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1. 发明申请

US20110108640A1 SHOWER HEAD FOR A SANITARY SHOWER FITTING 有权
标题翻译：淋浴头用于卫生淋浴配件
公开(公告)号：US20110108640A1
公开(公告)日：2011-05-12
申请号：US12886093
申请日：2010-09-20
申请人： Klaus Grohe , Hubert Moosmann , Ulrich Kinle , Markus Woehrle
发明人： Klaus Grohe , Hubert Moosmann , Ulrich Kinle , Markus Woehrle
IPC分类号： B05B1/14
CPC分类号： B05B1/3426 , B05B1/08 , B05B1/18
摘要： A shower head for a hand-held shower attachment, an overhead shower attachment or a side shower attachment contains, in its shower-head housing, a vortex chamber which is of funnel shape with the side wall curved. The funnel begins, at the location of the largest diameter, in a radial plane and then decreases in diameter along a curved contour to an exit, where the walls of the funnel run in the axial direction. At the location of the largest diameter of the vortex chamber, upstream of this tapering region, the water is let in tangentially in the circumferential direction and in the axial direction. The vortex which is generated by virtue of the water being let in tangentially accelerates its speed of rotation in the direction of the spray disc. Arranged at the end of the tapering region is a jet-outlet chamber which is very flat, but is of large diameter in relation to the vortex chamber. The vortex travels into this jet-outlet chamber, and therefore, even in the outer region, water jets exit with a massage action out of the jet-outlet openings which are present there.
摘要翻译：用于手持式淋浴附件的淋浴头，顶部花洒附件或侧淋浴附件在其淋浴头壳体中包含具有侧壁弯曲的漏斗形的涡流室。漏斗在最大直径的位置处以径向平面开始，然后沿着弯曲轮廓直径减小到出口，其中漏斗的壁在轴向方向上延伸。在涡流室的最大直径的位置处，在该锥形区域的上游，水在圆周方向和轴向方向上沿切线方向。由于水而产生的涡流切向地加速其在喷射盘的方向上的旋转速度。在锥形区域的端部排列的喷射出口室非常平坦，但相对于涡流室具有大的直径。涡流进入该喷射出口腔室，因此即使在外部区域中，喷射器也从出口开口出来，用按摩作用离开出口。

2. 发明授权

US5648493A Preparation of 7-(3-amino- and 3-amino-methyl-1-pyrrolidinyl)-3-quinolonecarboxylic acids and -naphthyridonecarboxylic acids 失效
标题翻译： 7-（3-氨基 - 和3-氨基 - 甲基-1-吡咯烷基）-3-喹诺酮羧酸和萘啶酮羧酸的制备
公开(公告)号：US5648493A
公开(公告)日：1997-07-15
申请号：US717748
申请日：1991-06-19
申请人： Uwe Petersen , Andreas Krebs , Thomas Schenke , Klaus Grohe , Michael Schriewer , Ingo Haller , Karl Georg Metzger , Rainer Endermann , Hans-Joachim Zeiler
发明人： Uwe Petersen , Andreas Krebs , Thomas Schenke , Klaus Grohe , Michael Schriewer , Ingo Haller , Karl Georg Metzger , Rainer Endermann , Hans-Joachim Zeiler
IPC分类号： C07D227/04 , A61K31/397 , A61K31/435 , A61K31/47 , A61P31/00 , C07D205/04 , C07D207/09 , C07D207/14 , C07D227/10 , C07D401/04 , C07D405/12 , C07D471/04 , C07D498/06 , C07D513/06 , C07D215/233
CPC分类号： C07D401/04 , C07D207/14 , C07D471/04 , Y02P20/55
摘要： Process for the preparation of antibacterial compounds of the formula ##STR1## comprises condensing an oxo compound of the formula ##STR2## with an amino compound of the formula ##STR3## to produce a compound of the formula ##STR4## reacting the compound of the formula (III) with a compound of the formula ##STR5## to give a compound of the formula ##STR6## and then eliminating the amino-protective group ##STR7##
摘要翻译：用于制备式（I）的抗菌化合物的方法包括将式IMA的（V）的氧代化合物与式VI的氨基化合物缩合以产生式（III）使式（III）的化合物与式（II）的化合物反应，得到式（IV）化合物，然后除去氨基保护基

