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1. 发明授权

US06212425B1 Apparatus for photodynamic diagnosis 有权
标题翻译：光动力诊断装置
公开(公告)号：US06212425B1
公开(公告)日：2001-04-03
申请号：US09043850
申请日：1998-09-18
申请人： Klaus Irion , Reinhold Baumgartner , Herbert Stepp , André Ehrhardt , Karlheinz Strobl
发明人： Klaus Irion , Reinhold Baumgartner , Herbert Stepp , André Ehrhardt , Karlheinz Strobl
IPC分类号： A61B500
CPC分类号： G01N21/6486 , A61B1/00186 , A61B1/043 , A61B1/055 , A61B1/0638 , A61B1/0646 , A61B5/0071 , A61B5/0084 , G01N21/6456
摘要： A device for “in vivo” diagnosis by means of a photosensibilisator light-induced reaction or a reaction caused by intrinsic fluorescence in biological tissue, having an illumination system, which is provided with at least one light source having a lamp system which generates incoherent light in a wavelength range of at least 380 to 680 nm, a light delivering unit which directs the light of said illumination system at the therapy and/or to-be-diagnosed tissue area, and an imaging, image-recording and image-transmitting unit which images the light coming from said tissue area in a proximal image plane. The device is distinguished in that the net spectral transmittance in the light delivering unit and in the image-generating unit of the device are selected in such a manner that, on the one hand, practically no light with a wavelength of &lgr; from the range utilized for excitation, which by nature has relatively high intensity, “reaches” via the image-generating unit of the device into the proximal image plane, whereas light with a wavelength of &lgr; from the range in which fluorescence occurs can reach the proximal image plane only if it comes from the illuminated tissue are and not from the illumination system.
摘要翻译：一种用于通过光敏效应器光诱导反应或由生物组织中的固有荧光引起的反应进行的“体内”诊断的装置，具有照明系统，其具有至少一个具有产生不相干光的灯系统的光源在至少380至680nm的波长范围内，将所述照明系统的光引导到治疗和/或待诊断的组织区域的光输送单元，以及成像，图像记录和图像发送单元其在近端图像平面中对来自所述组织区域的光进行成像。该装置的特征在于，以这样的方式选择装置中的光输送单元和图像生成单元中的净光谱透射率，一方面实际上不具有从所使用的范围的羔羊波长的光对于本质上具有相对高强度的激发，通过装置的图像生成单元“到达”到近端图像平面中，而从发生荧光的范围的波长为lamb的光可以仅到达近端图像平面如果它来自照明组织而不是来自照明系统。

2. 发明申请

US20060241499A1 Multifunctional fluorescence diagnosis system 有权
标题翻译：多功能荧光诊断系统
公开(公告)号：US20060241499A1
公开(公告)日：2006-10-26
申请号：US11361484
申请日：2006-02-24
申请人： Klaus Irion , Andre Ehrhardt , Reinhold Baumgartner , Herbert Stepp , Thomas Pongratz
发明人： Klaus Irion , Andre Ehrhardt , Reinhold Baumgartner , Herbert Stepp , Thomas Pongratz
IPC分类号： A61B6/00
CPC分类号： A61B5/413 , A61B1/00009 , A61B1/00186 , A61B1/043 , A61B1/0638 , A61B1/0646 , A61B1/307 , A61B5/0071 , A61B5/0084 , A61B5/721 , G01N21/6428 , G01N21/6456
摘要： A fluorescence diagnosis system has a viewing system at least one light source and a camera system. The at least one light source can be operated in three modes, a first generating white light, a second with a first fluorescence excitation light of a first excitation wavelength and a third in which a second fluorescence excitation light of a second excitation wavelength is generated producing a fluorescence image in the NIR range. The camera system is sensitive at least in the visible and the NIR range. The system further comprises an image processing system for converting the fluorescence image in the NIR range into a visible image.
摘要翻译：荧光诊断系统具有至少一个光源和相机系统的观察系统。所述至少一个光源可以以三种模式操作，第一产生白光，第二产生具有第一激发波长的第一荧光激发光，其中第三激发光产生第二激发波长的第二荧光激发光，产生产生 NIR范围内的荧光图像。至少在可见光和近红外范围内，相机系统是敏感的。该系统还包括用于将NIR范围内的荧光图像转换成可见图像的图像处理系统。

