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1. 发明授权

US5443780A Oriented films of polylactic acid and methods of producing same 失效
标题翻译：聚乳酸取向膜及其制备方法
公开(公告)号：US5443780A
公开(公告)日：1995-08-22
申请号：US265348
申请日：1994-06-24
申请人： Kiyoichi Matsumoto , Shu Tahara , Eiichi Ozeki , Makoto Ogaito , Masakazu Kobayashi
发明人： Kiyoichi Matsumoto , Shu Tahara , Eiichi Ozeki , Makoto Ogaito , Masakazu Kobayashi
IPC分类号： B29C47/88 , B29C55/00 , B29C55/02 , B29K67/00 , B29K105/32 , B29L7/00 , C08G63/08 , C08J5/18 , C08L67/00 , C08L67/04
CPC分类号： C08J5/18 , B29C55/005 , B29K2067/00 , B29K2067/046 , B29K2995/0059 , C08J2367/04
摘要： An oriented film with improved tensile strength and Young's modulus can be produced by melting and extruding poly-L-lactic acid and/or poly-D-lactic acid to form a film and, after the film is cooled rapidly, by subjecting it to a stretching process at a temperature above the glass transition temperature and below the cold-crystallization temperature. The stretching may be effected by a method of uniaxial stretching with constant width, successive biaxial stretching or simultaneous biaxial stretching. A thermal treatment may be effected after the stretching process. Films thus obtained have tensile strength over 6 kgf/mm.sup.2 in the stretching direction, Young's modulus over 220 kgf/mm.sup.2 in the stretching direction and transparency to visible light over 90%.
摘要翻译：可以通过熔融挤出聚-L-乳酸和/或聚-D-乳酸形成膜来制备具有改善的拉伸强度和杨氏模量的取向膜，并且在将膜快速冷却后，在高于玻璃化转变温度并低于冷结晶温度的温度下进行拉伸。拉伸可以通过具有恒定宽度，连续双轴拉伸或同时双轴拉伸的单轴拉伸的方法来实现。在拉伸过程之后可进行热处理。由此获得的拉伸强度在拉伸方向上的拉伸强度超过6kgf / mm2，拉伸方向的拉伸强度超过220kgf / mm2，透明度可见光超过90％。

2. 发明授权

US06174602B1 Spontaneously degradable fibers and goods made thereof 有权
标题翻译：自然降解纤维及其制成的商品
公开(公告)号：US06174602B1
公开(公告)日：2001-01-16
申请号：US09180628
申请日：1998-11-13
申请人： Masao Matsui , Eiichi Ozeki , Yoshikazu Kondo , Hiroshi Kajiyama
发明人： Masao Matsui , Eiichi Ozeki , Yoshikazu Kondo , Hiroshi Kajiyama
IPC分类号： D02G304
CPC分类号： D01D5/22 , D01F6/92 , D01F8/14 , Y10T428/2904 , Y10T428/2913 , Y10T428/2924 , Y10T428/2929 , Y10T428/2931 , Y10T428/2969
摘要： A spontaneously degradable fiber excellent in bulkiness, softness, stretchability and feeling, which comprises (A) a low heat-shrinkable fiber component comprising a high crystalline aliphatic polyester and (B) a high heat-shrinkable fiber component comprising an aliphatic polyester, e.g., a low crystalline or non-crystalline aliphatic polyester, and a block copolymer or a mixture the main component of which is an aliphatic polyester and which comprises a high-melting component and a low-melting component. Further, fibers excellent in self-crimpability or self-adhesion property and dividable fibers are obtained by suitably combining the fiber components (A) and (B) to form conjugated fibers or composite yarns.
摘要翻译：一种蓬松性，柔软性，拉伸性和感觉优异的自发降解纤维，其包含（A）低结晶性脂肪族聚酯的低热收缩性纤维成分和（B）含有脂肪族聚酯的高热收缩性纤维成分，低结晶或非结晶脂族聚酯，以及嵌段共聚物或其主要成分为脂肪族聚酯的混合物，其包含高熔点组分和低熔点组分。此外，通过将纤维组分（A）和（B）适当组合以形成复合纤维或复合纱线，可获得自卷曲性或自粘性和可分割纤维优异的纤维。

