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    • 2. 发明授权
    • Pancreatic spasmolytic polypeptide
    • 胰腺解痉多肽
    • US4370317A
    • 1983-01-25
    • US241851
    • 1981-03-09
    • Klavs H. JorgensenKarin D. JorgensenLars Thim
    • Klavs H. JorgensenKarin D. JorgensenLars Thim
    • A61K38/00C07K14/575A61K37/00
    • C07K14/575A61K38/00
    • The invention relates to a novel purified polypeptide which is recoverable from porcine pancreas glands. The amino acid composition of the said polypeptide has been determined to be as follows:Trp (2), Lys (4), His (1), Arg (5), Asx (10), Thr (3), Ser (9), Glx (12), Pro (12), Gly (6), Ala (6), Cys 1/2 (14), Val (7), Met (2), Ile (3), Leu (1), Try (2), Phe (7), wherein the determinations are subjected to the usual error of .+-.10 percent of the indicated figures. The partial amino acid sequence comprising a total of 45 amino acids from the N-terminal, is believed to be: ##STR1## wherein pyrGlu (residue 1) stands for pyroglutamic acid. The purified polypeptide is of utility as a medicament, for example as a spasmolytic agent, as an agent for treatment of gastroduodenal ulcers and as a diagnostic aid.
    • 本发明涉及可从猪胰腺中回收的新型纯化多肽。 已确定所述多肽的氨基酸组成如下:Trp(2),Lys(4),His(1),Arg(5),Asx(10),Thr(3),Ser(9) ,Glx(12),Pro(12),Gly(6),Ala(6),Cys 1/2(14),Val(7),Met(2),Ile(3) (2),Phe(7),其中所述测定经受所示图的+/- 10%的通常误差。 包含总共45个氨基酸的部分氨基酸序列被认为是:其中pyrGlu(残基1)代表焦谷氨酸。 纯化的多肽可用作药物,例如作为解痉药,作为治疗胃十二指肠溃疡的药剂和诊断辅助剂。