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1. 发明申请

US20060173204A1 New 3-aryl propionic acid derivatives and analogs 审中-公开
标题翻译：新的3-芳基丙酸衍生物和类似物
公开(公告)号：US20060173204A1
公开(公告)日：2006-08-03
申请号：US11388942
申请日：2006-03-24
申请人： Kjell Andersson , Maria Boije , Johan Gottfries , Tord Inghardt , Lanna Li , Eva-Lotte Alstermark
发明人： Kjell Andersson , Maria Boije , Johan Gottfries , Tord Inghardt , Lanna Li , Eva-Lotte Alstermark
IPC分类号： C07C303/02
CPC分类号： C07C233/25 , C07B2200/07 , C07C217/76 , C07C233/29 , C07C233/75 , C07C235/42 , C07C255/54 , C07C271/28 , C07C271/38 , C07C271/44 , C07C271/58 , C07C275/34 , C07C309/65 , C07C309/66 , C07C309/73 , C07C311/08 , C07C311/13 , C07C311/16 , C07C317/22 , C07C317/28 , C07C323/19 , C07C323/44 , C07C323/56 , C07C335/18 , C07C2601/14
摘要： Novel 3-aryl propionic acid derivatives and analogs, process and intermediate for their manufacture, pharmaceutical preparations containing them and the use of the compounds in clinical conditions associated with insulin resistance.
摘要翻译：新型3-芳基丙酸衍生物及其类似物，其制备方法和中间体，含有它们的药物制剂以及该化合物在与胰岛素抵抗相关的临床病症中的用途。

2. 发明授权

US06630600B1 3-aryl propionic acid derivatives and analogs 失效
标题翻译： 3-芳基丙酸衍生物和类似物
公开(公告)号：US06630600B1
公开(公告)日：2003-10-07
申请号：US09341931
申请日：1999-07-20
申请人： Kjell Andersson , Maria Boije , Johan Gottfries , Tord Inghardt , Lanna Li , Eva-Lotte Lindstedt Alstermark
发明人： Kjell Andersson , Maria Boije , Johan Gottfries , Tord Inghardt , Lanna Li , Eva-Lotte Lindstedt Alstermark
IPC分类号： C07C6976
CPC分类号： C07C233/25 , C07B2200/07 , C07C217/76 , C07C233/29 , C07C233/75 , C07C235/42 , C07C255/54 , C07C271/28 , C07C271/38 , C07C271/44 , C07C271/58 , C07C275/34 , C07C309/65 , C07C309/66 , C07C309/73 , C07C311/08 , C07C311/13 , C07C311/16 , C07C317/22 , C07C317/28 , C07C323/19 , C07C323/44 , C07C323/56 , C07C335/18 , C07C2601/14
摘要： Novel 3-aryl propionic acid derivatives and analogs, process and intermediate for their manufacture, pharmaceutical preparations containing them and the use of the compounds in clinical conditions associated with insulin resistance.
摘要翻译：新型3-芳基丙酸衍生物及其类似物，其制备方法和中间体，含有它们的药物制剂以及该化合物在与胰岛素抵抗相关的临床病症中的用途。

3. 发明授权

US06531622B1 Crytalline form of (s)-2 ethoxy -3-[4-(2-{4- methanesulfonyloxyphenyl} ethoxy)phenyl]propanoic acid 失效
标题翻译：（s）-2-乙氧基-3- [4-（2- {4-甲磺酰氧基苯基}乙氧基）苯基]丙酸的Crytalline形式
公开(公告)号：US06531622B1
公开(公告)日：2003-03-11
申请号：US10148821
申请日：2002-06-03
申请人： Maria Boije , Karol Horvath , Tord Inghardt
发明人： Maria Boije , Karol Horvath , Tord Inghardt
IPC分类号： A61K31255
CPC分类号： C07C309/66 , A61K31/192
摘要： The present invention relates to a novel crystalline form of the compound (S)-2-ethoxy-3-[4-(2-{4-methanesulfonyloxyphenyl}ethoxy)phenyl]propanoic acid, shown by formula (I), or a pharmaceutically-acceptable salt thereof, and solvates thereof. The invention also concerns methods of treating one or more metabolic disease conditions, particularly those associated with Insulin Resistance Syndrome, and the use of a crystalline form of the compound, or a pharmaceutically-acceptable salt thereof, or a solvate thereof, in the manufacture of a medicament for use in one or more of said conditions. The invention further concerns pharmaceutical compositions containing a crystalline form of the compound, or a pharmaceutically-acceptable salt thereof, or a solvate thereof, as active ingredient, as well as processes for the manufacture of a crystalline form of the compound, or a pharmaceutically-acceptable salt thereof, or a solvate thereof.
摘要翻译：本发明涉及式（I）所示的化合物（S）-2-乙氧基-3- [4-（2- {4-甲磺酰氧基苯基}乙氧基）苯基]丙酸的新结晶形式或药学上其可接受的盐及其溶剂合物。本发明还涉及治疗一种或多种代谢疾病病症，特别是与胰岛素抵抗综合征有关的代谢疾病病症的方法，以及使用化合物或其药学上可接受的盐或其溶剂合物的结晶形式在制备用于一种或多种所述条件的药物。本发明还涉及含有化合物或其药学上可接受的盐或其溶剂化物作为活性成分的结晶形式的药物组合物，以及制备该化合物的结晶形式的方法或药学上可接受的盐，其可接受的盐或其溶剂合物。

