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1. 发明授权

US5714543A Water soluble polymer additives for polyurethane-based pressure sensitive adhesives 失效
标题翻译：用于聚氨酯基压敏粘合剂的水溶性聚合物添加剂
公开(公告)号：US5714543A
公开(公告)日：1998-02-03
申请号：US180598
申请日：1994-01-13
申请人： Kishore R. Shah , Tak-Lung Chang , Agis Kydonieus
发明人： Kishore R. Shah , Tak-Lung Chang , Agis Kydonieus
IPC分类号： A61L15/58 , C09J175/04 , C08L75/00
CPC分类号： A61L15/585 , C09J175/04 , C08G2170/80
摘要： In accordance with the present invention novel polyurethane PSAs containing water soluble polymer additives have enhanced water uptake. The water soluble polymer additives suitable for use herein have a solubility parameter in poorly hydrogen-binding solvents (e.g., hexane, cyclohexane and the like) in the range of from 8-10. The water soluble polymers must also be free from moieties which will react with isocyanates. Such PSAs retain their transparency and peel strength characteristics and can still be employed as relatively thin films (i.e., 2 to 100 mils) while exhibiting only minimal swelling when in contact with moist environments.
摘要翻译：根据本发明，含有水溶性聚合物添加剂的新型聚氨酯PSA具有增强的吸水性。适用于本发明的水溶性聚合物添加剂在不良的氢结合溶剂（例如己烷，环己烷等）中的溶解度参数为8-10。水溶性聚合物也必须不含与异氰酸酯反应的部分。这样的PSA保持其透明度和剥离强度特性，并且仍然可以用作相对薄的膜（即，2至100密耳），同时在与潮湿环境接触时仅显示最小的溶胀。

2. 发明授权

US5527271A Thermoplastic hydrogel impregnated composite material 失效
标题翻译：热塑性水凝胶浸渍复合材料
公开(公告)号：US5527271A
公开(公告)日：1996-06-18
申请号：US220350
申请日：1994-03-30
申请人： Kishore R. Shah , Agis Kydonieus , Khosrow Jamshidi , Stefanie C. Decker , Tak-lung Chang
发明人： Kishore R. Shah , Agis Kydonieus , Khosrow Jamshidi , Stefanie C. Decker , Tak-lung Chang
IPC分类号： A61F13/00 , A61L15/16 , A61L15/60
CPC分类号： A61L15/60 , A61F13/00017 , A61F13/00042
摘要： A composite material for wound dressings having a fibrous wound-contacting substrate, such as cotton gauze, impregnated with a thermoplastic hydrogel forming polymer and methods of making the same.
摘要翻译：一种用于伤口敷料的复合材料，其具有浸渍有热塑性水凝胶形成聚合物的纤维缠绕接触衬底（例如棉纱布）及其制备方法。

3. 发明授权

US5827525A Buccal delivery system for therapeutic agents 失效
标题翻译：用于治疗剂的Buccal递送系统
公开(公告)号：US5827525A
公开(公告)日：1998-10-27
申请号：US711754
申请日：1996-09-10
申请人： Wei-Chi Liao , Agis Kydonieus , Kishore R. Shah
发明人： Wei-Chi Liao , Agis Kydonieus , Kishore R. Shah
IPC分类号： A61K9/70 , A61K9/00 , A61K31/198 , A61K38/55 , A61F13/00
CPC分类号： A61K31/198 , A61K38/556 , A61K9/006
摘要： A unidirectional buccal delivery system for the delivery of therapeutic agents over an extended period of time. The delivery system includes a matrix for releasing the drug into the oral cavity at a sustained rate and a means for securing the matrix to the palate or other adequate regions in the oral cavity.
摘要翻译：用于在延长的时间段内递送治疗剂的单向颊部递送系统。递送系统包括用于以持续速率将药物释放到口腔中的基质和用于将基质固定到口腔中的腭或其它适当区域的装置。

4. 发明授权

US5028431A Article for the delivery to animal tissue of a pharmacologically active agent 失效
标题翻译：用于给药物活性剂的动物组织递送的物品
公开(公告)号：US5028431A
公开(公告)日：1991-07-02
申请号：US406811
申请日：1989-09-13
申请人： Thomas J. Franz , Kishore R. Shah , Agis Kydonieus
发明人： Thomas J. Franz , Kishore R. Shah , Agis Kydonieus
IPC分类号： A61K9/70 , A61K31/57
CPC分类号： A61K9/703 , A61K31/57 , A61K9/7053
摘要： Described is an article for the controlled release and delivery to animal tissue of a pharmacologically active agent with or without an excipient and/or enhances which may be a causative factor in the occurrence of non-allergic or allergic contact dermatitis comprising an anti-dermatitis substance.
摘要翻译：描述了一种用于控制释放和递送具有或不具有赋形剂的药理学活性剂的动物组织和/或增强其可能是发生非过敏性或过敏性接触性皮炎的致病因素，其包含抗皮炎物质。

