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1. 发明授权

US08058290B2 7-substituted aza-indazoles, compositions containing same, production method and use thereof 有权
标题翻译： 7-取代的氮杂 - 吲唑，含有它们的组合物，其制备方法和用途
公开(公告)号：US08058290B2
公开(公告)日：2011-11-15
申请号：US12021638
申请日：2008-01-29
申请人： Kirsten Bjergarde , Anil Nair , Marcel Patek , Martha Ackerman-Berrier , Martin Smrcina , Eric Bacque , Michel Tabart , Baptiste Ronan , Vincent Leroy , Fabrice Viviani , Mark Dodson , Catherine Souaille
发明人： Kirsten Bjergarde , Anil Nair , Marcel Patek , Martha Ackerman-Berrier , Martin Smrcina , Eric Bacque , Michel Tabart , Baptiste Ronan , Vincent Leroy , Fabrice Viviani , Mark Dodson , Catherine Souaille
IPC分类号： A61K31/44 , C07D491/02
CPC分类号： C07D471/04
摘要： The disclosure relates to compounds of formula (I): which modulate the activity of proteins, particularly kinases, and to compositions containing the same, and to the use thereof as medicaments, in particular as anticancer agents.
摘要翻译：本公开涉及式（I）的化合物：其调节蛋白质，特别是激酶的活性，以及其含有该蛋白质的组合物的用途，以及其作为药物，特别是作为抗癌剂的用途。

2. 发明授权

US08314121B2 Imidazolone derivatives, preparation thereof as drugs, pharmaceutical compositions, and use thereof as protein kinase inhibitors, in particular CDC7 有权
标题翻译：咪唑啉酮衍生物，作为药物的制备，药物组合物及其作为蛋白激酶抑制剂的用途，特别是CDC7
公开(公告)号：US08314121B2
公开(公告)日：2012-11-20
申请号：US12415391
申请日：2009-03-31
申请人： Vincent Leroy , Eric Bacque , Emmanuel Conseiller , Anke Steinmetz , Baptiste Ronan , Jean-Philippe Letallec
发明人： Vincent Leroy , Eric Bacque , Emmanuel Conseiller , Anke Steinmetz , Baptiste Ronan , Jean-Philippe Letallec
IPC分类号： A01N43/42 , A01N43/00 , A61K31/44 , A61K31/00 , A61K31/535 , C07C241/00 , C07C243/00
CPC分类号： C07D471/04
摘要： The present invention relates to imidazolone derivatives of formula (I) to methods of preparing such derivatives, intermediates thereto, pharmaceutical compositions comprising such derivatives, and methods of inhibiting protein kinase, and methods of treatment comprising administration of such derivatives.
摘要翻译：本发明涉及式（I）的咪唑啉酮衍生物与制备此类衍生物的方法，其中间体，包含该衍生物的药物组合物，以及抑制蛋白激酶的方法，以及包括施用此类衍生物的治疗方法。

3. 发明申请

US20090253679A1 NEW IMIDAZOLONE DERIVATIVES, PREPARATION THEREOF AS DRUGS, PHARMACEUTICAL COMPOSITIONS, AND USE THEREOF AS PROTEIN KINASE INHIBITORS, IN PARTICULAR CDC7 有权
标题翻译：新的咪唑啉酮衍生物，其作为药物，药物组合物的制备，以及作为蛋白激酶抑制剂，特别是CDC7的用途
公开(公告)号：US20090253679A1
公开(公告)日：2009-10-08
申请号：US12415391
申请日：2009-03-31
申请人： Vincent Leroy , Eric Bacque , Emmanuel Conseiller , Anke Steinmetz , Baptiste Ronan , Jean-Philippe Letallec
发明人： Vincent Leroy , Eric Bacque , Emmanuel Conseiller , Anke Steinmetz , Baptiste Ronan , Jean-Philippe Letallec
IPC分类号： A61K31/397 , C07D401/06 , A61K31/437 , C12N9/99 , A61P7/00 , A61P3/00 , A61P11/06 , A61P37/08 , A61P25/00 , A61P19/02 , A61P3/10 , A61P35/00 , A61P21/00 , A61P17/06 , C07D413/06 , A61K31/5377 , A61K31/496 , A61K31/55 , C07D417/06 , A61K31/541
CPC分类号： C07D471/04
摘要： The present invention relates to imidazolone derivatives of formula (I) to methods of preparing such derivatives, intermediates thereto, pharmaceutical compositions comprising such derivatives, and methods of inhibiting protein kinase, and methods of treatment comprising administration of such derivatives.
摘要翻译：本发明涉及式（I）的咪唑啉酮衍生物与制备此类衍生物的方法，其中间体，包含该衍生物的药物组合物，以及抑制蛋白激酶的方法，以及包括施用此类衍生物的治疗方法。

