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1. 发明申请

US20090306454A1 Devices and Methods for Stimulation of Tissue 审中-公开
标题翻译：用于刺激组织的装置和方法
公开(公告)号：US20090306454A1
公开(公告)日：2009-12-10
申请号：US12083586
申请日：2006-05-03
申请人： Kimberly P. Cockerham , Harvey A. Fishman , Anthony Liu , Alissa M. Fitzgeral , Dorian Liepmann , Benjamin W. Chul , Michael F. Marmor , Wentai Liu , Juan G. Santiago
发明人： Kimberly P. Cockerham , Harvey A. Fishman , Anthony Liu , Alissa M. Fitzgeral , Dorian Liepmann , Benjamin W. Chul , Michael F. Marmor , Wentai Liu , Juan G. Santiago
IPC分类号： A61N1/36 , A61N2/00
CPC分类号： A61N1/36067 , A61M5/14276 , A61M2205/0244 , A61M2210/0612 , A61N1/0543 , A61N1/36017 , A61N1/36046 , A61N1/37205 , A61N1/37288 , A61N1/375 , A61N1/3787
摘要： Devices, systems and methods are provided for directly stimulating tissues, particularly muscle tissues, to modulate muscle contractions (i.e. provide reanimation of the muscle or to suppress undesired muscle contractions). Reanimation of muscles may be desired when damage to the brain, nervous system or neuromuscular junctions have occurred, causing a muscle tissue to lack sufficient motor control. Suppression of muscle contractions may be desired in situations of pathologically hyperactive muscles, such as in conditions of muscle spasm (e.g. blepharospasm and hemifacial spasm) or muscle dystonia. Direct stimulation is achieved by delivering a chemical agent directly to the muscle tissue, particularly the motor end plate, bypassing the nerves and neuromuscular junctions which may be damaged or diseased. Implanted hybrid chemical and electromagnetic stimulation devices can modulate muscle contraction in response to signals from a controller.
摘要翻译：提供装置，系统和方法用于直接刺激组织，特别是肌肉组织，以调节肌肉收缩（即，提供肌肉的再生或抑制不需要的肌肉收缩）。当发生对脑，神经系统或神经肌肉接头的损伤时，可能需要恢复肌肉，导致肌肉组织缺乏足够的运动控制。在病理性活动过度肌肉的情况下，例如肌肉痉挛（例如睑痉挛和半面肌痉挛）或肌肉肌张力障碍的情况下，可能需要抑制肌肉收缩。直接刺激通过将化学药剂直接递送到肌肉组织，特别是马达端板，绕过可能被损坏或患病的神经和神经肌肉接头来实现。植入式混合化学和电磁刺激装置可以响应于来自控制器的信号来调节肌肉收缩。

2. 发明授权

US10875792B2 System and method for high efficiency electrochemical desalination 有权
公开(公告)号：US10875792B2
公开(公告)日：2020-12-29
申请号：US16418487
申请日：2019-05-21
申请人： Steven Hawks , Michael Stadermann , Juan G. Santiago , Ashwin Ramachandran
发明人： Steven Hawks , Michael Stadermann , Juan G. Santiago , Ashwin Ramachandran
IPC分类号： C02F1/46 , C02F1/469
CPC分类号： C02F1/4691 , C02F2201/46
摘要： The present disclosure relates to a capacitive deionization (CDI) system for desalinating salt water. The system may have a capacitor formed by spaced apart first and second electrodes, which enable a fluid flow containing salt water to pass either between them or through them. An input electrical power source is configured to generate an electrical forcing signal between the two electrodes. The electrical forcing signal represents a periodic signal including at least one of voltage or current, and which can be represented as a Fourier series. One component of the Fourier series is a constant, and a second component of the Fourier series is a sinusoidal wave of non-zero frequency which has the highest amplitude of the additive components of the Fourier series. The amplitude of the sinusoidal wave component is between 0.85 and 1.25 times the amplitude of the periodic signal.