3. 发明授权

US5952450A Crosslinked polycarbonate and polylactic acid composition containing the same 失效
标题翻译：交联聚碳酸酯和含有它们的聚乳酸组合物
公开(公告)号：US5952450A
公开(公告)日：1999-09-14
申请号：US127075
申请日：1998-07-31
申请人： Jiro Ishihara , Hiroki Kuyama , Eiichi Ozeki , Takeshi Ishitoku , Masahide Tanaka , Naoya Sakamoto
发明人： Jiro Ishihara , Hiroki Kuyama , Eiichi Ozeki , Takeshi Ishitoku , Masahide Tanaka , Naoya Sakamoto
IPC分类号： C08G64/02 , C08G64/22 , C08G64/30 , C08G64/00
CPC分类号： C08G64/0216 , C08G64/226 , C08G64/305
摘要： A crosslinked polycarbonate is obtained by polycondensation of diol (A), trivalent or more polyhydric alcohol (B) whose arbitrary two hydroxy groups are not in the positional relationship of 1,2-disubstitution or 1,3-disubstitution, and carbonyl component (C) such as carbonic acid diesters. In the polycondensation step, no side reaction does not occur.This crosslinked polycarbonate is used as a modifier for polylactic acids. The brittleness of the polylactic acid is improved while maintaining mechanical strength, thermostability, and transparency.
摘要翻译：交联聚碳酸酯通过二醇（A），任意两个羟基不具有1,2-取代或1,3-取代的位置关系的三价以上的多元醇（B）和羰基成分（C ）如碳酸二酯。在缩聚步骤中，不会发生副反应。该交联聚碳酸酯用作聚乳酸的改性剂。改善聚乳酸的脆性，同时保持机械强度，热稳定性和透明度。

4. 发明授权

US5760144A Aliphatic polyester polymer blends, methods for manufacturing the same, and methods for milding aliphatic polyester polymer blends 失效
标题翻译：脂肪族聚酯聚合物共混物，其制造方法和温和的脂族聚酯聚合物共混物的方法
公开(公告)号：US5760144A
公开(公告)日：1998-06-02
申请号：US678661
申请日：1996-07-11
申请人： Eiichi Ozeki , Jun Nagata , Teizi Urakami
发明人： Eiichi Ozeki , Jun Nagata , Teizi Urakami
IPC分类号： C08L67/04 , C08F20/00
CPC分类号： C08L67/04
摘要： Biodegradable polymer blends comprising of a polylactic acid or a copolymer containing lactic acid as the main constituent, and a polyhydroxyalkanoate or a copolymer containing two or more hydroxyalkanoic acids as the constituents; methods for controlling the rate of biodegradation of a polylactic acid or a copolymer containing lactic acid as the main constituent, by blending as above; methods for manufacturing such aliphatic polyester polymer blends; and methods for molding such polymer blends; are provided. The aliphatic polyester polymer blends obtained in the invention are colorless and clear, and have excellent biodegradabilities, as well as excellent mechanical strengths. The blends can be molded similarly as in conventional thermoplastic resins, so that they can be utilized in many industries, without problems in the waste product treatment after the use. Furthermore, molded products with excellent qualities are obtained from the blends, because of their improved moldabilities.
摘要翻译：包含聚乳酸或含有乳酸为主要成分的共聚物的生物可降解聚合物共混物和含有两种或多种羟基链烷酸作为组分的聚羟基链烷酸酯或共聚物; 通过上述混合来控制聚乳酸或含有乳酸的共聚物作为主要成分的生物降解速率的方法; 制造这种脂族聚酯聚合物共混物的方法; 以及用于模塑这种聚合物共混物的方法; 被提供。本发明中得到的脂族聚酯聚合物共混物是无色透明的，具有优异的生物降解能力以及优异的机械强度。共混物可以类似于常规热塑性树脂来模塑，使得它们可以在许多工业中使用，在使用后的废物处理中没有问题。此外，由于其改进的成型性，从共混物获得具有优良品质的成型产品。

