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1. 发明授权

US10830740B2 Parallel separation system 有权
公开(公告)号：US10830740B2
公开(公告)日：2020-11-10
申请号：US13638676
申请日：2011-03-30
申请人： Klaus Gebauer
发明人： Klaus Gebauer
IPC分类号： G01N30/46 , B01D15/18 , G01N30/78 , G01N30/86
摘要： A method in a separation system including parallel fluid paths each having a separation module, includes providing a sensor of the same type in at least each of the parallel fluid paths except one: measuring a characteristic fluid property with at least one of the sensors in the parallel fluid paths; possibly measuring the same characteristic fluid property with a system sensor positioned in the outlet of the separation system; and comparing measured characteristic fluid properties to evaluate and/or qualify the performance of the separation system.

2. 发明授权

US10099047B2 Aseptic connection of separation or reaction systems 有权
公开(公告)号：US10099047B2
公开(公告)日：2018-10-16
申请号：US13521242
申请日：2011-01-10
申请人： Klaus Gebauer
发明人： Klaus Gebauer
IPC分类号： B01D15/08 , B01D35/30 , B01D25/00 , A61M39/16 , A61M39/18 , G01N30/96 , G01N30/88
摘要： A separation or reaction unit (1; 1′; 81; 81′; 101) and a method for aseptically connecting such units. The separation or reaction unit (1; 1′; 81; 81′; 101) comprises at last one fluid inlet (3a, 3b, 5a, 5b; 3a′, 3b′, 5a′, 5b′; 85a, 85b; 103a, 103b) and at least one fluid outlet (3a, 3b, 5a, 5b; 3a′, 3b′, 5a′, 5b′; 85a, 85b; 103a, 103b). At least one of the inlet or outlet is sealed by at least one film (7, 9; 11; 87a, 87b; 107a, 107b) and the contact surface between the film and the separation or reaction unit is aseptic. The films are adapted to be mated with a corresponding film on another separation or reaction unit or on a fluid distribution unit (20; 57; 61) which the separation or reaction unit possibly should be connected with and said mated films are adapted to be pulled out together two and two after mating such that corresponding fluid inlets/outlets on the two connected units are mated aseptically.

3. 发明申请

US20130048111A1 ASEPTIC CONNECTION OF SEPARATION OR REACTION SYSTEMS 审中-公开
标题翻译：分离或反应系统的自由连接
公开(公告)号：US20130048111A1
公开(公告)日：2013-02-28
申请号：US13521242
申请日：2011-01-10
申请人： Klaus Gebauer
发明人： Klaus Gebauer
IPC分类号： B01D35/30 , F17D1/00 , B23P11/00 , B01D15/10
CPC分类号： A61M39/162 , A61M39/16 , A61M39/165 , A61M39/18 , G01N30/96 , G01N2030/8881 , Y10T137/0402 , Y10T137/794
摘要： A separation or reaction unit (1; 1′; 81; 81′; 101) and a method for aseptically connecting such units. The separation or reaction unit (1; 1′; 81; 81′; 101) comprises at last one fluid inlet (3a, 3b, 5a, 5b; 3a′, 3b′, 5a′, 5b′; 85a, 85b; 103a, 103b) and at least one fluid outlet (3a, 3b, 5a, 5b; 3a′, 3b′, 5a′, 5b′; 85a, 85b; 103a, 103b). At least one of the inlet or outlet is sealed by at least one film (7, 9; 11; 87a, 87b; 107a, 107b) and the contact surface between the film and the separation or reaction unit is aseptic. The films are adapted to be mated with a corresponding film on another separation or reaction unit or on a fluid distribution unit (20; 57; 61) which the separation or reaction unit possibly should be connected with and said mated films are adapted to be pulled out together two and two after mating such that corresponding fluid inlets/outlets on the two connected units are mated aseptically.
摘要翻译：分离或反应单元（1; 1'; 81; 81'; 101）和用于无菌连接这些单元的方法。分离或反应单元（1; 1'; 81; 81'; 101）最后包括一个流体入口（3a，3b，5a，5b; 3a'，3b'，5a'，5b'; 85a，85b; 103a ，103b）和至少一个流体出口（3a，3b，5a，5b; 3a'，3b'，5a'，5b'; 85a，85b; 103a，103b）。入口或出口中的至少一个由至少一个膜（7,9; 11; 87a，87b; 107a，107b）密封，膜和分离或反应单元之间的接触表面是无菌的。这些膜适于与另一个分离或反应单元上的相应的膜或在分离或反应单元可能连接的流体分配单元（20; 57; 61）上配合，并且所述配合膜适于被拉动在两个连接的单元之间相应的流体入口/出口被配合在一起，在配合之后一起排出两个和两个。

