：抗菌喹啉衍生物
公开(公告)号：US08293732B2
公开(公告)日：2012-10-23
申请号：US12516249
申请日：2007-12-04
申请人： Jérôme Emile Georges Guillemont , Ismet Dorange , Magali Madeleine Simone Motte , Koenraad Jozef Lodewijk Marcel Andries , Anil Koul
发明人： Jérôme Emile Georges Guillemont , Ismet Dorange , Magali Madeleine Simone Motte , Koenraad Jozef Lodewijk Marcel Andries , Anil Koul
IPC分类号： A61K31/496 , A61K31/47 , A61K31/4725 , A61K31/4745 , A61K31/5377 , A61K31/541 , C07D215/227 , C07D401/06 , C07D405/06 , C07D487/04
CPC分类号： C07D215/227 , C07D401/06 , C07D401/10 , C07D405/06 , C07D405/10 , C07D409/10
摘要： The present invention relates to novel substituted quinoline derivatives according to the general Formula (Ia) or Formula (Ib): including any stereochemically isomeric form thereof, a N-oxide thereof, a pharmaceutically acceptable salt thereof or a solvate thereof. The claimed compounds are useful for the treatment of a bacterial infection. Also claimed is a composition comprising a pharmaceutically acceptable carrier and, as active ingredient, a therapeutically effective amount of the claimed compounds, the use of the claimed compounds or compositions for the manufacture of a medicament for the treatment of a bacterial infection and a process for preparing the claimed compounds.
摘要翻译：本发明涉及根据通式（Ia）或式（Ib）的新的取代喹啉衍生物：包括其任何立体化学异构形式，其N-氧化物，其药学上可接受的盐或其溶剂合物。所要求保护的化合物可用于治疗细菌感染。还要求保护的是包含药学上可接受的载体和作为活性成分的治疗有效量的要求保护的化合物的组合物，所要求保护的化合物或组合物在制备用于治疗细菌感染的药物中的用途和制备所要求保护的化合物。

8. 发明申请

US20100063061A1 ANTIBACTERIAL QUINOLINE DERIVATIVES 有权
标题翻译：抗生素喹啉衍生物
公开(公告)号：US20100063061A1
公开(公告)日：2010-03-11
申请号：US12516370
申请日：2007-12-04
申请人： Jérôme Emile Georges Guillemont , Magali Madeleine Simone Motte , Koenraad Jozef Lodewijk Marcel Andries , Anil Koul
发明人： Jérôme Emile Georges Guillemont , Magali Madeleine Simone Motte , Koenraad Jozef Lodewijk Marcel Andries , Anil Koul
IPC分类号： A61K31/496 , C07D215/00 , A61K31/47 , C07D401/02 , A61P31/04
CPC分类号： C07D215/227
摘要： The present invention relates to novel substituted quinoline derivatives according to the general formula (Ia) or formula (Ib): including any stereochemically isomeric form thereof,a pharmaceutically acceptable salt thereof, a N-oxide form thereof or a solvate thereof. The claimed compounds are useful for the treatment of a bacterial infection. Also claimed is a composition comprising a pharmaceutically acceptable carrier and, as active ingredient, a therapeutically effective amount of the claimed compounds, the use of the claimed compounds or compositions for the manufacture of a medicament for the treatment of a bacterial infection and a process for preparing the claimed compounds.
摘要翻译：本发明涉及根据通式（Ia）或式（Ib）的新的取代喹啉衍生物：包括其任何立体化学异构形式，其药学上可接受的盐，其N-氧化物形式或其溶剂合物。所要求保护的化合物可用于治疗细菌感染。还要求保护的是包含药学上可接受的载体和作为活性成分的治疗有效量的要求保护的化合物的组合物，所要求保护的化合物或组合物在制备用于治疗细菌感染的药物中的用途和制备所要求保护的化合物。