5. 发明授权

US09370589B2 Switching fluorescent nanoparticle probe and fluorescent particle imaging method using same 有权
标题翻译：开关荧光纳米粒子探针和荧光颗粒成像方法使用相同
公开(公告)号：US09370589B2
公开(公告)日：2016-06-21
申请号：US13818392
申请日：2011-08-08
申请人： Isao Hara , Eiichi Ozeki , Hideo Saji , Shunsaku Kimura , Masahiro Ono , Takashi Temma
发明人： Isao Hara , Eiichi Ozeki , Hideo Saji , Shunsaku Kimura , Masahiro Ono , Takashi Temma
IPC分类号： A61K9/14 , A61K49/00
CPC分类号： A61K49/0089 , A61K49/0032 , A61K49/0093 , Y10S977/773 , Y10S977/927
摘要： The present invention provides a novel fluorescent nanoparticle imaging probe having a switching function (a function to quench a fluorescent dye during nanoparticle preparation, and emit fluorescence during imaging). A switching fluorescent nanoparticle probe comprising: a molecular assembly composed of an amphiphilic block polymer having a hydrophilic block chain and a hydrophobic block chain; and a fluorescent dye encapsulated in the molecular assembly, wherein (a) the hydrophilic block chain comprises, as an essential hydrophilic structural unit, a unit selected from a sarcosine unit and an alkylene oxide unit, (b) the hydrophobic block chain comprises, as an essential hydrophobic structural unit, a unit selected from the group consisting of an amino acid unit and a hydroxylic acid unit, and (c) the fluorescent dye is a cyanine compound represented by the formula (I): and two or more molecules of the fluorescent dye are encapsulated in the single molecular assembly.
摘要翻译：本发明提供了具有开关功能（在纳米颗粒制备期间淬灭荧光染料并在成像期间发射荧光的功能）的新型荧光纳米颗粒成像探针。一种开关荧光纳米颗粒探针，包括：由具有亲水嵌段链和疏水性嵌段链的两亲嵌段聚合物组成的分子组合; 以及包封在分子组合中的荧光染料，其中（a）所述亲水性嵌段链包含作为必需亲水性结构单元的选自肌氨酸单元和烯化氧单元的单元，（b）所述疏水性嵌段链包含：必需的疏水结构单元，选自氨基酸单元和羟基酸单元的单元，和（c）荧光染料是由式（I）表示的花青化合物：和荧光染料被封装在单分子组装中。

6. 发明授权

US5667927A Toner for electrophotography and process for the production thereof 失效
标题翻译：电子照相用调色剂及其制造方法
公开(公告)号：US5667927A
公开(公告)日：1997-09-16
申请号：US605962
申请日：1996-02-23
申请人： Hideyuki Kubota , Eiichi Ozeki
发明人： Hideyuki Kubota , Eiichi Ozeki
IPC分类号： G03G9/087
CPC分类号： G03G9/08755 , G03G9/08762
摘要： A biodegradable or hydrolyzable toner for electrophotography, which permits the easy reclaiming and recycling of used copying paper, permits the easy deinking by an existing deinking system, can decrease environmental pollution caused by a toner waste, and has excellent toner properties owing to the uniform dispersion of additives, the toner containing, as a binder resin, a lactic acid-based resin of the formula (1),H--[--O--CH(CH.sub.3)--CO--].sub.n --OR (1)wherein R is an alkali metal or an alkaline earth metal, and n is an integer of 10 to 20,000.
摘要翻译：用于电子照相的可生物降解或可水解的调色剂，其允许容易地回收和再循环使用的复印纸，允许通过现有的脱墨系统容易地脱墨，可以减少由调色剂废物引起的环境污染，并且由于均匀分散而具有优异的调色剂性质的添加剂，所述调色剂含有作为粘合剂树脂的式（1）的乳酸基树脂，H - [ - O-CH（CH 3）-CO-] n -OR（1）其中R是碱金属或碱土金属，n为10〜20,000的整数。