4. 发明申请

US20110021534A1 2 -SUBSTITUTED- 3 -PHENYLPROPIONIC ACID DERIVATIVES AND THEIR USE IN THE TREATMENT OF INFLAMMATORY BOWEL DISEASE 审中-公开
标题翻译： 2-取代-3-苯基丙酸衍生物及其在治疗炎症性皮肤病中的应用
公开(公告)号：US20110021534A1
公开(公告)日：2011-01-27
申请号：US12530443
申请日：2008-03-07
申请人： Anders Broo , Johan Gottfries , Michael Kossenjans , Li Lanna , Eva-Lotte Lindstedt-Alstermark , Kristina A. Nilsson , Bengt Ohlsson , Maria Thorstensson , Maria Boije , Olof Sjogren
发明人： Anders Broo , Johan Gottfries , Michael Kossenjans , Li Lanna , Eva-Lotte Lindstedt-Alstermark , Kristina A. Nilsson , Bengt Ohlsson , Maria Thorstensson , Maria Boije , Olof Sjogren
IPC分类号： A61K31/216 , C07C309/66 , C07C303/30 , C07C321/20 , C07C319/20 , C07C69/612 , C07C67/28 , C07C69/614 , C07D213/55 , C07D295/185 , C07D263/32 , C07C317/44 , C07C315/04 , A61K31/255 , A61K31/435 , A61K31/495 , A61K31/421 , A61P1/00 , A61P1/04 , A61P29/00
CPC分类号： C07C323/56 , C07C271/28 , C07C309/66 , C07C317/44 , C07C323/62 , C07C327/28 , C07D213/55 , C07D231/12 , C07D263/32 , C07D263/34 , C07D277/24 , C07D277/30 , C07D295/04
摘要： The present invention relates to 2-(substituted sulphur, sulphone or sulphoxide)-3-(substituted phenyl) propionic acid derivatives, 2-(substituted oxygen)-3-(substituted phenyl) propionic acid derivatives, benzoic acid derivatives, and derivatives of 2-methyl-2-(phenoxy or phenylthio)propanoic acid and 2-(methylor ethyl)-2-(phenoxy or phenylthio)butanoic acid, to processes for preparing such compounds, to their use in the treatment of inflammatory conditions, and to pharmaceutical compositions containing them.
摘要翻译：本发明涉及2-（取代的硫，砜或亚砜）-3-（取代的苯基）丙酸衍生物，2-（取代的氧）-3-（取代的苯基）丙酸衍生物，苯甲酸衍生物及其衍生物 2-（苯氧基或苯硫基）丙酸和2-（甲基 - 乙基）-2-（苯氧基或苯硫基）丁酸制备此类化合物的方法，用于治疗炎性病症，以及含有它们的药物组合物。

5. 发明申请

US20110166157A1 2-Substituted-3-Phenylpropionic Acid Derivatives and Their Use in the Treatment of Inflammatory Bowel Disease 失效
标题翻译： 2-取代-3-苯基丙酸衍生物及其在炎症性肠病的治疗中的应用
公开(公告)号：US20110166157A1
公开(公告)日：2011-07-07
申请号：US13046288
申请日：2011-03-11
申请人： Anders Broo , Johan Gottfries , Michael Kossenjans , Li Lanna , Eva-Lotte Lindstedt-Alstermark , Kristina A. Nilsson , Bengt Ohlsson , Maria Thorstensson , Maria Boije , Per Olof Sjögren
发明人： Anders Broo , Johan Gottfries , Michael Kossenjans , Li Lanna , Eva-Lotte Lindstedt-Alstermark , Kristina A. Nilsson , Bengt Ohlsson , Maria Thorstensson , Maria Boije , Per Olof Sjögren
IPC分类号： A61K31/495 , C07C69/78 , A61K31/255 , C07C69/635 , A61K31/216 , C07D213/64 , A61K31/44 , C07D241/04 , C07D263/32 , A61K31/421 , C07D277/30 , A61K31/426 , A61P1/00
CPC分类号： C07C323/56 , C07C271/28 , C07C309/66 , C07C317/44 , C07C323/62 , C07C327/28 , C07D213/55 , C07D231/12 , C07D263/32 , C07D263/34 , C07D277/24 , C07D277/30 , C07D295/04
摘要： The present invention relates to 2-(substituted sulphur, sulphone or sulphoxide)-3-(substituted phenyl)propionic acid derivatives, 2-(substituted oxygen)-3-(substituted phenyl)propionic acid derivatives, benzoic acid derivatives, and derivatives of 2-methyl-2-(phenoxy or phenylthio)propanoic acid and 2-(methyl or ethyl)-2-(phenoxy or phenylthio)butanoic acid, to processes for preparing such compounds, to their use in the treatment of inflammatory conditions, and to pharmaceutical compositions containing them.
摘要翻译：本发明涉及2-（取代的硫，砜或亚砜）-3-（取代的苯基）丙酸衍生物，2-（取代的氧）-3-（取代的苯基）丙酸衍生物，苯甲酸衍生物及其衍生物 2-（苯氧基或苯硫基）丙酸和2-（甲基或乙基）-2-（苯氧基或苯硫基）丁酸，用于制备这些化合物，用于治疗炎性病症，以及含有它们的药物组合物。