5. 发明授权

US4767808A Article useful for administration of pharmacologically-active substances transdermally, orally, or by means of implant 失效
标题翻译：用于透皮，口服或通过植入物施用药理活性物质的制品
公开(公告)号：US4767808A
公开(公告)日：1988-08-30
申请号：US122862
申请日：1987-11-19
申请人： Agis Kydonieus , Kishore R. Shah , Bret Berner
发明人： Agis Kydonieus , Kishore R. Shah , Bret Berner
IPC分类号： A61K9/70 , A61K31/165 , A61K31/21 , A61K31/34 , A61K31/405 , A61K31/415 , A61K31/465 , A61K31/557 , A61M31/00 , A61K9/00
CPC分类号： A61K31/165 , A61K31/21 , A61K31/34 , A61K31/405 , A61K31/415 , A61K31/465 , A61K31/557 , A61K9/703 , A61K9/7084 , A61M31/002
摘要： Described is an article of manufacture useful for administration of pharmacologically-active substances, transdermally, orally or by means of subdermal implant comprising a solid vinyl plastisol layer for contacting a patient's tissue, internally or externally, the layer containing from about 20 up to about 70% by weight of a polyvinyl chloride resin or a polyvinyl chloride-polyvinyl acetate copolymer containing a minor proportion of vinyl acetate; from about 20-70% plasticizer composition; from about 0.5 up to 35% of a pharmacologically-active substance such as isosorbide dinitrate, nicotine, clonidine, guanfacine, indomethacin, glyceryl trinitrate and prostaglandin and optionally excipients. Also described is the novel plasticizer-polyvinyl chloride composition of matter comprising 1-dodecylhexahydro-2H-azepin-2-one and polyvinyl chloride resin taken together with a pharmacologically-active substance wherein the 1-dodecylhexahydro-2H-azepin-2-one not only acts as a plasticizer but also acts as a penetration enhancer (through tissue) for the pharmacologically-active substance.
摘要翻译：描述了可用于施用药理学活性物质，经皮，口服或通过皮下植入的制剂，其包括固体乙烯基增塑溶胶层，用于在内部或外部将患者组织接触含有约20至约70的层重量百分比的聚氯乙烯树脂或含有少量醋酸乙烯酯的聚氯乙烯 - 聚乙酸乙烯酯共聚物; 约20-70％的增塑剂组成; 约0.5至35％的药理学活性物质如硝酸异山梨酯，尼古丁，可乐定，胍法辛，吲哚美辛，三硝酸甘油酯和前列腺素以及任选的赋形剂。还描述了包含1-十二烷基六氢-2H-氮杂-2-酮和聚氯乙烯树脂与药理活性物质一起的物质的新型增塑剂 - 聚氯乙烯组合物，其中1-十二烷基六氢-2H-氮杂-2-酮不仅用作增塑剂，但也用作药理活性物质的渗透促进剂（通过组织）。

6. 发明授权

US5468501A Article useful for administration of pharmacologically-active substances transdermally, orally or by means of implant 失效
标题翻译：用于透皮，口服或通过植入物施用药理活性物质的物品
公开(公告)号：US5468501A
公开(公告)日：1995-11-21
申请号：US385205
申请日：1995-02-08
申请人： Agis Kydonieus , Kishore R. Shah , Bret Berner
发明人： Agis Kydonieus , Kishore R. Shah , Bret Berner
IPC分类号： A61K9/70 , A61K31/21 , A61M31/00 , A61F13/00
CPC分类号： A61K9/7084 , A61K31/21 , A61M31/002
摘要： A device useful for administration of pharmacologically-active substances transdermally, orally, or by means of subdermal implant includes an impermeable backing layer, a plasticized polyvinyl chloride layer, and an adhesive layer, wherein the plasticized polyvinyl chloride layer includes from about 20 up to about 70% by weight of a polyvinyl chloride resin, from about 20 up to about 70% by weight of a plasticizer, and from about 0.5 up to about 35% by weight of a pharmacologically-active substance such as isosorbide dinitrate, nicotine, clonidine, guanfacine, indomethacin, nitroglycerin, and prostaglandin and optionally excipients.
摘要翻译：用于通过皮下，口服或通过皮下植入来施用药理活性物质的装置包括不渗透背衬层，塑化聚氯乙烯层和粘合剂层，其中增塑聚氯乙烯层包括约20至约约 70重量％的聚氯乙烯树脂，约20至约70重量％的增塑剂和约0.5至约35重量％的药理活性物质如硝酸异山梨酯，尼古丁，可乐定，胍法辛，吲哚美辛，硝酸甘油和前列腺素以及任选的赋形剂。

