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    • 6. 发明授权
    • Benzophenone derivative, ultraviolet absorbent and external preparation
for skin
    • 二苯甲酮衍生物,紫外线吸收剂和皮肤外用剂
    • US5342610A
    • 1994-08-30
    • US963901
    • 1992-10-20
    • Mikiko KatohKeiichi UeharaSadaki Takata
    • Mikiko KatohKeiichi UeharaSadaki Takata
    • A61K8/49A61Q17/04C07C45/71C07C49/84C07H15/18F61K7/42C07H15/24
    • A61K8/60A61K8/4973A61Q17/04C07C45/71C07C49/84C07H15/18
    • Benzophenone derivatives expressed by the following general expression (1):A(C--B).sub.n (1)wherein A in the above general expression (1) is a residual group obtained by removing one hydroxyl group from sugar or sugar alcohol, andB is a benzophenone group shown by the following general expression (2) ##STR1## wherein R.sub.1 through R.sub.10 each is expressed by hydrogen, hydroxyl group, an alkoxy group, or the aforesaid binder C, and at least one of them is the binder C. In the case of an alkoxy group, preferably the number of carbon atoms is 1 to 4.C is equivalent to --O--R-- (O is oxygen, R is a fatty chain, and the number of carbon atoms therein is preferably 1 to 4), or 1 mole of glycerin with one hydroxyl group therein bound to A and another hydroxyl group to B. The benzophenone derivatives according to the present invention have excellent capability to absorb ultraviolet rays as well as high compatibility with polar solvent. Also the external preparation for skin in which the benzophenone derivatives are mixed can be mixed in a polar base with wide availability for industrial purpose.
    • 由下列通式(1)表示的二苯甲酮衍生物:A(CB)n(1)其中,上述通式(1)中的_A是通过从糖或糖醇中除去一个羟基而得到的残基,_B为 通过氢,羟基,烷氧基或上述粘合剂_C压制的以下通式(2)表示的二苯甲酮基,并且它们中的至少一个是粘合剂_C。 在烷氧基的情况下,优选碳原子数为1〜4。C表示-OR-(_O为氧,-R为脂肪链,其中碳原子数优选为1〜4) ,或1摩尔具有一个羟基的甘油与_A结合,另一个羟基结合成_B。 根据本发明的二苯甲酮衍生物具有优异的吸收紫外线的能力以及与极性溶剂的高相容性。 另外,将二苯甲酮衍生物混合的皮肤外用剂可以混合在极性碱中,具有广泛的工业用途。