4. 发明授权

US08377296B2 Filter holder in a chromatography column 有权
标题翻译：色谱柱中的过滤器支架
公开(公告)号：US08377296B2
公开(公告)日：2013-02-19
申请号：US13319816
申请日：2010-05-10
申请人： Klaus Gebauer , Mircea Georgescu
发明人： Klaus Gebauer , Mircea Georgescu
IPC分类号： B01D15/08
CPC分类号： B01D15/14 , B01D15/22 , G01N30/56 , G01N30/6004 , G01N30/6017 , G01N30/6026 , G01N30/603 , G01N30/6047
摘要： A filter holder to be used in a chromatography column is provided. Said filter holder comprising a filter squeezing part (356) facing the filter of the column essentially in the form of a plate and a squeezing means (354) adapted to squeeze the filter squeezing part (356) against the filter (204) to prevent any leakage of particulate medium from the bed space (209) of the column in between the filter holder and the filter (204). According to the invention said filter squeezing part (356) comprises at least one channel (338), providing fluid connections through the filter squeezing part (356) from the side of the filter squeezing part (356) facing the filter (204) and to the side of the filter squeezing part (356) facing the bed space (209).
摘要翻译：提供了用于色谱柱的过滤器保持器。所述过滤器保持器包括基本上为板形的面向柱的过滤器的过滤器挤压部分（356）和适于将过滤器挤压部分（356）挤压过滤器（204）的挤压装置（354），以防止任何颗粒介质从过滤器保持器和过滤器（204）之间的塔的空间（209）泄漏。根据本发明，所述过滤器挤压部分（356）包括至少一个通道（338），从面向过滤器（204）的过滤器挤压部分（356）的一侧提供通过过滤器挤压部分（356）的流体连接，并且过滤器挤压部分（356）的面向床空间（209）的一侧。

5. 发明申请

US20130011297A1 METHOD FOR STERILIZATION 审中-公开
标题翻译：灭菌方法
公开(公告)号：US20130011297A1
公开(公告)日：2013-01-10
申请号：US13634689
申请日：2011-03-14
申请人： Kieron D. Walsh , Asa Lagerlof , Klaus Gebauer
发明人： Kieron D. Walsh , Asa Lagerlof , Klaus Gebauer
IPC分类号： A61L2/07
CPC分类号： A61L2/07 , A61L2202/18
摘要： The present invention relates to a method for providing a sterile connected device, especially of sensitive material, such as material not compatible with sterilization by gamma irradiation. The method comprises providing connectors and a tubing in an autoclave bag, and autoclaving the sealed autoclave bag containing the connectors and tubing for sterilization. Optionally, the connectors and tubing are assembled prior to autoclave. Also provided are sterile, connected devices sterilized according to the present method.
摘要翻译：本发明涉及一种用于提供无菌连接装置，特别是敏感材料的方法，例如通过γ照射与灭菌不兼容的材料。该方法包括在高压釜袋中提供连接器和管道，并将包含连接器和管道的密封的高压灭菌器袋高压灭菌以进行灭菌。可选地，连接器和管道在高压釜之前组装。还提供了根据本方法灭菌的无菌连接装置。