3. 发明授权

US5751340A Method and apparatus for reducing the inherently dark grid pattern from the video display of images from fiber optic bundles 失效
标题翻译：用于从来自光纤束的图像的视频显示中减少固有的暗网格图案的方法和装置
公开(公告)号：US5751340A
公开(公告)日：1998-05-12
申请号：US701131
申请日：1996-08-21
申请人： Karlheinz Strobl , Bryan D. Kennedy , David Chatenever , Klaus Irion
发明人： Karlheinz Strobl , Bryan D. Kennedy , David Chatenever , Klaus Irion
IPC分类号： A61B1/00 , A61B1/04 , G02B6/04 , H04N5/21 , H04N5/217 , H04N5/225 , H04N5/357 , H04N5/235
CPC分类号： H04N5/2254 , A61B1/00165 , H04N5/217 , A61B1/042 , H04N2005/2255 , H04N5/21 , H04N5/3572
摘要： A method and apparatus for improving an image received from a endoscope having a flexible fiber optic bundle that produces an interstitial grid overlay due to the dead space between each fiber pixel. The interstitial grid pattern in the image, is substantially eliminated by processing the image through a linear digital filter to attenuate the first-order spatial frequency components that contribute most to the interstitial pattern. The filter employs relatively small convolution kernels that are optimized for specific fiber spacing. The image is then processed through the linear digital filter by convolving the respective pixels in the image by the derived coefficients. The image is improved and the grid pattern may also be reduced by a dilation process which involves processing the image through a dilation algorithm to "grow" the bright center of each fiber pixel in the image so that the effect of the grid pattern is reduced. The process involves filling in the dark area of the grid space with the color and intensity from the nearest fiber center to obtain an equivalent image representation. The dilation process uses a non-linear image processing algorithm to replace each pixel with the maximum pixel brightness in its immediate neighborhood depending on the selection of a kernel. The dilation kernel is selected by determining the number of detector (CCD) pixels that fit in a space between the fiber cores and then selecting a matrix size and kernel pattern.
摘要翻译：一种用于改善从具有柔性光纤束的内窥镜接收的图像的方法和装置，其由于每个光纤像素之间的死空间而产生间隙格栅覆盖。图像中的间质网格图案通过线性数字滤波器处理该图像而基本消除，以衰减对间隙图案贡献最大的一阶空间频率分量。滤波器采用针对特定光纤间隔进行优化的相对较小的卷积内核。然后通过线性数字滤波器对图像进行处理，方法是通过导出的系数卷积图像中的各个像素。图像被改善，并且网格图案也可以通过扩张处理来减少，该扩展处理涉及通过扩张算法处理图像以“增长”图像中的每个光纤像素的明亮中心，从而降低网格图案的效果。该过程包括从最近的纤维中心填充网格空间的暗区域，并获得等效图像表示的颜色和强度。扩张过程使用非线性图像处理算法来根据内核的选择以其近邻中的最大像素亮度来替换每个像素。通过确定拟合在纤维芯之间的空间中的检测器（CCD）像素的数量，然后选择矩阵大小和核心图案来选择扩张核。

4. 发明申请

US20070053204A1 Confocal microendoscope comprising optical fibres with a tapering diameter 审中-公开
标题翻译：共焦显微镜，包括具有锥形直径的光纤
公开(公告)号：US20070053204A1
公开(公告)日：2007-03-08
申请号：US10573141
申请日：2004-09-10
申请人： Ingo Krohne , Andre Ehrhardt , Klaus Irion , Herbert Stepp
发明人： Ingo Krohne , Andre Ehrhardt , Klaus Irion , Herbert Stepp
IPC分类号： A61B3/00 , A61B1/06 , G03B29/00 , G03B15/02 , G02B6/06 , F21V5/00
CPC分类号： A61B5/0068 , A61B5/0084 , G02B21/0028 , G02B23/2461
摘要： The invention relates to a confocal microendoscope, in which the diameter of optical fibres at the proximal end (8) of an optical fibre bundle (9) is greater than at the distal end (15). This permits the efficiency of coupling the light of a light source to be increased, without reducing the resolution of the microendoscope. In addition, the proximal ends (8) of the optical fibres (10) are arranged in a grid, for example, by means of a fibre receiving unit (11) that holds the individual optical fibres. A microlens unit (13) can also be provided, said unit allocating a microlens (14) to each optical fibre end.
摘要翻译：本发明涉及一种共焦显微镜，其中光纤束（9）的近端（8）处的光纤的直径大于远端（15）处的光纤直径。这允许在不降低微内镜的分辨率的情况下增加耦合光源的光的效率。此外，光纤（10）的近端（8）例如通过保持各个光纤的光纤接收单元（11）布置成格栅。还可以设置微透镜单元（13），所述单元向每个光纤端分配微透镜（14）。