7. 发明授权

US5322695A Moisture-vapor-permeable dressing 失效
标题翻译：水分透湿敷料
公开(公告)号：US5322695A
公开(公告)日：1994-06-21
申请号：US932747
申请日：1992-08-25
申请人： Kishore R. Shah , Agis Kydonieus , Dimitrios Apostolopoulos
发明人： Kishore R. Shah , Agis Kydonieus , Dimitrios Apostolopoulos
IPC分类号： A61K9/70 , A61L15/44 , A61L15/58 , A61L15/00 , A61F13/00
CPC分类号： A61K9/7084 , A61L15/44 , A61L15/58 , A61L2300/202 , A61L2300/206 , A61L2300/222 , A61L2300/404 , A61L2300/408
摘要： Described is a moisture-vapor-permeable and oxygen-permeable adhesive dressing for use in supplying a topical medicament to human skin in a controlled release manner, which dressing is unaffected by and impermeable to water in the liquid phase, which dressing when in use on human skin consists essentially of:(i) a polymeric backing material lamina having two surfaces, a first substantially planar surface and a second substantially planar surface;(ii) adhering to said first planar surface of said backing material a medication reservoir lamina having two surfaces, a first substantially planar surface and a second substantially planar surface, consisting essentially of an intimate mixture of:(a) a polyvinyl chloride polymer;(b) a polymeric plasticizer intimately admixed with said polyvinyl chloride and compatible with said polyvinyl chloride; and(c) a topical medicament compatible with said polyvinyl chloride and said plasticizer;said first substantially planar surface of said medication reservoir lamina adhering to said first substantially planar surface of said backing material in a continuous or discontinuous manner; and(iii) adhering to said second substantially planar surface of said medication reservoir lamina, a pressure-sensitive adhesive which is permeable to oxygen and moisture vapor but is unaffected by liquid water.
摘要翻译：描述了一种用于以控制释放的方式向人体皮肤供应局部药物的透湿透湿粘合剂，该敷料不受液相中的水的影响，并且不透水。人体皮肤基本上由以下部分组成：（i）具有两个表面的聚合物背衬材料层，第一基本上平坦的表面和第二基本平坦的表面; （ii）粘附在所述背衬材料的所述第一平坦表面上，具有两个表面的药物储存器层，第一基本上平坦的表面和第二基本平坦的表面，其基本上由以下组成的紧密混合物组成：（a）聚氯乙烯聚合物; （b）与所述聚氯乙烯密切混合并与所述聚氯乙烯相容的聚合物增塑剂; 和（c）与所述聚氯乙烯和所述增塑剂相容的局部药物; 所述药物储存器层的所述第一基本上平坦的表面以连续或不连续的方式粘附到所述背衬材料的所述第一基本上平坦的表面; 和（iii）粘附到所述药物储存器层的所述第二基本上平坦的表面，压敏粘合剂，其可渗透氧气和水汽，但不受液态水影响。