4. 发明授权

US08245506B2 Composite exhaust manifold 有权
标题翻译：复合排气歧管
公开(公告)号：US08245506B2
公开(公告)日：2012-08-21
申请号：US12297159
申请日：2007-03-28
申请人： Vincent Leroy
发明人： Vincent Leroy
IPC分类号： F01N13/10
CPC分类号： F01N13/1827 , F01N13/102 , F01N13/16 , F01N13/1805
摘要： This exhaust manifold comprises: an outer envelope comprising: at least one flange connected to the outer shell and having at least one gas circulation port, the outer envelope having at least one gas circulation port; at least one internal duct (31) arranged inside the outer envelope and opening via a gas circulation port, characterized in that: the or each internal duct (31) is formed, at least for the most part of its length, of a ceramic material and is engaged through the or each port; and it comprises an annular diaphragm (34) that is impermeable to the gases but radially and axially elastically deformable and positioned around the or each internal duct (31), between the or each internal duct (31) and the outer envelope (18), the diaphragm (34) being connected at its periphery to at least one out of the outer envelope (18) and the or each internal duct (20, 31).
摘要翻译：该排气歧管包括：外壳，包括：连接到外壳并具有至少一个气体循环端口的至少一个凸缘，所述外壳具有至少一个气体循环端口; 至少一个内部管道（31），其布置在所述外部封套内部并经由气体循环端口开口，其特征在于：所述或每个内部管道（31）至少在其大部分长度上形成陶瓷材料并通过该港口或每个港口进行; 并且其包括环形隔膜（34），其不透气体，但径向和轴向可弹性变形并定位在每个内部管道（31）周围或每个内部管道（31）与外部封套（18）之间，所述隔膜（34）在其周边与所述外封套（18）和所述每个内部导管（20,31）中的至少一个连接。

5. 发明申请

US20090266065A1 DOUBLE-SHELL MANIFOLD 有权
标题翻译：双壳管
公开(公告)号：US20090266065A1
公开(公告)日：2009-10-29
申请号：US11913586
申请日：2006-04-28
申请人： Edouard Barrieu , Vincent Leroy
发明人： Edouard Barrieu , Vincent Leroy
IPC分类号： F01N7/10
CPC分类号： F01N13/14 , F01N13/102 , F01N13/141 , F01N13/16 , F01N13/1811 , F01N13/1827 , F01N2260/08 , F01N2260/10 , F01N2470/24 , Y10T29/49398
摘要： The invention relates to an exhaust manifold (12) consisting of: an outer casing (18) comprising an outer shell (22) and a flange (24) which is welded to the outer shell (22) and which is equipped with a surface (24B) that is supported by an engine head and at least one hole (28) which opens onto said support surface (24A); and at least one internal conduit (20) which is disposed in the outer casing (18) and which terminates in a hole (28). The invention is characterised in that: each internal conduit (20) is formed from a ceramic material; and each internal conduit (20) extends through the flange (24) by means of each hole (28) and comprises an extension (32) that extends outside the outer casing (18) towards the exterior and beyond the support surface (24A).
摘要翻译：本发明涉及一种排气歧管（12），其包括：外壳（18），其包括外壳（22）和凸缘（24），所述凸缘（24）焊接到所述外壳（22）并且配备有表面 24B），其由发动机头部和至少一个通向所述支撑表面（24A）的孔（28）支撑; 和至少一个内部导管（20），其设置在所述外壳体（18）中并终止于孔（28）中。本发明的特征在于：每个内部管道（20）由陶瓷材料形成; 并且每个内部管道（20）通过每个孔（28）延伸穿过凸缘（24）并且包括延伸部分（32），其延伸到外部壳体（18）的外部并且超出支撑表面（24A）。

