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    • 1. 发明授权
    • Sheet forming tool and a method for the manufacture of a corrugated sheet
    • US09517501B2
    • 2016-12-13
    • US14232847
    • 2011-07-21
    • Kimwah ChinXiaolei ShengYang LiLhoden Chothutshang
    • Kimwah ChinXiaolei ShengYang LiLhoden Chothutshang
    • B21D13/02B29C53/24B31F1/24B21D13/10
    • B21D13/02B21D13/10B29C53/24B31F1/247Y10T428/12354
    • A sheet forming tool (1) for the manufacture of a corrugated sheet has a lower tool element (40) and an upper tool element (50), each of the upper tool element and the lower tool element having a front side (23, 33, 41) and a rear side (25, 35, 42). The lower tool element (40) comprises a first base element (2, 4, 6, 8) and a first finger element (3, 5, 7, 9) projecting from said first base element (2, 4, 6, 8). The first finger element (3, 5, 7, 9) forms a first ridge (22, 24, 26, 28) for forming a corrugation peak in the sheet. The upper tool element (50) comprises a second base element (12, 14) and a second finger element (13, 15) projecting from said second base element (12, 14), the second finger element (13, 15) forming a second ridge (32, 34) for forming a corrugation trough in said sheet. The first ridge (22, 24, 26, 28) is arranged opposite to the second ridge (32, 34) and the first ridge (22, 24, 26, 28) is offset from the second ridge (32, 34) so as to allow for an engagement of the first finger element (3, 5, 7, 9) and the second finger element (13, 15) in an engaged position. Each of the first ridge (22, 24, 26, 28) and second ridge (32, 34) comprises a main portion (20) and an end portion (11, 21) and the angle ? (36) between each of the first ridge (22, 24, 26, 28) and second ridge (32, 34) in the main portion (20) and the corresponding front side (23, 33, 41) is at least partly different from the angle between each of the first ridge (22, 24, 26, 28) and second ridge (32, 34) in the end portion (11, 21) and the corresponding front side and a space is provided between the first finger element (3, 5, 7, 9) and the neighboring second finger element (13, 15) in the engaged position.
    • 2. 发明申请
    • Sheet Forming Tool and a Method for the Manufacture of a Corrugated Sheet
    • US20140157856A1
    • 2014-06-12
    • US14232847
    • 2011-07-21
    • Kimwah ChinXiaolei ShengYang LiLhoden Chothutshang
    • Kimwah ChinXiaolei ShengYang LiLhoden Chothutshang
    • B21D13/02
    • B21D13/02B21D13/10B29C53/24B31F1/247Y10T428/12354
    • A sheet forming tool (1) for the manufacture of a corrugated sheet has a lower tool element (40) and an upper tool element (50), each of the upper tool element and the lower tool element having a front side (23, 33, 41) and a rear side (25, 35, 42). The lower tool element (40) comprises a first base element (2, 4, 6, 8) and a first finger element (3, 5, 7, 9) projecting from said first base element (2, 4, 6, 8). The first finger element (3, 5, 7, 9) forms a first ridge (22, 24, 26, 28) for forming a corrugation peak in the sheet. The upper tool element (50) comprises a second base element (12, 14) and a second finger element (13, 15) projecting from said second base element (12, 14), the second finger element (13, 15) forming a second ridge (32, 34) for forming a corrugation trough in said sheet. The first ridge (22, 24, 26, 28) is arranged opposite to the second ridge (32, 34) and the first ridge (22, 24, 26, 28) is offset from the second ridge (32, 34) so as to allow for an engagement of the first finger element (3, 5, 7, 9) and the second finger element (13, 15) in an engaged position. Each of the first ridge (22, 24, 26, 28) and second ridge (32, 34) comprises a main portion (20) and an end portion (11, 21) and the angle ? (36) between each of the first ridge (22, 24, 26, 28) and second ridge (32, 34) in the main portion (20) and the corresponding front side (23, 33, 41) is at least partly different from the angle between each of the first ridge (22, 24, 26, 28) and second ridge (32, 34) in the end portion (11, 21) and the corresponding front side and a space is provided between the first finger element (3, 5, 7, 9) and the neighbouring second finger element (13, 15) in the engaged position.
    • 10. 发明授权
    • Human FGF receptor and β-Klotho binding proteins
    • 人FGF受体和β-Klotho结合蛋白
    • US09517264B2
    • 2016-12-13
    • US13641041
    • 2011-04-13
    • Roger FachiniIan FoltzSeog Joon HanSusie Miki HarrisShaw-Fen Sylvia HuChadwick Terence KingYang LiJi LuMark Leo MichaelsJeonghoon Sun
    • Roger FachiniIan FoltzSeog Joon HanSusie Miki HarrisShaw-Fen Sylvia HuChadwick Terence KingYang LiJi LuMark Leo MichaelsJeonghoon Sun
    • A61K39/395C07K16/28C07K16/40
    • A61K39/3955C07K16/2863C07K16/40C07K2317/21C07K2317/31C07K2317/32C07K2317/75C07K2317/92C07K2319/75
    • The present invention provides compositions and methods relating to or derived from antigen binding proteins and antigen binding protein-FGF21 fusions that specifically bind to β-Klotho, or β-Klotho and one or more of FGFR1c, FGFR2c, FGFR3c, and FGFR4. In some embodiments the antigen binding proteins and antigen binding protein-FGF21 fusions induce FGF21-like signaling. In some embodiments, an antigen binding protein or antigen binding protein-FGF21 fusion antigen binding component is a fully human, humanized, or chimeric antibody, binding fragments and derivatives of such antibodies, and polypeptides that specifically bind to β-Klotho, or β-Klotho and one or more of FGFR1c, FGFR2c, FGFR3c, and FGFR4. Other embodiments provide nucleic acids encoding such antigen binding proteins and antigen binding protein-FGF21 fusions, and fragments and derivatives thereof, and polypeptides, cells comprising such polynucleotides, methods of making such antigen binding proteins and antigen binding protein-FGF21 fusions, and fragments and derivatives thereof, and polypeptides, and methods of using such antigen binding proteins and antigen binding protein-FGF21 fusions, fragments and derivatives thereof, and polypeptides, including methods of treating or diagnosing subjects suffering from type 2 diabetes, obesity, NASH, metabolic syndrome and related disorders or conditions.
    • 本发明提供与抗原结合蛋白和特异性结合β-Klotho或β-Klotho以及FGFR1c,FGFR2c,FGFR3c和FGFR4中的一种或多种的抗原结合蛋白和抗原结合蛋白-FGF21融合相关或衍生的组合物和方法。 在一些实施方案中,抗原结合蛋白和抗原结合蛋白FGF21融合物诱导FGF21样信号传导。 在一些实施方案中,抗原结合蛋白或抗原结合蛋白FGF21融合抗原结合组分是完全人,人源化或嵌合抗体,所述抗体的结合片段和衍生物,以及特异性结合β-Klotho或β- Klotho和FGFR1c,FGFR2c,FGFR3c和FGFR4中的一种或多种。 其他实施方案提供编码这种抗原结合蛋白和抗原结合蛋白-FGF21融合体的核酸,及其片段和衍生物,以及多肽,包含这种多核苷酸的细胞,制备这种抗原结合蛋白的方法和抗原结合蛋白-FGF21融合物, 其衍生物和多肽,以及使用这种抗原结合蛋白和抗原结合蛋白-FGF21融合体,其片段和衍生物和多肽的方法,包括治疗或诊断患有2型糖尿病,肥胖症,NASH,代谢综合征和 相关疾病或病症。