5. 发明申请

US20070060792A1 Method and apparatus for generating at least one section of a virtual 3D model of a body interior 有权
标题翻译：用于产生身体内部的虚拟3D模型的至少一个部分的方法和装置
公开(公告)号：US20070060792A1
公开(公告)日：2007-03-15
申请号：US11503196
申请日：2006-08-11
申请人： Wolfgang Draxinger , Margarita Noll , Herbert Stepp , Klaus Irion
发明人： Wolfgang Draxinger , Margarita Noll , Herbert Stepp , Klaus Irion
IPC分类号： A61B1/00
CPC分类号： A61B5/1077 , A61B1/00009 , A61B1/042 , A61B5/065 , A61B8/12 , A61B34/20 , A61B90/361 , A61B2034/105 , A61B2034/2048 , A61B2034/2051
摘要： A method for generating at least one section of a virtual 3D model of a body interior, in particular a hollow organ, uses data that are provided by at least one endoscope introduced into the body interior. The data comprise at least one position and orientation of the endoscope, the at least one position and orientation being as signed at least one distance between the endoscope and the at least one point on a surface of the body interior, and at least one endoscopic image of the surface of the body interior in the region of the at least one point on the surface of the body interior. From the said data relating to a number of different positions and orientations of the endoscope is/are generated the section or sections of the 3D model in superposition with the associated endoscopic image. An appropriate apparatus is also described.
摘要翻译：用于产生身体内部，特别是中空器官的虚拟3D模型的至少一个部分的方法使用由引入到身体内部的至少一个内窥镜提供的数据。所述数据包括所述内窥镜的至少一个位置和取向，所述至少一个位置和取向在所述内窥镜与所述主体内部的表面上的所述至少一个点之间具有至少一个距离，并且至少一个内窥镜图像在身体内表面上的至少一个点的区域中的身体内部的表面。从与所述内窥镜的多个不同位置和取向相关的所述数据生成与相关联的内窥镜图像重叠的3D模型的部分或部分。还描述了适当的装置。

6. 发明申请

US20050065513A1 Medical instrument for the treatment of tissue by means of a high-frequency current and medical system with a medical instrument of this type 失效
标题翻译：用于通过高频电流处理组织的医疗仪器和具有这种类型的医疗器械的医疗系统
公开(公告)号：US20050065513A1
公开(公告)日：2005-03-24
申请号：US10946936
申请日：2004-09-22
申请人： Klaus Irion , Ulrich Hagelauer
发明人： Klaus Irion , Ulrich Hagelauer
IPC分类号： A61B18/14 , A61B19/00
CPC分类号： A61B18/149 , A61B18/1482 , A61B34/20 , A61B90/361 , A61B2034/2051
摘要： The invention relates to a medical instrument for treating tissue by means of high-frequency current. The inventive instrument comprises at least one electrode that can be impinged upon with a high-frequency current and that is disposed on the distal end of an elongated electrode carrier. At least one electromagnetically active position sensor is disposed in the distal zone of the electrode carrier in the direct vicinity of the at least one electrode in such a manner that it detects the intracorporeal position and/or location of the at least one electrode. The invention further relates to a medical system that comprises such an instrument.
摘要翻译：本发明涉及一种通过高频电流处理组织的医疗器械。本发明的仪器包括至少一个可以用高频电流撞击并且设置在细长电极载体的远端上的电极。至少一个电磁活动位置传感器以这样的方式设置在电极载体的远端区域中，其方式是直接接近至少一个电极，以便检测至少一个电极的体内位置和/或位置。本发明还涉及包括这种仪器的医疗系统。

7. 发明申请

US20070073109A1 Lighting system for endoscopic examinations 有权
标题翻译：内镜检查照明系统
公开(公告)号：US20070073109A1
公开(公告)日：2007-03-29
申请号：US11524681
申请日：2006-09-21
申请人： Klaus Irion
发明人： Klaus Irion
IPC分类号： A61B1/00 , A61B1/06
CPC分类号： A61B1/0051 , A61B1/0615 , A61B1/0676 , A61B1/0684
摘要： The invention relates to a lighting system for endoscopic examinations having a lighting unit that includes at least two LED elements for illuminating an area of examination that is to be observed by means of an endoscope optic. To create a lighting system for endoscopic examinations that ensures a constantly sufficient illumination of the area of examination, it is proposed according to the invention that the direction of radiation of the lighting unit can be displaced between a direction essentially perpendicular to the direction of observation of the endoscope optic upon insertion into the area of examination and a direction essentially in the direction of observation of the endoscope optic after insertion into the area of examination.
摘要翻译：本发明涉及一种用于内窥镜检查的照明系统，其具有照明单元，该照明单元包括用于照亮通过内窥镜视觉观察的检查区域的至少两个LED元件。为了创建用于内窥镜检查的照明系统，其确保了检查区域的持续充分的照明，根据本发明提出，照明单元的辐射方向可以在基本上垂直于观察方向的方向之间移位插入到检查区域中的内窥镜，以及插入到检查区域之后，基本上在观察内窥镜的方向上的方向。