6. 发明授权

US5217759A Process for the continuous dip coating of a steel strip 失效
标题翻译：钢带连续浸渍涂层的工艺
公开(公告)号：US5217759A
公开(公告)日：1993-06-08
申请号：US684285
申请日：1991-04-12
申请人： Marcel Lamberigts , Vincent Leroy
发明人： Marcel Lamberigts , Vincent Leroy
IPC分类号： C22C18/04 , B32B15/01 , C23C2/06 , C23C2/12
CPC分类号： C23C2/06 , C23C2/12 , Y10S428/939 , Y10T428/12757 , Y10T428/12799
摘要： A process for continuous dip coating of a steel strip by passing it through a zinc bath containing aluminum and silicon wherein the aluminum content is approximately 55% by weight, the silicon content is 1% to 2% by weight, and the bath further includes strontium in a quantity in the range of 0.0001% to 0.2% by weight and at least one other element selected from among vanadium in a quantity in the range of 0.02% to 0.2% by weight and chromium in the range of 0.005% to 0.2% by weight. The addition of strontium and chromium and/or vanadium stabilizes the structure of the coating and reduces the formation of acicular precipitates of silicon. The coating has an improved adherence and ductility which permits it to be formed without cracking, while retaining an excellent resistance to corrosion. The resulting crystallization pattern of the coating is also finer and more regular and is independent of the substrate.
摘要翻译：通过使钢带通过含有铝和硅的锌浴，其中铝含量为约55重量％，硅含量为1重量％至2重量％，并且浴还包含锶其量为0.0001重量％至0.2重量％，另外选自钒中的至少一种元素，其含量范围为0.02重量％至0.2重量％，铬在0.005至0.2重量％的范围内由铬重量。添加锶和铬和/或钒稳定了涂层的结构，并减少了硅的针状沉淀物的形成。该涂层具有改善的粘附性和延展性，其允许其形成而不发生裂纹，同时保持优异的耐腐蚀性。所得涂层的结晶图案也更细，更规则，并且与基材无关。

7. 发明授权

US08261778B2 Motor vehicle exhaust pipe 有权
标题翻译：汽车排气管
公开(公告)号：US08261778B2
公开(公告)日：2012-09-11
申请号：US12600546
申请日：2008-05-16
申请人： Vincent Leroy , Catherine Guyard , Sylvain Pellissard
发明人： Vincent Leroy , Catherine Guyard , Sylvain Pellissard
IPC分类号： F16L9/14
CPC分类号： F01N13/16 , F01N13/102 , F01N13/14 , F01N2310/02 , F01N2310/10 , F01N2310/14
摘要： A motor vehicle exhaust pipe includes: an outer metal tube; at least one inner tube made from an inorganic matrix composite material and disposed inside the outer metal tube, each inner tube being arranged longitudinally and having a pre-determined longitudinal length and a gap being provided between each inner tube and the outer tube; and elements for maintaining each inner tube in position in relation to the outer tube. The elements for maintaining each inner tube in position in relation to the outer tube include at least one retaining element disposed in the gap between the inner tube and the outer tube, each retaining element exerting a minimum pressure of between 10−4 MPa and 10−1 MPa on the inner tube. All of the elements used to maintain one inner tube in position have a cumulative longitudinal length equal to less than half of the longitudinal length of the inner tube.
摘要翻译：机动车排气管包括：外金属管; 至少一个由无机基质复合材料制成并且设置在外金属管内部的内管，每个内管纵向布置并具有预定的纵向长度，并且在每个内管和外管之间设置间隙; 以及用于将每个内管相对于外管保持在适当位置的元件。用于将每个内管保持在相对于外管的位置的元件包括设置在内管和外管之间的间隙中的至少一个保持元件，每个保持元件施加在10-4MPa和10ps之间的最小压力，内管1 MPa。用于将一个内管保持就位的所有元件具有等于小于内管的纵向长度的一半的累积纵向长度。