3. 发明授权

US5574161A 7-(aminomethyl-oxa-7-aza-bicyclo[3.3.0]oct-7-yl)quinolonecarboxylic and 7-(aminomethyl-oxa-7-aza-bicyclo[3.3.0]oct-7-yl naphthyridonecarboxylic acid derivatives 失效
标题翻译： 7-（氨基甲基 - 氧杂-7-氮杂 - 双环[3.3.0]辛-7-基）喹啉酮羧酸和7-（氨基甲基 - 氧杂-7-氮杂 - 双环[3.3.0]辛-7-基萘啶酮羧酸衍生物
公开(公告)号：US5574161A
公开(公告)日：1996-11-12
申请号：US320035
申请日：1994-10-07
申请人： Uwe Petersen , Thomas Schenke , Klaus Grohe , Klaus-Dieter Bremm , Rainer Endermann , Karl G. Metzger
发明人： Uwe Petersen , Thomas Schenke , Klaus Grohe , Klaus-Dieter Bremm , Rainer Endermann , Karl G. Metzger
IPC分类号： A61K31/47 , A61K31/435 , A61K31/4375 , A61K31/4709 , A61K31/4741 , A61P31/04 , C07D491/04 , C07D491/048 , C07D519/00 , A61K31/535 , A61K31/54 , C07D497/06 , C07D498/06
CPC分类号： C07D491/04
摘要： The invention relates to novel derivatives of quinolone-carboxylic acid and naphthyridonecarboxylic acid which are substituted in the 7 position by a 1- (or 5-)amino-methyl-2- (or 3-)oxa-7-aza-bicyclo[3.3.0]oct-7-yl residue, their salts, processes for their preparation and antibacterial agents containing these compounds.
摘要翻译：本发明涉及喹诺酮羧酸和萘啶酮羧酸的新衍生物，其在7位被1-（或5-）氨基 - 甲基-2-（或3-）氧杂-7-氮杂 - 双环[3.3 0]辛-7-基残基，其盐，其制备方法和含有这些化合物的抗菌剂。

4. 发明授权

US5571812A 7-amino-1-cyclopropyl-6,8-dihalogeno- 1,4-dihydro-4-oxo-3-quinolinecarboxylic acid antibacterial agents 失效
标题翻译： 7-氨基-1-环丙基-6,8-二卤代-1,4-二氢-4-氧代-3-喹啉羧酸抗菌剂
公开(公告)号：US5571812A
公开(公告)日：1996-11-05
申请号：US875572
申请日：1992-04-27
申请人： Uwe Petersen , Klaus Grohe , Hans-Joachim Zeiler , Karl G. Metzger
发明人： Uwe Petersen , Klaus Grohe , Hans-Joachim Zeiler , Karl G. Metzger
IPC分类号： A61K31/47 , A61K31/495 , A61K31/535 , A61K31/54 , A61P31/04 , C07D215/56 , C07D401/04 , C07D409/04 , C07D409/12 , C07D413/04 , C07D417/04
CPC分类号： C07D215/56 , C07D401/04 , C07D409/12 , C07D413/04
摘要： The invention is related to 7-amino-1-cyclopropyl-6,8- dihalogeno-1,4-dihydro-4-oxo-3-quinoline-carboxylic acids of the formula (I) ##STR1## in which X.sup.1, X.sup.2, R.sup.1 and R.sup.2 have the meaning as pointed out in the following specification. Moreover, the invention is related to a process for the production of the compounds of formula (I) and to antibacterial agents containing them.
摘要翻译：本发明涉及式（I）的7-氨基-1-环丙基-6,8-二卤代-1,4-二氢-4-氧代-3-喹啉羧酸（Ⅰ），其中X1 ，X2，R1和R2具有以下说明书中指出的含义。此外，本发明涉及制备式（I）化合物的方法和含有它们的抗菌剂。

5. 发明授权

US5565614A 2,4,5-trihalogeno-and 2,3,4,5-tetrahalogenobenzene derivatives 失效
标题翻译： 2,4,5-三卤代 - 和2,3,4,5-四卤代苯衍生物
公开(公告)号：US5565614A
公开(公告)日：1996-10-15
申请号：US419969
申请日：1995-04-07
申请人： Erich Klauke , Uwe Petersen , Klaus Grohe
发明人： Erich Klauke , Uwe Petersen , Klaus Grohe
IPC分类号： C07C17/14 , C07C17/16 , C07C33/46 , C07C45/29 , C07C45/43 , C07C47/52 , C07C47/55 , C07C51/58 , C07C63/04 , C07C63/70 , C07C233/00 , C07D215/56 , C07D401/04 , C07D413/04
CPC分类号： C07C17/14 , C07C17/16 , C07C255/00 , C07C33/46 , C07C45/292 , C07C45/43 , C07C47/55 , C07C63/70 , C07D215/56 , C07D401/04 , C07D413/04
摘要： 2,4,5-Trihalogenobenzene derivatives of the formula ##STR1## is which R is --COOH, --COCl, --COF, --CN, --CONH.sub.2, --CH.sub.2 OH, --CH.sub.2 Cl, --CHCl.sub.2, --CCl.sub.3 or --CHO,R.sup.1 is H, Cl or F, andR.sup.2 is Cl or F,it only being possible for R.sup.1 or R.sup.2 to be F, and processes for their preparation starting from benzonitriles reacted with potassium fluoride. The novel compounds are intermediates for antibacterials such as quinolone carboxylic acids.
摘要翻译：式（Ia）的2,4,5-三卤代苯衍生物是其中R是-COOH，-COCl，-COF，-CN，-CONH 2，-CH 2 OH，-CH 2 Cl，-CHCl 2，-CCl 3或-CHO，R 1是 H，Cl或F，R2为Cl或F，只有R1或R2可能为F，并且从与氟化钾反应的苯甲腈开始制备它们的制备方法。新型化合物是抗菌剂如喹诺酮羧酸的中间体。