8. 发明申请

US20060268552A1 Light source for endoscopy or microscopy 有权
标题翻译：内窥镜或显微镜的光源
公开(公告)号：US20060268552A1
公开(公告)日：2006-11-30
申请号：US11442579
申请日：2006-05-26
申请人： Klaus Irion , Andre Ehrhardt , Markus Simmen
发明人： Klaus Irion , Andre Ehrhardt , Markus Simmen
IPC分类号： F21V29/00
CPC分类号： F21V29/51 , A61B1/0669 , A61B1/12 , F21V29/67 , F21V29/717 , F21V29/763 , F21V29/83 , F21V29/89 , F28D15/0275
摘要： A light source for endoscopy or microscopy comprises a lamp, a heat sink, the heat sink being thermally connected to the lamp and at least one heat pipe, which is thermally connected to the heat sink and which dissipates the heat that is generated by the lamp and transferred to the heat sink.
摘要翻译：用于内窥镜检查或显微镜的光源包括灯，散热器，散热器热连接到灯和至少一个热管，其热连接到散热器并且散发由灯产生的热量并转移到散热器。

9. 发明申请

US20060256544A1 Light system for photodynamic diagnosis and/or therapy 失效
标题翻译：用于光动力学诊断和/或治疗的光系统
公开(公告)号：US20060256544A1
公开(公告)日：2006-11-16
申请号：US11432014
申请日：2006-05-11
申请人： Klaus Irion , Andre Ehrhardt , Andreas Schmal
发明人： Klaus Irion , Andre Ehrhardt , Andreas Schmal
IPC分类号： G03B15/02
CPC分类号： G02B6/4298 , A61B5/0059 , A61N5/0601 , A61N5/062 , G02B6/4225 , G02B6/4226
摘要： A light system for medical photodynamic applications comprises an incoherent light source emitting a light with a power and a light guide which has a distal end and an entrance interface. The entrance interface and the light source have a position relative to one another and are able to be positioned relative to one another. The light system further comprises a luminous power meter for measuring a luminous power emitted at the distal end of the light guide, a motorized positioning unit for positioning the entrance interface and the light source relative to one another, and a control unit which controls the positioning unit as a function of the luminous power measured by the luminous power meter.
摘要翻译：用于医疗光动力学应用的光系统包括发射具有光焦度的光和具有远端和入射界面的光导的非相干光源。入口接口和光源具有相对于彼此的位置，并且能够相对于彼此定位。光系统还包括用于测量在光导的远端发射的发光功率的光功率计，用于相对于彼此定位入口界面和光源的电动定位单元，以及控制单元，其控制定位单位作为由发光度计测量的发光功率的函数。

10. 发明授权

US06832985B2 Endoscopic system with instrument position and orientation display 失效
标题翻译：内窥镜系统，仪器位置和方向显示
公开(公告)号：US06832985B2
公开(公告)日：2004-12-21
申请号：US10205807
申请日：2002-07-26
申请人： Klaus Irion , Hartmut Wenzler , Peter Schwarz
发明人： Klaus Irion , Hartmut Wenzler , Peter Schwarz
IPC分类号： A61B104
CPC分类号： A61B1/00045 , A61B1/04
摘要： An endoscopic system includes at least one endoscope having an objective which generates an image of an area to be observed, at least one video recorder which records the image generated by the objective, at least one instrument, a position-sensing device which detects a position of the at least one instruments, and an assessment and control unit to which an output signal of the video recorder and the position-sensing device are applied and which displays on a monitor the image and symbols representing the position of the instrument. The position-sensing device includes a sensor which also detects orientation of the instrument, and the assessment and control unit displays symbols which indicate, in addition to the position the orientation of the instrument.
摘要翻译：内窥镜系统包括至少一个内窥镜，其具有生成待观察区域的图像的目标，至少一个记录由物镜生成的图像的视频记录器，至少一个仪器，检测位置的位置感测装置以及评估和控制单元，其中施加了录像机和位置感测装置的输出信号，并且在监视器上显示表示仪器位置的图像和符号。位置检测装置包括还检测仪器的取向的传感器，并且评估和控制单元除了显示仪器的方位之外还显示符号。

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