8. 发明授权

US07482448B2 Compounds and compositions as cathepsin inhibitors 失效
标题翻译：化合物和组合物作为组织蛋白酶抑制剂
公开(公告)号：US07482448B2
公开(公告)日：2009-01-27
申请号：US11409601
申请日：2006-04-24
申请人： Sukanthini Thurairatnam , David John Aldous , Vincent Leroy , Andreas Paul Timm
发明人： Sukanthini Thurairatnam , David John Aldous , Vincent Leroy , Andreas Paul Timm
IPC分类号： C07D413/12 , C07D413/14 , C07D265/30 , C07D267/10
CPC分类号： C07D263/56 , A61K38/00 , C07D263/32 , C07D267/10 , C07D271/06 , C07D271/10 , C07D271/107 , C07D295/195 , C07D295/215 , C07D413/04 , C07D413/12 , C07K5/06191
摘要： Novel inhibitors of cathepsin S, K, B, and L, the pharmaceutically acceptable salts and N-oxides thereof, their uses as therapeutic agents and the methods of their making.
摘要翻译：组织蛋白酶S，K，B和L的新型抑制剂，其药学上可接受的盐和N-氧化物，它们作为治疗剂的用途及其制备方法。

9. 发明授权

US09805122B2 Search engine and method for performing a search for objects that correspond to a search request 有权
公开(公告)号：US09805122B2
公开(公告)日：2017-10-31
申请号：US14238487
申请日：2011-08-12
申请人： Jan Seedorf , Saverio Niccolini , Martin Stiemerling , Flavio Junqueira , Marco Serafini , Ivan Kelly , Vincent Leroy , Berkant Barla Cambazoglu
发明人： Jan Seedorf , Saverio Niccolini , Martin Stiemerling , Flavio Junqueira , Marco Serafini , Ivan Kelly , Vincent Leroy , Berkant Barla Cambazoglu
IPC分类号： G06F17/30
CPC分类号： G06F17/30864
摘要： A search engine for finding objects that correspond to a search request, including an input module for receiving a keyword query from a user, and a search module being configured to map the keyword query to the identifiers of objects that semantically match the keyword or the plurality of keywords contained in the keyword query, and to generate a search result that contains a listing of matching object identifiers, is characterized in that the search module is further configured to generate the search result by considering network layer information about the user within the process of mapping the keyword query to identifiers of matching objects, wherein the network layer information include sophisticated information the search module receives from a dedicated entity.

10. 发明申请

US20140109559A1 Exhaust Manifold With Thin Flanges 审中-公开
标题翻译：排气歧管与薄法兰
公开(公告)号：US20140109559A1
公开(公告)日：2014-04-24
申请号：US13319211
申请日：2010-11-08
申请人： Vincent Leroy , Marc-Antoine Belpeer
发明人： Vincent Leroy , Marc-Antoine Belpeer
IPC分类号： F01N13/10
CPC分类号： F01N13/10 , F01N13/102 , F01N13/105 , F01N13/141 , F01N13/1805 , F01N13/1816 , F01N13/1872
摘要： An exhaust manifold for an engine has at least one collecting pipe for conveying exhaust gases. Several exhaust gas inlets are in fluid communication with the collecting pipe. Several flanges each define one of the exhaust gas inlets. Each flange has an external face adapted to be pressed against a receiving surface of the engine. Several back flanges are each associated to one of the flanges and are adapted to press the corresponding flange against the receiving surface. The flanges are areas of a single plate, which has a thickness between 0.2 and 2 mm. The areas are continuously connected to one another by other areas of the plate. The collecting pipe is not integral with the plate. The manifold has leak tight connections connecting the collecting pipe to each of the flanges.
摘要翻译：用于发动机的排气歧管具有用于输送废气的至少一个收集管。几个排气入口与收集管流体连通。几个法兰每个限定一个排气入口。每个凸缘具有适于被压靠在发动机的接收表面上的外表面。几个后凸缘各自与凸缘中的一个相连，并且适于将相应的凸缘压靠在接收表面上。法兰是单板的区域，其厚度在0.2和2mm之间。这些区域通过板的其它区域彼此连续连接。收集管不与板组成一体。歧管具有将收集管连接到每个凸缘的泄漏连接。

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