6. 发明授权

US5530158A 2,4,5-trihalogeno- and 2,3,4,5-tetrahalogenobenzene derivatives 失效
标题翻译： 2,4,5-三卤代 - 和2,3,4,5-四卤代苯衍生物
公开(公告)号：US5530158A
公开(公告)日：1996-06-25
申请号：US409282
申请日：1995-03-23
申请人： Erich Klauke , Uwe Petersen , Klaus Grohe
发明人： Erich Klauke , Uwe Petersen , Klaus Grohe
IPC分类号： C07C17/14 , C07C17/16 , C07C33/46 , C07C45/29 , C07C45/43 , C07C47/52 , C07C47/55 , C07C51/58 , C07C63/04 , C07C63/70 , C07C233/00 , C07D215/56 , C07D401/04 , C07D413/04
CPC分类号： C07C17/14 , C07C17/16 , C07C255/00 , C07C33/46 , C07C45/292 , C07C45/43 , C07C47/55 , C07C63/70 , C07D215/56 , C07D401/04 , C07D413/04
摘要： 2,4,5-Trihalogenobenzene derivatives of the formula ##STR1## in which R is --COOH, --COCl, --COF, --CN, --CONH.sub.2, --CH.sub.2 OH, --CH.sub.2 Cl, --CHCl.sub.2, --CCl.sub.3 or --CHO,R.sup.1 is H, Cl or F, andR.sup.2 is Cl or F,it only being possible for R.sup.1 or R.sup.2 to be F, and processes for their preparation starting from benzonitriles reacted with potassium fluoride. The novel compounds are intermediates for antibacterials such as quinolone carboxylic acids.
摘要翻译：其中R是-COOH，-COCl，-COF，-CN，-CONH 2，-CH 2 OH，-CH 2 Cl，-CHCl 2，-CCl 3或-CHO的式“IMAGE”的2,4,5-三卤代苯衍生物，R1是 H，Cl或F，R2为Cl或F，只有R1或R2可能为F，并且从与氟化钾反应的苯甲腈开始制备它们的制备方法。新型化合物是抗菌剂如喹诺酮羧酸的中间体。

7. 发明授权

US5284842A Quinolone- and naphthridone carboxylic acid derivatives, process for their production, antibacterial compositions and feed additives containing them 失效
标题翻译：喹诺酮和萘啶酮羧酸衍生物，其制备方法，抗菌组合物和含有它们的饲料添加剂
公开(公告)号：US5284842A
公开(公告)日：1994-02-08
申请号：US931746
申请日：1992-08-18
申请人： Uwe Petersen , Thomas Schenke , Klaus Grohe , Michael Schriewer , Ingo Haller , Karl G. Metzger , Rainer Endermann , Hans-Joachim Zeiler
发明人： Uwe Petersen , Thomas Schenke , Klaus Grohe , Michael Schriewer , Ingo Haller , Karl G. Metzger , Rainer Endermann , Hans-Joachim Zeiler
IPC分类号： C07D207/12 , C07D211/42 , C07D211/48 , C07D401/04 , C07D405/14 , C07D455/04 , C07D471/04 , C07D487/10 , C07D491/10 , C07D498/06 , C07D498/10 , C07D513/10 , C07D519/00 , A61K31/47
CPC分类号： C07D401/04 , C07D207/12 , C07D211/42 , C07D211/48 , C07D405/14 , C07D455/04 , C07D471/04 , C07D487/10 , C07D491/10 , C07D513/10
摘要： An antibacterially active quinolone or naphthyridonecarboxylic acid derivative of the formula ##STR1## in which R.sup.1 stands for various organic radical,R.sup.2 stands for hydrogen, alkyl having 1 to 4 carbon atoms or (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl,R.sup.3 stands for hydrogen or amino,R.sup.4 stands for a radical of the formula ##STR2## A stands for N or C--R.sup.5, whereinR.sup.5 stands for hydrogen, halogen methyl, cyano or nitro or else together with R.sup.1 can form a bridge of the structure ##STR3## or a pharmaceutically utilizable hydrate, acid addition salt, alkali metal salt, alkaline earth metal salt, silver salt or guanidinium salt of the carboxylic acid when R.sup.2 is hydrogen.
摘要翻译：其中R1代表各种有机基团，R2代表氢，具有1至4个碳原子的烷基或（5-甲基-2-氧代-1,3-二氧杂环戊烯）的式为“IMAGE”的抗菌活性喹诺酮或萘啶酮羧酸衍生物 -4-基）甲基，R3代表氢或氨基，R4代表下式基团A表示N或C-R5，其中R5代表氢，卤素甲基，氰基或硝基，或者与当R 2为氢时，R 1可以形成结构或可药用的水合物，酸加成盐，碱金属盐，碱土金属盐，银盐或胍盐的桥。