9. 发明申请

US20100048585A1 QUINOLINE DERIVATIVES AS ANTIBACTERIAL AGENTS 有权
标题翻译：喹诺酮衍生物作为抗菌剂
公开(公告)号：US20100048585A1
公开(公告)日：2010-02-25
申请号：US11993145
申请日：2006-06-26
申请人： Koenraad Jozef Lodewijk Marcel Andries , Anil Koul , Jérôme Emile Georges Guilliemont , David Francis Alain Lancois , Magali Madeleine Simone Motte , Ismet Dorange , Leo Jacobus Jozef Backx , Lieven Meerpoel
发明人： Koenraad Jozef Lodewijk Marcel Andries , Anil Koul , Jérôme Emile Georges Guilliemont , David Francis Alain Lancois , Magali Madeleine Simone Motte , Ismet Dorange , Leo Jacobus Jozef Backx , Lieven Meerpoel
IPC分类号： A61K31/497 , C07D215/20 , C07D401/10 , C07D405/10 , C07D213/02 , A61K31/47 , A61K31/4439 , A61K31/443 , A61K31/4545 , A61P31/04
CPC分类号： A61K31/47 , C07D215/227
摘要： Use of a compound for the manufacture of a medicament for the treatment of a bacterial infection provided that the bacterial infection is other than a Mycobacterial infection, said compound being a compound of formula (Ia) or (Ib) a pharmaceutically acceptable acid or base addition salt thereof, a stereochemically isomeric form thereof, a tautomeric form thereof or a N-oxide form thereof, wherein R1 is hydrogen, halo, haloalkyl, cyano, hydroxy, Ar, Het, alkyl, alkyloxy, alkylthio, alkyloxyalkyl, alkylthioalkyl, Ar-alkyl or di(Ar)alkyl; p is 1, 2, 3 or 4; R2 is hydrogen, hydroxy, mercapto, alkyloxy, alkyloxyalkyloxy, alkylthio, mono or di(alkyl)amino or a radical of formula; R3 is alkyl, Ar, Ar-alkyl, Het or Het-alkyl; q is 1, 2 or 3; R4 and R5 are hydrogen, alkyl or benzyl; or R4 and R5 together and including the N to which they are attached may form a ring; R6 is hydrogen, halo, haloalkyl, hydroxy, Ar, alkyl, alkyloxy, alkylthio, alkyloxyalkyl, alkythioalkyl, Ar-alkyl or di(Ar)alkyl; or two vicinal R6 radicals may be taken together to form a bivalent radical of formula —CH═CH—CH═CH—; r is 1, 2, 3, 4 or 5; R7 is hydrogen, alkyl, Ar or Het; R8 is hydrogen or alkyl; R9 is oxo; or R8 and R9 together form the radical —CH═CH—N═.
摘要翻译：使用化合物制造用于治疗细菌感染的药物，只要细菌感染不是分枝杆菌感染，所述化合物是式（Ia）或（Ib）的化合物，其药学上可接受的酸或碱加成其盐，其立体化学异构形式，其互变异构形式或其N-氧化物形式，其中R 1是氢，卤素，卤代烷基，氰基，羟基，Ar，Het，烷基，烷氧基，烷硫基，烷氧基烷基，烷硫基烷基，烷基或二（Ar）烷基; p为1,2,3或4; R2是氢，羟基，巯基，烷氧基，烷氧基烷氧基，烷硫基，一或二（烷基）氨基或式的基团; R3是烷基，Ar，Ar-烷基，Het或Het-烷基; q为1,2或3; R4和R5是氢，烷基或苄基; 或R 4和R 5一起并包括它们所连接的N可以形成环; R 6是氢，卤素，卤代烷基，羟基，Ar，烷基，烷氧基，烷硫基，烷氧基烷基，链仲烷基，芳烷基或二（Ar）或两个连位的R6基团可以一起形成式-CH = CH-CH = CH-的二价基团; r为1,2,3,4或5; R7是氢，烷基，Ar或Het; R8是氢或烷基; R9是氧代; 或R8和R9一起形成基团-CH = CH-N =。

10. 发明授权

US07915292B2 Antibacterial quinoline derivatives 有权
标题翻译：抗菌喹啉衍生物
公开(公告)号：US07915292B2
公开(公告)日：2011-03-29
申请号：US11996786
申请日：2006-07-26
申请人： Jérôme Emile Georges Guillemont , David Francis Alain Lançois , Elisabeth Thérèse Jeanne Pasquier , Koenraad Jozef Lodewijk Marcel Andries , Anil Koul
发明人： Jérôme Emile Georges Guillemont , David Francis Alain Lançois , Elisabeth Thérèse Jeanne Pasquier , Koenraad Jozef Lodewijk Marcel Andries , Anil Koul
IPC分类号： C07D215/00 , A61K31/472
CPC分类号： C07D215/227 , C07D215/12 , C07D215/48 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/06 , C07D405/12 , C07D413/06 , C07D417/06
摘要： The present invention relates to novel substituted quinoline derivatives according to the general Formula (Ia) or Formula (Ib): the pharmaceutically acceptable acid or base addition salts thereof, the quaternary amines thereof, the stereochemically isomeric forms thereof, the tautomeric forms thereof and the N-oxide forms thereof. The claimed compounds are useful for the treatment of a bacterial disease including a mycobacterial disease, particularly those diseases caused by pathogenic mycobacteria such as Mycobacterium tuberculosis, M. bovis, M. avium and M. marinum. Also claimed is a composition comprising a pharmaceutically acceptable carrier and, as active ingredient, a therapeutically effective amount of the claimed compounds, the use of the claimed compounds or compositions for the manufacture of a medicament for the treatment of bacterial diseases and a process for preparing the claimed compounds.
摘要翻译：本发明涉及根据通式（Ia）或式（Ib）的新的取代喹啉衍生物：其药学上可接受的酸或碱加成盐，其季胺，其立体化学异构形式，其互变异构形式和 N-氧化物形式。所要求保护的化合物可用于治疗细菌性疾病，包括分枝杆菌病，特别是由致病性分枝杆菌引起的疾病，例如结核分枝杆菌，牛分枝杆菌，鸟分枝杆菌和马氏海绵体。还要求保护的是包含药学上可接受的载体和作为活性成分的治疗有效量的要求保护的化合物的组合物，所要求保护的化合物或组合物在制备用于治疗细菌性疾病的药物中的用途以及制备方法要求保护的化合物。

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