3. 发明授权

US08277628B2 Method and apparatus using electric field for improved biological assays 有权
标题翻译：使用电场改进生物测定的方法和装置
公开(公告)号：US08277628B2
公开(公告)日：2012-10-02
申请号：US12170941
申请日：2008-07-10
申请人： Mostafa Ronaghi , Tarun Khurana , Juan G. Santiago
发明人： Mostafa Ronaghi , Tarun Khurana , Juan G. Santiago
IPC分类号： G01N27/26
CPC分类号： B01L3/502761 , B01J2219/00317 , B01J2219/00459 , B01J2219/00466 , B01J2219/00596 , B01J2219/00648 , B01J2219/00653 , B01J2219/00702 , B01L2200/0668 , B01L2300/0819 , B01L2400/0415
摘要： Disclosed are a method and apparatus that use an electric field for improved biological assays. The electric field is applied across a device having wells, which receive reactants, which carry a charge. The device thus uses a controllable voltage source between the first and second electrodes, which is controllable to provide a positive charge and a negative charge to a given electrode. By controlled use of the electric field charged species in a fluid in a fluid channel are directed into or out of the well by an electric field between the electrodes. The present method involves the transport of fluids, as in a microfluidic device, and the electric field-induced movement of reactive species according to various assay procedures, such as DNA sequencing, synthesis or the like.
摘要翻译：公开了使用电场进行改进的生物测定的方法和装置。电场被施加在具有井的装置上，该装置具有承载电荷的反应物。因此，该器件在第一和第二电极之间使用可控电压源，其可控制以向给定电极提供正电荷和负电荷。通过控制使用流体通道中的流体中的电场带电物质通过电极之间的电场被引导进入或离开阱。本方法涉及如在微流体装置中的流体的运输，以及根据各种测定程序（例如DNA测序，合成等）的反应物种的电场诱导运动。

4. 发明授权

US07951278B2 Method of detecting directly undetectable analytes using directly detectable spacer molecules 有权
标题翻译：使用直接可检测的间隔分子检测直接不可检测的分析物的方法
公开(公告)号：US07951278B2
公开(公告)日：2011-05-31
申请号：US11880479
申请日：2007-07-20
申请人： Juan G. Santiago , Tarun Khurana
发明人： Juan G. Santiago , Tarun Khurana
IPC分类号： G01N27/26
CPC分类号： G01N27/44726
摘要： The present invention provides a method of indirectly detecting at least one directly undetectable analyte of interest. According to the method, a leading electrolyte and a trailing electrolyte are provided. In addition, a mixture of the at least one directly undetectable analyte and at least two directly detectable spacer molecules is provided. The directly detectable spacer molecules and the directly undetectable analyte are then concentrated and separated into zones using isotachophoresis. A displacement between the zones of directly detectable spacer molecules is then used to determine the presence of the directly undetectable analyte.
摘要翻译：本发明提供间接检测至少一种直接不可检测的感兴趣分析物的方法。根据该方法，提供了主要的电解质和拖尾电解质。此外，提供至少一种直接不可检测的分析物和至少两种直接可检测的间隔分子的混合物。然后将直接可检测的间隔基分子和直接不可检测的分析物浓缩并使用等速电泳分离成区域。然后使用直接可检测的间隔分子区域之间的位移来确定直接不可检测的分析物的存在。

5. 发明申请

US20100210029A1 DEVICE AND METHODS OF DETECTION OF AIRBORNE AGENTS 有权
标题翻译：检测飞机代理的装置和方法
公开(公告)号：US20100210029A1
公开(公告)日：2010-08-19
申请号：US12597742
申请日：2008-04-25
申请人： Carl D. Meinhart , Brian Piorek , Seung Joon Lee , Martin Moskovits , Sanjoy Banerjee , Juan G. Santiago
发明人： Carl D. Meinhart , Brian Piorek , Seung Joon Lee , Martin Moskovits , Sanjoy Banerjee , Juan G. Santiago
IPC分类号： G01N21/65 , G01N27/26
CPC分类号： G01N21/658 , G01N21/0332 , G01N21/05 , G01N33/0057 , G01N2021/0346 , G01N2201/06113 , G01N2201/1087 , Y10S977/902
摘要： Provided are methods, devices and systems that utilize free-surface fluidics and SERS for analyte detection with high sensitivity and specificity. The molecules can be airborne agents, including but not limited to explosives, narcotics, hazardous chemicals, or other chemical species. The free-surface fluidic architecture is created using an open microchannel, and exhibits a large surface to volume ratio. The free-surface fluidic interface can filter interferent molecules, while concentrating airborne analyte molecules. The microchannel flow enables controlled aggregation of SERS-active probe particles in the flow, thereby enhancing the detector's sensitivity.
摘要翻译：提供了利用自由表面流体学和SERS用于具有高灵敏度和特异性的分析物检测的方法，装置和系统。分子可以是空气传播剂，包括但不限于爆炸物，麻醉剂，危险化学品或其他化学物质。自由表面流体结构使用开放的微通道产生，并且表现出大的表面与体积比。自由表面流体界面可以过滤干扰分子，同时浓缩空气中的分析物。微通道流动使SERS活性探针颗粒在流动中受控聚集，从而提高检测器的灵敏度。