6. 发明申请

US20120267299A1 METHOD FOR DRY PACKING CHROMATOGRAPHY COLUMNS 有权
标题翻译：干包装色谱柱的方法
公开(公告)号：US20120267299A1
公开(公告)日：2012-10-25
申请号：US13518029
申请日：2010-12-20
申请人： Klaus Gebauer , Elisabeth Hallgren , Raf Lemmens , Ola Lind , Bjorn Lundgren , Jamil Shanagar , Kajsa Stridsberg-Friden , Helena Widegren
发明人： Klaus Gebauer , Elisabeth Hallgren , Raf Lemmens , Ola Lind , Bjorn Lundgren , Jamil Shanagar , Kajsa Stridsberg-Friden , Helena Widegren
IPC分类号： B01D15/20 , B65B55/08 , B65B1/04
CPC分类号： G01N30/56 , B01D15/206 , B01D15/32 , B01D15/361 , B01D15/3804 , B01J20/22 , B01J20/28 , B01J20/28011 , B01J20/28016 , B01J20/285 , B01J20/3092 , G01N30/28 , G01N30/482
摘要： The invention provides a packing method for high efficiency chromatography columns starting from dry swellable particles, as well as columns packed by the method and the use of the columns in separation of biomolecules. In the packing method, an amount of dry swellable particles sufficient to give a swollen volume in a liquid of about 105-120% of the column chamber volume is transferred to the column, the column is closed and the liquid is provided to the column.
摘要翻译：本发明提供了一种从干燥可溶胀颗粒开始的高效色谱柱的包装方法，以及通过该方法包装的色谱柱和分离生物分子中色谱柱的用途。在包装方法中，足以使柱体积体积的约105-120％的液体中的溶胀体积的干燥可溶胀颗粒的量转移到柱中，将柱关闭并将液体提供给塔。

7. 发明申请

US20110107582A1 AUTOMATED INSTALLATION PROCEDURE FOR A DISPOSABLE FLOW PATH 有权
标题翻译：自动化安装程序，用于一次性流动路径
公开(公告)号：US20110107582A1
公开(公告)日：2011-05-12
申请号：US13000645
申请日：2009-06-04
申请人： Kine Frej , Niklas Edblad , Klaus Gebauer , Lars Kanon
发明人： Kine Frej , Niklas Edblad , Klaus Gebauer , Lars Kanon
IPC分类号： B23P11/00
CPC分类号： G01N30/60 , B01D15/18 , G01N2030/8804 , Y10T29/49771 , Y10T29/49826
摘要： This invention provides an automated installation procedure for assembling a disposable flow path: providing a disposable flow path comprising tubing and a plurality of sensors onto a re-usable instrument; qualifying said tubing and said plurality of sensors to be on the flow path based on a standard; and determining if the tubing and the plurality of sensors comply with characteristics and performance according to limits for specifications or acceptance criteria.
摘要翻译：本发明提供了一种用于组装一次性流动路径的自动化安装程序：提供包括管道和多个传感器到可重复使用的仪器上的一次性流路; 基于标准，将所述管道和所述多个传感器合格在流路上; 以及根据规格或验收标准的限制来确定管道和多个传感器是否符合特性和性能。

8. 发明授权

US07534345B2 Chromatography column distribution system 有权
标题翻译：色谱柱分配系统
公开(公告)号：US07534345B2
公开(公告)日：2009-05-19
申请号：US10571194
申请日：2004-09-22
申请人： Klaus Gebauer
发明人： Klaus Gebauer
IPC分类号： B01D15/08
CPC分类号： B01D15/14 , G01N30/6017 , Y10T137/6851
摘要： A chromatography column distribution system (101) comprises a set of first bed support ribs (107) extending radially from a inner, first radial position (R1) near the centre of the plate to a outer radial position nearer to the periphery (109) of the plate and at least one set of intermediate bed support ribs (117, 119) starting at an intermediate radial position (R2, R3) and extending to an outer radial position nearer to the periphery (109) of the plate (101), whereby channels are formed between adjacent bed support ribs (107, 117, 119). The desired local effective channel height is intended to vary in accordance with a predetermined formula from said first radial position (R1) to said outer radial position, and in accordance with the present invention the transverse cross-sectional areas of said ribs (107, 117, 119) or said channels are adapted such that the actual local effective channel height is within 15% of the desired local effective channel height over portions of the distribution system situated between said first radial position (R1) and said outer radial position, wherein the total length of said portions correspond to at least 80% of the distance between said first radial position (R1) and said outer radial position.
摘要翻译：色谱柱分配系统（101）包括一组第一床支撑肋（107），其从靠近板的中心的内部第一径向位置（R1）径向延伸到更接近外围（109）的外径向位置所述板和至少一组中间床支撑肋（117,119）从中间径向位置（R2，R3）开始并延伸到更接近所述板（101）的周边（109）的外径向位置，由此通道形成在相邻的床支撑肋（107,117,119）之间。期望的局部有效通道高度旨在根据从所述第一径向位置（R1）到所述外径向位置的预定公式变化，并且根据本发明，所述肋（107,117）的横截面积，119）或所述通道适于使得实际的局部有效通道高度在位于所述第一径向位置（R1）和所述外径向位置之间的分配系统的部分上的期望的局部有效通道高度的15％以内，其中所述部分的总长度对应于所述第一径向位置（R1）和所述外部径向位置之间的距离的至少80％。