8. 发明授权

US5252734A Antibacterial 5-alkylquinolonecarboxylic acids 失效
标题翻译：抗菌5-烷基喹诺酮羧酸
公开(公告)号：US5252734A
公开(公告)日：1993-10-12
申请号：US831778
申请日：1992-02-05
申请人： Michael Schriewer , Klaus Grohe , Andreas Krebs , Uwe Petersen , Thomas Schenke , Ingo Haller , Karl G. Metzger , Rainer Endermann , Hans-Joachim Zeiler
发明人： Michael Schriewer , Klaus Grohe , Andreas Krebs , Uwe Petersen , Thomas Schenke , Ingo Haller , Karl G. Metzger , Rainer Endermann , Hans-Joachim Zeiler
IPC分类号： C07D215/56 , C07D471/04 , C07D487/04 , C07D487/08 , C07D498/04 , C07D498/06 , C07D513/06 , C07F1/10
CPC分类号： C07D215/56 , C07D471/04 , C07D487/04 , C07D487/08
摘要： Antibacterial 5-alkylquinolonecarboxylic acids of the formula ##STR1## in which R.sup.3 is C.sub.1 -C.sub.4 - alkyl,R.sup.1 is optionally substituted alkyl or cycloalkyl, alkenyl, alkoxy, amino or alkylamino or optionally substituted phenyl,R.sup.2 is hydrogen or optionally substituted alkyl,R.sup.4 is a nitrogen-containing heterocyclic radical, andA is hydrogen, halogen, methyl, cyano or nitro, or forms a bridge with R.sup.1.and hydrates and salts thereof.
摘要翻译：式为“IMAGE”的抗菌5-烷基喹诺酮羧酸，其中R 3为C 1 -C 4烷基，R 1为任选取代的烷基或环烷基，烯基，烷氧基，氨基或烷基氨基或任选取代的苯基，R 2为氢或任选取代的烷基，R 4 是含氮杂环基，A是氢，卤素，甲基，氰基或硝基，或与R1形成桥。及其水合物和盐。

9. 发明授权

US5202337A 7-(2,7-diazabicyclo[3.3.0]octyl)-3-quinoline- and -naphthyridone-carboxylic acid derivatives 失效
标题翻译： 7-（2,7-二氮杂双环（3.3.0）十八烷基）-3-喹啉 - 和 - 邻苯二甲酰基羧酸衍生物
公开(公告)号：US5202337A
公开(公告)日：1993-04-13
申请号：US771700
申请日：1991-10-03
申请人： Uwe Petersen , Thomas Schenke , Michael Schriewer , Klaus Grohe , Andreas Krebs , Ingo Haller , Karl G. Metzger , Klaus-Dieter Bremm , Rainer Endermann , Hans-Joachim Zeiler
发明人： Uwe Petersen , Thomas Schenke , Michael Schriewer , Klaus Grohe , Andreas Krebs , Ingo Haller , Karl G. Metzger , Klaus-Dieter Bremm , Rainer Endermann , Hans-Joachim Zeiler
IPC分类号： A01N43/40 , A01N43/42 , A23K20/116 , A23L3/3544 , A61K31/47 , A61P31/04 , C07D471/14 , C07D487/04 , C07D487/08 , C07D487/14 , C07D513/04 , C07D513/14 , C07D519/00
CPC分类号： C07D471/14 , A23K20/116 , A23L3/3544 , A61K31/47 , C07D487/04 , C07D487/14 , C07D513/14
摘要： The invention relates to new 7-(2,7-Diazabicyclo[3.3.0]octyl)-3-quinolone- and -naphthyridonecarboxylic acid derivatives, processes for their preparation, and antibacterial agents and feed additives containing them.
摘要翻译：本发明涉及新的7-（2,7-二氮杂双环[3.3.0]辛基）-3-喹诺酮和 - 萘啶酮羧酸衍生物，其制备方法，以及含有它们的抗菌剂和饲料添加剂。

10. 外观设计

USD329912S Faucet handle 失效
公开(公告)号：USD329912S
公开(公告)日：1992-09-29
申请号：US350536
申请日：1989-05-11
申请人： Klaus Grohe
设计人： Klaus Grohe

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