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1. 发明授权

US5409956A Indan derivative and thromboxane antagonist containing the same 失效
标题翻译： Indan衍生物和含有相同的血栓素拮抗剂
公开(公告)号：US5409956A
公开(公告)日：1995-04-25
申请号：US107823
申请日：1993-08-30
申请人： Kiyoshi Yoshida , Yoshiaki Yamaji , Tadashi Kurimoto , Ryuichi Sato , Motoki Torizuka
发明人： Kiyoshi Yoshida , Yoshiaki Yamaji , Tadashi Kurimoto , Ryuichi Sato , Motoki Torizuka
IPC分类号： A61K31/19 , A61K31/195 , A61K31/22 , A61K31/38 , A61K31/50 , A61K38/22 , A61K38/55 , A61P9/00 , A61P43/00 , C07C311/13 , C07C311/17 , C07C311/19 , C07C311/29 , C07C311/42 , C07D231/20 , C07D237/04 , C07D333/34 , A01N37/12 , C07C311/00
CPC分类号： A61K38/2242 , A61K38/55 , A61K38/556 , C07C311/13 , C07C311/17 , C07C311/19 , C07C311/29 , C07C311/42 , C07D231/20 , C07D237/04 , C07D333/34 , C07C2102/08
摘要： The present invention relates to indan derivatives represented by the formula (1) or pharmaceutically acceptable salts thereof: ##STR1## [wherein R.sup.1 represents C1 to C12 alkyl, benzyl, styryl, naphthyl, optionally substituted phenyl or optionally substituted thienyl; R.sup.2 represents carboxyl, C1 to C4 alkoxycarbonyl, ##STR2## Y represents --(CH.sub.2).sub.p -- (wherein p represents an integer of 0 to 5), --CO--(CH.sub.2).sub.q .about., --CH(OH)--(CH.sub.2).sub.q .about., (wherein q represents an integer of 1 to 4, and the symbol .about. represents a linkage to R.sup.2), oxymethylene or ethylene; and n represents an integer of 1 to 4]. The compounds according to the present invention potently antagonize the action of thromboxane A.sub.2, and therefore useful for the treatment and prevention of diseases caused by thromboxane A.sub.2 such as angiosis, vasospasm, asthma and the like.
摘要翻译： PCT No.PCT / JP92 / 00236 Sec。 371日期：1993年8月30日 102（e）日期1993年8月30日PCT提交1992年2月28日PCT公布。出版物WO92 / 15558 本发明涉及由式（1）表示的茚满衍生物或其药学上可接受的盐：其中R1表示C1〜C12烷基，苄基，苯乙烯基，萘基，任意取代苯基或任选取代的噻吩基; R 2表示羧基，C 1〜C 4烷氧基羰基，Y表示 - （CH 2）p - （其中p表示0〜5的整数），-CO-（CH 2）q DIFFERENCE，-CH（OH） - （CH 2）q DIFFERENCE，（其中q表示1至4的整数，符号DIFFERENCE表示与R 2的连接），甲醛或亚乙基; n表示1〜4的整数]。根据本发明的化合物有效地拮抗血栓素A2的作用，因此可用于治疗和预防由血栓素A2引起的疾病，例如血管紧张素，血管痉挛，哮喘等。

2. 发明授权

US4427869A Method for manufacturing panel assemblies for automobiles 失效
标题翻译：汽车面板组件的制造方法
公开(公告)号：US4427869A
公开(公告)日：1984-01-24
申请号：US428524
申请日：1982-09-30
申请人： Toshio Kimura , Kunitoshi Kataoka , Yoshiaki Yamaji , Hiromi Iwasaki , Shinichi Yamashita
发明人： Toshio Kimura , Kunitoshi Kataoka , Yoshiaki Yamaji , Hiromi Iwasaki , Shinichi Yamashita
IPC分类号： B62D65/00 , B23K11/11 , B23K11/14 , B60J5/00 , B62D25/10 , B62D25/12 , B23K11/00
CPC分类号： B23K11/14 , B21D39/026
摘要： Method is disclosed for manufacturing a panel assembly comprised of an inner panel and an outer panel which are welded together at the peripheral portions thereof. The method comprises steps of forming a plurality of raised portions having projections in the inner panel along at least one peripheral portion thereof so that the raised portions project in a direction opposite to the outer panel, folding a peripheral portion of the outer panel over the peripheral portion of the inner panel so that the peripheral portion of the outer panel covers the raised portions in the inner panel, applying anvils to the outer panel at portions corresponding to the raised portions and applying welding electrodes to the peripheral portion of the outer panel which is folded over the raised portions of the inner panel so as to depress the peripheral portion of the outer panel to the raised portion simultaneously applying a welding current in series through at least two of the welding electrodes for welding the peripheral portion of the outer panel to the raised portion of the inner panel. The process is effective to prevent thermal deformations and depression marks on the outer panel.
摘要翻译：公开了用于制造由内板和外板组成的面板组件的方法，其在其周边部分被焊接在一起。该方法包括以下步骤：沿着至少一个周边部分形成在内板中具有凸起的多个凸起部分，使得凸起部分沿与外板相反的方向突出，将外板的周边部分折叠在周边所述外板的周边部分覆盖所述内板的凸起部分，在对应于所述凸起部分的部分处将砧片施加到所述外板上，并将焊接电极施加到所述外板的外围部分折叠在内板的凸起部分上，以便将外板的周边部分压缩到凸起部分，同时通过至少两个焊接电极串联施加焊接电流，以将外板的周边部分焊接到内板的凸起部分。该过程有效防止外板上的热变形和凹陷痕迹。

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