7. 发明申请

US20150031988A1 NANO-PARTICLES FOR INTERNAL RADIATION THERAPY OF INVOLVED AREA, AND THERAPY SYSTEM 审中-公开
标题翻译：涉及领域内部辐射治疗的纳米颗粒和治疗系统
公开(公告)号：US20150031988A1
公开(公告)日：2015-01-29
申请号：US14344562
申请日：2012-09-12
申请人： Eri Takeuchi , Isao Hara , Ryo Yamahara , Eiichi Ozeki , Shunsaku Kimura , Kensuke Kurihara
发明人： Eri Takeuchi , Isao Hara , Ryo Yamahara , Eiichi Ozeki , Shunsaku Kimura , Kensuke Kurihara
IPC分类号： A61K51/12 , A61K51/06 , A61B18/02 , A61B18/14 , A61B5/06 , A61B18/18
CPC分类号： A61K51/1244 , A61B5/055 , A61B5/061 , A61B5/0813 , A61B6/037 , A61B6/12 , A61B6/4258 , A61B6/485 , A61B6/508 , A61B8/085 , A61B18/0218 , A61B18/1477 , A61B18/1815 , A61B2018/0293 , A61B2018/1869 , A61K49/0054 , A61K49/0086 , A61K51/06 , A61K51/12 , A61K51/1237 , A61K2123/00 , A61N5/10 , A61N2005/1011 , A61N2005/1021 , A61N2005/1052 , A61N2005/1098
摘要： The present invention provides a therapeutic system that is widely applicable to general solid cancers, can achieve both a reduction in side effects of cancer therapy and suppression of cancer recurrence and metastasis, and requires no expensive drug such as an antibody; and a nanoparticle for internal radiation therapy. A system for internal radiation therapy of a vascular lesion site comprising: a device comprising a means for acquiring image data showing a position of a vascular lesion site, and a means for positioning a needle, which should be punctured into the vascular lesion site, at the vascular lesion site based on the image data; and a nanoparticle comprising an amphiphilic block polymer comprising a hydrophilic block having a sarcosine unit and a hydrophobic block having a lactic acid unit, and a substance labeled with a β-ray emitting nuclide. The nanoparticle for internal radiation therapy.
摘要翻译：本发明提供广泛适用于一般实体癌症的治疗系统，可以实现癌症治疗的副作用降低和癌症复发和转移的抑制，并且不需要昂贵的药物如抗体; 和用于内部放射治疗的纳米颗粒。一种用于血管损伤部位的内部放射治疗的系统，包括：装置，包括用于获取显示血管病变部位的位置的图像数据的装置，以及用于定位针头的装置，其应穿刺入血管损伤部位，基于图像数据的血管病变部位; 以及包含两亲性嵌段聚合物的纳米颗粒，所述两亲性嵌段聚合物包含具有肌氨酸单元的亲水性嵌段和具有乳酸单元的疏水性嵌段，以及用发射核素发射的核素标记的物质。用于内部放射治疗的纳米颗粒。

8. 发明申请

US20130336896A1 SWITCHING-TYPE FLUORESCENT NANOPARTICLE PROBE, AND FLUORESCENT MOLECULAR IMAGING METHOD USING SAME 有权
标题翻译：切换型荧光纳米粒子探针和使用相同的荧光分子成像方法
公开(公告)号：US20130336896A1
公开(公告)日：2013-12-19
申请号：US14002327
申请日：2012-03-01
申请人： Hideo Saji , Shunsaku Kimura , Masahiro Ono , Takashi Temma , Isao Hara , Eiichi Ozeki
发明人： Hideo Saji , Shunsaku Kimura , Masahiro Ono , Takashi Temma , Isao Hara , Eiichi Ozeki
IPC分类号： A61K49/00
CPC分类号： A61K49/0054 , A61K49/0032 , A61K49/0034 , A61K49/0069 , A61K49/0093
摘要： [Problem] To provide a novel fluorescent nanoparticle imaging probe having a switching function (a function to quench a fluorescent dye in a blood component and emit fluorescence in a tumor or an inflamed site to be imaged).[Solution] A fluorescent nanoparticle probe comprising: a molecular assembly composed of an amphiphilic block polymer having a hydrophilic block chain and a hydrophobic block chain; and a fluorescent dye encapsulated in the assembly, wherein (a) the hydrophilic block chain comprises, as an essential hydrophilic structural unit, a unit selected from a sarcosine unit and an alkylene oxide unit, (b) the hydrophobic block chain comprises, as an essential hydrophobic structural unit, a unit selected from the group consisting of an amino acid unit and a hydroxylic acid unit, and (c) the fluorescent dye is a polylactic acid-bound cyanine compound comprising: a fluorescent group represented by the formula (I): and a polylactic acid group having 5 to 50 lactic acid units, and two or more molecules of the fluorescent dye are encapsulated in the single molecular assembly.
摘要翻译： [问题]提供具有切换功能（在血液成分中淬灭荧光染料并在肿瘤中发射荧光或成像的发炎部位的功能）的新型荧光纳米粒子成像探针。 [解决方案]荧光纳米颗粒探针，其包含：由具有亲水性嵌段链和疏水性嵌段链的两亲嵌段聚合物组成的分子组合; 以及包封在所述组件中的荧光染料，其中（a）所述亲水性嵌段链包含作为必需亲水性结构单元的选自肌氨酸单元和烯化氧单元的单元，（b）所述疏水性嵌段链包含作为必要的疏水结构单元，选自氨基酸单元和羟基酸单元的单元，和（c）荧光染料是聚乳酸结合的花青化合物，包括：由式（I）表示的荧光基团，和具有5〜50个乳酸单元的聚乳酸基团和2个以上的荧光染料分子被包封在单分子组装体中。