8. 发明授权

US4758434A Article useful for administration of pharmacologically-active substances transdermally, orally, or by means of implant 失效
标题翻译：用于透皮，口服或通过植入物施用药理活性物质的制品
公开(公告)号：US4758434A
公开(公告)日：1988-07-19
申请号：US847635
申请日：1986-04-03
申请人： Agis Kydonieus , Kishore R. Shah , Bret Berner
发明人： Agis Kydonieus , Kishore R. Shah , Bret Berner
IPC分类号： A61K9/70 , A61K31/21 , A61M31/00 , A61L15/03 , A61F13/00
CPC分类号： A61K9/703 , A61K31/21 , A61K9/7084 , A61M31/002
摘要： Described is an article of manufacture useful for administration of pharmacologically-active substances, transdermally, orally or by means of subdermal implant comprising a solid vinyl plastisol layer for contacting a patient's tissue, internally or externally, the layer containing from about 20 up to about 70% by weight of a polyvinyl chloride resin or a polyvinyl chloride-polyvinyl acetate copolymer containing a minor proportion of vinyl acetate; from about 20-70% plasticizer composition; from abotu 0.5 up to 35% of pharmacologically-active substance such as isosorbide dinitrate, nicotine, clonidine, guanfacine, indomethacin, glyceryl trinitrate and prostaglandin and optionally excipients. Also described is the novel plasticizer-polyvinyl chloride composition of matter comprising 1-dodecylhexahydro-2H-azepin-2-one and polyvinyl chloride resin taken together with a pharmacologically-active substance whereint he 1-dodecylhexahydro-2H-azepin-2-one not only acts as a plasticizer but also acts as a penetration enhancer (through tissue) for the pharmacologically-active substance.
摘要翻译：描述了可用于施用药理学活性物质，经皮，口服或通过皮下植入的制剂，其包括固体乙烯基增塑溶胶层，用于在内部或外部将患者组织接触含有约20至约70的层重量百分比的聚氯乙烯树脂或含有少量醋酸乙烯酯的聚氯乙烯 - 聚乙酸乙烯酯共聚物; 约20-70％的增塑剂组成; 来自abotu 0.5至35％的药理活性物质如硝酸异山梨酯，尼古丁，可乐定，胍法西林，吲哚美辛，三硝酸甘油酯和前列腺素以及任选的赋形剂。还描述了包含1-十二烷基六氢-2H-氮杂-2-酮和聚氯乙烯树脂与药物活性物质一起的新型增塑剂 - 聚氯乙烯组合物，其中1-十二烷基六氢-2H-氮杂-2-酮不包括仅用作增塑剂，但也用作药理活性物质的渗透促进剂（通过组织）。

9. 发明授权

US5580573A Temperature activated controlled release 失效
标题翻译：温度启动控制释放
公开(公告)号：US5580573A
公开(公告)日：1996-12-03
申请号：US88496
申请日：1993-07-07
申请人： Agis Kydonieus , Kishore R. Shah , Stefanie C. Decker
发明人： Agis Kydonieus , Kishore R. Shah , Stefanie C. Decker
IPC分类号： A61K9/20 , A61K9/28 , A61K9/70 , A61F13/02
CPC分类号： A61K9/7007 , A61K9/2027 , A61K9/2846
摘要： A polymeric device for the controlled release of active agents contained in the device in which the polymer has a glass transition temperature greater than the normal storage or non use temperature of the device. When heated to or above the glass transition temperature of the polymer, the active agent is released. The release of active agent can be switched on or off by the adjustment of the temperature of the polymeric device above or below the glass transition temperature of the polymer.
摘要翻译：用于控制释放装置中的活性剂的聚合物装置，其中聚合物的玻璃化转变温度高于装置的正常储存或非使用温度。当加热到聚合物的玻璃化转变温度以上时，活性剂被释放。活性剂的释放可以通过调节聚合物的温度高于或低于聚合物的玻璃化转变温度来打开或关闭。

10. 再颁专利

USRE34089E Article useful for administration of pharmacologically-active substances transdermally, orally, or by means of implant 失效
公开(公告)号：USRE34089E
公开(公告)日：1992-10-06
申请号：US554499
申请日：1990-07-19
申请人： Agis Kydonieus , Kishore R. Shah , Bret Berner
发明人： Agis Kydonieus , Kishore R. Shah , Bret Berner
IPC分类号： A61K9/70 , A61K31/165 , A61K31/21 , A61K31/34 , A61K31/405 , A61K31/415 , A61K31/465 , A61K31/557 , A61M31/00
CPC分类号： A61K31/165 , A61K31/21 , A61K31/34 , A61K31/405 , A61K31/415 , A61K31/465 , A61K31/557 , A61K9/703 , A61K9/7084 , A61M31/002
摘要： Described is an article of manufacture useful for administration of pharmacologically-active substances, transdermally, orally or by means of subdermal implant comprising a solid vinyl plastisol layer for contacting a patient's tissue, internally or externally, the layer containing from about 20 up to about 70% by weight of a polyvinyl chloride resin or a polyvinyl chloride-polyvinyl acetate copolymer containing a minor proportion of vinyl acetate; from about 20-70% plasticizer composition, from about 0.5 up to 35% of pharmacologically-active substance such as isosorbide dinitrate, nicotine, clonidine, guanfacine, indomethacin, glyceryl trinitrate and prostaglandin and optionally excipients. Also described is the novel plasticizer-polyvinyl chloride composition of matter comprising 1-dodecylhexahydro-2H-azepin-2-one and polyvinyl chloride resin taken together with a pharmacologically-active substance .[.whereint he.]. .Iadd.wherein the .Iaddend.1-dodecylhexahydro-2H-azepin-2-one not only acts as a plasticizer but also acts as a penetration enhancer (through tissue) for the pharmacologically-active substance.

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