6. 发明授权

US07316543B2 Electroosmotic micropump with planar features 有权
标题翻译：具有平面特征的Electroosmotic微型泵
公开(公告)号：US07316543B2
公开(公告)日：2008-01-08
申请号：US10449564
申请日：2003-05-30
申请人： Kenneth E. Goodson , Thomas W. Kenny , Juan G. Santiago , Daniel J. Laser , Chuan-Hua Chen
发明人： Kenneth E. Goodson , Thomas W. Kenny , Juan G. Santiago , Daniel J. Laser , Chuan-Hua Chen
IPC分类号： H02K44/00 , H02K44/08 , F04B37/02 , F04F11/00
CPC分类号： F04B19/006 , F04B17/00
摘要： An electroosmotic micropump having a plurality of thin, closely-spaced, approximately planar, transversel aligned partitions formed in or on a substrate, among which electroosmotic flow (EOF) is generated. Electrodes are located within enclosed inlet and outlet manifolds on either side of the partition array. Inlet and outlet ports enable fluid to be pumped into and through the micropump and through an external friction load or head. Insulating layer coatings on the formed substrate limit substrate leakage current during pumping operation.
摘要翻译：一种具有形成在基底中或基底上的多个薄的，紧密间隔的大致平面的横向对准的隔离物的电渗微型泵，其中产生电渗流（EOF）。电极位于分隔阵列任一侧封闭的入口和出口歧管内。入口和出口端口使流体能够泵入并穿过微型泵并通过外部摩擦负载或头部。所形成的衬底上的绝缘层涂层在泵送操作期间限制衬底漏电流。

7. 发明授权

US07131486B2 Electroosmotic microchannel cooling system 有权
公开(公告)号：US07131486B2
公开(公告)日：2006-11-07
申请号：US10385086
申请日：2003-03-10
申请人： Kenneth E. Goodson , Chuan-Hua Chen , David E. Huber , Linan Jiang , Thomas W. Kenny , Jae-Mo Koo , Daniel J. Laser , James C. Mikkelsen , Juan G. Santiago , Evelyn Ning-Yi Wang , Shulin Zeng , Lian Zhang
发明人： Kenneth E. Goodson , Chuan-Hua Chen , David E. Huber , Linan Jiang , Thomas W. Kenny , Jae-Mo Koo , Daniel J. Laser , James C. Mikkelsen , Juan G. Santiago , Evelyn Ning-Yi Wang , Shulin Zeng , Lian Zhang
IPC分类号： F28F7/00
CPC分类号： H01L23/473 , F04B19/006 , F28D15/00 , F28F2260/02 , H01L2224/16225 , H01L2224/32145 , H01L2224/32225 , H01L2224/45169 , H01L2224/48227 , H01L2224/73265 , H01L2225/06562 , H01L2924/01078 , H01L2924/01322 , H01L2924/09701 , H01L2924/10158 , H01L2924/10253 , H01L2924/1461 , H01L2924/3011 , H01L2924/00
摘要： Apparatus and methods according to the present invention preferably utilize electroosmotic pumps that are capable of generating high pressure and flow without moving mechanical parts and the associated generation of unacceptable electrical and acoustic noise, as well as the associated reduction in reliability. These electroosmotic pumps are preferably fabricated with materials and structures that improve performance, efficiency, and reduce weight and manufacturing cost relative to presently available micropumps. These electroosmotic pumps also preferably allow for recapture of evolved gases and deposited materials, which may provide for long-term closed-loop operation. Apparatus and methods according to the present invention also allow active regulation of the temperature of the device through electrical control of the flow through the pump and can utilize multiple cooling loops to allow independent regulation of the special and temporal characteristics of the device temperature profiles. Novel microchannel structures are also described.

8. 发明授权

US07057198B2 Depth-of-field micron resolution velocimetry with pulsed images of injected solid particles 有权
标题翻译：使用注入固体颗粒的脉冲图像进行深度微米分辨率测速
公开(公告)号：US07057198B2
公开(公告)日：2006-06-06
申请号：US10713672
申请日：2003-11-13
申请人： Carl D. Meinhart , Juan G. Santiago , Ronald J. Adrian , Steve T. Wereley
发明人： Carl D. Meinhart , Juan G. Santiago , Ronald J. Adrian , Steve T. Wereley
IPC分类号： G01N15/06
CPC分类号： G01N15/1427 , G01F1/712 , G01N15/1459 , G01N15/1463 , G01N2015/1075 , G01N2015/1447
摘要： Method and apparatus for measuring fluid motion with micron scale spatial resolution, in which fluorescent particles are injected into a fluid body in a test device, the test device is broadly illuminated with pulses of light at the excitation frequency of the fluorescent particles, the fluorescent light is collected by a microscope objective lens, and the light thus collected is relayed through a fluorescent filter to an image recording device, the depth of field of the objective lens defining the thickness of a two-dimensional measurement plane.
摘要翻译：用于以微米尺度空间分辨率测量流体运动的方法和装置，其中将荧光颗粒注入到测试装置中的流体中，测试装置被广泛地用荧光颗粒的激发频率的光脉冲照射，荧光灯由显微镜物镜收集，并且将如此收集的光通过荧光过滤器中继到图像记录装置，物镜的景深限定二维测量平面的厚度。