9. 发明申请

US20100101943A1 RADIOACTIVE FLUORINE ANION CONCENTRATING DEVICE AND METHOD 审中-公开
标题翻译：放射性荧光阴离子浓缩装置及方法
公开(公告)号：US20100101943A1
公开(公告)日：2010-04-29
申请号：US12532957
申请日：2007-03-26
申请人： Ren Iwata , Eiichi Ozeki , Hiroaki Nakanishi , Katsumasa Sakamoto , Ryo Yamahara
发明人： Ren Iwata , Eiichi Ozeki , Hiroaki Nakanishi , Katsumasa Sakamoto , Ryo Yamahara
IPC分类号： G21G4/08
CPC分类号： G21G1/001 , C01B7/20 , G21G2001/0015
摘要： A radioactive fluoride anion concentrating device capable of concentrating 18F− ions speedily and efficiently. A flow cell (11) is composed of a metal plate electrode (21), an insulating sheet (23) and a carbon plate electrode (25) located so that the sides of electrodes may be opposed to each other with the insulating sheet (23) inserted between them. An example of the plate metal plate electrode (21) is obtained by forming a film of metallic material on an insulation plate, and an example of the insulating sheet (23) is a PDMS from which a groove being a channel (26) having a thickness of ≦500 μm is cut out. The thickness of the sheet is desirably about 100 μm. The upper and lower sides of the flow cell (11) are fixed by fixing jigs (27) and (29).
摘要翻译：一种能够快速有效地浓缩18F离子的放射性氟化物阴离子浓缩装置。流动池（11）由金属板电极（21），绝缘片（23）和碳板电极（25）构成，使得电极的侧面可以用绝缘片（23）彼此相对）插入它们之间。通过在绝缘板上形成金属材料膜，得到板状金属板电极（21）的一例，绝缘片（23）的一个例子是PDMS，作为沟道（26）的槽，具有切割厚度为＆amp; 500;500μm。片材的厚度优选为约100μm。流动池（11）的上侧和下侧通过固定夹具（27）和（29）固定。

10. 发明申请

US20080019908A1 Novel amphiphilic substance, and drug delivery system and molecular imaging system using the same 有权
标题翻译：新型两亲物质，以及药物输送系统和分子成像系统使用相同
公开(公告)号：US20080019908A1
公开(公告)日：2008-01-24
申请号：US11812131
申请日：2007-06-15
申请人： Hitoshi Akitsu , Eiichi Ozeki , Ryoji Fushimi , Shunsaku Kimura , Masashi Isozaki , Shigenori Nozawa
发明人： Hitoshi Akitsu , Eiichi Ozeki , Ryoji Fushimi , Shunsaku Kimura , Masashi Isozaki , Shigenori Nozawa
IPC分类号： A61K49/00 , A61K38/00 , A61P43/00 , C07K14/00
CPC分类号： C08G69/10 , A61K49/0034 , A61K49/0043 , A61K49/0052 , A61K49/0093 , B82Y5/00
摘要： The present invention provides a novel amphiphilic substance, a nanoparticle using the novel amphiphilic substance, which can be used as a nanocarrier having high biocompatibility, a drug delivery system and a probe useful for the system, and, a molecular imaging system and a probe useful for the system. An amphiphilic block polymer comprising a hydrophilic block; and a hydrophobic block, wherein the hydrophilic block is a hydrophilic polypeptide chain having 10 or more sarcosine units, and the hydrophobic block is a hydrophobic molecular chain comprising units selected from the group consisting of amino acid units and hydroxyl acid units as essential structural units, and having 5 or more of the essential structural units.
摘要翻译：本发明提供一种新颖的两亲物质，使用该新型两亲性物质的纳米粒子，其可以用作具有高生物相容性的纳米载体，药物递送系统和可用于该系统的探针，以及分子成像系统和有用的探针为系统。包含亲水嵌段的两亲嵌段聚合物; 和疏水嵌段，其中所述亲水嵌段是具有10个或更多个肌氨酸单元的亲水性多肽链，疏水嵌段是包含选自氨基酸单元和羟基酸单元作为必需结构单元的单元的疏水分子链，并具有5个以上的基本结构单元。

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