6. 发明授权

US06288096B1 Thiazolidinedione, oxazolidinedione and oxadiazolidinedione derivatives 失效
标题翻译：噻唑烷二酮，恶唑烷二酮和恶二唑烷二酮衍生物
公开(公告)号：US06288096B1
公开(公告)日：2001-09-11
申请号：US09091875
申请日：1998-06-25
申请人： Kjell Andersson , Maria Boije , Eva-Lotte Lindstedt , Bengt Ljung , Bo Nordén
发明人： Kjell Andersson , Maria Boije , Eva-Lotte Lindstedt , Bengt Ljung , Bo Nordén
IPC分类号： C07D27734
CPC分类号： C07D263/44 , C07D271/07 , C07D277/34
摘要： Novel thiazolidinedione, oxazolidinedione and oxadiazolidinedione derivatives, process for their manufacture, pharmaceutical preparations containing them and the use of the compounds in conditions associated with insulin resistance.
摘要翻译：新的噻唑烷二酮，恶唑烷二酮和恶二唑烷二酮衍生物，其制备方法，含有它们的药物制剂以及该化合物在与胰岛素抵抗相关的条件下的用途。

7. 发明授权

US08785681B2 2-substituted-3-phenylpropionic acid derivatives and their use in the treatment of inflammatory bowel disease 失效
标题翻译： 2-取代-3-苯基丙酸衍生物及其在治疗炎性肠病中的应用
公开(公告)号：US08785681B2
公开(公告)日：2014-07-22
申请号：US13046288
申请日：2011-03-11
申请人： Anders Broo , Johan Gottfries , Michael Kossenjans , Li Lanna , Eva-Lotte Lindstedt-Alstermark , Kristina A. Nilsson , Bengt Ohlsson , Maria Thorstensson , Per Olof Sjögren
发明人： Anders Broo , Johan Gottfries , Michael Kossenjans , Li Lanna , Eva-Lotte Lindstedt-Alstermark , Kristina A. Nilsson , Bengt Ohlsson , Maria Thorstensson , Maria Boije
IPC分类号： C07C321/00 , C07C323/00 , C07C325/00 , C07C335/00 , C07C381/00
CPC分类号： C07C323/56 , C07C271/28 , C07C309/66 , C07C317/44 , C07C323/62 , C07C327/28 , C07D213/55 , C07D231/12 , C07D263/32 , C07D263/34 , C07D277/24 , C07D277/30 , C07D295/04
摘要： The present invention relates to 2-(substituted sulphur, sulphone or sulphoxide)-3-(substituted phenyl)propionic acid derivatives, 2-(substituted oxygen)-3-(substituted phenyl)propionic acid derivatives, benzoic acid derivatives, and derivatives of 2-methyl-2-(phenoxy or phenylthio)propanoic acid and 2-(methyl or ethyl)-2-(phenoxy or phenylthio)butanoic acid, to processes for preparing such compounds, to their use in the treatment of inflammatory conditions, and to pharmaceutical compositions containing them.
摘要翻译：本发明涉及2-（取代的硫，砜或亚砜）-3-（取代的苯基）丙酸衍生物，2-（取代的氧）-3-（取代的苯基）丙酸衍生物，苯甲酸衍生物及其衍生物 2-（苯氧基或苯硫基）丙酸和2-（甲基或乙基）-2-（苯氧基或苯硫基）丁酸，用于制备这些化合物，用于治疗炎性病症，以及含有它们的药物组合物。

8. 发明授权

US06750252B2 Tri-substituted phenyl derivatives and analogues 失效
标题翻译：三取代苯基衍生物和类似物
公开(公告)号：US06750252B2
公开(公告)日：2004-06-15
申请号：US10148850
申请日：2002-11-13
申请人： Maria Boije , Jonas Fägerhag , Eva-Lotte Lindstedt Alstermark , Bengt Ohlsson
发明人： Maria Boije , Jonas Fägerhag , Eva-Lotte Lindstedt Alstermark , Bengt Ohlsson
IPC分类号： A61K31255
CPC分类号： C07C59/64 , C07C69/734 , C07C271/28 , C07C309/66
摘要： The present invention relates to certain tri-substituted phenyl derivatives and analogues of formula (I), to a process for preparing such compounds, having the utility in clinical conditions associated with insulin resistance, to methods for their therapeutic use and to pharmaceutical compositions containing them.
摘要翻译：本发明涉及某些三取代的苯基衍生物和式（I）的类似物，涉及一种制备此类化合物的方法，具有与胰岛素抵抗相关的临床病症的效用，其治疗用途的方法和含有它们的药物组合物。

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