9. 发明申请

US20060243650A1 Chromatography column distribution system 有权
标题翻译：色谱柱分配系统
公开(公告)号：US20060243650A1
公开(公告)日：2006-11-02
申请号：US10571194
申请日：2004-09-22
申请人： Klaus Gebauer
发明人： Klaus Gebauer
IPC分类号： B01D15/08
CPC分类号： B01D15/14 , G01N30/6017 , Y10T137/6851
摘要： A chromatography column distribution system (101) comprises a set of first bed support ribs (107) extending radially from a inner, first radial position (R1) near the centre of the plate to a outer radial position nearer to the periphery (109) of the plate and at least one set of intermediate bed support ribs (117, 119) starting at an intermediate radial position (R2, R3) and extending to an outer radial position nearer to the periphery (109) of the plate (101), whereby channels are formed between adjacent bed support ribs (107, 117, 119). The desired local effective channel height is intended to vary in accordance with a predetermined formula from said first radial position (R1) to said outer radial position, and in accordance with the present invention the transverse cross-sectional areas of said ribs (107, 117, 119) or said channels are adapted such that the actual local effective channel height is within 15% of the desired local effective channel height over portions of the distribution system situated between said first radial position (R1) and said outer radial position, wherein the total length of said portions correspond to at least 80% of the distance between said first radial position (R1) and said outer radial position.
摘要翻译：色谱柱分配系统（101）包括从靠近板的中心的内部第一径向位置（R 1）径向延伸到更靠近周边（109）的外径向位置的一组第一床支撑肋（107）和从中间径向位置（R 2，R 3）开始并延伸到更接近板（101）的周边（109）的外径向位置的至少一组中间床支撑肋（117,119）），由此在相邻的床支撑肋（107,117,119）之间形成通道。期望的局部有效通道高度旨在根据从所述第一径向位置（R 1）到所述外径向位置的预定公式来变化，并且根据本发明，所述肋（107,104）的横截面积或所述通道适于使得实际的局部有效通道高度在位于所述第一径向位置（R 1）和所述外径向位置之间的分配系统的部分上的期望的局部有效通道高度的15％以内，其中所述部分的总长度对应于所述第一径向位置（R 1）和所述外径向位置之间的距离的至少80％。

10. 发明申请

US20050236312A1 Method and device for packing chromatography columns 失效
标题翻译：填充色谱柱的方法和装置
公开(公告)号：US20050236312A1
公开(公告)日：2005-10-27
申请号：US10514856
申请日：2003-05-30
申请人： Klaus Gebauer
发明人： Klaus Gebauer
IPC分类号： B01D15/00 , B01D15/08 , B01D15/20 , G01N30/56
CPC分类号： B01D15/206 , G01N30/56 , G01N2030/565 , G01N30/6017
摘要： A column comprising a first end (2a) provided with a column packing means and a second end (2b) provided with a fluid collection means for collecting fluid from over some or all of the internal cross-section of the column, wherein said first and second ends (2a, 2b) are held apart by a column wall. The second end (2b) is provided with blocking means (52, 72, 82, 92) movable between a blocking position where said blocking means (52, 72, 82, 92) substantially obstructs the collection of fluid from a predetermined portion (CR, CR1, CR2) of the cross-section of the column and an non-blocking position where it does not substantially obstruct the collection of fluid from the predetermined portion (CR, CR1, CR2) of the cross-section of the column. This allows the resistance to flow through the collection means to be modified to control where the bed media is deposited over the cross-section of the column.
摘要翻译：一种柱，包括设置有柱填充装置的第一端（2a）和设置有用于从所述塔的一部分或全部内部横截面收集流体的流体收集装置的第二端（2b），其中所述第一和第二端（2a，2b）被柱壁隔开。第二端（2b）设置有阻挡装置（52,72,82,92），阻挡装置（52,72,82,92）可在阻挡位置之间移动，阻塞装置（52,72,82,92）基本上阻挡来自预定部分的流体收集 CR，CR 1，CR 2）和不阻塞从横截面的预定部分（CR，CR 1，CR 2）收集流体的非阻塞位置的列。这允许电阻流过收集装置以进行修改以控制床介质沉积在柱的横截面上的位置。

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