9. 发明申请

US20150191717A1 SIMULTANEOUS EXTRACTION AND SEPARATION OF RNA AND DNA FROM SINGLE CELLS USING ELECTROPHORETIC TECHNIQUES 审中-公开
标题翻译：使用电泳技术从单细胞中同时提取和分离RNA和DNA
公开(公告)号：US20150191717A1
公开(公告)日：2015-07-09
申请号：US14593925
申请日：2015-01-09
申请人： Juan G. Santiago , Hirofumi Shintaku
发明人： Juan G. Santiago , Hirofumi Shintaku
IPC分类号： C12N15/10 , G01N27/447 , C12Q1/68
CPC分类号： A61B1/00009 , A61B1/0005 , A61B1/05 , A61B1/0676 , C12N15/101 , C12Q1/6806 , G01N27/44791 , G06T7/0016 , G06T7/254 , G06T2207/10068 , G06T2207/30032 , C12Q2565/125 , C12Q2565/629
摘要： Devices and methods for preparing RNA and DNA from single cells are disclosed. In particular, the invention relates to a method of simultaneously extracting RNA and DNA from single cells and separating the nucleic acids electrophoretically. An electric field is used to lyse a single target cell, such that the plasma membrane is selectively disrupted without lysing the nuclear membrane. Cytoplasmic RNA is separated from the nucleus by performing isotachophoresis (ITP) in the presence of a sieving matrix that preferentially reduces the mobility of the nucleus. During ITP, the cytoplasmic RNA accumulates at an ITP interface between leading and trailing electrolytes and can later be extracted free of nuclear DNA. The method can be performed in a microfluidic device that fully automates all steps of the process.
摘要翻译：公开了从单细胞制备RNA和DNA的装置和方法。特别地，本发明涉及从单个细胞同时提取RNA和DNA并且电泳分离核酸的方法。电场用于裂解单个靶细胞，使得质膜选择性地破裂而不裂解核膜。在筛选基质的存在下，通过进行等速电泳（ITP），从细胞质中分离细胞质RNA，其优先降低细胞核的迁移率。在ITP期间，细胞质RNA在前导电解质和尾部电解质之间的ITP界面处积累，并且可以随后被提取而不含核DNA。该方法可以在完全自动化该过程的所有步骤的微流体装置中进行。

10. 发明申请

US20130008789A1 METHOD AND APPARATUS USING ELECTRIC FIELD FOR IMPROVED BIOLOGICAL ASSAYS 失效
标题翻译：使用电场改进生物测定的方法和装置
公开(公告)号：US20130008789A1
公开(公告)日：2013-01-10
申请号：US13618228
申请日：2012-09-14
申请人： Mostafa Ronaghi , Tarun Khurana , Juan G. Santiago
发明人： Mostafa Ronaghi , Tarun Khurana , Juan G. Santiago
IPC分类号： B03C7/02 , B81B1/00
CPC分类号： B01L3/502761 , B01J2219/00317 , B01J2219/00459 , B01J2219/00466 , B01J2219/00596 , B01J2219/00648 , B01J2219/00653 , B01J2219/00702 , B01L2200/0668 , B01L2300/0819 , B01L2400/0415
摘要： Disclosed are a method and apparatus that use an electric field for improved biological assays. The electric field is applied across a device having wells, which receive reactants, which carry a charge. The device thus uses a controllable voltage source between the first and second electrodes, which is controllable to provide a positive charge and a negative charge to a given electrode. By controlled use of the electric field charged species in a fluid in a fluid channel are directed into or out of the well by an electric field between the electrodes. The present method involves the transport of fluids, as in a microfluidic device, and the electric field-induced movement of reactive species according to various assay procedures, such as DNA sequencing, synthesis or the like.
摘要翻译：公开了使用电场进行改进的生物测定的方法和装置。电场被施加在具有井的装置上，该装置具有承载电荷的反应物。因此，该器件在第一和第二电极之间使用可控电压源，其可控制以向给定电极提供正电荷和负电荷。通过控制使用流体通道中的流体中的电场带电物质通过电极之间的电场被引导进入或离开阱。本方法涉及如在微流体装置中的流体的运输，以及根据各种测定程序（例如DNA测序，合成等）的反应物种的电场诱导运动。

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